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Re: Heard back from NIH RE: trial - they say it's secondary not primary...

By Guest guest, in Health, Medicine and Natural Healing 12

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Guest guest   

Guest guest
Posted

If it's too low naturally (or because of disease of some type) and not caused by medication or another cause, she doesn't have PA at all, but another issue.

le said:

1) NIH says her renin is too high to be PA.

2) NIH says she doesn't qualify for the PA study but they have another going that she may qualify for.

I believe le also said her BP is low. Wouldn't that, by itself, rule out PA?

Val

From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of Bingham

Or quite likely there's some missing peices to the puzzle that we haven't gotten all the facts on everything yet, like meds, etc, and something may be falsely, or causing an elevated renin. There may be a factor driving the renin up and the adenoma is still the cause of the PA given we have a confirmed adenoma. The odds that the adenoma is the cause of primary and that there's something raising the renin (meds, testing process, etc) is much higher than the odds of it being secondary PA and the existence of the adenoma is just a bystander. But it's medicine, anything goes sometimes.

> > > From: danielle_cairns <danielle_cairns@>> > > Subject: Heard back from NIH RE: trial - they say it's secondary not primary...> > > hyperaldosteronism > > > Date: Monday, May 28, 2012, 2:54 PM> > > > > > So I have been corresponding with Dr. L at NIH about joining their trial for primary hyperaldosteronism. They have reviewed my films and labs and came back on Friday and said I am ineligible because they believe I have secondary hyperaldosteronism. He said that despite the fact that I have an adrenal adenoma and high aldosterone, my renin is too high for it to be primary. I am so confused. He said there

is another trial they might like to enroll me in and that the cause of my disease may be genetic. I am so frustrated/worried now because I thought I was close to getting answers. Does anyone know what the workup for secondary might involve?? I am just trying to ease my nerves - the internet can be a scary place when you are looking for medical info :) Thanks!!! -D

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Guest guest   

Guest guest
Posted

Depends on what her team calls hypotensive assuming they are taking BP ACCURATELY and with a accurate machine. She does have an adrenal adenoma as I recall. No thumbnail so cannot really comment any further. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 4, 2012, at 10:26, <jclark24p@...> wrote:

If she was 90/60 and BP went up 20 to 110/80 she wouldn't be considered hypotensive would she?

>

> >

> > le said:

> >

> >

> >

> > 1) NIH says her renin is too high to be PA.

> >

> > 2) NIH says she doesn't qualify for the PA study but they have

> > another going that she may qualify for.

> >

> >

> >

> > I believe le also said her BP is low. Wouldn't that, by

> > itself, rule out PA?

> >

> >

> >

> > Val

> >

> >

> >

> > From: hyperaldosteronism [mailto:hyperaldosteronism

> > ] On Behalf Of Bingham

> >

> >

> > Or quite likely there's some missing peices to the puzzle that we

> > haven't gotten all the facts on everything yet, like meds, etc, and

> > something may be falsely, or causing an elevated renin. There may be

> > a factor driving the renin up and the adenoma is still the cause of

> > the PA given we have a confirmed adenoma. The odds that the adenoma

> > is the cause of primary and that there's something raising the renin

> > (meds, testing process, etc) is much higher than the odds of it

> > being secondary PA and the existence of the adenoma is just a

> > bystander. But it's medicine, anything goes sometimes.

> >

> >

> >

> > > > > From: danielle_cairns <danielle_cairns@>

> > > > > Subject: Heard back from NIH RE: trial -

> > they say it's secondary not primary...

> > > > > hyperaldosteronism

> > > > > Date: Monday, May 28, 2012, 2:54 PM

> >

> > > > >

> > > > > So I have been corresponding with Dr. L at NIH about joining

> > their trial for primary hyperaldosteronism. They have reviewed my

> > films and labs and came back on Friday and said I am ineligible

> > because they believe I have secondary hyperaldosteronism. He said

> > that despite the fact that I have an adrenal adenoma and high

> > aldosterone, my renin is too high for it to be primary. I am so

> > confused. He said there is another trial they might like to enroll

> > me in and that the cause of my disease may be genetic. I am so

> > frustrated/worried now because I thought I was close to getting

> > answers. Does anyone know what the workup for secondary might

> > involve?? I am just trying to ease my nerves - the internet can be a

> > scary place when you are looking for medical info :) Thanks!!! -D

> >

> >

> >

> >

> >

>

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Guest guest   

Guest guest
Posted

OK, I missed it because it is not listed in MedlinePlus.

> > > >

> > > > le said:

> > > >

> > > >

> > > >

> > > > 1) NIH says her renin is too high to be PA.

> > > >

> > > > 2) NIH says she doesn't qualify for the PA study but they have

> another going that she may qualify for.

> > > >

> > > >

> > > >

> > > > I believe le also said her BP is low. Wouldn't that, by

> itself, rule out PA?

> > > >

> > > >

> > > >

> > > > Val

> > > >

> > > >

> > > >

> > > > From: hyperaldosteronism

> [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > >

> > > >

> > > >

> > > >

> > > > Or quite likely there's some missing peices to the puzzle that we

> haven't gotten all the facts on everything yet, like meds, etc, and

> something may be falsely, or causing an elevated renin. There may be a

> factor driving the renin up and the adenoma is still the cause of the PA

> given we have a confirmed adenoma. The odds that the adenoma is the

> cause of primary and that there's something raising the renin (meds,

> testing process, etc) is much higher than the odds of it being secondary

> PA and the existence of the adenoma is just a bystander. But it's

> medicine, anything goes sometimes.

> > > >

> > > >

> > > >

> > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > Subject: Heard back from NIH RE: trial

> - they say it's secondary not primary...

> > > > > > > hyperaldosteronism

> <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> ogroups.com>

> > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >

> > > > > > >

> > > > > > > So I have been corresponding with Dr. L at NIH about joining

> their trial for primary hyperaldosteronism. They have reviewed my films

> and labs and came back on Friday and said I am ineligible because they

> believe I have secondary hyperaldosteronism. He said that despite the

> fact that I have an adrenal adenoma and high aldosterone, my renin is

> too high for it to be primary. I am so confused. He said there is

> another trial they might like to enroll me in and that the cause of my

> disease may be genetic. I am so frustrated/worried now because I thought

> I was close to getting answers. Does anyone know what the workup for

> secondary might involve?? I am just trying to ease my nerves - the

> internet can be a scary place when you are looking for medical info :)

> Thanks!!! -D

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

See why we need a thumbnail? I am considering not responding to questions without a thumbnail. Thoughts?CE GRIMMay your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 4, 2012, at 18:45, <jclark24p@...> wrote:

OK, I missed it because it is not listed in MedlinePlus.

> > > >

> > > > le said:

> > > >

> > > >

> > > >

> > > > 1) NIH says her renin is too high to be PA.

> > > >

> > > > 2) NIH says she doesn't qualify for the PA study but they have

> another going that she may qualify for.

> > > >

> > > >

> > > >

> > > > I believe le also said her BP is low. Wouldn't that, by

> itself, rule out PA?

> > > >

> > > >

> > > >

> > > > Val

> > > >

> > > >

> > > >

> > > > From: hyperaldosteronism

> [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > >

> > > >

> > > >

> > > >

> > > > Or quite likely there's some missing peices to the puzzle that we

> haven't gotten all the facts on everything yet, like meds, etc, and

> something may be falsely, or causing an elevated renin. There may be a

> factor driving the renin up and the adenoma is still the cause of the PA

> given we have a confirmed adenoma. The odds that the adenoma is the

> cause of primary and that there's something raising the renin (meds,

> testing process, etc) is much higher than the odds of it being secondary

> PA and the existence of the adenoma is just a bystander. But it's

> medicine, anything goes sometimes.

> > > >

> > > >

> > > >

> > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > Subject: Heard back from NIH RE: trial

> - they say it's secondary not primary...

> > > > > > > hyperaldosteronism

> <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> ogroups.com>

> > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >

> > > > > > >

> > > > > > > So I have been corresponding with Dr. L at NIH about joining

> their trial for primary hyperaldosteronism. They have reviewed my films

> and labs and came back on Friday and said I am ineligible because they

> believe I have secondary hyperaldosteronism. He said that despite the

> fact that I have an adrenal adenoma and high aldosterone, my renin is

> too high for it to be primary. I am so confused. He said there is

> another trial they might like to enroll me in and that the cause of my

> disease may be genetic. I am so frustrated/worried now because I thought

> I was close to getting answers. Does anyone know what the workup for

> secondary might involve?? I am just trying to ease my nerves - the

> internet can be a scary place when you are looking for medical info :)

> Thanks!!! -D

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

I knew she was on Loryna, the problem was that it is not listed in MedlinePlus,

which is where the VA sends me to look up meds. I just tried to look it up in

drugs.com and WARNING, IF YOU TRY IT MAKE SURE YOUR ANTI-VIRUS SOFTWARE IS

UPDATE - NORTON SAVED ME!

I stopped using a thumbnail because many were complaining.

> > > > > >

> > > > > > le said:

> > > > > >

> > > > > >

> > > > > >

> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >

> > > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > > another going that she may qualify for.

> > > > > >

> > > > > >

> > > > > >

> > > > > > I believe le also said her BP is low. Wouldn't that, by

> > > itself, rule out PA?

> > > > > >

> > > > > >

> > > > > >

> > > > > > Val

> > > > > >

> > > > > >

> > > > > >

> > > > > > From: hyperaldosteronism

> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > Or quite likely there's some missing peices to the puzzle that we

> > > haven't gotten all the facts on everything yet, like meds, etc, and

> > > something may be falsely, or causing an elevated renin. There may be a

> > > factor driving the renin up and the adenoma is still the cause of the PA

> > > given we have a confirmed adenoma. The odds that the adenoma is the

> > > cause of primary and that there's something raising the renin (meds,

> > > testing process, etc) is much higher than the odds of it being secondary

> > > PA and the existence of the adenoma is just a bystander. But it's

> > > medicine, anything goes sometimes.

> > > > > >

> > > > > >

> > > > > >

> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > > Subject: Heard back from NIH RE: trial

> > > - they say it's secondary not primary...

> > > > > > > > > hyperaldosteronism

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > ogroups.com>

> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >

> > > > > > > > >

> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > > their trial for primary hyperaldosteronism. They have reviewed my films

> > > and labs and came back on Friday and said I am ineligible because they

> > > believe I have secondary hyperaldosteronism. He said that despite the

> > > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > > too high for it to be primary. I am so confused. He said there is

> > > another trial they might like to enroll me in and that the cause of my

> > > disease may be genetic. I am so frustrated/worried now because I thought

> > > I was close to getting answers. Does anyone know what the workup for

> > > secondary might involve?? I am just trying to ease my nerves - the

> > > internet can be a scary place when you are looking for medical info :)

> > > Thanks!!! -D

> > > > > >

> > > > >

> > > >

> > >

> >

> >

>

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Guest guest   

Guest guest
Posted

Makes me wonder if NIH missed it for the same reason?

> > > > >

> > > > > le said:

> > > > >

> > > > >

> > > > >

> > > > > 1) NIH says her renin is too high to be PA.

> > > > >

> > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > another going that she may qualify for.

> > > > >

> > > > >

> > > > >

> > > > > I believe le also said her BP is low. Wouldn't that, by

> > itself, rule out PA?

> > > > >

> > > > >

> > > > >

> > > > > Val

> > > > >

> > > > >

> > > > >

> > > > > From: hyperaldosteronism

> > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > >

> > > > >

> > > > >

> > > > >

> > > > > Or quite likely there's some missing peices to the puzzle that we

> > haven't gotten all the facts on everything yet, like meds, etc, and

> > something may be falsely, or causing an elevated renin. There may be a

> > factor driving the renin up and the adenoma is still the cause of the PA

> > given we have a confirmed adenoma. The odds that the adenoma is the

> > cause of primary and that there's something raising the renin (meds,

> > testing process, etc) is much higher than the odds of it being secondary

> > PA and the existence of the adenoma is just a bystander. But it's

> > medicine, anything goes sometimes.

> > > > >

> > > > >

> > > > >

> > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > Subject: Heard back from NIH RE: trial

> > - they say it's secondary not primary...

> > > > > > > > hyperaldosteronism

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > ogroups.com>

> > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > >

> > > > > > > >

> > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > their trial for primary hyperaldosteronism. They have reviewed my films

> > and labs and came back on Friday and said I am ineligible because they

> > believe I have secondary hyperaldosteronism. He said that despite the

> > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > too high for it to be primary. I am so confused. He said there is

> > another trial they might like to enroll me in and that the cause of my

> > disease may be genetic. I am so frustrated/worried now because I thought

> > I was close to getting answers. Does anyone know what the workup for

> > secondary might involve?? I am just trying to ease my nerves - the

> > internet can be a scary place when you are looking for medical info :)

> > Thanks!!! -D

> > > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

If she told them she was on it. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 4, 2012, at 19:35, msmith_1928 <janeray1940@...> wrote:

Makes me wonder if NIH missed it for the same reason?

> > > > >

> > > > > le said:

> > > > >

> > > > >

> > > > >

> > > > > 1) NIH says her renin is too high to be PA.

> > > > >

> > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > another going that she may qualify for.

> > > > >

> > > > >

> > > > >

> > > > > I believe le also said her BP is low. Wouldn't that, by

> > itself, rule out PA?

> > > > >

> > > > >

> > > > >

> > > > > Val

> > > > >

> > > > >

> > > > >

> > > > > From: hyperaldosteronism

> > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > >

> > > > >

> > > > >

> > > > >

> > > > > Or quite likely there's some missing peices to the puzzle that we

> > haven't gotten all the facts on everything yet, like meds, etc, and

> > something may be falsely, or causing an elevated renin. There may be a

> > factor driving the renin up and the adenoma is still the cause of the PA

> > given we have a confirmed adenoma. The odds that the adenoma is the

> > cause of primary and that there's something raising the renin (meds,

> > testing process, etc) is much higher than the odds of it being secondary

> > PA and the existence of the adenoma is just a bystander. But it's

> > medicine, anything goes sometimes.

> > > > >

> > > > >

> > > > >

> > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > Subject: Heard back from NIH RE: trial

> > - they say it's secondary not primary...

> > > > > > > > hyperaldosteronism

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > ogroups.com>

> > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > >

> > > > > > > >

> > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > their trial for primary hyperaldosteronism. They have reviewed my films

> > and labs and came back on Friday and said I am ineligible because they

> > believe I have secondary hyperaldosteronism. He said that despite the

> > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > too high for it to be primary. I am so confused. He said there is

> > another trial they might like to enroll me in and that the cause of my

> > disease may be genetic. I am so frustrated/worried now because I thought

> > I was close to getting answers. Does anyone know what the workup for

> > secondary might involve?? I am just trying to ease my nerves - the

> > internet can be a scary place when you are looking for medical info :)

> > Thanks!!! -D

> > > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

I would think a thumbnail can be dropped after maybe 100 messages if everyone knows all the details of person X. However if one comes back later will need the thumbnail again at least I will. I recall the complaint was the trouble of how to do a thumbnail. My mail program permits me to have a long signature. For example one is our welcome which I use as my signature with this message. Whoops can not don from my iPhone. Sorry. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 4, 2012, at 19:13, <jclark24p@...> wrote:

I knew she was on Loryna, the problem was that it is not listed in MedlinePlus, which is where the VA sends me to look up meds. I just tried to look it up in drugs.com and WARNING, IF YOU TRY IT MAKE SURE YOUR ANTI-VIRUS SOFTWARE IS UPDATE - NORTON SAVED ME!

I stopped using a thumbnail because many were complaining.

> > > > > >

> > > > > > le said:

> > > > > >

> > > > > >

> > > > > >

> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >

> > > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > > another going that she may qualify for.

> > > > > >

> > > > > >

> > > > > >

> > > > > > I believe le also said her BP is low. Wouldn't that, by

> > > itself, rule out PA?

> > > > > >

> > > > > >

> > > > > >

> > > > > > Val

> > > > > >

> > > > > >

> > > > > >

> > > > > > From: hyperaldosteronism

> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > Or quite likely there's some missing peices to the puzzle that we

> > > haven't gotten all the facts on everything yet, like meds, etc, and

> > > something may be falsely, or causing an elevated renin. There may be a

> > > factor driving the renin up and the adenoma is still the cause of the PA

> > > given we have a confirmed adenoma. The odds that the adenoma is the

> > > cause of primary and that there's something raising the renin (meds,

> > > testing process, etc) is much higher than the odds of it being secondary

> > > PA and the existence of the adenoma is just a bystander. But it's

> > > medicine, anything goes sometimes.

> > > > > >

> > > > > >

> > > > > >

> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > > Subject: Heard back from NIH RE: trial

> > > - they say it's secondary not primary...

> > > > > > > > > hyperaldosteronism

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > ogroups.com>

> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >

> > > > > > > > >

> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > > their trial for primary hyperaldosteronism. They have reviewed my films

> > > and labs and came back on Friday and said I am ineligible because they

> > > believe I have secondary hyperaldosteronism. He said that despite the

> > > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > > too high for it to be primary. I am so confused. He said there is

> > > another trial they might like to enroll me in and that the cause of my

> > > disease may be genetic. I am so frustrated/worried now because I thought

> > > I was close to getting answers. Does anyone know what the workup for

> > > secondary might involve?? I am just trying to ease my nerves - the

> > > internet can be a scary place when you are looking for medical info :)

> > > Thanks!!! -D

> > > > > >

> > > > >

> > > >

> > >

> >

> >

>

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Guest guest   

Guest guest
Posted

Maybe, although with her renin at 2.24 or higher it would have had to make a

fairly high increase. I did find some info on it and it claimed the MCB in it

was equal to 25mg of Spironolactone. I know in my case my renin went from 0.1

w/o Spiro to 0.51 a month after I started Spiro. (Is probably a poor example

considering there was a 3 year lapse between tests and I am twice her size and

age!)

> > > > > >

> > > > > > le said:

> > > > > >

> > > > > >

> > > > > >

> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >

> > > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > > another going that she may qualify for.

> > > > > >

> > > > > >

> > > > > >

> > > > > > I believe le also said her BP is low. Wouldn't that, by

> > > itself, rule out PA?

> > > > > >

> > > > > >

> > > > > >

> > > > > > Val

> > > > > >

> > > > > >

> > > > > >

> > > > > > From: hyperaldosteronism

> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > Or quite likely there's some missing peices to the puzzle that we

> > > haven't gotten all the facts on everything yet, like meds, etc, and

> > > something may be falsely, or causing an elevated renin. There may be a

> > > factor driving the renin up and the adenoma is still the cause of the PA

> > > given we have a confirmed adenoma. The odds that the adenoma is the

> > > cause of primary and that there's something raising the renin (meds,

> > > testing process, etc) is much higher than the odds of it being secondary

> > > PA and the existence of the adenoma is just a bystander. But it's

> > > medicine, anything goes sometimes.

> > > > > >

> > > > > >

> > > > > >

> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > > Subject: Heard back from NIH RE: trial

> > > - they say it's secondary not primary...

> > > > > > > > > hyperaldosteronism

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > ogroups.com>

> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >

> > > > > > > > >

> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > > their trial for primary hyperaldosteronism. They have reviewed my films

> > > and labs and came back on Friday and said I am ineligible because they

> > > believe I have secondary hyperaldosteronism. He said that despite the

> > > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > > too high for it to be primary. I am so confused. He said there is

> > > another trial they might like to enroll me in and that the cause of my

> > > disease may be genetic. I am so frustrated/worried now because I thought

> > > I was close to getting answers. Does anyone know what the workup for

> > > secondary might involve?? I am just trying to ease my nerves - the

> > > internet can be a scary place when you are looking for medical info :)

> > > Thanks!!! -D

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Posted

Or if she did tell them, which is most likely she did, did the doc bother to look at the drugs profile (literally cross checking it against what he was r/o (the renin) or look it up since a neph likely wasn't 100% UTD on newer meds or meds related to another specialty.

Makes me wonder if NIH missed it for the same reason?> > > > >> > > > > le said:> > > > >> > > > >> > > > >> > > > > 1) NIH says her renin is too high to be PA.> > > > >> > > > > 2) NIH says she doesn't qualify for the PA study but they have> > another going that she may qualify for.> > > > >> > > > >> > > > >> > > > > I believe le also said her BP is low. Wouldn't that, by> > itself, rule out PA?> > > > >> > > > >> > > > >> > > > > Val> > > > >> > > > >> > > > >> >

> > > From: hyperaldosteronism > > [mailto:hyperaldosteronism ] On Behalf Of Bingham> > > > >> > > > >> > > > >> > > > >> > > > > Or quite likely there's some missing peices to the puzzle that we> > haven't gotten all the facts on everything yet, like meds, etc, and> > something may be falsely, or causing an elevated renin. There may be a> > factor driving the renin up and the adenoma is still the cause of the PA> >

given we have a confirmed adenoma. The odds that the adenoma is the> > cause of primary and that there's something raising the renin (meds,> > testing process, etc) is much higher than the odds of it being secondary> > PA and the existence of the adenoma is just a bystander. But it's> > medicine, anything goes sometimes.> > > > >> > > > >> > > > >> > > > > > > > From: danielle_cairns <danielle_cairns@>> > > > > > > > Subject: Heard back from NIH RE: trial> > - they say it's secondary not primary...> > > > > > > > hyperaldosteronism > >

<http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\> > ogroups.com>> > > > > > > > Date: Monday, May 28, 2012, 2:54 PM> > > > >> > > > > > > >> > > > > > > > So I have been corresponding with Dr. L at NIH about joining> > their trial for primary hyperaldosteronism. They have reviewed my films> > and labs and came back on Friday and said I am ineligible because they> > believe I have secondary hyperaldosteronism. He said that despite the> > fact that I have an adrenal adenoma and high aldosterone, my renin is> > too high for it to be primary. I am so confused. He said there is> >

another trial they might like to enroll me in and that the cause of my> > disease may be genetic. I am so frustrated/worried now because I thought> > I was close to getting answers. Does anyone know what the workup for> > secondary might involve?? I am just trying to ease my nerves - the> > internet can be a scary place when you are looking for medical info :)> > Thanks!!! -D> > > > >> > > >> > >> >>

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Posted

, just to be clear, this would have been Endos at NIH who do this all the

time. The way it works as I understand it is they have a standard meeting every

Friday and review all candidates and review current protocols. Although you

could very well be right, this means it got by a minimum of 4 Endos who do this

all the time.

> > > > > >

> > > > > > le said:

> > > > > >

> > > > > >

> > > > > >

> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >

> > > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > > another going that she may qualify for.

> > > > > >

> > > > > >

> > > > > >

> > > > > > I believe le also said her BP is low. Wouldn't that, by

> > > itself, rule out PA?

> > > > > >

> > > > > >

> > > > > >

> > > > > > Val

> > > > > >

> > > > > >

> > > > > >

> > > > > > From: hyperaldosteronism

> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > Or quite likely there's some missing peices to the puzzle that we

> > > haven't gotten all the facts on everything yet, like meds, etc, and

> > > something may be falsely, or causing an elevated renin. There may be a

> > > factor driving the renin up and the adenoma is still the cause of the PA

> > > given we have a confirmed adenoma. The odds that the adenoma is the

> > > cause of primary and that there's something raising the renin (meds,

> > > testing process, etc) is much higher than the odds of it being secondary

> > > PA and the existence of the adenoma is just a bystander. But it's

> > > medicine, anything goes sometimes.

> > > > > >

> > > > > >

> > > > > >

> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > > Subject: Heard back from NIH RE: trial

> > > - they say it's secondary not primary...

> > > > > > > > > hyperaldosteronism

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > ogroups.com>

> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >

> > > > > > > > >

> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > > their trial for primary hyperaldosteronism. They have reviewed my films

> > > and labs and came back on Friday and said I am ineligible because they

> > > believe I have secondary hyperaldosteronism. He said that despite the

> > > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > > too high for it to be primary. I am so confused. He said there is

> > > another trial they might like to enroll me in and that the cause of my

> > > disease may be genetic. I am so frustrated/worried now because I thought

> > > I was close to getting answers. Does anyone know what the workup for

> > > secondary might involve?? I am just trying to ease my nerves - the

> > > internet can be a scary place when you are looking for medical info :)

> > > Thanks!!! -D

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Posted

See why I recommend no meds for testing. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 5, 2012, at 2:39, Bingham <jlkbbk2003@...> wrote:

Or if she did tell them, which is most likely she did, did the doc bother to look at the drugs profile (literally cross checking it against what he was r/o (the renin) or look it up since a neph likely wasn't 100% UTD on newer meds or meds related to another specialty.

Makes me wonder if NIH missed it for the same reason?> > > > >> > > > > le said:> > > > >> > > > >> > > > >> > > > > 1) NIH says her renin is too high to be PA.> > > > >> > > > > 2) NIH says she doesn't qualify for the PA study but they have> > another going that she may qualify for.> > > > >> > > > >> > > > >> > > > > I believe le also said her BP is low. Wouldn't that, by> > itself, rule out PA?> > > > >> > > > >> > > > >> > > > > Val> > > > >> > > > >> > > > >> >

> > > From: hyperaldosteronism > > [mailto:hyperaldosteronism ] On Behalf Of Bingham> > > > >> > > > >> > > > >> > > > >> > > > > Or quite likely there's some missing peices to the puzzle that we> > haven't gotten all the facts on everything yet, like meds, etc, and> > something may be falsely, or causing an elevated renin. There may be a> > factor driving the renin up and the adenoma is still the cause of the PA> >

given we have a confirmed adenoma. The odds that the adenoma is the> > cause of primary and that there's something raising the renin (meds,> > testing process, etc) is much higher than the odds of it being secondary> > PA and the existence of the adenoma is just a bystander. But it's> > medicine, anything goes sometimes.> > > > >> > > > >> > > > >> > > > > > > > From: danielle_cairns <danielle_cairns@>> > > > > > > > Subject: Heard back from NIH RE: trial> > - they say it's secondary not primary...> > > > > > > > hyperaldosteronism > >

<http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\> > ogroups.com>> > > > > > > > Date: Monday, May 28, 2012, 2:54 PM> > > > >> > > > > > > >> > > > > > > > So I have been corresponding with Dr. L at NIH about joining> > their trial for primary hyperaldosteronism. They have reviewed my films> > and labs and came back on Friday and said I am ineligible because they> > believe I have secondary hyperaldosteronism. He said that despite the> > fact that I have an adrenal adenoma and high aldosterone, my renin is> > too high for it to be primary. I am so confused. He said there is> >

another trial they might like to enroll me in and that the cause of my> > disease may be genetic. I am so frustrated/worried now because I thought> > I was close to getting answers. Does anyone know what the workup for> > secondary might involve?? I am just trying to ease my nerves - the> > internet can be a scary place when you are looking for medical info :)> > Thanks!!! -D> > > > >> > > >> > >> >>

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Posted

Or again she did not consider it a med and list it. Need her response. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Jun 5, 2012, at 9:22, <jclark24p@...> wrote:

, just to be clear, this would have been Endos at NIH who do this all the time. The way it works as I understand it is they have a standard meeting every Friday and review all candidates and review current protocols. Although you could very well be right, this means it got by a minimum of 4 Endos who do this all the time.

> > > > > >

> > > > > > le said:

> > > > > >

> > > > > >

> > > > > >

> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >

> > > > > > 2) NIH says she doesn't qualify for the PA study but they have

> > > another going that she may qualify for.

> > > > > >

> > > > > >

> > > > > >

> > > > > > I believe le also said her BP is low. Wouldn't that, by

> > > itself, rule out PA?

> > > > > >

> > > > > >

> > > > > >

> > > > > > Val

> > > > > >

> > > > > >

> > > > > >

> > > > > > From: hyperaldosteronism

> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > Or quite likely there's some missing peices to the puzzle that we

> > > haven't gotten all the facts on everything yet, like meds, etc, and

> > > something may be falsely, or causing an elevated renin. There may be a

> > > factor driving the renin up and the adenoma is still the cause of the PA

> > > given we have a confirmed adenoma. The odds that the adenoma is the

> > > cause of primary and that there's something raising the renin (meds,

> > > testing process, etc) is much higher than the odds of it being secondary

> > > PA and the existence of the adenoma is just a bystander. But it's

> > > medicine, anything goes sometimes.

> > > > > >

> > > > > >

> > > > > >

> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > > > > Subject: Heard back from NIH RE: trial

> > > - they say it's secondary not primary...

> > > > > > > > > hyperaldosteronism

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > ogroups.com>

> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >

> > > > > > > > >

> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining

> > > their trial for primary hyperaldosteronism. They have reviewed my films

> > > and labs and came back on Friday and said I am ineligible because they

> > > believe I have secondary hyperaldosteronism. He said that despite the

> > > fact that I have an adrenal adenoma and high aldosterone, my renin is

> > > too high for it to be primary. I am so confused. He said there is

> > > another trial they might like to enroll me in and that the cause of my

> > > disease may be genetic. I am so frustrated/worried now because I thought

> > > I was close to getting answers. Does anyone know what the workup for

> > > secondary might involve?? I am just trying to ease my nerves - the

> > > internet can be a scary place when you are looking for medical info :)

> > > Thanks!!! -D

> > > > > >

> > > > >

> > > >

> > >

> >

>

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Guest guest
Posted

Hey, I think you have the answer - then we could rule it Secondary PA due to Pregnancy! > >> > > > > >> >> > > > > > le said:> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > 1) NIH says her renin is too high to be PA.> >> > > > > >> >> > > > > > 2) NIH says she doesn't qualify for the PA study but they have> >> > > another going that she may qualify for.> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > I believe le also said her BP is low. Wouldn't that, by> >> > > itself, rule out PA?> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > Val> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > From: hyperaldosteronism > >> > > [mailto:hyperaldosteronism ] On Behalf Of Bingham> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > Or quite likely there's some missing peices to the puzzle that we> >> > > haven't gotten all the facts on everything yet, like meds, etc, and> >> > > something may be falsely, or causing an elevated renin. There may be a> >> > > factor driving the renin up and the adenoma is still the cause of the PA> >> > > given we have a confirmed adenoma. The odds that the adenoma is the> >> > > cause of primary and that there's something raising the renin (meds,> >> > > testing process, etc) is much higher than the odds of it being secondary> >> > > PA and the existence of the adenoma is just a bystander. But it's> >> > > medicine, anything goes sometimes.> >> > > > > >> >> > > > > >> >> > > > > >> >> > > > > > > > > From: danielle_cairns <danielle_cairns@>> >> > > > > > > > > Subject: Heard back from NIH RE: trial> >> > > - they say it's secondary not primary...> >> > > > > > > > > hyperaldosteronism > >> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\> >> > > ogroups.com>> >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM> >> > > > > >> >> > > > > > > > >> >> > > > > > > > > So I have been corresponding with Dr. L at NIH about joining> >> > > their trial for primary hyperaldosteronism. They have reviewed my films> >> > > and labs and came back on Friday and said I am ineligible because they> >> > > believe I have secondary hyperaldosteronism. He said that despite the> >> > > fact that I have an adrenal adenoma and high aldosterone, my renin is> >> > > too high for it to be primary. I am so confused. He said there is> >> > > another trial they might like to enroll me in and that the cause of my> >> > > disease may be genetic. I am so frustrated/worried now because I thought> >> > > I was close to getting answers. Does anyone know what the workup for> >> > > secondary might involve?? I am just trying to ease my nerves - the> >> > > internet can be a scary place when you are looking for medical info :)> >> > > Thanks!!! -D> >> > > > > >> >> > > > >> >> > > >> >> > >> >> >> >> > > > >>

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Guest guest
Posted

Dr Grim also had a question about Depakote. It is known to affect the liver and

Platelet count.

> > >> > > > > >

> > >> > > > > > le said:

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > 1) NIH says her renin is too high to be PA.

> > >> > > > > >

> > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> have

> > >> > > another going that she may qualify for.

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > I believe le also said her BP is low. Wouldn't

> that, by

> > >> > > itself, rule out PA?

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > Val

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > From: hyperaldosteronism

> > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> Bingham

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > Or quite likely there's some missing peices to the puzzle

> that we

> > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> and

> > >> > > something may be falsely, or causing an elevated renin. There

> may be a

> > >> > > factor driving the renin up and the adenoma is still the cause

> of the PA

> > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> the

> > >> > > cause of primary and that there's something raising the renin

> (meds,

> > >> > > testing process, etc) is much higher than the odds of it being

> secondary

> > >> > > PA and the existence of the adenoma is just a bystander. But

> it's

> > >> > > medicine, anything goes sometimes.

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > >> > > > > > > > > Subject: Heard back from NIH

> RE: trial

> > >> > > - they say it's secondary not primary...

> > >> > > > > > > > > hyperaldosteronism

> > >> > >

> <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> \

> > >> > > ogroups.com>

> > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > >> > > > > >

> > >> > > > > > > > >

> > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> about joining

> > >> > > their trial for primary hyperaldosteronism. They have reviewed

> my films

> > >> > > and labs and came back on Friday and said I am ineligible

> because they

> > >> > > believe I have secondary hyperaldosteronism. He said that

> despite the

> > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> renin is

> > >> > > too high for it to be primary. I am so confused. He said there

> is

> > >> > > another trial they might like to enroll me in and that the

> cause of my

> > >> > > disease may be genetic. I am so frustrated/worried now because

> I thought

> > >> > > I was close to getting answers. Does anyone know what the

> workup for

> > >> > > secondary might involve?? I am just trying to ease my nerves -

> the

> > >> > > internet can be a scary place when you are looking for medical

> info :)

> > >> > > Thanks!!! -D

> > >> > > > > >

> > >> > > > >

> > >> > > >

> > >> > >

> > >> >

> > >>

> > >

> > >

> >

>

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Guest guest
Posted

That would be Secondary hyperaldosteronism. PA means Primary hyperaldosteronism.

> > >> > > > > >

> > >> > > > > > le said:

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > 1) NIH says her renin is too high to be PA.

> > >> > > > > >

> > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> have

> > >> > > another going that she may qualify for.

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > I believe le also said her BP is low. Wouldn't

> that, by

> > >> > > itself, rule out PA?

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > Val

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > From: hyperaldosteronism

> > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> Bingham

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > Or quite likely there's some missing peices to the puzzle

> that we

> > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> and

> > >> > > something may be falsely, or causing an elevated renin. There

> may be a

> > >> > > factor driving the renin up and the adenoma is still the cause

> of the PA

> > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> the

> > >> > > cause of primary and that there's something raising the renin

> (meds,

> > >> > > testing process, etc) is much higher than the odds of it being

> secondary

> > >> > > PA and the existence of the adenoma is just a bystander. But

> it's

> > >> > > medicine, anything goes sometimes.

> > >> > > > > >

> > >> > > > > >

> > >> > > > > >

> > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > >> > > > > > > > > Subject: Heard back from NIH

> RE: trial

> > >> > > - they say it's secondary not primary...

> > >> > > > > > > > > hyperaldosteronism

> > >> > >

> <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> \

> > >> > > ogroups.com>

> > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > >> > > > > >

> > >> > > > > > > > >

> > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> about joining

> > >> > > their trial for primary hyperaldosteronism. They have reviewed

> my films

> > >> > > and labs and came back on Friday and said I am ineligible

> because they

> > >> > > believe I have secondary hyperaldosteronism. He said that

> despite the

> > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> renin is

> > >> > > too high for it to be primary. I am so confused. He said there

> is

> > >> > > another trial they might like to enroll me in and that the

> cause of my

> > >> > > disease may be genetic. I am so frustrated/worried now because

> I thought

> > >> > > I was close to getting answers. Does anyone know what the

> workup for

> > >> > > secondary might involve?? I am just trying to ease my nerves -

> the

> > >> > > internet can be a scary place when you are looking for medical

> info :)

> > >> > > Thanks!!! -D

> > >> > > > > >

> > >> > > > >

> > >> > > >

> > >> > >

> > >> >

> > >>

> > >

> > >

> >

>

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Guest guest
Posted

Sorry if I confused you, I only used the same term others have used in this

thread. If you want to get technical, PA actually means Primary Aldosteronism

and some use HA for Hyperaldosteronism but it sometimes confuses those with a

HeadAche!

> > > >> > > > > >

> > > >> > > > > > le said:

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > >> > > > > >

> > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > have

> > > >> > > another going that she may qualify for.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > that, by

> > > >> > > itself, rule out PA?

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Val

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > From: hyperaldosteronism

> > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > Bingham

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > that we

> > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > and

> > > >> > > something may be falsely, or causing an elevated renin. There

> > may be a

> > > >> > > factor driving the renin up and the adenoma is still the cause

> > of the PA

> > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > the

> > > >> > > cause of primary and that there's something raising the renin

> > (meds,

> > > >> > > testing process, etc) is much higher than the odds of it being

> > secondary

> > > >> > > PA and the existence of the adenoma is just a bystander. But

> > it's

> > > >> > > medicine, anything goes sometimes.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > >> > > > > > > > > Subject: Heard back from NIH

> > RE: trial

> > > >> > > - they say it's secondary not primary...

> > > >> > > > > > > > > hyperaldosteronism

> > > >> > >

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > \

> > > >> > > ogroups.com>

> > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >> > > > > >

> > > >> > > > > > > > >

> > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > about joining

> > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > my films

> > > >> > > and labs and came back on Friday and said I am ineligible

> > because they

> > > >> > > believe I have secondary hyperaldosteronism. He said that

> > despite the

> > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > renin is

> > > >> > > too high for it to be primary. I am so confused. He said there

> > is

> > > >> > > another trial they might like to enroll me in and that the

> > cause of my

> > > >> > > disease may be genetic. I am so frustrated/worried now because

> > I thought

> > > >> > > I was close to getting answers. Does anyone know what the

> > workup for

> > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > the

> > > >> > > internet can be a scary place when you are looking for medical

> > info :)

> > > >> > > Thanks!!! -D

> > > >> > > > > >

> > > >> > > > >

> > > >> > > >

> > > >> > >

> > > >> >

> > > >>

> > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this

mean renin would increase to try to keep you from loosing sodium.

http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607

> > > >> > > > > >

> > > >> > > > > > le said:

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > >> > > > > >

> > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > have

> > > >> > > another going that she may qualify for.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > that, by

> > > >> > > itself, rule out PA?

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Val

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > From: hyperaldosteronism

> > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > Bingham

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > that we

> > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > and

> > > >> > > something may be falsely, or causing an elevated renin. There

> > may be a

> > > >> > > factor driving the renin up and the adenoma is still the cause

> > of the PA

> > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > the

> > > >> > > cause of primary and that there's something raising the renin

> > (meds,

> > > >> > > testing process, etc) is much higher than the odds of it being

> > secondary

> > > >> > > PA and the existence of the adenoma is just a bystander. But

> > it's

> > > >> > > medicine, anything goes sometimes.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > >> > > > > > > > > Subject: Heard back from NIH

> > RE: trial

> > > >> > > - they say it's secondary not primary...

> > > >> > > > > > > > > hyperaldosteronism

> > > >> > >

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > \

> > > >> > > ogroups.com>

> > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >> > > > > >

> > > >> > > > > > > > >

> > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > about joining

> > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > my films

> > > >> > > and labs and came back on Friday and said I am ineligible

> > because they

> > > >> > > believe I have secondary hyperaldosteronism. He said that

> > despite the

> > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > renin is

> > > >> > > too high for it to be primary. I am so confused. He said there

> > is

> > > >> > > another trial they might like to enroll me in and that the

> > cause of my

> > > >> > > disease may be genetic. I am so frustrated/worried now because

> > I thought

> > > >> > > I was close to getting answers. Does anyone know what the

> > workup for

> > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > the

> > > >> > > internet can be a scary place when you are looking for medical

> > info :)

> > > >> > > Thanks!!! -D

> > > >> > > > > >

> > > >> > > > >

> > > >> > > >

> > > >> > >

> > > >> >

> > > >>

> > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this

mean renin would increase to try to keep you from loosing sodium.

http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607

> > > >> > > > > >

> > > >> > > > > > le said:

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > >> > > > > >

> > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > have

> > > >> > > another going that she may qualify for.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > that, by

> > > >> > > itself, rule out PA?

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Val

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > From: hyperaldosteronism

> > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > Bingham

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > that we

> > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > and

> > > >> > > something may be falsely, or causing an elevated renin. There

> > may be a

> > > >> > > factor driving the renin up and the adenoma is still the cause

> > of the PA

> > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > the

> > > >> > > cause of primary and that there's something raising the renin

> > (meds,

> > > >> > > testing process, etc) is much higher than the odds of it being

> > secondary

> > > >> > > PA and the existence of the adenoma is just a bystander. But

> > it's

> > > >> > > medicine, anything goes sometimes.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > >> > > > > > > > > Subject: Heard back from NIH

> > RE: trial

> > > >> > > - they say it's secondary not primary...

> > > >> > > > > > > > > hyperaldosteronism

> > > >> > >

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > \

> > > >> > > ogroups.com>

> > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >> > > > > >

> > > >> > > > > > > > >

> > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > about joining

> > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > my films

> > > >> > > and labs and came back on Friday and said I am ineligible

> > because they

> > > >> > > believe I have secondary hyperaldosteronism. He said that

> > despite the

> > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > renin is

> > > >> > > too high for it to be primary. I am so confused. He said there

> > is

> > > >> > > another trial they might like to enroll me in and that the

> > cause of my

> > > >> > > disease may be genetic. I am so frustrated/worried now because

> > I thought

> > > >> > > I was close to getting answers. Does anyone know what the

> > workup for

> > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > the

> > > >> > > internet can be a scary place when you are looking for medical

> > info :)

> > > >> > > Thanks!!! -D

> > > >> > > > > >

> > > >> > > > >

> > > >> > > >

> > > >> > >

> > > >> >

> > > >>

> > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this

mean renin would increase to try to keep you from loosing sodium.

http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607

> > > >> > > > > >

> > > >> > > > > > le said:

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > >> > > > > >

> > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > have

> > > >> > > another going that she may qualify for.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > that, by

> > > >> > > itself, rule out PA?

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Val

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > From: hyperaldosteronism

> > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > Bingham

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > that we

> > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > and

> > > >> > > something may be falsely, or causing an elevated renin. There

> > may be a

> > > >> > > factor driving the renin up and the adenoma is still the cause

> > of the PA

> > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > the

> > > >> > > cause of primary and that there's something raising the renin

> > (meds,

> > > >> > > testing process, etc) is much higher than the odds of it being

> > secondary

> > > >> > > PA and the existence of the adenoma is just a bystander. But

> > it's

> > > >> > > medicine, anything goes sometimes.

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > >

> > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > >> > > > > > > > > Subject: Heard back from NIH

> > RE: trial

> > > >> > > - they say it's secondary not primary...

> > > >> > > > > > > > > hyperaldosteronism

> > > >> > >

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > \

> > > >> > > ogroups.com>

> > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >> > > > > >

> > > >> > > > > > > > >

> > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > about joining

> > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > my films

> > > >> > > and labs and came back on Friday and said I am ineligible

> > because they

> > > >> > > believe I have secondary hyperaldosteronism. He said that

> > despite the

> > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > renin is

> > > >> > > too high for it to be primary. I am so confused. He said there

> > is

> > > >> > > another trial they might like to enroll me in and that the

> > cause of my

> > > >> > > disease may be genetic. I am so frustrated/worried now because

> > I thought

> > > >> > > I was close to getting answers. Does anyone know what the

> > workup for

> > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > the

> > > >> > > internet can be a scary place when you are looking for medical

> > info :)

> > > >> > > Thanks!!! -D

> > > >> > > > > >

> > > >> > > > >

> > > >> > > >

> > > >> > >

> > > >> >

> > > >>

> > > >

> > > >

> > >

> >

>

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Guest guest   

Guest guest
Posted

And her plasm/serum Na should have been low. Still not clear how this would lead to increase in renin as low blood sodium can occur without change in blood volume. On Jun 5, 2012, at 2:42 PM, Francis Bill SUSPECTED PA wrote: It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this mean renin would increase to try to keep you from loosing sodium. http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607 > > > >> > > > > > > > > >> > > > > > le said: > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > 1) NIH says her renin is too high to be PA. > > > >> > > > > > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they > > have > > > >> > > another going that she may qualify for. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > I believe le also said her BP is low. Wouldn't > > that, by > > > >> > > itself, rule out PA? > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Val > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > From: hyperaldosteronism > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of > > Bingham > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Or quite likely there's some missing peices to the puzzle > > that we > > > >> > > haven't gotten all the facts on everything yet, like meds, etc, > > and > > > >> > > something may be falsely, or causing an elevated renin. There > > may be a > > > >> > > factor driving the renin up and the adenoma is still the cause > > of the PA > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is > > the > > > >> > > cause of primary and that there's something raising the renin > > (meds, > > > >> > > testing process, etc) is much higher than the odds of it being > > secondary > > > >> > > PA and the existence of the adenoma is just a bystander. But > > it's > > > >> > > medicine, anything goes sometimes. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@> > > > >> > > > > > > > > Subject: Heard back from NIH > > RE: trial > > > >> > > - they say it's secondary not primary... > > > >> > > > > > > > > hyperaldosteronism > > > >> > > > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\ > > \ > > > >> > > ogroups.com> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM > > > >> > > > > > > > > >> > > > > > > > > > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH > > about joining > > > >> > > their trial for primary hyperaldosteronism. They have reviewed > > my films > > > >> > > and labs and came back on Friday and said I am ineligible > > because they > > > >> > > believe I have secondary hyperaldosteronism. He said that > > despite the > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my > > renin is > > > >> > > too high for it to be primary. I am so confused. He said there > > is > > > >> > > another trial they might like to enroll me in and that the > > cause of my > > > >> > > disease may be genetic. I am so frustrated/worried now because > > I thought > > > >> > > I was close to getting answers. Does anyone know what the > > workup for > > > >> > > secondary might involve?? I am just trying to ease my nerves - > > the > > > >> > > internet can be a scary place when you are looking for medical > > info :) > > > >> > > Thanks!!! -D > > > >> > > > > > > > > >> > > > > > > > >> > > > > > > >> > > > > > >> > > > > >> > > > > > > > > > > > > > >

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Posted

And her plasm/serum Na should have been low. Still not clear how this would lead to increase in renin as low blood sodium can occur without change in blood volume. On Jun 5, 2012, at 2:42 PM, Francis Bill SUSPECTED PA wrote: It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this mean renin would increase to try to keep you from loosing sodium. http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607 > > > >> > > > > > > > > >> > > > > > le said: > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > 1) NIH says her renin is too high to be PA. > > > >> > > > > > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they > > have > > > >> > > another going that she may qualify for. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > I believe le also said her BP is low. Wouldn't > > that, by > > > >> > > itself, rule out PA? > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Val > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > From: hyperaldosteronism > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of > > Bingham > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Or quite likely there's some missing peices to the puzzle > > that we > > > >> > > haven't gotten all the facts on everything yet, like meds, etc, > > and > > > >> > > something may be falsely, or causing an elevated renin. There > > may be a > > > >> > > factor driving the renin up and the adenoma is still the cause > > of the PA > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is > > the > > > >> > > cause of primary and that there's something raising the renin > > (meds, > > > >> > > testing process, etc) is much higher than the odds of it being > > secondary > > > >> > > PA and the existence of the adenoma is just a bystander. But > > it's > > > >> > > medicine, anything goes sometimes. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@> > > > >> > > > > > > > > Subject: Heard back from NIH > > RE: trial > > > >> > > - they say it's secondary not primary... > > > >> > > > > > > > > hyperaldosteronism > > > >> > > > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\ > > \ > > > >> > > ogroups.com> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM > > > >> > > > > > > > > >> > > > > > > > > > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH > > about joining > > > >> > > their trial for primary hyperaldosteronism. They have reviewed > > my films > > > >> > > and labs and came back on Friday and said I am ineligible > > because they > > > >> > > believe I have secondary hyperaldosteronism. He said that > > despite the > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my > > renin is > > > >> > > too high for it to be primary. I am so confused. He said there > > is > > > >> > > another trial they might like to enroll me in and that the > > cause of my > > > >> > > disease may be genetic. I am so frustrated/worried now because > > I thought > > > >> > > I was close to getting answers. Does anyone know what the > > workup for > > > >> > > secondary might involve?? I am just trying to ease my nerves - > > the > > > >> > > internet can be a scary place when you are looking for medical > > info :) > > > >> > > Thanks!!! -D > > > >> > > > > > > > > >> > > > > > > > >> > > > > > > >> > > > > > >> > > > > >> > > > > > > > > > > > > > >

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And her plasm/serum Na should have been low. Still not clear how this would lead to increase in renin as low blood sodium can occur without change in blood volume. On Jun 5, 2012, at 2:42 PM, Francis Bill SUSPECTED PA wrote: It this ppt slideshow it says Depakote can cause Hyponatremia. If so would this mean renin would increase to try to keep you from loosing sodium. http://www.slideworld.org/slideshow.aspx/Hyponatremia-ppt-3607 > > > >> > > > > > > > > >> > > > > > le said: > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > 1) NIH says her renin is too high to be PA. > > > >> > > > > > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they > > have > > > >> > > another going that she may qualify for. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > I believe le also said her BP is low. Wouldn't > > that, by > > > >> > > itself, rule out PA? > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Val > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > From: hyperaldosteronism > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of > > Bingham > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > Or quite likely there's some missing peices to the puzzle > > that we > > > >> > > haven't gotten all the facts on everything yet, like meds, etc, > > and > > > >> > > something may be falsely, or causing an elevated renin. There > > may be a > > > >> > > factor driving the renin up and the adenoma is still the cause > > of the PA > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is > > the > > > >> > > cause of primary and that there's something raising the renin > > (meds, > > > >> > > testing process, etc) is much higher than the odds of it being > > secondary > > > >> > > PA and the existence of the adenoma is just a bystander. But > > it's > > > >> > > medicine, anything goes sometimes. > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@> > > > >> > > > > > > > > Subject: Heard back from NIH > > RE: trial > > > >> > > - they say it's secondary not primary... > > > >> > > > > > > > > hyperaldosteronism > > > >> > > > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\ > > \ > > > >> > > ogroups.com> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM > > > >> > > > > > > > > >> > > > > > > > > > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH > > about joining > > > >> > > their trial for primary hyperaldosteronism. They have reviewed > > my films > > > >> > > and labs and came back on Friday and said I am ineligible > > because they > > > >> > > believe I have secondary hyperaldosteronism. He said that > > despite the > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my > > renin is > > > >> > > too high for it to be primary. I am so confused. He said there > > is > > > >> > > another trial they might like to enroll me in and that the > > cause of my > > > >> > > disease may be genetic. I am so frustrated/worried now because > > I thought > > > >> > > I was close to getting answers. Does anyone know what the > > workup for > > > >> > > secondary might involve?? I am just trying to ease my nerves - > > the > > > >> > > internet can be a scary place when you are looking for medical > > info :) > > > >> > > Thanks!!! -D > > > >> > > > > > > > > >> > > > > > > > >> > > > > > > >> > > > > > >> > > > > >> > > > > > > > > > > > > > >

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Depakote is also know to cause Pancreatitis.

> > > > >> > > > > >

> > > > >> > > > > > le said:

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > >> > > > > >

> > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > > have

> > > > >> > > another going that she may qualify for.

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > > that, by

> > > > >> > > itself, rule out PA?

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > Val

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > From: hyperaldosteronism

> > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > > Bingham

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > > that we

> > > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > > and

> > > > >> > > something may be falsely, or causing an elevated renin. There

> > > may be a

> > > > >> > > factor driving the renin up and the adenoma is still the cause

> > > of the PA

> > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > > the

> > > > >> > > cause of primary and that there's something raising the renin

> > > (meds,

> > > > >> > > testing process, etc) is much higher than the odds of it being

> > > secondary

> > > > >> > > PA and the existence of the adenoma is just a bystander. But

> > > it's

> > > > >> > > medicine, anything goes sometimes.

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > >

> > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > >> > > > > > > > > Subject: Heard back from NIH

> > > RE: trial

> > > > >> > > - they say it's secondary not primary...

> > > > >> > > > > > > > > hyperaldosteronism

> > > > >> > >

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > \

> > > > >> > > ogroups.com>

> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > >> > > > > >

> > > > >> > > > > > > > >

> > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > > about joining

> > > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > > my films

> > > > >> > > and labs and came back on Friday and said I am ineligible

> > > because they

> > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > despite the

> > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > > renin is

> > > > >> > > too high for it to be primary. I am so confused. He said there

> > > is

> > > > >> > > another trial they might like to enroll me in and that the

> > > cause of my

> > > > >> > > disease may be genetic. I am so frustrated/worried now because

> > > I thought

> > > > >> > > I was close to getting answers. Does anyone know what the

> > > workup for

> > > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > > the

> > > > >> > > internet can be a scary place when you are looking for medical

> > > info :)

> > > > >> > > Thanks!!! -D

> > > > >> > > > > >

> > > > >> > > > >

> > > > >> > > >

> > > > >> > >

> > > > >> >

> > > > >>

> > > > >

> > > > >

> > > >

> > >

> >

>

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From medlineplus

Renin is a protein (enzyme) released by special kidney cells when you have

decreased salt (sodium levels) or low blood volume.

Renin also plays a role in the release of aldosterone, a hormone that helps

control the body's salt and water balance.

> > > > > >> > > > > >

> > > > > >> > > > > > le said:

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >> > > > > >

> > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study

> > but they

> > > > have

> > > > > >> > > another going that she may qualify for.

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > I believe le also said her BP is low.

> > Wouldn't

> > > > that, by

> > > > > >> > > itself, rule out PA?

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > Val

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > From: hyperaldosteronism

> > > > > >> > > [mailto:hyperaldosteronism ] On Behalf

> > Of

> > > > Bingham

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > Or quite likely there's some missing peices to

> > the puzzle

> > > > that we

> > > > > >> > > haven't gotten all the facts on everything yet, like

> > meds, etc,

> > > > and

> > > > > >> > > something may be falsely, or causing an elevated renin.

> > There

> > > > may be a

> > > > > >> > > factor driving the renin up and the adenoma is still

> > the cause

> > > > of the PA

> > > > > >> > > given we have a confirmed adenoma. The odds that the

> > adenoma is

> > > > the

> > > > > >> > > cause of primary and that there's something raising the

> > renin

> > > > (meds,

> > > > > >> > > testing process, etc) is much higher than the odds of

> > it being

> > > > secondary

> > > > > >> > > PA and the existence of the adenoma is just a

> > bystander. But

> > > > it's

> > > > > >> > > medicine, anything goes sometimes.

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > >

> > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > >> > > > > > > > > Subject: Heard back

> > from NIH

> > > > RE: trial

> > > > > >> > > - they say it's secondary not primary...

> > > > > >> > > > > > > > > hyperaldosteronism

> > > > > >> > >

> > > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho

> > \

> > > > \

> > > > > >> > > ogroups.com>

> > > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >> > > > > >

> > > > > >> > > > > > > > >

> > > > > >> > > > > > > > > So I have been corresponding with Dr. L at

> > NIH

> > > > about joining

> > > > > >> > > their trial for primary hyperaldosteronism. They have

> > reviewed

> > > > my films

> > > > > >> > > and labs and came back on Friday and said I am ineligible

> > > > because they

> > > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > > despite the

> > > > > >> > > fact that I have an adrenal adenoma and high

> > aldosterone, my

> > > > renin is

> > > > > >> > > too high for it to be primary. I am so confused. He

> > said there

> > > > is

> > > > > >> > > another trial they might like to enroll me in and that

> > the

> > > > cause of my

> > > > > >> > > disease may be genetic. I am so frustrated/worried now

> > because

> > > > I thought

> > > > > >> > > I was close to getting answers. Does anyone know what the

> > > > workup for

> > > > > >> > > secondary might involve?? I am just trying to ease my

> > nerves -

> > > > the

> > > > > >> > > internet can be a scary place when you are looking for

> > medical

> > > > info :)

> > > > > >> > > Thanks!!! -D

> > > > > >> > > > > >

> > > > > >> > > > >

> > > > > >> > > >

> > > > > >> > >

> > > > > >> >

> > > > > >>

> > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

> >

>

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