Fw: PLEASE POST~~RE:HARVARD STUDY~MGUS/MULTIPLE MYELOMA

[Guest guest]

From: " sey (by way of ilena rose) " <fuchsmorrissey@...>

Sent: Thursday, April 12, 2001 6:16 PM

Subject: PLEASE POST~~RE:HARVARD STUDY~MGUS/MULTIPLE MYELOMA

> Ilena please post this to all as my concerns are valid for ALL breast

> implant exposed women and their children who took " hits " via the placental

> barrier through fetal cells in autoimmunity. MY QUESTION: Why did the

> Harvard researchers with their so-called " new " MGUS/MYELOMA study NOT AT

ALL

> address the genetic susceptibility issues of myeloma and silicone gel

breast

> implants? PLEASE NOTE STUDY: NCI/1994 Induction of Plasmacytomas With

> Silicone Gel In Genetically Susceptible Strains of Mice, M. Potter, S.

> on, F. Wiener, X.F.Zhang, and F.W. (Dr.FRED MILLER who many

> know.He has done his study on myeloma. Remember?)ALSO NOTE:

> EDITORIALS~Silicone Gel, Induction of Plasma Cell Tumors, and Genetic

> Susceptibility in Mice:GENETIC SUSCEPTIBLITY IS A KEY WORD TO TAKE NOTE

> OF... a Call for Epidemlologic Investigation of Women with Silicone Breast

> Implants, S.E. Salmon, R.A. (both myeloma specialists). This

editorial

> clearly states " perhaps some reassurance can be gotten from the fact that

> experimental plasmacytomas can be induced only under...conditions in

> GENETICALLY SUSCEPTIBLE MICE " . WE ARE TALKING ABOUT " ENHANCEMENT " OF

> AUTOIMMUNITY HERE! NOTE:genetically susceptible! It goes on to state,If

the

> same is true (and it is a big " IF " ), then most women with implants are

> probably not at increased risk for MGUS and multiple myeloma. SO AGAIN, in

> the HARVARD STUDY where does it address the genetic susceptibility

> part/issues? The Harvard study, I feel DISTORTED the study and its

findings

> with their " MEDICAL WORDS OF ART " dismissing and not addressing the

genetic

> susceptiblility part with MGUS/MYELOMA and breast implants. Did the

Harvard

> researchers do a very, VERY detailed genetic pedigree/genetic histories on

> ALL OF THEIR HUMAN RESEARCH SUBJECTS? OOPS, they failed to address this

> issue also. MY own grandmother (she also had RA, " clustering " of

> autoimmunity) and mom both died from myeloma, were both smokers...I, to

date

> have MS, asthma, a poorly defined CTD, problems in my spine at L4,L5, have

> had a elevated IgM & had 3M/McGhan implants from 1976-1993, ending in a

> mastectomy in 1993. But even with the MS/multiple sclerosis I have to

date,

> that did NOT show up until 1998 with abnormal MRI's of my brain! My very

> first ever MRI of my brain was NORMAL in 1995. Then in 1998 there was a

huge

> change...I was a late bloomer! I am dealing with ENHANCED

> autoimmunity/chemically~induced autoimmunity as are our children. AND THIS

> FAMILY IS NOT ALONE AT ALL AS THERE ARE SO MANY OTHERS! I guess I am a

LATE

> BLOOMER with diseases! Maybe I am a late bloomer for getting myeloma too!

> Time will indeed tell. I am not worried, because I have life to live! Just

> want to say I feel that Harvard researchers are missing the boat with

> ENHANCED autoimmunity, genetics and failed to address MGUS, myeloma,

> silicone breast implants and the genetic predispostion! They distorted

their

> findings with " medical words of art " . SO WHAT IS NEW? And I should not

have

> a child with scleroderma, a swallowing disorder and an " acral bone

> dysplasia " to this damning degree which this little girl, our has,

as

> did she & two her sisters took " hits " of this adjuvant via the placental

> barrier through fetal cells in autoimmunity along with the time factor of

> exposure. Genetics was the foundation, NOT THE CAUSE. The " cause " was the

> environmental trigger/time factor of exposure (RE: from silicone breast

> implants)...Different triggers produce DIFFERENT symptoms, sometimes

UNIQUE

> symptoms. And no, you do not have to aggree with my words. This is my own

> personal viewpoints and expressed concerning with what I have personally

> lived in my own life. My concerns are VALID! Take care,

>

>

> >From: " sey " <fuchsmorrissey@...> (by way of ilena

rose)

> >Recipient List Suppressed:;

> >Subject: BREAST IMPLANTS ARE THE ENHANCEMENT OF THE IMMUNE SYSTEM

> >Date: Fri, 6 Apr 2001 20:46:06 -0700

> >

> >IILENA, PLEASE POST TO ALL. LADIES PLEASE REMEMBER WHEN YOU READ THIS

STUDY

> >BELOW THAT WAS POSTED ON THE MYELOMA LIST I AM ON: An adjuvant is a

> >substance that can ENHANCE the immune response to a foreign material

(such

> >as a protein). REMEMBER: ENHANCE, ( " enhance " is the important " medical

word

> >of art " chosen in this saying)... ENHANCE a foreign material (silicone)

> >such

> >as a protein~ which protein excesses are common in many diseases,

PRIMARILY

> >THOSE THAT STIMULATE THE IMMUNE SYSTEM, SUCH AS LUPUS, MULTIPLE

MYELOMA/MM

> >AND SIMILAR CONDITIONS...similar conditions like RA, MS AND

> >SCLERODERMA/ " clustering " of autoimmunity besides lupus and myeloma. I

feel

> >that not alot with the exposure to breast implants will get myeloma only

> >those with the genetic predispostion, BUT BREAST IMPLANTS WILL INDEED

> >ENHANCE THE IMMUNE RESPONSE as we are ALL dealing with the total

> >ENHANCEMENT

> >of ones immune response whether end result is " classic autoimmunity " or

> > " not

> >classic autoimmunity " . I do see this as we are living it as my maternal

> >grandmother who had very, very bad RA/ " clustering " of autoimmunity died

> >from

> >myeloma. My mother died from myeloma June1994. They both were smokers,

took

> > " hits " of a different trigger smoking: Aflatoxin/aspergillus flavus,

> >Tobacco, Ammonia, The p-53 Tumor Suppressor Gene, which is cancer's

missing

> >link. My children and I were exposed to breast implants. These children

> >took

> > " hits " via the placental barrier through fetal cells in autoimmunity.

> >Breast

> >feeding was extra " hits " . I have MS, asthma, a poorly defined CTD,

> >problems

> >in the spine at L4-L5 and more. Our daughters have health concerns. Our

10

> >yr old has scleroderma (scleroderma runs hand-in-hand with silica

> >exposure),

> >a swallowing disorder and an " acral bone dysplasia " (silica binds the

> >bone).

> >I will go further as I question MICROCHIMERISM/GVHD~FETAL CELLS IN

> >AUTOIMMUNITY. Microchimerism which refers to " the presence of foreign

cells

> >in one's body. So put microchimerism which is the presence of foreign

cells

> >in one's body along with taking " hits " of foreign protein excesses

> >(silicone

> >in this case) along with a genetic predisposition/ " clustering " of

> >autoimmunity and a POSSIBLE " TWO HIT " THEORY...Then how many " hits " does

it

> >take to cross the threshold to the chronic/defined disease? " Two hits " ,

> > " five hits " , " ten hits " or more? AND what about HERVs, ALU and jumping

> >genes

> >in this whole process? END RESULT, I feel will indeed be the enhancement

> >of

> >the immune system, plain and simple! CAUSATION OF SILICONE is the

> >ENHANCEMENT OF THE IMMUNE RESPONSE! AND different triggers will produce

> >different symptoms, sometime UNIQUE symptoms. Living this 24/7 in my own

> >family. These researchers from Harvard as others need to look at the big

> >picture of the ENHANCEMENT OF THE IMMUNE RESPONSE. Which is the immune

> >system only going through the proper changes given the environmental

> >trigger/time factor of exposure which is ENHANCING the immune system

> >totally. Because the enhancement the immune system goes out of control as

> >it

> >was programmed in a different way, seeing what it was exposed to, in

this

> >case silicone breast implants! Researchers care to see what they wish to

> >see...and the medical mind should not/CAN NOT be made up once and for all

> >that breast implants are " safe " and have an " acceptable risk " . They are

not

> >safe, nor have an acceptable risk IF one wishes to OBSERVE WELL with that

> >open-mind which is indeed VITAl to medicine, science and research to

uphold

> >itself to that higher standard of DO NO HARM. Breast implants ENHANCE the

> >immune system. Take care, Fuchs-sey

> >Fuchssey@...

> >

> >

> > >From: " Kathleen Beymer " <kjbeymer@...>

> > > " IMF List " <myeloma@...>, " MMA List "

> > ><myeloma@...>

> > >Subject: [MMA] No Link Seen Between

> > >Date: Sat, 31 Mar 2001 14:14:08 -0800

> > >

> > >Multiple Myeloma Association (MMA) -

> > >http://www.webspawner.com/users/myelomaexchange/

> > >

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> > >No Link Seen Between

> > >MGUS and Breast Implants

> > >-------------------------------------------------------------------

> > >BOSTON--The purported association between breast implants and

> > >monoclonal gammopathy of undetermined significance seems to

> > >be fading.

> > >

> > > A Harvard team reported that the rate of MGUS was comparable

> > >among 288 women who'd had or still had breast

> > >implants and 288 women who'd never had implants-five vs. four

> > >patients.

> > >

> > > It was the sixth study, though the first cohort study using

> > >stored blood samples instead of medical records, to find no

> > >association. In contrast, three case series and the National

> > >Cancer Institute's registry, all reported in 1996, reported an

> > >association.

> > >

> > > The nine with MGUS came from the 32,826 women in the

> > >prospective Nurses' Health Study who provided 30 ml of blood in

> > >1988 for future research. None of the nine had developed

> > >multiple myeloma or other hematologic disease by 1996, reported

> > >rheumatologist W. Karlson of Brigham and Women's and

> > >olleagues in the March 26 Archives of Internal Medicine.

> > >Eventually 24% of women with MGUS develop multiple myeloma,

> > >macroglobulinemia, amyloidosis, or related diseases.

> > >

> > > Among the five women with implants who developed MGUS, three

> > >had devices filled with silicone gel, though a separate analysis

> > >showed no significant association between this kind of device

> > >and MGUS. One woman had a saline implant and the other was unknown.

> > >

> > > The five women averaged eight years older than the four in the

> > >control group with MGUS. The investigstors said this indicated

> > >that implants do not cause MGUS at a younger than expected age.

> > >Other reports found multiple myeloma developing at unusually

> > >young ages among women with silicone breast implants.

> > >

> > >

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