Alcohol Intolerance

[Guest guest]

Hi Rich and All,

could you please explain in detail about the

partial

blockades in the Krebcycles or respiratory chains of the red,

" slow-twitch "

skeletal muscle cells. I have never heard of these cells. Where are they

found

in the body and in what percentage relative to other skeletal muscle

cells? Why would just those be effected?

Thanks

Mike

[Guest guest]

Interesting, Doris. When my liver detox panel came back, GSDL's comment that

my sulfite oxidase deficiency could be genetic or acquired. As one was never

done before I got sick, or before I took DMPS or DMSA, who knows? That is

one of the reasons I am interested in their genetic detox panel. However,

your comment made me think back. Alcoholism runs in my family - quite

severely on my father's side, and moderately on my mother's side. I do

believe I inherited a propensity to drink, and an ability to handle alcohol

quite well. In my younger days, I went through periods when I drank more

heavily than at other times, for various reasons. I would have been more of

a binge drinker, or weekend warrior type, but during those times, could

drink the majority of people I knew under the table. Men I knew commented on

my ability to drink like them, or better. One day that thought scared me,

and I made the decision to significantly reduce the amount I drank when I

did drink. I was still drinking sociably when I got sick, although in

moderation by then. When I crashed a few years later, I was absolutely

intolerant, actually even before the DMSA or DMPS. I wonder if something

activated a semi-dormant genetic enzyme deficiency, or whether something in

the general CFIDS malfunctioning cascade, somehow screwed up and I acquired

this deficiency? Or, perhaps a little of both, as Dr. Cheney seems to think.

Perhaps the mercury itself, stirred up by the attempts to chelate it?

Donna in NC

Re: Re: alcohol intolerance

> I question the genetic factor, just because at certain times during my

illness I have been extremely alcohol intolerant, while at other times I am

not much at all. I am benefiting currently from a high protein diet (which

we just discussed on a separate thread as being a problem with the kreb's

cycle) and currently can drink alcohol without much problems. I don't drink

much of course, I think it would do me in. But a beer now and then is no

problem for about the last year. But I have been very sick during much of

that time. At other times I wasn't as symptomatic, but the alcohol killed

me.

>

> I wonder if it has something to do with mercury, or with supplements I am

taking now that maybe I wasn't then.

> Thanks,

> Doris

[Guest guest]

Thanks, Rich.

I am intrigued by the genetic detox test, and will try to call and see if

they'll give me the cost. If they won't tell me, I'll have my EI doc's

office call. They have an account with GSDL, so I'm sure they will be able

to get some information. Hope it can find a way around the aspirin. That,

more than cost may be a good enough reason for me not to do it. The first

test nearly killed me when I had to take the aspirin.

Donna in NC

Re: alcohol intolerance

> Donna,

>

> I suspect that your cysteine is low because you are unable to tolerate

many of the things that would supply it. And if you are low in cysteine,

it is not surprising that you would be low in glutathione also, because

cysteine is usually the limiting amino acid for synthesis of glutathione in

the body.

>

> Thanks for posting the information on the new Great Smokies test. It

sounds pretty interesting. Looks like it would give a lot more information

than the detox panels they have been offering, and also show whether

deficiencies in detox are genetic or not. I wonder what it costs?

>

> Rich

[Guest guest]

Lynn,

I'm of Italian descent, grandfather made his own wine, and I grew up

drinking it, so I should have wine drinking genes also. I too had a very

high stress job with long hours, strenuous workout program, and loved it.

Now I'm alcohol intolerant, sulfur intolerant, glutamine, aspartame, MSG

intolerant, not to mention extreme food intolerances, severe MCS....but I do

think there is a lot to be said for our environmental exposures along the

way to getting ill.

Donna in NC

Alcohol Intolerance

> You can put me into the category of Alcohol Tolerance as well. I do have

some metabolism issues when I drink (mostly red wine with dinner) bit no

sickness. I tend to get the same flushing over my face as I do when I

over-exert or eat carbohydrates. It lasts for about a half hour. Besides

that I don't get any ill effects from alcohol or sulphur products. I am of

French descent and I think that maybe the genes to drink wine come with

that!

>

> I also had a higher stress busy life before I became sick(but I loved

it). So I guess you can put me in that same subset.

>

> Lynn

[Guest guest]

Doris,

Since the RDA for niacin for normal, healthy women is 14 mg per day,

and the recommended upper limit is 35 mg per day, both from the

Institute of Medicine, yes, I would call 100 mg per day " high, " and

that may account for your alcohol tolerance. Note that the upper

limit recommendation is based on avoiding flushes in some people, but

there's really no evidence that flushes are harmful, and some people

think they are actually beneficial. At much higher niacin intakes,

though, there is evidence of liver problems.

Rich

> How much niacin do you call " high " ? I used to take 500-1000 for

> coagulation, but it was making me sicker and sicker so I stopped

taking it.

> Now it is just what is in my B100 pill. So if that is enough, then

maybe

> that is it, because I didn't used to take any B vitamins other than

the

> standard multivitamin (when I was alcohol intolerant.) I don't

think it

> could be the protein, because I just started that the past 2 months

and the

> intolerance stopped before that.

> Thanks,

> Doris

> ----- Original Message -----

> From: " rvankonynen " <richvank@a...>

> > As I mentioned in my message to Rob, it could be high niacin in

your

> > supplements or high tryptophan in your high protein diet. Both

these

> > will help to supply more NAD+ to the liver cells, and that,

together

> > with the enzymes alcohol dehydrogenase and aldehyde

dehydrogenase, is

> > what enables the liver to break down alcohol. I think the NAD+

> > supply would be the most important factor in your case, because

you

> > clearly genetically have the enzymes, since at times you are

fairly

> > alcohol-tolerant. The lack of enough NAD+ shuts down

gluconeogenesis

> > in the liver, and that's what brings on the symptoms associated

with

> > hypoglycemia and lactic acidosis. If you don't have those

symptoms,

> > and at the same time the normal alcohol effects that you do

notice do

> > go away in a normal length of time, then I would say that your

liver

> > is processing alcohol well, and you must not be short of NAD+.

> >

> > Rich

[Guest guest]

Count me in for alcohol intolerance. Interestingly, before my sudden

CFS onset, I was playing softball and would always have a beer or two

after the game. Then, I was unable to tolerate starting about two

years before the sudden onset. I am still alcohol intolerant even

tho I am still working. Also interestingly, my wife, who is healthy,

became alcohol intolerant about the same time I did.

Mike C.

> Lynn,

> I'm of Italian descent, grandfather made his own wine, and I grew up

> drinking it, so I should have wine drinking genes also. I too had a

very

> high stress job with long hours, strenuous workout program, and

loved it.

> Now I'm alcohol intolerant, sulfur intolerant, glutamine,

aspartame, MSG

> intolerant, not to mention extreme food intolerances, severe MCS

[Guest guest]

Let me add another example to this. I became v intolerant to alcohol 25

years ago and stopped drinking. Alcohol did knock me around - nausea,

hangover feeling etc.

10 years later I got CFS. Still couldn't drink.

A few years ago I found I COULD tolerate a drink or two, no problem.

(always testing and hopeful, as you can see!)

As I still had all the CFS symptoms, I decided this alcohol tolerance might

be due to my regular intake of the liver-assisting herb, silymarin / milk

thistle.

(Now I have had to stop drinking at all again, because it inflamed my

ulcers/ helicobacter infection, but alcohol still doesn't affect me

hangover/nausea etc -wise as it used to).

On the subject of wine, even when I could drink spirits and

preservative-free beer during my new tolerance, I still couldn't drink

wine. I am not troubled by sulphur foods, but I am badly affected by

sulphur dioxide and other related preservatives 220 to 224. Wine contains

at least four things that are or may be a problem for me other than alcohol

- grapes, histamines, molds, preservatives.

Some of this may be applicable to others.

n

At 07:34 15/09/02, you wrote:

> > The question of why some PWCs can tolerate alcohol is a very

> > intriguing one. There are some on this list who have reported that

> > they can. I have studied a few cases in detail in which this is

> > true. I think that some of them developed great liver capacity for

> > processing alcohol before they became ill with CFS, and perhaps their

> > livers have enough NAD+ to be able to continue to carry on

> > gluconeogenesis even while they use some of their NAD+ to support the

> > enzymes alcohol dehydrogenase and aldehyde dehydrogenase. For

> > example, one of these cases was a diplomat who had been accustomed to

> > attending frequent diplomatic events at which drinking was the norm,

> > before he became ill.

[Guest guest]

Mike,

The skeletal muscles include both red, " slow-twitch, " type I muscle

cells and white, " fast-twitch, " type IIb muscle cells. (There are

also type IIa cells, which are somewhat of a mixture of the other

two.) The type I cells have mitochondria (and thus Krebs cycles and

respiratory chains) and myoglobin, and carry out oxidative

metabolism. The type II cells don't have mitochondria, and operate

on anerobic glycolysis.

The type I cells are more efficient and are best suited to long-term,

sustained activity. The type II cells can respond to quick, brief

movements better.

You have probably seen muscle that is dominated by the two types

respectively, when you have eaten " red meat " and " white meat " from

chicken. In a chicken, the dark meat (dominated by type I cell) is

in the legs, and the the white meat is associated with the muscles

used in flying, because chickens spend most of their time walking,

and thus need the sustained, efficient cells in their leg muscles.

They fly only briefly, so the fast-twitch type II cells power their

wings. Ducks have type 1 cells in their flying muscles, because they

do sustained flying for long times.

In humans, there is a mix of the two types of cells in the various

skeletal muscles, depending on what they are used for. The mix can

be changed by the type of exercise, such as sprinting vs. distance

running.

It has been found that in CFS the skeletal muscles operate more

anaerobically than in normal, healthy people. An example is the

measurements of VO2 max and anaerobic threshold on a bicycle

exerciser. For this to be true, it must be true that the type I

muscle fibers are not able to carry out aerobic metabolism as readily

as normal, since they are the ones that are normally aerobic. That's

why I say that they are the ones involved.

It's also found that many PWCs have elevated citric acid in their

urine on a urinary organic acids test. This points the finger at the

citric acid cycle (also called the Krebs cycle). There must be a

partial blockade just downstream of citric acid in the Krebs cycle.

The enzyme downstream is aconitase, and it is known that aconitase

can be blocked by peroxynitrite, and that peroxynitrite rises if

glutathione is depleted, which has been observed in PWCs. So the

story seems to hang together pretty well. The citric acid in the

urine has to be coming from a cell type that is a dominant part of

the body's total cellular mass, or it would not show up so strongly

in the urine. That then implicates the Krebs cycles of the type 1

skeletal muscle cells, since we already know from the above that

these cells have a partially blocked aerobic metabolism.

In some PWCs the citric acid is not elevated in the urine. In these

cases, it may not be the Krebs cycles that are blockaded, but perhaps

the partial blockade is elsewhere, such as in the pyruvate

dehydrogenase complex before the Krebs cycle or in the respiratory

chains after it. These are different subsets.

Because of symptoms and signs associated with the neurons, I suspect

that they may also have partial blockades, but I don't have very

direct evidence for this. There could be other cells involved as

well, but I think there is good evidence for the red,

" slow-twitch, " type I skeletal muscle cells. As another piece of

data, one PWC said that he seemed to intentionally carry out rapid

motions, " just because he could. "

I realize that this is a rather long chain of logical inferences, but

it is supported at several points by evidence, so I think it probably

represents the truth, at least in the main subset of PWCs.

Rich

> Hi Rich and All,

> could you please explain in detail

about the

> partial

> blockades in the Krebcycles or respiratory chains of the red,

> " slow-twitch "

> skeletal muscle cells. I have never heard of these cells. Where are

they

> found

> in the body and in what percentage relative to other skeletal muscle

> cells? Why would just those be effected?

>

> Thanks

>

> Mike

[Guest guest]

Mike,

I think it's really interesting that you became alcohol intolerant

two years before your sudden onset of CFS. If my hypotheses are

correct, this would mean that your skeletal muscle cells were already

somewhat depleted in glutathione at that time, so that they were

having to rely more on glycolysis and the Cori cycle even then. But

it wasn't until you got exposed to an infection two years later, and

the immune system placed a big demand on the remaining supplies of

cysteine and glutathione to fight it, that your skeletal muscle cell

glutathione level dropped to the point that you developed really

serious partial blockades in the Krebs cycles of the skeletal muscle

cells.

In that two-year period, did you notice less physical endurance? Did

you notice whether your muscles hurt more after exercise? I think my

hypotheses would predict those things.

I don't know how to explain what's going on in your wife's case, but

if I were her, I would make sure my diet included significant amounts

of animal-based protein (milk, eggs, or meat) and antioxidant

nutrients, on the chance that she is also glutathione-depleted.

Rich

> > Lynn,

> > I'm of Italian descent, grandfather made his own wine, and I grew

up

> > drinking it, so I should have wine drinking genes also. I too had

a

> very

> > high stress job with long hours, strenuous workout program, and

> loved it.

> > Now I'm alcohol intolerant, sulfur intolerant, glutamine,

> aspartame, MSG

> > intolerant, not to mention extreme food intolerances, severe MCS

[Guest guest]

n,

Thanks for posting this information about your case. It does seem to

be consistent with the idea that building up the liver so that it has

more capacity can improve the alcohol tolerance in CFS.

By the way, I have not yet found a PWC with comorbid serious liver

disease. I have a feeling that it might not be possible to remain

alive with CFS if the liver is not functioning fairly well, so that

it can convert the excess lactate and/or pyruvate generated back to

glucose. PWCs are depending on their livers much more than normal,

healthy people, if my hypotheses are correct.

In my view, the reason why the liver can keep on carrying on aerobic

metabolism while the muscle aerobic metabolism has been seriously

curtailed is that the liver has first access (via the portal vein) to

the cysteine and the other amino acids coming in from the gut that

are needed to make glutathione, and because it is set up genetically

to express a higher concentration of the rate-limiting enzyme for

making glutathione (this has been measured).

I think this is an example of a built-in " soft " failure mode, which

preserves life while sacrificing some skeletal muscle function.

Lately there have been a few philosophical/religious comments on the

list, and let me just say that I believe that the human body is

constructed according to a very well thought-out design, not a willy-

nilly result of random mutation and selection. I think that

these " soft " failure modes are just one example of that. I realize

that there won't be universal agreement on this topic, but that's my

two cents!

Rich

> > > The question of why some PWCs can tolerate alcohol is a very

> > > intriguing one. There are some on this list who have reported

that

> > > they can. I have studied a few cases in detail in which this is

> > > true. I think that some of them developed great liver capacity

for

> > > processing alcohol before they became ill with CFS, and perhaps

their

> > > livers have enough NAD+ to be able to continue to carry on

> > > gluconeogenesis even while they use some of their NAD+ to

support the

> > > enzymes alcohol dehydrogenase and aldehyde dehydrogenase. For

> > > example, one of these cases was a diplomat who had been

accustomed to

> > > attending frequent diplomatic events at which drinking was the

norm,

> > > before he became ill.

[Guest guest]

Rich,

There are a couple of us who have HEPC as well as CFS. During the 11 months I

took high-dose, daily dose alpha interferon, I became very, very ill and we

almost cleared the HEPC, but my body

developed antibodies to the interferon. My liver enzymes are near normal. The

last biopsy 8 years ago was fibrosis with some bridging. Doc says since I'm not

a candidate for any therapy, no

need to do another one.

BTW, I take a lot of Milk Thistle and can drink an occasional glass of good red

wine without terrible aftereffects. Cheap wine does me in. Sulfites.

Beck

rvankonynen wrote:

> n,

>

> Thanks for posting this information about your case. It does seem to

> be consistent with the idea that building up the liver so that it has

> more capacity can improve the alcohol tolerance in CFS.

>

> By the way, I have not yet found a PWC with comorbid serious liver

> disease. I have a feeling that it might not be possible to remain

> alive with CFS if the liver is not functioning fairly well, so that

> it can convert the excess lactate and/or pyruvate generated back to

> glucose. PWCs are depending on their livers much more than normal,

> healthy people, if my hypotheses are correct.

>

> In my view, the reason why the liver can keep on carrying on aerobic

> metabolism while the muscle aerobic metabolism has been seriously

> curtailed is that the liver has first access (via the portal vein) to

> the cysteine and the other amino acids coming in from the gut that

> are needed to make glutathione, and because it is set up genetically

> to express a higher concentration of the rate-limiting enzyme for

> making glutathione (this has been measured).

>

> I think this is an example of a built-in " soft " failure mode, which

> preserves life while sacrificing some skeletal muscle function.

> Lately there have been a few philosophical/religious comments on the

> list, and let me just say that I believe that the human body is

> constructed according to a very well thought-out design, not a willy-

> nilly result of random mutation and selection. I think that

> these " soft " failure modes are just one example of that. I realize

> that there won't be universal agreement on this topic, but that's my

> two cents!

>

> Rich

>

>

[Guest guest]

Beck,

Thanks for the information. I gather that when you had the treatment

for Hep C, you didn't yet have CFS. It sounds as though you too have

built up your liver, using milk thistle. This may account for your

having enough liver capacity to be able to tolerate good red wine.

Incidentally, are you aware of the hepatitis C treatment developed by

Dr. Burt Berkson of Las Cruces, NM? He uses silymarin (from milk

thistle), alpha lipoic acid, selenium, and B vitamins, and claims to

have good success. Here's an early abstract of this work:

" Med Klin 1999 Oct 15;94 Suppl 3:84-9

A conservative triple antioxidant approach to the treatment of

hepatitis C. Combination of alpha lipoic acid (thioctic acid),

silymarin, and selenium: three case histories.

Berkson BM.

Integrative Medical Center of New Mexico, New Mexico State

University, Las Cruces, USA. burt@...

BACKGROUND: There has been an increase in the number of adults

seeking liver transplantation for hepatitis C in the last few years

and the count is going up rapidly. There is no reliable and effective

therapy for chronic hepatitis C since interferon and antivirals work

no more than 30% of the time, and liver transplant surgery is

uncertain and tentative over the long run. This is because,

ultimately, residual hepatitis C viremia infects the new liver.

Furthermore, liver transplantation can be painful, disabling and

extremely costly. TREATMENT PROGRAM: The author describes a low cost

and efficacious treatment program in 3 patients with cirrhosis,

portal hypertension and esophageal varices secondary to chronic

hepatitis C infection. This effective and conservative regimen

combines 3 potent antioxidants (alpha-lipoic acid [thioctic acid],

silymarin, and selenium) that possess antiviral, free radical

quenching and immune boosting qualities. CONCLUSION: There are no

remarkably effective treatments for chronic hepatitis C in general

use. Interferon and antivirals have less than a 30% response rate and

because of the residual viremia, a newly transplanted liver usually

becomes infected again. The triple antioxidant combination of alpha-

lipoic acid, silymarin and selenium was chosen for a conservative

treatment of hepatitis C because these substances protect the liver

from free radical damage, increase the levels of other fundamental

antioxidants, and interfere with viral proliferation. The 3 patients

presented in this paper followed the triple antioxidant program and

recovered quickly and their laboratory values remarkably improved.

Furthermore, liver transplantation was avoided and the patients are

back at work, carrying out their normal activities, and feeling

healthy. The author offers a more conservative approach to the

treatment of hepatitis C, that is exceedingly less expensive. One

year of the triple antioxidant therapy described in this paper costs

less than $2,000, as compared to mor than $300,000 a year for liver

transplant surgery. It appears reasonable, that prior to liver

transplant surgery evaluation, or during the transplant evaluation

process, the conservative triple antioxidant treatment approach

should be considered. If these is a significant betterment in the

patient's condition, liver transplant surgery may be avoided. "

Rich

>

> > n,

> >

> > Thanks for posting this information about your case. It does

seem to

> > be consistent with the idea that building up the liver so that it

has

> > more capacity can improve the alcohol tolerance in CFS.

> >

> > By the way, I have not yet found a PWC with comorbid serious liver

> > disease. I have a feeling that it might not be possible to remain

> > alive with CFS if the liver is not functioning fairly well, so

that

> > it can convert the excess lactate and/or pyruvate generated back

to

> > glucose. PWCs are depending on their livers much more than

normal,

> > healthy people, if my hypotheses are correct.

> >

> > In my view, the reason why the liver can keep on carrying on

aerobic

> > metabolism while the muscle aerobic metabolism has been seriously

> > curtailed is that the liver has first access (via the portal

vein) to

> > the cysteine and the other amino acids coming in from the gut that

> > are needed to make glutathione, and because it is set up

genetically

> > to express a higher concentration of the rate-limiting enzyme for

> > making glutathione (this has been measured).

> >

> > I think this is an example of a built-in " soft " failure mode,

which

> > preserves life while sacrificing some skeletal muscle function.

> > Lately there have been a few philosophical/religious comments on

the

> > list, and let me just say that I believe that the human body is

> > constructed according to a very well thought-out design, not a

willy-

> > nilly result of random mutation and selection. I think that

> > these " soft " failure modes are just one example of that. I

realize

> > that there won't be universal agreement on this topic, but that's

my

> > two cents!

> >

> > Rich

> >

> >

[Guest guest]

Rich,

Well here's the funniest thing. By pure coincidence, I gave up alcohol 5 days

ago -- I

think just before this discussion started. I felt tired for a few days and then

better

than before but after 3 days, my craving for meat went. No more late night trips

to the

fridge.

To answer your earlier question BTW, my supplementation of B vitamins is limited

to a

150% RDA B complex plus additional B12.

Rob

[Guest guest]

In addition, many allergists, like Theron Randolph, have hypothesized

that alchololic beverages are some of the most allerginic substances

you can ingest.

He, and others , have posed, as a rule of thumb that, the faster a

substance enters the bloodstream, the greater it's allergenic

potential to cause problems. Thus meats and fats would have a lower

allerginic potential, while things like raw sugar and alcohol would

have higher potential.

Too, and this seems more plausible to me, many alcoholic beverages

contain in their purest form some of the most common allergenic

substances for most people. These being: cane sugar, wheat, corn, or

other grains, yeast and yeast by products.

Just another thought,

Zippy

[Guest guest]

Rob,

Hmmm. So maybe the alcohol was calling for more niacin to make NAD+,

and the tryptophan from the meat was supplying it. Well, stranger

things have happened; maybe so. . .

Rich

> Rich,

>

> Well here's the funniest thing. By pure coincidence, I gave up

alcohol 5 days ago -- I

> think just before this discussion started. I felt tired for a few

days and then better

> than before but after 3 days, my craving for meat went. No more

late night trips to the

> fridge.

>

> To answer your earlier question BTW, my supplementation of B

vitamins is limited to a

> 150% RDA B complex plus additional B12.

>

> Rob

[Guest guest]

Hi Mike C. and All,

Mike, I was wondering if you can

associate any causal

event that happened at or just previous to the time that you became

alcohol intolerant.

Did you have a flu or virus or bacterial infection or chemical

exposure

or take some medication during that time period or recently previous to

that period.

Mike

[Guest guest]

Mike, that is a good question. The answer in my case is no. I just

started getting headaches/sinus problems when having one or two

beers after softball games (1992 or so). Then, the sinus situation

became worse and worse until I was having daily sinus h/a. So for me

it was a gradual thing maybe caused by my immune system weakening

and/or overreacting to the air quality in Dallas which has been

declining for the last 15 years. FYI, my wife noticed a much worse

condition the day following some wine or drinks (12 years ago), so

even though she is very healthy she rarely drinks because of the

aftereffects.

Mike C.

> Hi Mike C. and All,

> Mike, I was wondering if you can

> associate any causal

> event that happened at or just previous to the time that you became

> alcohol intolerant.

> Did you have a flu or virus or bacterial infection or chemical

> exposure

> or take some medication during that time period or recently

previous to

> that period.

>

>

> Mike

[Guest guest]

No headache here Helen, just spinning tiddlyness after 1/3 a glass of

wine! I always felt that I had 1 1/10 the tolerance of my well friends.

Once, age 17 or so I drank 2 glasses and I experienced nausea, and a

wildly spinning head.....thats the worst symptoms I ever experienced.

However I do actually feel slightly drunk (brainfog or more?? Not sure)

all the time.

I recently read about acetaldehyde toxicity, and since I think I may

have a candida problem it all clicks for me. Molybdenum is mentioned

here again and I know I'm deficient.

http://www.candidapage.com/aldehyde.shtml

Will be interested to hear how others react to alcohol.

Anne (NZ, 37, CFS/FMS 21 years)

>

> Back in 1978 I realized that every time I drank anything, even a very

> small amount of alcohol, I got a headache within ten minutes. So I

quit

> drinking entirely. Ten years later I got my CFS diagnosis.

>

> Just wondering if the rest of you manifest alcohol intolerance in the

> same way, a headache soon after ingestion.

>

> Helen

>

[Guest guest]

Started not being able to tolerate alcohol before CFS was evident.Head

ache,longer hangover.

best wishes

nil

alcohol intolerance

> Back in 1978 I realized that every time I drank anything, even a very

> small amount of alcohol, I got a headache within ten minutes. So I quit

> drinking entirely. Ten years later I got my CFS diagnosis.

>

> Just wondering if the rest of you manifest alcohol intolerance in the

> same way, a headache soon after ingestion.

>

> Helen

>

>

[Guest guest]

Hi Helen,

My alcohol intolerance starts with an all-over body overheating. It feels like

humidity - as if I am suddenly very hot and weak. I feel a sensation like hot

water going through my veins. Then I get light-headed and very woozy/brain

fogged.

The day or after I get a vicious sore throat and glands problem.

Kindest regards,

Annette

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[Guest guest]

Me, too! I still drink wine or beer on week ends but limit myself

and do not have any alcoholic beverages a few hours before bedtime.

I can have up to two (wow!) glasses of wine - maybe more if I really

spread them out over time (Like at an afternoon party or something)

My husband's first diagnosis of me was that I am allergic to alcohol.

>

> Started not being able to tolerate alcohol before CFS was

evident.Head

> ache,longer hangover.

> best wishes

> nil

> alcohol intolerance

>

>

> > Back in 1978 I realized that every time I drank anything, even a

very

> > small amount of alcohol, I got a headache within ten minutes. So

I quit

> > drinking entirely. Ten years later I got my CFS diagnosis.

> >

> > Just wondering if the rest of you manifest alcohol intolerance

in the

> > same way, a headache soon after ingestion.

> >

> > Helen

> >

> >

>

[Guest guest]

Hi All,

I have seen a deal about alcohol intolerance on this site in the past.

Can someone tell me what form this takes: is it just increased

sensitivity or something different?

Graham

[Guest guest]

Hi Graham,

Please see my post of Sunday 7th pm, which details exact effects on me.

There are a number of posts relating to the same topic, which suggest

each of us is affected differently.

Hope that's helpful, enjoy the day.

> Can someone tell me what form this takes: is it just increased

> sensitivity or something different?

>

> Graham

>

[Guest guest]

I can only say that from my point of view I had to stop drinking

alcohol altogether as it made me so ill. I only had to have one or two

pints of lager and I would have a hangover for days, I guess that my

metabolism was so slow that the alcohol stayed in my system longer!!

Not pleasant though when you have things to do.

Glynis

> Can someone tell me what form this takes: is it just increased

> sensitivity or something different?

>

> Graham

>

[Guest guest]

Hi Graham

http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?l611360

Look down this listing of possible problem areas.

See the associations for MDD2

Non-Goitrous Congenital Hypothyroidism

Aldehyde Dehydrogenase I ? as under

http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600463

this latter may explain some or all of the problem with alcohol

Bob

>> Hi All,> > I have seen a deal about alcohol intolerance on this site in the past.