Re: Heard back from NIH RE: trial - they say it's secondary not primary...

June 5, 2012

Can't find where she gave any NA information.

> > > > > >> > > > > >

> > > > > >> > > > > > le said:

> > > > > >> > > > > >

> > > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >> > > > > >

> > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study

> > but they

> > > > have

> > > > > >> > > another going that she may qualify for.

> > > > > >> > > > > >

> > > > > >> > > > > > I believe le also said her BP is low.

> > Wouldn't

> > > > that, by

> > > > > >> > > itself, rule out PA?

> > > > > >> > > > > >

> > > > > >> > > > > > Val

> > > > > >> > > > > >

> > > > > >> > > > > > From: hyperaldosteronism

> > > > > >> > > [mailto:hyperaldosteronism ] On Behalf

> > Of

> > > > Bingham

> > > > > >> > > > > >

> > > > > >> > > > > > Or quite likely there's some missing peices to

> > the puzzle

> > > > that we

> > > > > >> > > haven't gotten all the facts on everything yet, like

> > meds, etc,

> > > > and

> > > > > >> > > something may be falsely, or causing an elevated renin.

> > There

> > > > may be a

> > > > > >> > > factor driving the renin up and the adenoma is still

> > the cause

> > > > of the PA

> > > > > >> > > given we have a confirmed adenoma. The odds that the

> > adenoma is

> > > > the

> > > > > >> > > cause of primary and that there's something raising the

> > renin

> > > > (meds,

> > > > > >> > > testing process, etc) is much higher than the odds of

> > it being

> > > > secondary

> > > > > >> > > PA and the existence of the adenoma is just a

> > bystander. But

> > > > it's

> > > > > >> > > medicine, anything goes sometimes.

> > > > > >> > > > > >

> > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > >> > > > > > > > > Subject: Heard back

> > from NIH

> > > > RE: trial

> > > > > >> > > - they say it's secondary not primary...

> > > > > >> > > > > > > > > hyperaldosteronism

> > > > > >> > >

> > > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho

> > \

> > > > \

> > > > > >> > > ogroups.com>

> > > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >> > > > > >

> > > > > >> > > > > > > > >

> > > > > >> > > > > > > > > So I have been corresponding with Dr. L at

> > NIH

> > > > about joining

> > > > > >> > > their trial for primary hyperaldosteronism. They have

> > reviewed

> > > > my films

> > > > > >> > > and labs and came back on Friday and said I am ineligible

> > > > because they

> > > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > > despite the

> > > > > >> > > fact that I have an adrenal adenoma and high

> > aldosterone, my

> > > > renin is

> > > > > >> > > too high for it to be primary. I am so confused. He

> > said there

> > > > is

> > > > > >> > > another trial they might like to enroll me in and that

> > the

> > > > cause of my

> > > > > >> > > disease may be genetic. I am so frustrated/worried now

> > because

> > > > I thought

> > > > > >> > > I was close to getting answers. Does anyone know what the

> > > > workup for

> > > > > >> > > secondary might involve?? I am just trying to ease my

> > nerves -

> > > > the

> > > > > >> > > internet can be a scary place when you are looking for

> > medical

> > > > info

> > > > > >> > > Thanks!!! -D

> > > > > >> > > > > >

> > > > > >> > > > >

> > > > > >> > > >

> > > > > >> > >

> > > > > >> >

> > > > > >>

> > > > > >

> > > > >

> > > >

> > >

> >

>

June 5, 2012

Don't know if it is related but she did post that glucose was a bit low.

> > > > > >> > > > > >

> > > > > >> > > > > > le said:

> > > > > >> > > > > >

> > > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > >> > > > > >

> > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > > > have

> > > > > >> > > another going that she may qualify for.

> > > > > >> > > > > >

> > > > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > > > that, by

> > > > > >> > > itself, rule out PA?

> > > > > >> > > > > >

> > > > > >> > > > > > Val

> > > > > >> > > > > >

> > > > > >> > > > > > From: hyperaldosteronism

> > > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > > > Bingham

> > > > > >> > > > > >

> > > > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > > > that we

> > > > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > > > and

> > > > > >> > > something may be falsely, or causing an elevated renin. There

> > > > may be a

> > > > > >> > > factor driving the renin up and the adenoma is still the cause

> > > > of the PA

> > > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > > > the

> > > > > >> > > cause of primary and that there's something raising the renin

> > > > (meds,

> > > > > >> > > testing process, etc) is much higher than the odds of it being

> > > > secondary

> > > > > >> > > PA and the existence of the adenoma is just a bystander. But

> > > > it's

> > > > > >> > > medicine, anything goes sometimes.

> > > > > >> > > > > >

> > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > >> > > > > > > > > Subject: Heard back from NIH

> > > > RE: trial

> > > > > >> > > - they say it's secondary not primary...

> > > > > >> > > > > > > > > hyperaldosteronism

> > > > > >> > >

> > > >

<http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > > \

> > > > > >> > > ogroups.com>

> > > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > >> > > > > >

> > > > > >> > > > > > > > >

> > > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > > > about joining

> > > > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > > > my films

> > > > > >> > > and labs and came back on Friday and said I am ineligible

> > > > because they

> > > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > > despite the

> > > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > > > renin is

> > > > > >> > > too high for it to be primary. I am so confused. He said there

> > > > is

> > > > > >> > > another trial they might like to enroll me in and that the

> > > > cause of my

> > > > > >> > > disease may be genetic. I am so frustrated/worried now because

> > > > I thought

> > > > > >> > > I was close to getting answers. Does anyone know what the

> > > > workup for

> > > > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > > > the

> > > > > >> > > internet can be a scary place when you are looking for medical

> > > > info

> > > > > >> > > Thanks!!! -D

> > > > > >> > > > > >

> > > > > >> > > > >

> > > > > >> > > >

> > > > > >> > >

> > > > > >> >

> > > > > >>

> > > > > >

> > > > >

> > > >

> > >

> >

>

June 5, 2012

While I can't find a link with Depakote and PA. I did find this related to

anti-convulsant drugs and adrenal function.

From pubmed

The effects of anti-convulsant drugs on adrenal function.

Putignano P, Kaltsas GA, Satta MA, Grossman AB.

Source

Department of Endocrinology, St. Bartholomew's Hospital, London, UK.

Abstract

Since the adrenal cortex and medulla are intimately interrelated, the effects of

anticonvulsant drugs may affect both of these hormonal systems. Anticonvulsants

are commonly used long-term for the treatment of epilepsy, chronic pain

syndromes and affective disorders. In patients where adrenal function needs to

be evaluated, the clinician should be aware of the potential interactions

between anticonvulsant medication and the hypothalamo-pituitary-adrenal axis.

Carbamazepine, phenytoin and phenobarbitone induce the liver P450 cytochrome

enzyme system and stimulate steroid clearance. Therefore, patients investigated

for Cushing's syndrome may show a falsely positive dexamethasone suppression

test, and patients with adrenal insufficiency on steroid replacement may require

increased doses of steroids; furthermore, increased

corticosteroid-binding-globulin levels are also associated with chronic

anticonvulsant administration. In addition, concomitant treatment with

benzodiazepines, probably acting via the GABA pathway, can also alter the

ACTH/cortisol response to stressful stimuli. Direct and indirect evidence

suggest that benzodiazepines, acetazolamide and magnesium sulphate can also

interfere with the renin-angiotensin-aldosterone system. Finally, to our

knowledge, no systemic data are yet available in the human on the effect of

antiepileptics on the function of the adrenal medulla and/or catecholamine

metabolism; however, as the adrenal medulla receives part of its blood supply

from the cortex, it is possible that alterations of cortical hormonal

composition might affect adrenal medulla function overall.

PMID: 9694568 [PubMed - indexed for MEDLINE]

> > > >> > > > > >

> > > >> > > > > > le said:

> > > >> > > > > >

> > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > >> > > > > >

> > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > have

> > > >> > > another going that she may qualify for.

> > > >> > > > > >

> > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > that, by

> > > >> > > itself, rule out PA?

> > > >> > > > > >

> > > >> > > > > > Val

> > > >> > > > > >

> > > >> > > > > > From: hyperaldosteronism

> > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > Bingham

> > > >> > > > > >

> > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > that we

> > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > and

> > > >> > > something may be falsely, or causing an elevated renin. There

> > may be a

> > > >> > > factor driving the renin up and the adenoma is still the cause

> > of the PA

> > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > the

> > > >> > > cause of primary and that there's something raising the renin

> > (meds,

> > > >> > > testing process, etc) is much higher than the odds of it being

> > secondary

> > > >> > > PA and the existence of the adenoma is just a bystander. But

> > it's

> > > >> > > medicine, anything goes sometimes.

> > > >> > > > > >

> > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > >> > > > > > > > > Subject: Heard back from NIH

> > RE: trial

> > > >> > > - they say it's secondary not primary...

> > > >> > > > > > > > > hyperaldosteronism

> > > >> > >

> > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > \

> > > >> > > ogroups.com>

> > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > >> > > > > >

> > > >> > > > > > > > >

> > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > about joining

> > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > my films

> > > >> > > and labs and came back on Friday and said I am ineligible

> > because they

> > > >> > > believe I have secondary hyperaldosteronism. He said that

> > despite the

> > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > renin is

> > > >> > > too high for it to be primary. I am so confused. He said there

> > is

> > > >> > > another trial they might like to enroll me in and that the

> > cause of my

> > > >> > > disease may be genetic. I am so frustrated/worried now because

> > I thought

> > > >> > > I was close to getting answers. Does anyone know what the

> > workup for

> > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > the

> > > >> > > internet can be a scary place when you are looking for medical

> > info

> > > >> > > Thanks!!! -D

> > > >> > > > > >

> > > >> > > > >

> > > >> > > >

> > > >> > >

> > > >> >

> > > >>

> > > >

> > >

> >

>

June 5, 2012

Guess this one is related to Depakote as valproate is the same as depakote.

From pubmed

Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of

valproate in the mouse model of maximal electroshock.

£ukawski K, Janowska A, Jakubus T, Tochman-Gawda A, Czuczwar SJ.

Source

Department of Physiopathology, Institute of Agricultural Medicine, Jaczewskiego

2, 20-090 Lublin, Poland. lukaw@...

Abstract

Angiotensin AT1 receptor antagonists, drugs affecting the renin-angiotensin

system, are commonly used in the treatment of hypertension and congestive heart

failure. It is also known that the renin-angiotensin system exists in the brain

and therefore it may be involved in the regulation of seizure susceptibility.

The aim of the current study was to evaluate the effects of losartan

(2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methy\

l]imidazole) and telmisartan

(49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]-19-yl)methyl]-[1,19-biphen\

yl]-2-carboxylic acid), the angiotensin AT1 receptor antagonists which are

widely used in clinical practice, on the protective action of conventional

antiepileptic drugs (carbamazepine, phenytoin, valproate and phenobarbital)

against maximal electroshock-induced seizures in mice. Losartan (10, 20 and 50

mg/kgi.p.) and telmisartan (5, 10 and 30 mg/kgi.p.) did not influence the

threshold for electroconvulsions. However, both drugs potentiated the

anticonvulsant activity of valproate. Losartan (50 mg/kgi.p.) decreased its ED50

value from 249.8 to 194.6 mg/kg while telmisartan (30 mg/kgi.p.) lowered the

ED50 value for valproate from 249.8 to 190.6 mg/kg. The antiseizure action of

the remaining antiepileptics was not affected by losartan or telmisartan. The

observed interactions between tested angiotensin AT1 receptor antagonists and

valproate were pharmacodynamic in nature as either losartan or telmisartan did

not alter total brain concentrations of valproate. This finding can be important

for epileptic patients receiving valproate and also angiotensin AT1 receptor

antagonists due to other medical causes.

PMID: 20465998 [PubMed - indexed for MEDLINE]

> > > > >> > > > > >

> > > > >> > > > > > le said:

> > > > >> > > > > >

> > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > >> > > > > >

> > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > > have

> > > > >> > > another going that she may qualify for.

> > > > >> > > > > >

> > > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > > that, by

> > > > >> > > itself, rule out PA?

> > > > >> > > > > >

> > > > >> > > > > > Val

> > > > >> > > > > >

> > > > >> > > > > > From: hyperaldosteronism

> > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > > Bingham

> > > > >> > > > > >

> > > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > > that we

> > > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > > and

> > > > >> > > something may be falsely, or causing an elevated renin. There

> > > may be a

> > > > >> > > factor driving the renin up and the adenoma is still the cause

> > > of the PA

> > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > > the

> > > > >> > > cause of primary and that there's something raising the renin

> > > (meds,

> > > > >> > > testing process, etc) is much higher than the odds of it being

> > > secondary

> > > > >> > > PA and the existence of the adenoma is just a bystander. But

> > > it's

> > > > >> > > medicine, anything goes sometimes.

> > > > >> > > > > >

> > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > >> > > > > > > > > Subject: Heard back from NIH

> > > RE: trial

> > > > >> > > - they say it's secondary not primary...

> > > > >> > > > > > > > > hyperaldosteronism

> > > > >> > >

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > \

> > > > >> > > ogroups.com>

> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > >> > > > > >

> > > > >> > > > > > > > >

> > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > > about joining

> > > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > > my films

> > > > >> > > and labs and came back on Friday and said I am ineligible

> > > because they

> > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > despite the

> > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > > renin is

> > > > >> > > too high for it to be primary. I am so confused. He said there

> > > is

> > > > >> > > another trial they might like to enroll me in and that the

> > > cause of my

> > > > >> > > disease may be genetic. I am so frustrated/worried now because

> > > I thought

> > > > >> > > I was close to getting answers. Does anyone know what the

> > > workup for

> > > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > > the

> > > > >> > > internet can be a scary place when you are looking for medical

> > > info

> > > > >> > > Thanks!!! -D

> > > > >> > > > > >

> > > > >> > > > >

> > > > >> > > >

> > > > >> > >

> > > > >> >

> > > > >>

> > > > >

> > > >

> > >

> >

>

June 5, 2012

But that doesn't mean there is a direct cause and effect relationship or that it only acts a certain way. Just being stressed out and anxious over the test can also release renin thus elevating it, the time of day the test was done could influence the renin level. If she (or anyone) is dehydrated during the test renin may be high. And the BCP that she is on in this case, even with the retention of sodium that BCP's can cause to some degree, it still is known to increase renin according to studies

June 5, 2012

From Wikipedia

Hyperaldosteronism, also aldosteronism, is a medical condition where too much

aldosterone is produced by the adrenal glands, which can lead to lowered levels

of potassium in the blood also known as hypokalemia.

In endocrinology, the terms primary and secondary are used to describe the

abnormality (e.g., elevated aldosterone) in relation to the defect, i.e., the

tumor's location.

Primary

Primary aldosteronism (hyporeninemic hyperaldosteronism) was previously thought

to be most commonly caused by an adrenal adenoma, termed Conn's syndrome.

However, recent studies have shown that bilateral idiopathic adrenal hyperplasia

is the cause in up to 70% of cases. Differentiating between the two is important

as this determines treatment. Adrenal carcinoma is an extremely rare cause of

primary hyperaldosteronism. Two familial forms have been identified: Type I (

dexamethasone suppressible ) and Type II

Secondary

Secondary hyperaldosteronism (also hyperreninism, or hyperreninemic

hyperaldosteronism) is due to overactivity of the renin-angiotensin system.

Secondary refers to an abnormality that indirectly results in pathology through

a predictable physiologic pathway, i.e., a renin producing tumor leads to

increased aldosterone, as the body's aldosterone production is normally

regulated by renin levels.

One cause is a juxtaglomerular cell tumor. Another is renal artery stenosis in

which the reduced blood supply across the juxtaglomerular apparatus stimulates

the production of renin. Also fibromuscular hyperplasia may cause secondary

hyperaldosteronism. Other causes can come from the tubules: hyporeabsorption of

sodium (as seen in Bartter and Gitelman syndromes) will lead to

hypovolemia/hypotension, which will activate the RAA system.

Diagnostic workup

When taking a blood test, the aldosterone-to-renin ratio is abnormally increased

in primary hyperaldosteronism, and decreased or normal but with high renin in

secondary hyperaldosteronism.

> > > > >> > > > > >

> > > > >> > > > > > le said:

> > > > >> > > > > >

> > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > >> > > > > >

> > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study but they

> > > have

> > > > >> > > another going that she may qualify for.

> > > > >> > > > > >

> > > > >> > > > > > I believe le also said her BP is low. Wouldn't

> > > that, by

> > > > >> > > itself, rule out PA?

> > > > >> > > > > >

> > > > >> > > > > > Val

> > > > >> > > > > >

> > > > >> > > > > > From: hyperaldosteronism

> > > > >> > > [mailto:hyperaldosteronism ] On Behalf Of

> > > Bingham

> > > > >> > > > > >

> > > > >> > > > > > Or quite likely there's some missing peices to the puzzle

> > > that we

> > > > >> > > haven't gotten all the facts on everything yet, like meds, etc,

> > > and

> > > > >> > > something may be falsely, or causing an elevated renin. There

> > > may be a

> > > > >> > > factor driving the renin up and the adenoma is still the cause

> > > of the PA

> > > > >> > > given we have a confirmed adenoma. The odds that the adenoma is

> > > the

> > > > >> > > cause of primary and that there's something raising the renin

> > > (meds,

> > > > >> > > testing process, etc) is much higher than the odds of it being

> > > secondary

> > > > >> > > PA and the existence of the adenoma is just a bystander. But

> > > it's

> > > > >> > > medicine, anything goes sometimes.

> > > > >> > > > > >

> > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > >> > > > > > > > > Subject: Heard back from NIH

> > > RE: trial

> > > > >> > > - they say it's secondary not primary...

> > > > >> > > > > > > > > hyperaldosteronism

> > > > >> > >

> > > <http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho\

> > > \

> > > > >> > > ogroups.com>

> > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > >> > > > > >

> > > > >> > > > > > > > >

> > > > >> > > > > > > > > So I have been corresponding with Dr. L at NIH

> > > about joining

> > > > >> > > their trial for primary hyperaldosteronism. They have reviewed

> > > my films

> > > > >> > > and labs and came back on Friday and said I am ineligible

> > > because they

> > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > despite the

> > > > >> > > fact that I have an adrenal adenoma and high aldosterone, my

> > > renin is

> > > > >> > > too high for it to be primary. I am so confused. He said there

> > > is

> > > > >> > > another trial they might like to enroll me in and that the

> > > cause of my

> > > > >> > > disease may be genetic. I am so frustrated/worried now because

> > > I thought

> > > > >> > > I was close to getting answers. Does anyone know what the

> > > workup for

> > > > >> > > secondary might involve?? I am just trying to ease my nerves -

> > > the

> > > > >> > > internet can be a scary place when you are looking for medical

> > > info

> > > > >> > > Thanks!!! -D

> > > > >> > > > > >

> > > > >> > > > >

> > > > >> > > >

> > > > >> > >

> > > > >> >

> > > > >>

> > > > >

> > > >

> > >

> >

>

June 5, 2012

The question is what effect does Depakote have on renin aldo and sodium? Looks

like it may have an effect as search on pubmed and other places seen to show.

> > > > > > >> > > > > >

> > > > > > >> > > > > > le said:

> > > > > > >> > > > > >

> > > > > > >> > > > > > 1) NIH says her renin is too high to be PA.

> > > > > > >> > > > > >

> > > > > > >> > > > > > 2) NIH says she doesn't qualify for the PA study

> > > but they

> > > > > have

> > > > > > >> > > another going that she may qualify for.

> > > > > > >> > > > > >

> > > > > > >> > > > > > I believe le also said her BP is low.

> > > Wouldn't

> > > > > that, by

> > > > > > >> > > itself, rule out PA?

> > > > > > >> > > > > >

> > > > > > >> > > > > > Val

> > > > > > >> > > > > >

> > > > > > >> > > > > > From: hyperaldosteronism

> > > > > > >> > > [mailto:hyperaldosteronism ] On Behalf

> > > Of

> > > > > Bingham

> > > > > > >> > > > > >

> > > > > > >> > > > > > Or quite likely there's some missing peices to

> > > the puzzle

> > > > > that we

> > > > > > >> > > haven't gotten all the facts on everything yet, like

> > > meds, etc,

> > > > > and

> > > > > > >> > > something may be falsely, or causing an elevated renin.

> > > There

> > > > > may be a

> > > > > > >> > > factor driving the renin up and the adenoma is still

> > > the cause

> > > > > of the PA

> > > > > > >> > > given we have a confirmed adenoma. The odds that the

> > > adenoma is

> > > > > the

> > > > > > >> > > cause of primary and that there's something raising the

> > > renin

> > > > > (meds,

> > > > > > >> > > testing process, etc) is much higher than the odds of

> > > it being

> > > > > secondary

> > > > > > >> > > PA and the existence of the adenoma is just a

> > > bystander. But

> > > > > it's

> > > > > > >> > > medicine, anything goes sometimes.

> > > > > > >> > > > > >

> > > > > > >> > > > > > > > > From: danielle_cairns <danielle_cairns@>

> > > > > > >> > > > > > > > > Subject: Heard back

> > > from NIH

> > > > > RE: trial

> > > > > > >> > > - they say it's secondary not primary...

> > > > > > >> > > > > > > > > hyperaldosteronism

> > > > > > >> > >

> > > > >

<http://us.mc1107.mail./mc/compose?to=hyperaldosteronism%40yaho

> > > \

> > > > > \

> > > > > > >> > > ogroups.com>

> > > > > > >> > > > > > > > > Date: Monday, May 28, 2012, 2:54 PM

> > > > > > >> > > > > >

> > > > > > >> > > > > > > > >

> > > > > > >> > > > > > > > > So I have been corresponding with Dr. L at

> > > NIH

> > > > > about joining

> > > > > > >> > > their trial for primary hyperaldosteronism. They have

> > > reviewed

> > > > > my films

> > > > > > >> > > and labs and came back on Friday and said I am ineligible

> > > > > because they

> > > > > > >> > > believe I have secondary hyperaldosteronism. He said that

> > > > > despite the

> > > > > > >> > > fact that I have an adrenal adenoma and high

> > > aldosterone, my

> > > > > renin is

> > > > > > >> > > too high for it to be primary. I am so confused. He

> > > said there

> > > > > is

> > > > > > >> > > another trial they might like to enroll me in and that

> > > the

> > > > > cause of my

> > > > > > >> > > disease may be genetic. I am so frustrated/worried now

> > > because

> > > > > I thought

> > > > > > >> > > I was close to getting answers. Does anyone know what the

> > > > > workup for

> > > > > > >> > > secondary might involve?? I am just trying to ease my

> > > nerves -

> > > > > the

> > > > > > >> > > internet can be a scary place when you are looking for

> > > medical

> > > > > info

> > > > > > >> > > Thanks!!! -D

> > > > > > >> > > > > >

> > > > > > >> > > > >

> > > > > > >> > > >

> > > > > > >> > >

> > > > > > >> >

> > > > > > >>

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

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