Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 , You know it I'll finish... Just sometimes time draggs a bit. Am takin 1,200 riba at a weight of 168 which is 15.7mg/kg. The weight based cut off for cutting 1,200 down to 1,000 is 187. A typical riba dose is 13mg/kg so I'm 20% higher than that. I have an awful high dose of the riba but I love the stuff. Think I'll ask if I can take more. Mike > > Hot dam Mike ,if i can make 18 months and you can satisfy a 28 yr old theirs an = in their some where . Youll finish, at 48 its not that bad . Why hell if ya brought that 28 year old up for a roll ide probably have a heart attack for real . > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 , If the wife rolled me I'd have a heart attack out of shock too. Don't even remember if it was good or not it was so long ago. LMAO Mike - In Hepatitis C , eric snyder <1122snyder@v...> wrote: > > Hot dam Mike ,if i can make 18 months and you can satisfy a 28 yr old theirs an = in their some where . Youll finish, at 48 its not that bad . Why hell if ya brought that 28 year old up for a roll ide probably have a heart attack for real . > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 Mike, You're a sick puppy! You restore my faith in human kind. Sally <not requesting additional riba for recreational use> (actually, I still have a few of the Mexican Riba caps) Re: Status , You know it I'll finish... Just sometimes time draggs a bit. Am takin 1,200 riba at a weight of 168 which is 15.7mg/kg. The weight based cut off for cutting 1,200 down to 1,000 is 187. A typical riba dose is 13mg/kg so I'm 20% higher than that. I have an awful high dose of the riba but I love the stuff. Think I'll ask if I can take more. Mike > > Hot dam Mike ,if i can make 18 months and you can satisfy a 28 yr old theirs an = in their some where . Youll finish, at 48 its not that bad . Why hell if ya brought that 28 year old up for a roll ide probably have a heart attack for real . > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 You go for that before-treatment fling, I guarantee your libido will take a hit from the meds. Still, I remember when I did get some fooling around during treatment, it sure helped my temper. I'd be nice and calm for a couple of days. . . Michele PS If you've done the combo before, this won't be too different. My girlfriend was on a trial of real high doses of the combo, since she'd not responded to earlier treatment, and it was really hard on her. At 6 months she still was positive so I advocated for getting off the treatment, but she was stubborn and by the end of treatment she was negative! And still is 2 years after. It just takes dogged stubborness, not bravery, to get through this. Oh yeah, and not killing yourself, that helps too! I was supposed to see my hepGod last month but " forgot " because I know she'll put me on some new form of torture and my spirit quails at the thought. But it's not like I feel that great anyhow so I might as well jump all the way in The Lake of Torment. Sigh! We can whine to eachother, oK? __________________________________________ DSL – Something to write home about. Just $16.99/mo. or less. dsl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 Michele, Yes, I've been down the road before, and even was non-detected at 12 weeks, but then the damm.. er danged stuff came back, and with a vengance! Oh, Riba does such ugly things to my temper. Like you, not tantrums, but snide and snippy. Just heard from the pharmacy. They have to special order the juice <I knew that> and the riba seems to be a standard dose for the less than rubenesque such as myself. I'll have to speak to the doc about that. Do you guys know, is there any harm in starting out lower on Riba and boosting it up after a few weeks? I'm your support, Michele. Anything my snide and snippy self can do to help. Sally RE: Status You go for that before-treatment fling, I guarantee your libido will take a hit from the meds. Still, I remember when I did get some fooling around during treatment, it sure helped my temper. I'd be nice and calm for a couple of days. . . Michele PS If you've done the combo before, this won't be too different. My girlfriend was on a trial of real high doses of the combo, since she'd not responded to earlier treatment, and it was really hard on her. At 6 months she still was positive so I advocated for getting off the treatment, but she was stubborn and by the end of treatment she was negative! And still is 2 years after. It just takes dogged stubborness, not bravery, to get through this. Oh yeah, and not killing yourself, that helps too! I was supposed to see my hepGod last month but " forgot " because I know she'll put me on some new form of torture and my spirit quails at the thought. But it's not like I feel that great anyhow so I might as well jump all the way in The Lake of Torment. Sigh! We can whine to eachother, oK? __________________________________________ DSL - Something to write home about. Just $16.99/mo. or less. dsl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 Sally, Think you want riba nice and high to start with the quicker you hit undetectable the more likely to stay clear. They call it viral kenetics in the lit and it means the speed of the drop in HCV/liter. Viral kenetics dude it's all the rage now... Makes sense cause the fewer bugs the fewer that can mutate into treatment resistant. Standard dose? 1,200 or 1,000? typical break point is about 187 lbs. The lighter you are for your dose range the higher the odds of svr. It will also help you to stay PO all the time which is what I like about it. Once you get on TX we can share wall punching techniques. Mike > > Michele, > > Yes, I've been down the road before, and even was non-detected at 12 weeks, > but then the damm.. er danged stuff came back, and with a vengance! > > Oh, Riba does such ugly things to my temper. Like you, not tantrums, but > snide and snippy. > > Just heard from the pharmacy. They have to special order the juice <I knew > that> and the riba seems to be a standard dose for the less than rubenesque > such as myself. I'll have to speak to the doc about that. Do you guys know, > is there any harm in starting out lower on Riba and boosting it up after a > few weeks? > > I'm your support, Michele. Anything my snide and snippy self can do to help. > > > Sally > > RE: Status > > > You go for that before-treatment fling, I guarantee > your libido will take a hit from the meds. Still, I > remember when I did get some fooling around during > treatment, it sure helped my temper. I'd be nice and > calm for a couple of days. . . > > Michele > > PS If you've done the combo before, this won't be too different. My > girlfriend was on a trial of real high doses of the combo, since she'd not > responded to earlier treatment, and it was really hard on her. At 6 months > she still was positive so I advocated for getting off the treatment, but she > was stubborn and by the end of treatment she was negative! And still is 2 > years after. It just takes dogged stubborness, not bravery, to get through > this. Oh yeah, and not > killing yourself, that helps too! > > I was supposed to see my hepGod last month but > " forgot " because I know she'll put me on some new form > of torture and my spirit quails at the thought. But > it's not like I feel that great anyhow so I might as > well jump all the way in The Lake of Torment. Sigh! We > can whine to eachother, oK? > > > > > __________________________________________ > DSL - Something to write home about. > Just $16.99/mo. or less. > dsl. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 Mike even though tx and your sit suck you still maintan a good humor about all this crap thinking back i dont know if i could have reacted the same ,in the begining tx gave me a bad something i was quick on somebodys case, in the middle and end i was too tired to care by then i had went from 180 lbs to 130 lbs i figure i couda forced another month or 2 maybe even 2 yrs with a 20% dose reduction for a month but the way me and my lab folks had it figured the 18 months was enough .If i were you i would get a pcr at 2 weeks when you end tx and 1 month that way if you show pos you can jump back on tx for a few more months with out having to start from 0 point Usually if you can make a 2 week clean pcr and a clean1 month pcr you got it If ida shone pos at the end of 18 months i planned to do the last 4 on infergen sure glad it didnt come to that cause the way we saw it at work if 2 yrs didnt do it ide ah had to wait for another tx which in my case was no problem but using a few tricks learned on the job and takeing the riba as stated on the product info slip which no docs seem to read , you get a 70% better up take taken with 50 grms fat 50 grms carbs 50 grms protein, so at pill time i would have what ever fit the bill i think my favorite was peanut butter and beer ,but i had several combos sometimes a couple of those canned milkshakes to keep weight on or a nice tv dinner anthying to come close to fitting that bill. At 3 points my riba levels were so hi me and doc cut the crap back to 2 pills a day for a week each time . His reply was it does make 1 hell of a difference dosent it. And i swore to myself whatever it took to get it the 1st time i would do. It was real important not to give this virus a chance to gain any restisance to meds and a 2nd round would have meant the virus had the resistance factor on its side and that was one thing i wanted to avoid at all cost .Just about everything i did was planned with alot of research and common sense before the start of tx .I did have a heads up that helped working in the right place at right time and i guess some luck . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 6, 2006 Report Share Posted January 6, 2006 The last treatment I went through, I didn't start the Riba until 6 months in (my MD says I don't tolerate it too well, glad she noticed) but my viral rate dropped to undetectable in 12 weeks on the interferon ONLY. I understand that the interferon kills the virus off, and the Ribavirin keeps new viruses from forming. Anyway, it was a blessing for me not to have to be on the Riba the whole time. When I did start, I had to start Procrit too, because my hemoglobin went to 8, my platelets went down to 50, my white blood count went down to 2.8 and my albumin down to 3.0. I developed that high-in-the chest congestion and shortness of breath so typical for Riba users, and had to take Zofran (a chemo side-effect drug) to keep from vomiting all the time. Oh what fun! And that was at 80mg per day, all I could tolerate. I started out at 1200 mg per day, and it got taken down to that. I just don't do well with it. Or it with me, whatever. . . I agree the faster your viral count drops, the better the overall lookout. What I don't understand is how mine could drop so fast (the second treatment it went to undetectable in 4 weeks out of 52 weeks of treatment) and still relapse 2 months after the end of treatment. Damn! I'm ready for those wall-punching lessons any time, treatment or no! Michele __________________________________________ DSL – Something to write home about. Just $16.99/mo. or less. dsl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Hay Michele ,thats a bad break but i bet you have had this hcv for many years like me .The liver is a big organ and that is where the hep mainly resides, as it is damaged its harder for the drugs to penetrate even with a good liver it can take some time to completly saturate and that is what has to happin. Just 1 infected cell left starts the whole thing all over.72 weeks seems to be the magic mark that was the mark i figured out when working in the bio lab and i have been watching these forums lateley and non responders and relapsers are doing great with the 18 month tx finally getting svr .I jumped on your judgement about your docs being so good because their are very few reasons a person like yourself should still be positive thats why i tell people to get a pcr 2 nd week off tx 1 month 2month 3 month up to 7 that way if you relaps you can restart tx right away with out any ground lost for people like you who respond its just a matter of time till you svr .At month 4 for me i still had 69,000 viruses per cc/ml and they were tough i used every trick i learned in the research lab to to get them. Then it was just a little math to know how long i would have to tx . The things i used to come up with a plan factored in things like month of 1st neg pcr 7 months for me ,shape of liver viral rep rates, viral type, that hardened 69,000 virus that didnt want to give in so easy,, math and research stats from other studies looking at the half life of the pegintron which dosent make 7 days in most people so what do ya do about that easy .Back up plans in case of relaps ,if i would have relapsed at end of 18 months i planned on doing another 4,5, months on infergen that would have brought me to the 2 yr mark which i straped in for anyway but luckely didnt have to do .I thought i might as well do the time up front 1 shot with everything i had ,if that hadent worked i knew i would have to wait for the next generation meds or go alternative like with the angstrom silver looking back i could kick myself now for not using that 1st no sides . I did alot of hard core research into that some people think its a hoax and i can assure you its not silver preps are listed in the U.S.formulary and pharmacopia until the mid 70s and go way back i have some of the U.S. formularys and pharmacopias here with perscribers info the whats and hows it was used ,the only reason its not in use today is it cant be patented and the big drug companys sucker us for billions with replacement patented expensive drugs . One still in use that works great is silver sulfadiazine burn cream i had a couple of serious welding burns and that made quick work of them no nastys penetrate that and you know how easy burns get infected ,this cream is by perscription . I know you dont beleive in these things and you want to see studies on this vs hcv but their will never be any ,inf and rib tx costs about $40,000 a year vs $2000 to $3000 for silver products and who do you think puts all the negitive adds on this ,if the hcv public knew about this guess who loses billions ,people getting tx 2,3, 4 times ,theirs $200 thousand. They will do what ever it takes to keep people like you in dought, but in general all the evadence is right in front of you if ya know where to look .I know the way the game is played i helped em play it squeing studies to make the outcome look good when we all knew it sucked but they payed for that outcome people think the F.D.A.does these studies, the drug companys do them and present their and i mean their results to the F.D.A. hence all the law suites like vioxx bextra celebrex to name a few recent ,they were all garbage studies done and paid for by the drug companies. So they pay out 50 million in law suites they made billions on that garbage in the years it was out. Last i saw Schering the makers of pegintron and the patent holders on ribavirin made 10 billion last yr .I thought they were stupid for selling the patent on ribavirin they had the market to them selves ,later i found out they will shortley have the next drug for the hcv cocktail and be on top again not so dum after all . Hope ya didnt take me knocking your docs too hard it just burns me up to hear stories like yours knowing the svr was taken from you its a damm shame to say the least .. eric Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Michelel, Can you try the new ribavarin replacement it should be available soon. It's for people like you that can't take the riba. If you'd had a good riba dose I bet you'd have svr. What a shame to go thru all that. How a bout amatadine and INF. I think the Italians are still doing studies it's not as good as riba but no sides and better than INF alone. mike > > Hay Michele ,thats a bad break but i bet you have had this hcv for many years like me .The liver is a big organ and that is where the hep mainly resides, as it is damaged its harder for the drugs to penetrate even with a good liver it can take some time to completly saturate and that is what has to happin. Just 1 infected cell left starts the whole thing all over.72 weeks seems to be the magic mark that was the mark i figured out when working in the bio lab and i have been watching these forums lateley and non responders and relapsers are doing great with the 18 month tx finally getting svr .I jumped on your judgement about your docs being so good because their are very few reasons a person like yourself should still be positive thats why i tell people to get a pcr 2 nd week off tx 1 month 2month 3 month up to 7 that way if you relaps you can restart tx right away with out any ground lost for people like you who respond its just a matter of time till you svr .At month 4 for me i > still had 69,000 viruses per cc/ml and they were tough i used every trick i learned in the research lab to to get them. Then it was just a little math to know how long i would have to tx . The things i used to come up with a plan factored in things like month of 1st neg pcr 7 months for me ,shape of liver viral rep rates, viral type, that hardened 69,000 virus that didnt want to give in so easy,, math and research stats from other studies looking at the half life of the pegintron which dosent make 7 days in most people so what do ya do about that easy .Back up plans in case of relaps ,if i would have relapsed at end of 18 months i planned on doing another 4,5, months on infergen that would have brought me to the 2 yr mark which i straped in for anyway but luckely didnt have to do .I thought i might as well do the time up front 1 shot with everything i had ,if that hadent worked i knew i would have to wait for the next generation meds or go alternative like with the angstrom silver > looking back i could kick myself now for not using that 1st no sides . I did alot of hard core research into that some people think its a hoax and i can assure you its not silver preps are listed in the U.S.formulary and pharmacopia until the mid 70s and go way back i have some of the U.S. formularys and pharmacopias here with perscribers info the whats and hows it was used ,the only reason its not in use today is it cant be patented and the big drug companys sucker us for billions with replacement patented expensive drugs . One still in use that works great is silver sulfadiazine burn cream i had a couple of serious welding burns and that made quick work of them no nastys penetrate that and you know how easy burns get infected ,this cream is by perscription . I know you dont beleive in these things and you want to see studies on this vs hcv but their will never be any ,inf and rib tx costs about $40,000 a year vs $2000 to $3000 for silver products and who do you think puts all the > negitive adds on this ,if the hcv public knew about this guess who loses billions ,people getting tx 2,3, 4 times ,theirs $200 thousand. They will do what ever it takes to keep people like you in dought, but in general all the evadence is right in front of you if ya know where to look .I know the way the game is played i helped em play it squeing studies to make the outcome look good when we all knew it sucked but they payed for that outcome people think the F.D.A.does these studies, the drug companys do them and present their and i mean their results to the F.D.A. hence all the law suites like vioxx bextra celebrex to name a few recent ,they were all garbage studies done and paid for by the drug companies. So they pay out 50 million in law suites they made billions on that garbage in the years it was out. Last i saw Schering the makers of pegintron and the patent holders on ribavirin made 10 billion last yr .I thought they were stupid for selling the patent on ribavirin they had > the market to them selves ,later i found out they will shortley have the next drug for the hcv cocktail and be on top again not so dum after all . Hope ya didnt take me knocking your docs too hard it just burns me up to hear stories like yours knowing the svr was taken from you its a damm shame to say the least . eric > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Thanks, I'll mention it to my HepGod when I see her. MK --- mike <hope_chem_survive@...> wrote: > Michelel, > > Can you try the new ribavarin replacement it should > be available > soon. It's for people like you that can't take the > riba. If you'd > had a good riba dose I bet you'd have svr. What a > shame to go thru > all that. How a bout amatadine and INF. I think > the Italians are > still doing studies it's not as good as riba but no > sides and better > than INF alone. > > mike > > > > > > > > Hay Michele ,thats a bad break but i bet you > have had this hcv > for many years like me .The liver is a big organ and > that is where > the hep mainly resides, as it is damaged its harder > for the drugs to > penetrate even with a good liver it can take some > time to completly > saturate and that is what has to happin. Just 1 > infected cell left > starts the whole thing all over.72 weeks seems to be > the magic mark > that was the mark i figured out when working in the > bio lab and i > have been watching these forums lateley and non > responders and > relapsers are doing great with the 18 month tx > finally getting svr .I > jumped on your judgement about your docs being so > good because their > are very few reasons a person like yourself should > still be positive > thats why i tell people to get a pcr 2 nd week off > tx 1 month 2month > 3 month up to 7 that way if you relaps you can > restart tx right away > with out any ground lost for people like you who > respond its just a > matter of time till you svr .At month 4 for me i > > still had 69,000 viruses per cc/ml and they were > tough i used > every trick i learned in the research lab to to get > them. Then it was > just a little math to know how long i would have to > tx . The things i > used to come up with a plan factored in things like > month of 1st neg > pcr 7 months for me ,shape of liver viral rep rates, > viral type, that > hardened 69,000 virus that didnt want to give in so > easy,, math and > research stats from other studies looking at the > half life of the > pegintron which dosent make 7 days in most people so > what do ya do > about that easy .Back up plans in case of relaps ,if > i would have > relapsed at end of 18 months i planned on doing > another 4,5, months > on infergen that would have brought me to the 2 yr > mark which i > straped in for anyway but luckely didnt have to do > .I thought i might > as well do the time up front 1 shot with everything > i had ,if that > hadent worked i knew i would have to wait for the > next generation > meds or go alternative like with the angstrom silver > > looking back i could kick myself now for not > using that 1st no > sides . I did alot of hard core research into that > some people think > its a hoax and i can assure you its not silver preps > are listed in > the U.S.formulary and pharmacopia until the mid 70s > and go way back i > have some of the U.S. formularys and pharmacopias > here with > perscribers info the whats and hows it was used ,the > only reason its > not in use today is it cant be patented and the big > drug companys > sucker us for billions with replacement patented > expensive drugs . > One still in use that works great is silver > sulfadiazine burn cream i > had a couple of serious welding burns and that made > quick work of > them no nastys penetrate that and you know how easy > burns get > infected ,this cream is by perscription . I know you > dont beleive in > these things and you want to see studies on this vs > hcv but their > will never be any ,inf and rib tx costs about > $40,000 a year vs $2000 > to $3000 for silver products and who do you think > puts all the > > negitive adds on this ,if the hcv public knew > about this guess who > loses billions ,people getting tx 2,3, 4 times > ,theirs $200 > thousand. They will do what ever it takes to keep > people like you in > dought, but in general all the evadence is right in > front of you if > ya know where to look .I know the way the game is > played i helped em > play it squeing studies to make the outcome look > good when we all > knew it sucked but they payed for that outcome > people think the > F.D.A.does these studies, the drug companys do them > and present their > and i mean their results to the F.D.A. hence all the > law suites like > vioxx bextra celebrex to name a few recent ,they > were all garbage > studies done and paid for by the drug companies. So > they pay out 50 > million in law suites they made billions on that > garbage in the > years it was out. Last i saw Schering the makers of > pegintron and the > patent holders on ribavirin made 10 billion last yr > .I thought they > were stupid for selling the patent on ribavirin they > had > > the market to them selves ,later i found out they > will shortley > have the next drug for the hcv cocktail and be on > top again not so > dum after all . Hope ya didnt take me knocking your > docs too hard it > just burns me up to hear stories like yours knowing > the svr was taken > from you its a damm shame to say the least . eric > > > > > > > > > > > > [Non-text portions of this message have been > removed] > > > > > > > __________________________________________ DSL – Something to write home about. Just $16.99/mo. or less. dsl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Michele,You were so close, had you have jumped right back into tx soon as you converted to pos ,say 4 to 6 months of additional tx you wouldnt be having this chat but thanks to your excelent docs they let you miss the boat . That is truley a god damm shame . But as i said you got nothing to loose with the altertinives just get a base line pcr take the stuff for 4 months get another pcr if no result can it .The angstrom silver droped my count from 3 million copys per cc/ml to 750 ,000 per cc/ml in 8 months, fact ,no need to ask hep god seems like they pointed you in the wrong direction anyway. Looking at your tx it just burns me up ,you were so close just 1 more little push and no more monster . But those docs most of them are like that ,and with no input from you thats where it ended sad .I wish i had your docs name because i would have something to say to them .By the way im sure you know they have boosters for reds whites and platelets and weed for sides or you can go the script route as you did but the good ol weed works best . Sincerly Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Mike ,you know the higher doses of ribavirin cause more bone marro surpression . When i started i used 1000 mgs per day and taking with the right diet ,my levels got so hi i had to cut back 3 times but only had trouble with reds at 8 months[ procritt] whites were down towards end 18 months. But in most extra riba causes bone marrow surpression.Watch it, as long as your blood can take it go for it but for Jane ,Dick and Tom the outcome is a bad cbc usually . I was thinkin that riba is some bad shit if i had to do it again ide use aceatone instead of riba or maybe cosmoline and xylene ,what do ya think. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally ,stick with the doseing on the product info any extra ribavirin can cause bone marrow surpression which this drug is famous for anyway ,you dont want your cbc to go to hell ,thats a good reason to stop tx and riba by weight is tough enough. Take it with the right diet and youll be ok ,the weed works wonders for sides . IM WITH YA on this one any problems give me an E Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 , The dosage of Riba the doc gave me, 1200mg, is for an average weight person. I'm about double that. Sally Re: Status Sally ,stick with the doseing on the product info any extra ribavirin can cause bone marrow surpression which this drug is famous for anyway ,you dont want your cbc to go to hell ,thats a good reason to stop tx and riba by weight is tough enough. Take it with the right diet and youll be ok ,the weed works wonders for sides . IM WITH YA on this one any problems give me an E Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally you should not have any real worries now . For the time being watch for your 1st clear pcr then add 1 yr and as i said when tx stops moniter your pcr closely 2 week 1 month up to 7 so if you convert to pos you can get right back on tx with no ground lost. I know you dont want to start from 0 point ,so if ya gotta do an extra 4 ,6 months its worth it plus i droped my ph to 4.5 most days makeing my little house for those boys not so hospitable ,but that was after my 4 month pcr and things were not looking so easy ,that last 69,000 took me another 4 months to clear they were some battle hardened boys but i turned the heat up on em and they decieded it was not to comefy so they split ,from that point it was just a matter of time on tx ,ask your doc ever heard of anyone takeing 8 months to clear and then svr for 33 months type 1b 25 yr old infection ,you know that virus was through and through my liver and i knew ide need the extra time for drugs to penetrate my whole liver just 1 infected cell bursting with thousands of copys of the virus un monitered and i was in trouble hence the careful monitoring at tx end . damm shame about michele had i have only known what went on she was so close ida given her the same advice and followed she would have svr her damm doc c s er Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally, Yeha, it's based on one single study in the US. We don't really have weight dosing in the US. I read the study and disagreed with the US conclusions. In Europe smarter statisticians reviewed the data and use real weight based doses. In the US we use 1,000mg or 1,200mg with peg INF for geno 1. Lower doses of Riba per body weight mean lower SVR rates. Check out the studies on riba dose, SVR's for low riba usually start in the 20s and go up to high 40s or 50 for geno 1. Heavy people get screwed in the TX in the US cause they don't give em enough riba to stay clear. Like says the latest guidelines are for 36 weeks of treatment after no HCV RNA detected. Doses below about 10mg/kg are way too weak for genotype 1. A dose of 13mg/kg is a normal weight based dose for an average weight person. With the bad liver and older age you probably need every chance you can get and all you can do is baby yourself and eat as much riba as you can stand. I'm almost up to 16mg/kg and plan to cut back to 15mg/kg. Yeah, I know it's killing my bone marrow but I can regrow all the bone marrow I need after svr. Who needs bone marrow anyway bone marrow is for sissies. Since you did not give me your weight I calculated weight based doses based on 1,200. No sane person should be up around 16mg/kg like me without weekly medical testing but I'm totally bonkers and want to live real bad. You might figure out something with the old riba and my weight based calculations to get a dose of say 13/mg/kg to 14mg/kg which will give you a chance and is on the high side but with in weight based guide lines. I hate the thought of you going through tx with lousy odds of svr just because of some piss poor data analysis in the US. Here is a weight based dose table for 1,200. Doses below Weight Dose mg/kg 400 1,200 6.60 375 1,200 7.04 350 1,200 7.54 325 1,200 8.12 300 1,200 8.80 275 1,200 9.60 250 1,200 10.56 225 1,200 11.73 200 1,200 13.20 187 1,200 14.12 168 1,200 15.71 Note that if you weigh more than 225lbs your dose is just too low. That's me at the bottom at 168lbs. Here are some doses that put various weight levels near 13mg/kg. I don't know if these high doses are right for folks who are heavy. The relationship between weight and dose needed may not be linear and thus not applicable for the extreems. I'd get a European doc or European Dose Guide Lines to tell me how much to take and than get out the old Mexican Riba and figure out how long it will last at the proper weight based dose. Weight Dose mg/kg 400 2,300 12.65 375 2,200 12.91 350 2,100 13.20 325 1,900 12.86 300 1,800 13.20 275 1,600 12.80 250 1,500 13.20 225 1,300 12.71 200 1,200 13.20 187 1,200 14.12 168 1,200 15.71 All the research I did pre treatment showed the more riba/weight the better the results. I actually tried to take 1,300 per day but could not hang with it at my weight of 180lbs. Could not sleep and got all itchy which is happening again. Mike > > , > > The dosage of Riba the doc gave me, 1200mg, is for an average weight person. > I'm about double that. > > Sally > > Re: Status > > > Sally ,stick with the doseing on the product info any extra ribavirin can > cause bone marrow surpression which this drug is famous for anyway ,you dont > want your cbc to go to hell ,thats a good reason to stop tx and riba by > weight is tough enough. Take it with the right diet and youll be ok ,the > weed works wonders for sides . IM WITH YA on this one any problems give me > an E > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Ha Mike ,the bone marrow surpression is a now thing ya know the bone marrow makes your reds whites and a host of other crap its not being eaten away it just kinda gets lazy.About 1000 mgs was all i could take.Any more surpression and a tx stop could be in future its a balanceing game.At group in MD that is the main complaint that riba is kicking my butt or messing up my cbc . I stuck to my dose of 120 mcgs and 1000mgs of riba even though through tx i was alaways losing weight started at 180 and ended at 130 i figured the lower weight and higher dose for a 180 pounder my starting weight,couldnt hurt unless it cut into my cbcs or made me any more under the weather so to say ,and here i sit all by my lonesom sept for k 9er and hes talkin about goin out for some strange ,i might have to do the same sounds like a good idea. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally, remember that 20 yr old some of you were kinda of teasing ,turns out she got hep as a new born through a transfusion and really is stage 4 ,goes by darker goddess .I asked a friend on another forum and they say as far as they know its true ,the poor kid has something to worry about . Hell i dont give a dam about dying at 47 i figure i have pretty much seen the world and its offerings but at 20 shes seen nothing . Not a damm thing fair about this life . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 HEY Mike and : They did two bone marrow biopsies on me when they were trying to diagnose what I had, and my bone marrow was doing really well, putting out plenty of cells. What happened to make my plateleet and white blood cells so low was my spleen was enlarged from backed-up blood that couldn't get through my scarred liver, and the enlarged spleen became more active and killed the cells off. They called it Pancytopenia. The Riba did lower my red blood count, though, and I had to take a Procrit every week. Just telling you how it was for me. . . Michele > Ha Mike ,the bone marrow surpression is a now thing > ya know the bone marrow makes your reds whites and a > host of other crap its not being eaten away it just > kinda gets lazy.About 1000 mgs was all i could > take.Any more surpression and a tx stop could be in > future its a balanceing game.At group in MD that is > the main complaint that riba is kicking my butt or > messing up my cbc .> > > > > __________________________________________ DSL – Something to write home about. Just $16.99/mo. or less. dsl. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 , U and the k9 have a good time. Any you 2 get is bound to be strange in more ways than one. Is it a double date? Nice lady and her cute pooch? Which one of u2 is dating the lady? For you the dose was 12.2mg/kg to start with which seems a bit low. I started at 13mg/kg. At end of TX you were 16.9mg/kg which is off the richter scale high. Your right, more riba would of probably put you in the hospital later in the TX. Your 16.9 is scarry I can't believe your doc gave you a dose like that for a 130lb man. That's like a dose of 2,000 for a 260lb person. You were pissing blood and pure riba I bet... Here is a weird thought , one reason you were a slow responder is maybe cause your weight based riba dose was low at first and as your weight dropped the weight based dose was increased. The side effect that caused you to lose your appitite may be why your a SVRer now. Riba dose has to get up to a critical level to have any effect and then it starts to become effective and the more the better as long as you stay out of the hospital. All I'm saying is it's good to take a high weight based dose if you can tolerate it and watch the dose as your weight changes so you don't OD and keep tabs on the blood cells as they die like flies. Like your doc and my doc we both were way over dose guidelines so the docs don't pay attention to it like they should. Im cutting back from 15.7mg/kg to 14.4mg/kg myself and avoid the possible hospital and big mandatory reductions if I can. Figure that 15mg/kg is about the highest I ever heard of in a large study and just a tiny improvement in anemia and white cells would improve the odds of completing the rest of TX. Mike Mike my counts: wbc 1.7 rbc 3.61 hemoglobin 12.1 hemocrit 35.3 > > Ha Mike ,the bone marrow surpression is a now thing ya know the bone marrow makes your reds whites and a host of other crap its not being eaten away it just kinda gets lazy.About 1000 mgs was all i could take.Any more surpression and a tx stop could be in future its a balanceing game.At group in MD that is the main complaint that riba is kicking my butt or messing up my cbc . I stuck to my dose of 120 mcgs and 1000mgs of riba even though through tx i was alaways losing weight started at 180 and ended at 130 i figured the lower weight and higher dose for a 180 pounder my starting weight,couldnt hurt unless it cut into my cbcs or made me any more under the weather so to say ,and here i sit all by my lonesom sept for k 9er and hes talkin about goin out for some strange ,i might have to do the same sounds like a good idea. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 , Thank you so much for blaming me for teasing Darker Goddess. All I saw was inconsistency and I was unable to follow what she wanted. She would make a request or demand for information or something and then never follow up on it. As far as I could tell she never bothered to read them. Quite likely brain fog to the point that communication is difficult. But I just got frustrated at no feedback on efforts to help. Sally RE: Status Sally, remember that 20 yr old some of you were kinda of teasing ,turns out she got hep as a new born through a transfusion and really is stage 4 ,goes by darker goddess .I asked a friend on another forum and they say as far as they know its true ,the poor kid has something to worry about . Hell i dont give a dam about dying at 47 i figure i have pretty much seen the world and its offerings but at 20 shes seen nothing . Not a damm thing fair about this life . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Michele, That sounds awful. Even I feel sorry to see you suffer like that and I have no human feelings at all just ask my wife. Doc says I'm not quite bad enough for blood med of any kind. My wbc 1.7 count worries me I don't want to get another cold and have a dose reduction. Lost 80% of the wbc's I started with. Anemia is not that bad you just adjust to it after a few months. Cutting back my riba 8% to a reasonable but still very high dose seems smart to me what's the point of havin a real high dose if you get severly reduced on adverse effect. Nurse though I looked like crap this week and wanted the doc to start me right away on rbc and wbc meds. She remembered me from two months ago and couldn't hardly believe I was the same guy with all the weight loss. Thank goodness it's slowing. Mali offers you an hug with her Monkey. She says Monk goood. Which means may the healing powers of my Monkey permiate you being and bring you inner peace. Mike > > HEY Mike and : > > They did two bone marrow biopsies on me when they were > trying to diagnose what I had, and my bone marrow was > doing really well, putting out plenty of cells. What > happened to make my plateleet and white blood cells so > low was my spleen was enlarged from backed-up blood > that couldn't get through my scarred liver, and the > enlarged spleen became more active and killed the > cells off. They called it Pancytopenia. The Riba did > lower my red blood count, though, and I had to take a > Procrit every week. > Just telling you how it was for me. . . > Michele > > > > > > Ha Mike ,the bone marrow surpression is a now thing > > ya know the bone marrow makes your reds whites and a > > host of other crap its not being eaten away it just > > kinda gets lazy.About 1000 mgs was all i could > > take.Any more surpression and a tx stop could be in > > future its a balanceing game.At group in MD that is > > the main complaint that riba is kicking my butt or > > messing up my cbc .> > > > > > > > > > > > > > __________________________________________ > DSL – Something to write home about. > Just $16.99/mo. or less. > dsl. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally, im not blaming you im just telling you the story you cant have that riba rage yet settle down Im trying to say its a god dam shame a 20 yr old has to deal with that. I cant imagine dealing with that at 20 .I dont know anything about the girl folowing along but if she couldnt i can see why. At 20 and having to deal with that ,its strikes me as sad that a young lady of 20 would be in stage 4 . Hell i thought of all here you would at least have a symphatic ear ,but maybe i put the original message to you in wrong terms if i did my my mistake sorry i gave you that impression this can be a hard method of communication, for me anyway .I guess im just an old through back to ma Bell Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2006 Report Share Posted January 7, 2006 Sally, She was also always asking about SEX too which I find upsetting. Mike > > , > > Thank you so much for blaming me for teasing Darker Goddess. All I saw was > inconsistency and I was unable to follow what she wanted. She would make a > request or demand for information or something and then never follow up on > it. As far as I could tell she never bothered to read them. Quite likely > brain fog to the point that communication is difficult. But I just got > frustrated at no feedback on efforts to help. > > Sally > > RE: Status > > > Sally, remember that 20 yr old some of you were kinda of teasing ,turns out > she got hep as a new born through a transfusion and really is stage 4 ,goes > by darker goddess .I asked a friend on another forum and they say as far as > they know its true ,the poor kid has something to worry about . Hell i dont > give a dam about dying at 47 i figure i have pretty much seen the world and > its offerings but at 20 shes seen nothing . Not a damm thing fair about this > life . > > > Quote Link to comment Share on other sites More sharing options...
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