Re: Serzone

[Guest guest]

Elena,

What is serzone?

J

>From: Elena P <brit71@...>

>Reply- onelist

> onelist

>Subject: Re: [ ]More Liver Info.

>Date: Fri, 13 Aug 1999 08:45:50 -0700 (PDT)

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>From: Elena P <brit71@...>

>

>No I haven't, but Paxil (which is what im taking) is

>basically the same as prozac. However, it wasnt the

>paxil that gave me the toxic reaction it was the

>Serzone. It could have also been caused by vitamin

>accumalation.

>Elena

>

>--- susan johnson <shireen42@...> wrote:

> > From: " susan johnson " <shireen42@...>

> >

> > Elena,

> >

> > Did yu ever take prozac? I ask that because my

> > symptoms are those of a drug

> > induced liver problem. I take prozac and recently

> > heard it can be toxic to

> > liver.

> >

> > J

> >

> >

> > >From: Elena P <brit71@...>

> > >Reply- onelist

> > > onelist

> > >Subject: Re: [ ]More Liver Info.

> > >Date: Thu, 12 Aug 1999 09:16:43 -0700 (PDT)

> > >MIME-Version: 1.0

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><19990812161643.1870.rocketmail@...>

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> > >

> > >From: Elena P <brit71@...>

> > >

> > >Thanks for you info Barbara. I have a positive ANA

> > and

> > >ASMA and was taking Serzone and Paxil. My enzymes

> > >increased rapidly and when I stopped taking serzone

> > my

> > >enzymes returned to normal. As far as I know they

> > are

> > >still normal even though I take paxil. At the time

> > i

> > >was also taking vitamins, so they could have also

> > been

> > >the problem. Maybe my liver is just more sensitive,

> > >having AIH.

> > >Elena

> > >

> > >

> > >--- Barbara Renick <brenick@...> wrote:

> > > > From: Barbara Renick <brenick@...>

> > > >

> > > > You may be correct that drugs triggered your

> > > > problem, but this is

> > > > probably not the case for those with AIH or PSC.

> > It

> > > > is my understanding

> > > > that hepatitis due to drug exposure goes away

> > when

> > > > the drug is

> > > > withdrawn.

> > > >

> > > > I had taken Prozac and was curious about whether

> > > > that had triggered my

> > > > AIH. I actually went to the library and read an

> > > > article in the

> > > > Psychiatric Journal about Prozac and hepatitis

> > to be

> > > > sure. In the cases

> > > > they cited, Prozac indeed could cause hepatitis,

> > but

> > > > the hepatitis went

> > > > away when the Prozac was stopped.

> > > > Hepatitis induced by Prozac is rare.

> > > >

> > > > I do avoid drugs such as Tylenol today though. I

> > am

> > > > taking Zoloft now

> > > > and it is not working as well as Prozac did for

> > me,

> > > > but I am reluctant

> > > > to go back to Prozac because, as you said, it

> > can be

> > > > harmful to those

> > > > with damaged livers.

> > > >

> > > > Elena P wrote:

> > > > >

> > > > > From: Elena P <brit71@...>

> > > > >

> > > > > I think this is what happened to me; drugs

> > > > triggered

> > > > > liver inflammation.

> > > > > ..............................

> > > > >

> > > > > 4LIVERBook Source: " When Your Doctor Doesn't

> > Know

> > > > > Best! "

> > > > > Medical Mistakes That

> > Even

> > > > the

> > > > > Best Doctors Make-

> > > > > and How to Protect

> > Yourself.

> > > > > By: N. Podell, MD

> > and

> > > > > Proctor

> > > > > Simon & Schuster, New

> > York,

> > > > 1995

> > > > > What's Going On With My Gut? (page 249)

> > > > > ERROR: Your Doctor Prescribes a Drug That

> > Makes

> > > > Your

> > > > > Liver Damage Worse

> > > > > FACTS: Almost every drug can trigger liver

> > > > > inflammation in a rare

> > > > > susceptible person, and we have to live with

> > this

> > > > > uncertainty wheneverwe

> > > > > prescribe or use drugs. But certain drugs are

> > > > more

> > > > > likely than othersto

> > > > > irritate the liver. These should be watched

> > > > closely

> > > > > in people who have

> > > > > recent case of hepatitis, who have ongoing

> > > > diseases of

> > > > > the liver, orwho turn

> > > > > out to be especially sensitive to certain

> > > > medications.

> > > > > You should be particularly alert to the

> > potential

> > > > > liver toxicity of twovery

> > > > > popular over-the-counter medicines:

> > acetaminophen

> > > > > (Tylenol), which is a

> > > > > painkiller; and niacin(Vitamin B3), which is

> > used

> > > > to

> > > > > control cholesterol.

> > > > > Tylenol in high doses damages the liver,

> > > > particularly

> > > > > if you also drink

> > > > > alcohol. Niacin is safe in low doses

> > contained in

> > > > > most multivitamins. But

> > > > > in the high doses that are used to lower blood

> > > > > cholesterol--andespecially

> > > > > above 3,000 milligrams per day--niacin can

> > cause

> > > > liver

> > > > > inflammation inmany

> > > > > people. In a March 1994 issue of The Journal

> > of

> > > > the

> > > > > American Medical

> > > > > Association, researchers from the Medical

> > College

> > > > of

> > > > > Virginia confirmed

> > > > > earlier findings and concluded that the

> > > > > sustained-release niacin (whichmany

> > > > > patients prefer because it causes less

> > flushing)

> > > > was

> > > > > more toxic to theliver

> > > > > than the standard non-sustained-released type.

> > > > > If you already have liver damage or disease,

> > the

> > > > risk

> > > > > of problems fromthese

> > > > > two drugs increases significantly. Here's a

> > list

> > > > of a

> > > > > few drugs thatare

> > > > > most likely to harm a patient with a damaged

> > > > liver:

> > > > > acetaminophen (Tylenol

> > > > > products)AccutanealcoholAldometanabolic

> > > > > steroidsAntabuse

> > > > >

> > > >

> >

> >BactrimCapotenDilantinElavilFansidarFloxinMevacorniacinNormodynePravachol

> > > > >

> >

>=== message truncated ===

>

>===

>Elena AIH

>San Diego, CA

>_________________________________________________________

>

[Guest guest]

Its an anti anxiety drug, which I used for a phobia

(which I guess now is a phobia of doctors!)

--- susan johnson <shireen42@...> wrote:

> From: " susan johnson " <shireen42@...>

>

> Elena,

>

> What is serzone?

>

> J

>

>

> >From: Elena P <brit71@...>

> >Reply- onelist

> > onelist

> >Subject: Re: [ ]More Liver Info.

> >Date: Fri, 13 Aug 1999 08:45:50 -0700 (PDT)

> >MIME-Version: 1.0

> >From errors-165537-5164-shireen42 Fri Aug 13

> 08:45:50 1999

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>

<19990813154550.29462.rocketmail@...>

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> >From: Elena P <brit71@...>

> >

> >No I haven't, but Paxil (which is what im taking)

> is

> >basically the same as prozac. However, it wasnt the

> >paxil that gave me the toxic reaction it was the

> >Serzone. It could have also been caused by vitamin

> >accumalation.

> >Elena

> >

> >--- susan johnson <shireen42@...> wrote:

> > > From: " susan johnson " <shireen42@...>

> > >

> > > Elena,

> > >

> > > Did yu ever take prozac? I ask that because my

> > > symptoms are those of a drug

> > > induced liver problem. I take prozac and

> recently

> > > heard it can be toxic to

> > > liver.

> > >

> > > J

> > >

> > >

> > > >From: Elena P <brit71@...>

> > > >Reply- onelist

> > > > onelist

> > > >Subject: Re: [ ]More Liver Info.

> > > >Date: Thu, 12 Aug 1999 09:16:43 -0700 (PDT)

> > > >MIME-Version: 1.0

> > > >From errors-165537-5119-shireen42 Thu Aug 12

> > > 09:15:58 1999

> > > >Received: from [209.207.164.209] by hotmail.com

> > > (2.1) with ESMTP id

> > > >MHotMailB97C3E3E00C2D82197E6D1CFA4D120DC0; Thu

> Aug

> > > 12 09:15:58 1999

> > > >Received: (qmail 28326 invoked by alias); 12

> Aug

> > > 1999 16:15:35 -0000

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> 12

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> web104.mail.com)

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> > > -0000

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> > >

>

><19990812161643.1870.rocketmail@...>

> > > >Received: from [204.240.140.6] by

> > > web104.mail.com; Thu, 12 Aug 1999

> > > >09:16:43 PDT

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> > > contact

> > > > -owneronelist

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> > > >

> > > >From: Elena P <brit71@...>

> > > >

> > > >Thanks for you info Barbara. I have a positive

> ANA

> > > and

> > > >ASMA and was taking Serzone and Paxil. My

> enzymes

> > > >increased rapidly and when I stopped taking

> serzone

> > > my

> > > >enzymes returned to normal. As far as I know

> they

> > > are

> > > >still normal even though I take paxil. At the

> time

> > > i

> > > >was also taking vitamins, so they could have

> also

> > > been

> > > >the problem. Maybe my liver is just more

> sensitive,

> > > >having AIH.

> > > >Elena

> > > >

> > > >

> > > >--- Barbara Renick <brenick@...> wrote:

> > > > > From: Barbara Renick <brenick@...>

> > > > >

> > > > > You may be correct that drugs triggered your

> > > > > problem, but this is

> > > > > probably not the case for those with AIH or

> PSC.

> > > It

> > > > > is my understanding

> > > > > that hepatitis due to drug exposure goes

> away

> > > when

> > > > > the drug is

> > > > > withdrawn.

> > > > >

> > > > > I had taken Prozac and was curious about

> whether

> > > > > that had triggered my

> > > > > AIH. I actually went to the library and read

> an

> > > > > article in the

> > > > > Psychiatric Journal about Prozac and

> hepatitis

> > > to be

> > > > > sure. In the cases

> > > > > they cited, Prozac indeed could cause

> hepatitis,

> > > but

> > > > > the hepatitis went

> > > > > away when the Prozac was stopped.

> > > > > Hepatitis induced by Prozac is rare.

> > > > >

> > > > > I do avoid drugs such as Tylenol today

> though. I

> > > am

> > > > > taking Zoloft now

> > > > > and it is not working as well as Prozac did

> for

> > > me,

> > > > > but I am reluctant

> > > > > to go back to Prozac because, as you said,

> it

> > > can be

> > > > > harmful to those

> > > > > with damaged livers.

> > > > >

> > > > > Elena P wrote:

> > > > > >

> > > > > > From: Elena P <brit71@...>

> > > > > >

> > > > > > I think this is what happened to me; drugs

> > > > > triggered

> > > > > > liver inflammation.

> > > > > > ..............................

> > > > > >

> > > > > > 4LIVERBook Source: " When Your Doctor

> Doesn't

> > > Know

> > > > > > Best! "

> > > > > > Medical Mistakes That

> > > Even

> > > > > the

> > > > > > Best Doctors Make-

> > > > > > and How to Protect

> > > Yourself.

> > > > > > By: N.

> Podell, MD

> > > and

> > > > > > Proctor

>

=== message truncated ===

===

Elena AIH

San Diego, CA

_________________________________________________________

[Guest guest]

LOL! Phobia of doctors! I took serzone for a while for depression but it

didn't work for me.

Dianne A.

[Guest guest]

This is some very important, additional information I came across on another

Hep C support forum (HepCnet). http://www.hepcnet.net

I copied and pasted it here. This is very important information. Read what

the FDA had to say about this drug in 2002. Read the last sentence again and

again.

Please pass this along to everyone you know who has Hep C and is taking

AntiD's.

By LAURAN NEERGAARD, AP Medical Writer

WASHINGTON - The maker of Serzone will pull the controversial antidepressant

off the U.S. market next month, blaming a decline in sales rather than concern

about a risk of liver failure.

The end to U.S. sales comes after Serzone was pulled off the market in many

other countries, and as maker Bristol-Myers Squibb was under mounting pressure

from lawsuits. Serzone has been linked to dozens of cases of liver failure and

injury, including at least 20 deaths.

A Bristol-Myers spokesman confirmed the decision in an interview Wednesday, a

day after the company notified wholesalers that distribution would end June

14.

The end to sales " is long overdue, " said Dr. Sidney Wolfe of the consumer

group Public Citizen. " None of the other antidepressants causes liver damage

like

this. "

Wolfe last spring sued the Food and Drug Administration (news - web sites)

seeking to force a ban on Serzone. That suit will proceed in an effort to also

end sales of generic versions of Serzone, called nefazodone, Wolfe said.

An Alabama attorney said he would ask the company and the FDA to go a step

further and recall Serzone, saying that patients shouldn't continue to buy and

use the pills between now and June 14.

" I really think that's a ploy to take the heat off, " said Jere Beasley, an

attorney in Montgomery, Ala., representing 30 families in Serzone lawsuits.

" It's not going to solve the problem. "

Bristol-Myers spokesman Rob Hutchison said that the decision had nothing to

do with safety questions and that the company would continue to vigorously

defend the pending lawsuits.

" We still believe, and I believe the FDA does, too, as well as physicians,

that nefazodone is an important therapeutic option for patients with

depression, " Hutchison said.

Instead, the company is discontinuing Serzone because of rapidly declining

sales after generic competitors hit the market last year, he said. " Our market

share is very small. "

Sales of 16 other very old products also will cease, he added.

Bristol-Myers ended Serzone sales in Europe over a year ago, citing declining

sales. Canadian regulators banned the drug last fall because of the liver

risk. Sales in Australia and New Zealand are about to end, too.

The FDA has received reports of at least 55 cases of liver failure, including

20 deaths, and another 39 cases of less severe liver injury since Serzone

began selling in 1994. In 2002, the FDA added to Serzone's label its strongest

type of warning about the liver risk, maintaining that liver toxicity is a rare

risk adequately managed by warning patients.

But Wolfe notes that the World Health Organization (news - web sites) and

Canadian regulators last year compared a number of popular antidepressants and

found only Serzone was linked to an increased risk of serious liver injury.

Canadian authorities said they banned the drug because there was no way to

predict which patients would be at risk for liver failure. Routine liver tests

haven't reduced that risk, they said.

[Guest guest]

In a message dated 1/11/05 4:54:51 PM Mountain Standard Time,

SSRI medications writes:

> Serzone, a preferred anti-depressant as “no long term side-effectsâ€

>

So I guess having your liver explode isn't a longterm side effect??????

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

In a message dated 1/11/05 4:54:51 PM Mountain Standard Time,

SSRI medications writes:

> Serzone, a preferred anti-depressant as “no long term side-effectsâ€

>

So I guess having your liver explode isn't a longterm side effect??????

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

>

>

>

>

> Last year sometime I remember seeing on a 'news' program a young

woman dying in a hospital bed because of a liver transplant going

bad; a transplant she needed because anti depressants destroyed her

first one. .......I think it might have been Serzone that caused her

original liver failure.

[Guest guest]

>

>

>

>

> Last year sometime I remember seeing on a 'news' program a young

woman dying in a hospital bed because of a liver transplant going

bad; a transplant she needed because anti depressants destroyed her

first one. .......I think it might have been Serzone that caused her

original liver failure.

[Guest guest]

>

>

>

>

> Last year sometime I remember seeing on a 'news' program a young

woman dying in a hospital bed because of a liver transplant going

bad; a transplant she needed because anti depressants destroyed her

first one. .......I think it might have been Serzone that caused her

original liver failure.

[Guest guest]

>

>

>

>

> Last year sometime I remember seeing on a 'news' program a young

woman dying in a hospital bed because of a liver transplant going

bad; a transplant she needed because anti depressants destroyed her

first one. .......I think it might have been Serzone that caused her

original liver failure.

[Guest guest]

In a message dated 1/12/05 5:46:36 PM Mountain Standard Time,

SSRI medications writes:

> .......I think it might have been Serzone that caused her

> original liver failure.

>

Yep, that's the drug. Now it's Strattera that causes liver damage.

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

In a message dated 1/12/05 5:46:36 PM Mountain Standard Time,

SSRI medications writes:

> .......I think it might have been Serzone that caused her

> original liver failure.

>

Yep, that's the drug. Now it's Strattera that causes liver damage.

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

In a message dated 1/12/05 5:46:36 PM Mountain Standard Time,

SSRI medications writes:

> .......I think it might have been Serzone that caused her

> original liver failure.

>

Yep, that's the drug. Now it's Strattera that causes liver damage.

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

In a message dated 1/12/05 5:46:36 PM Mountain Standard Time,

SSRI medications writes:

> .......I think it might have been Serzone that caused her

> original liver failure.

>

Yep, that's the drug. Now it's Strattera that causes liver damage.

" Blind Reason "

a novel of pharmaceutical intrigue

Think your antidepressant is safe? Think again. It's

Unsafe At Any Dose

[Guest guest]

next to paxil, this is probably the worst drug ever to hit the market. it

causes liver failure and death. nobody should take this drug. hasn't it been

taken off the market, or at least severely restricted in its use? bad drug.

bad bad bad drug.

as for 98% of the population being mentally ill -- the pharmaceutical

companies redefined mental illness so that nobody with a heart or a brain can

escape

a dx of some sort. it's all bullshit to sell drugs. if people would stop

eating crap loaded with dangerous chemicals, they might actually feel better.

[Guest guest]

Good point, . I guess my choice of word (mental illness) was off.

I only know what I've been taught so far in school, but I tend to agree with

what you wrote

Gab

[Guest guest]

Good point, . I guess my choice of word (mental illness) was off.

I only know what I've been taught so far in school, but I tend to agree with

what you wrote

Gab

[Guest guest]

Good point, . I guess my choice of word (mental illness) was off.

I only know what I've been taught so far in school, but I tend to agree with

what you wrote

Gab

[Guest guest]

Good point, . I guess my choice of word (mental illness) was off.

I only know what I've been taught so far in school, but I tend to agree with

what you wrote

Gab

[Guest guest]

Dear Gab,

You said:

<<I did not conduct a valid and reliable research on how many people have

> mental illness. I simply threw out 98 percent as a number based on my

> mental calculations of how many people have confessed having some form of

mental

> health issues once they found out I was a therapist. Am I off a bit?

> Maybe....this is not being published in a medical journal so I didn't think

that my

> estimation was so crucial to be exact.>>

** I think you're off more than a bit. You're making being a

human being a mental disease and the normal challenges in life " mental

health issues " . The drug companies are responsible for this type of

belief. It sells more drugs.

It is normal to have difficult passages in life, baggage we carry

with us from childhood and/or other relationships, and times where we

simply feel overworked, overtired, and overwhelmed.

Other cultures, especially those whose foundation for day-to-day

living is spiritually based, understand the wide range of emotions

experienced by humans as being perfectly normal. Sadness is no less

valid an emotion than joy. In our culture, we have been brainwashed

by the drug industry to believe something is very wrong if we are not

completely happy all the time.

It is not recognized that our emotions serve a purpose -- they tell

us that we need to address something in our lives. Unfortunately,

today more than ever, the something that needs addressing is more

often nutrition than an issues we are avoiding or failing to

recognize.

--

Regards,

[Guest guest]

Dear Gab,

You said:

<<I did not conduct a valid and reliable research on how many people have

> mental illness. I simply threw out 98 percent as a number based on my

> mental calculations of how many people have confessed having some form of

mental

> health issues once they found out I was a therapist. Am I off a bit?

> Maybe....this is not being published in a medical journal so I didn't think

that my

> estimation was so crucial to be exact.>>

** I think you're off more than a bit. You're making being a

human being a mental disease and the normal challenges in life " mental

health issues " . The drug companies are responsible for this type of

belief. It sells more drugs.

It is normal to have difficult passages in life, baggage we carry

with us from childhood and/or other relationships, and times where we

simply feel overworked, overtired, and overwhelmed.

Other cultures, especially those whose foundation for day-to-day

living is spiritually based, understand the wide range of emotions

experienced by humans as being perfectly normal. Sadness is no less

valid an emotion than joy. In our culture, we have been brainwashed

by the drug industry to believe something is very wrong if we are not

completely happy all the time.

It is not recognized that our emotions serve a purpose -- they tell

us that we need to address something in our lives. Unfortunately,

today more than ever, the something that needs addressing is more

often nutrition than an issues we are avoiding or failing to

recognize.

--

Regards,

[Guest guest]

Dear Gab,

You said:

<<I did not conduct a valid and reliable research on how many people have

> mental illness. I simply threw out 98 percent as a number based on my

> mental calculations of how many people have confessed having some form of

mental

> health issues once they found out I was a therapist. Am I off a bit?

> Maybe....this is not being published in a medical journal so I didn't think

that my

> estimation was so crucial to be exact.>>

** I think you're off more than a bit. You're making being a

human being a mental disease and the normal challenges in life " mental

health issues " . The drug companies are responsible for this type of

belief. It sells more drugs.

It is normal to have difficult passages in life, baggage we carry

with us from childhood and/or other relationships, and times where we

simply feel overworked, overtired, and overwhelmed.

Other cultures, especially those whose foundation for day-to-day

living is spiritually based, understand the wide range of emotions

experienced by humans as being perfectly normal. Sadness is no less

valid an emotion than joy. In our culture, we have been brainwashed

by the drug industry to believe something is very wrong if we are not

completely happy all the time.

It is not recognized that our emotions serve a purpose -- they tell

us that we need to address something in our lives. Unfortunately,

today more than ever, the something that needs addressing is more

often nutrition than an issues we are avoiding or failing to

recognize.

--

Regards,

[Guest guest]

Dear Gab,

You said:

<<I did not conduct a valid and reliable research on how many people have

> mental illness. I simply threw out 98 percent as a number based on my

> mental calculations of how many people have confessed having some form of

mental

> health issues once they found out I was a therapist. Am I off a bit?

> Maybe....this is not being published in a medical journal so I didn't think

that my

> estimation was so crucial to be exact.>>

** I think you're off more than a bit. You're making being a

human being a mental disease and the normal challenges in life " mental

health issues " . The drug companies are responsible for this type of

belief. It sells more drugs.

It is normal to have difficult passages in life, baggage we carry

with us from childhood and/or other relationships, and times where we

simply feel overworked, overtired, and overwhelmed.

Other cultures, especially those whose foundation for day-to-day

living is spiritually based, understand the wide range of emotions

experienced by humans as being perfectly normal. Sadness is no less

valid an emotion than joy. In our culture, we have been brainwashed

by the drug industry to believe something is very wrong if we are not

completely happy all the time.

It is not recognized that our emotions serve a purpose -- they tell

us that we need to address something in our lives. Unfortunately,

today more than ever, the something that needs addressing is more

often nutrition than an issues we are avoiding or failing to

recognize.

--

Regards,

[Guest guest]

Let's give Gab a chance to absorb the data he's getting.

Gab, hope you get some info out of all this you can use, the fact that you

are searching is very promising and I think commendable. We do see things

differently here but if you give us a chance you might actually find some

stuff you agree with.

Best,

Jim

Dear Gab,

You said:

<<I did not conduct a valid and reliable research on how many people have

> mental illness. I simply threw out 98 percent as a number based on my

> mental calculations of how many people have confessed having some form of

mental

> health issues once they found out I was a therapist. Am I off a bit?

> Maybe....this is not being published in a medical journal so I didn't

think that my

> estimation was so crucial to be exact.>>

** I think you're off more than a bit. You're making being a

human being a mental disease and the normal challenges in life " mental

health issues " . The drug companies are responsible for this type of

belief. It sells more drugs.

It is normal to have difficult passages in life, baggage we carry

with us from childhood and/or other relationships, and times where we

simply feel overworked, overtired, and overwhelmed.

Other cultures, especially those whose foundation for day-to-day

living is spiritually based, understand the wide range of emotions

experienced by humans as being perfectly normal. Sadness is no less

valid an emotion than joy. In our culture, we have been brainwashed

by the drug industry to believe something is very wrong if we are not

completely happy all the time.

It is not recognized that our emotions serve a purpose -- they tell

us that we need to address something in our lives. Unfortunately,

today more than ever, the something that needs addressing is more

often nutrition than an issues we are avoiding or failing to

recognize.

--

Regards,