3D Treatment thoughts

[Guest guest]

Hi everybody

Ive listened to all the talk about not bothering to do the 3D TX.

[interferon/Riba with the Protease Inhibitor added.]

So I decided to do a little research on this topic, and see for myself if it is worthwhile to try the 3D TX or not.....'if you have already failed the combo TX'.

I tend to disagree that trying the I/R TX again, with the Protease Viral Inhibitor added, is worthless.

I know I havent done the TX even once, but I have been keeping my ears open to the reports, and everyones posts, in this group, and several others.

So here is what I think.

This is just my opinion, so please dont beat me up too badly.

Im a nice guy, trying to help. :-)

[1] LIVING PROOF

Gloria failed her first TX, [the 48 wk I/R combo].

She did the 3D TX, and reached SVR, [i/R + PVI].

I havent talked with anyone else who did this, as Gloria was on a Clinical Trial, and I dont know of anyone else on a CT.

I have looked in www.clinicaltrials.gov for the results of Gloria's trial, but the results have not been posted yet.

I wanted to see what percentage of people had reached SVR using the 3D, in her CT.

[2] ARTICLES

Interim Results from Study 107 Highlight the Potential Role of Telaprevir-Based Regimens in HCV Patients Who Failed Prior Treatment

Oct 28, 2009

http://investors.vrtx.com/releasedetail.cfm?ReleaseID=419250

57% of prior treatment null responder patients achieved an SVR with a 48-week telaprevir-based regimen

http://www.reuters.com/article/idUSN2727066420091028

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More than 80% of Hepatitis C Patients Treated in Study C208 Achieved an SVR with Telaprevir-Based Regimens

http://health.dir./group/ /message/20038

10-31-09

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Schering-Plough reports data on hepatitis C drug

http://health.dir./group/ /message/20081

"When you add boceprevir to these individuals, these null responders, you canget a sustained response, a cure of up to 55 percent, in the mostdifficult-to-treat individuals," said Quo, the principal investigator inthe study.

11-2-2009

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Im very tired so I will stop with these few articles.

Im sure there are more articles like this in the Links Library - Folders - 000C HCV NEWS ARCHIEVE.

2009

http://health.dir./group/ /links/NEWS_ARTICLES_001251495695/

2010

http://health.dir./group/ /links/000A___HCV_NEWS_ARCHIEVE_001262375126/

The point I was trying to show is that with the Protease Viral Inhibitor added to the Combo TX [i/R], the 3D TX could potentually be a good thing, and you might reach SVR.

Providing your body can handle the Interferon and/or Ribaviron.

The results also depend on your genotype, Im sure.

I just hate the thought of anyone giving up because they failed with the I/R TX combo.

[Even more than once.]

Of course your Hdoc would be able to advise you better than I ever could.

I personally believe that there is still hope for each of us, and that the combo I/R TX with the PVI may be a good thing.

It seems to me that the old I/R TX combo has less than a 40% SVR rate.

Even 55% is a better chance for non-responders if they do the 3D TX.

And for first timers, up to 80% SVR, is really good news [depending on genotype again].

Then another thing to think about is that there is bunches of stuff comming in the pipeline.

Its fasinating to me to hear about all the angles of study going on.

I know its going to take a few more years probably for some of this stuff to hit your doctors office, but it is on the way.

Thank God that HCV progresses slowly in most of us, because we might just have the time to wait.

My friends, please dont give up hope.

love

don in ks