Re: Dr. Zagon e-mail response

December 13, 2010

-- Dr Zagon's opinion is different from Dr Bihari's and other LDN

doctors' opinions. Dr Bihari was very clear that taking it at the

prescribed hours at night was important. Dr Bihari saw thousands of

patients on LDN. So while we know that Dr Zagon doesn't think it is

important, Dr Bihari's clinical experience indicated that it did (Dr Bihari

recently passed so we can't ask him directly anymore). Does anyone know

how Dr Berkson prescribes it?

--

>Hello All,

>

>I was worried that taking the LDN during the day would not work from

>everyone's responses so I wrote an e-mail to Dr. Zagon. I thought I would

>share his response:

>

>I wrote to him:

>

>On 12/10/2010 6:15 PM, DeBruycker wrote:

>

>Dr. Zagon,

>

>I am taking LDN now during the daytime for autoimmune diseases such as

>Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

>just as effective if you take it during the day as nighttime?

>

>Thank you.

>

>Hopeful.

>

>Dear Ms. D:

> Absolutely. A lot of folks have disturbed sleep and switch to the

> morning.

> There is a myth going around that somehow you can take it only

> in the evening.

>Dr. Zagon

>

~~~ There is no way to peace; peace is the way ~~~~

--A.J. Muste

December 13, 2010

The few times I tried morning dosing as an experiment I went right back to

evening dosing. I have the serious illness multiple sclerosis, so morning dosing

does not work for me.

Art

--

> >

> >Dr. Zagon,

> >

> >I am taking LDN now during the daytime for autoimmune diseases such as

> >Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

> >just as effective if you take it during the day as nighttime?

> >

> >Thank you.

> >

> >Hopeful.

> >

> >Dear Ms. D:

> > Absolutely. A lot of folks have disturbed sleep and switch to the

> > morning.

> > There is a myth going around that somehow you can take it only

> > in the evening.

> >Dr. Zagon

> >

>

> ~~~ There is no way to peace; peace is the way ~~~~

> --A.J. Muste

>

December 13, 2010

Hi,

Dr. Berkson starts all of his patients off on 3 mg. to be taken every night. He also believes in prescribing some kind of medication to help with initial anxiety or sleep issues for the first few weeks. He then says that "if they can take it" to move onto 4.5 mg. He does not believe in "anytime dosing".

I am still taking 3 mg but I now take it every other night. I had tried going up in dose but had problems with the increase. So far, my lab results (HCV) still seem to be the same, no matter if I take the LDN every night or every other night.

Nola Chris

Re: [low dose naltrexone] Dr. Zagon e-mail response

-- Dr Zagon's opinion is different from Dr Bihari's and other LDN

doctors' opinions. Dr Bihari was very clear that taking it at the

prescribed hours at night was important. Dr Bihari saw thousands of

patients on LDN. So while we know that Dr Zagon doesn't think it is

important, Dr Bihari's clinical experience indicated that it did (Dr Bihari

recently passed so we can't ask him directly anymore). Does anyone know

how Dr Berkson prescribes it?

--

>Hello All,

>

>I was worried that taking the LDN during the day would not work from

>everyone's responses so I wrote an e-mail to Dr. Zagon. I thought I would

>share his response:

>

>I wrote to him:

>

>On 12/10/2010 6:15 PM, DeBruycker wrote:

>

>Dr. Zagon,

>

>I am taking LDN now during the daytime for autoimmune diseases such as

>Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

>just as effective if you take it during the day as nighttime?

>

>Thank you.

>

>Hopeful.

>

>Dear Ms. D:

> Absolutely. A lot of folks have disturbed sleep and switch to the

> morning.

> There is a myth going around that somehow you can take it only

> in the evening.

>Dr. Zagon

>

~~~ There is no way to peace; peace is the way ~~~~

--A.J. Muste

December 13, 2010

Art,

I tried daytime LDN dosing for my progressive MS and it did not halt my disease

progression like the night time LDN dosing does.

, LDN user over 7 yrs

===========================

> > >

> > >Dr. Zagon,

> > >

> > >I am taking LDN now during the daytime for autoimmune diseases such as

> > >Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

> > >just as effective if you take it during the day as nighttime?

> > >

> > >Thank you.

> > >

> > >Hopeful.

> > >

> > >Dear Ms. D:

> > > Absolutely. A lot of folks have disturbed sleep and switch to the

> > > morning.

> > > There is a myth going around that somehow you can take it only

> > > in the evening.

> > >Dr. Zagon

> > >

> >

> > ~~~ There is no way to peace; peace is the way ~~~~

> > --A.J. Muste

> >

>

December 13, 2010

,

Berkson prescribes LDN to be taken according to the Bihari dosing protocol

========================

> >

> >Dr. Zagon,

> >

> >I am taking LDN now during the daytime for autoimmune diseases such as

> >Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

> >just as effective if you take it during the day as nighttime?

> >

> >Thank you.

> >

> >Hopeful.

> >

> >Dear Ms. D:

> > Absolutely. A lot of folks have disturbed sleep and switch to the

> > morning.

> > There is a myth going around that somehow you can take it only

> > in the evening.

> >Dr. Zagon

> >

>

> ~~~ There is no way to peace; peace is the way ~~~~

> --A.J. Muste

>

December 13, 2010

Although I myself follow the Bihari protocol, as this was the way I started, was

successful and therefore continued, I am somewhat concerned that we seem to be

so fixed in opinion about how to proceed. Dr. Bihari might have been the first

to acknowledge that new and more experiences are coming up and are just as

valid. Dr. Tom Gilhooly is one of the doctors with many patients on day time

dosing, he also says that different problems respond differently in dosing and

timing. I believe that there is a whole lot to learn about LDN and thanks to all

these people (amongst others Zagon/Gilhooly/Lawrence and many many more) we do

learn different sides. At the conference in Birmingham/UK it was interesting to

hear about the two halves of the molecule, left and right and their different

functions. Videos of those presentations are available through the LDN Research

Trust.

I can see where the successful people are coming from, having followed the

Bihari-protocol myself, but I have MS and I am not sensitive to medication.

Other people have quite different issues. Shouldn't we therefore be more

flexible in our opinion about what the " right " protocol is?

Some people are doing well on twice a day and higher than 4.5mg. Now of course

there will be some newbie taking this sentence out of context and then state

that this is the " done " thing.

Silvia, (the cat amongst the pigeons? Sorry, but worth contemplating, I think)

> >

> >Dr. Zagon,

> >

> >I am taking LDN now during the daytime for autoimmune diseases such as

> >Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

> >just as effective if you take it during the day as nighttime?

> >

> >Thank you.

> >

> >Hopeful.

> >

> >Dear Ms. D:

> > Absolutely. A lot of folks have disturbed sleep and switch to the

> > morning.

> > There is a myth going around that somehow you can take it only

> > in the evening.

> >Dr. Zagon

> >

>

> ~~~ There is no way to peace; peace is the way ~~~~

> --A.J. Muste

>

December 14, 2010

i am also noticing that LDN works for some illnesses during the daytime hours.

So far I have not seen anyone with chronic progressive multiple sclerosis

succeed in halting the progression of their disease on the daytime dosing, only

succeeding halting progression with night dosing. I have seen those with

Relapsing/Remitting MS succeed with day dosing of LDN, not sure all of

them(RRMS) succeed with the daytime LDN dosing. Endorphins are so low with

chronic progressive MS that I think the largest endorphins boost that takes

place in the middle of the night between 2am and 4am is what is needed to halt

chronic progressive forms of MS.

LDN user over 7 yrs for chronic progressive MS

December 14, 2010

In the five plus years being a member here I have read of one person claiming to

be taking LDN twice a day. This person posted a handful of times, then

disappeared.

Art

--

> > >

> > >Dr. Zagon,

> > >

> > >I am taking LDN now during the daytime for autoimmune diseases such as

> > >Raynauds, Sjogrens, fibro, and maybe some sort of arthritis. Will it be

> > >just as effective if you take it during the day as nighttime?

> > >

> > >Thank you.

> > >

> > >Hopeful.

> > >

> > >Dear Ms. D:

> > > Absolutely. A lot of folks have disturbed sleep and switch to the

> > > morning.

> > > There is a myth going around that somehow you can take it only

> > > in the evening.

> > >Dr. Zagon

> > >

> >

> > ~~~ There is no way to peace; peace is the way ~~~~

> > --A.J. Muste

> >

>

December 14, 2010

Hi,I've been taking LDN continuously since March of this year for Crohn's disease.Due to having lost my kidney function due to mesalazine I was first on for IBD and an apparent correlation between a further decline in my kidney function and my starting LDN, I have been expiermenting with different regimines for taking LDN myself.I had found my best result with LDN was taking 3mg per day at night but because of the kidney issue I have been trying other regimes to see if there is any positive effect on my kidney function whilst maintaining my positive results for my Crohn's (Not quite 100% in remission, as evidence by faecal calproectin test which shows my bowel still inflammed but I have no other symptoms other than slightly sub-par bowel movements - 2 a day, of generally

good quality and I take no other medication for IBD other than Vitamin D3 5000 IU / day and 75mg / day zinc)Firstly I tried LDN 3mg every second day, then every 3rd, 4th - I found every 2nd day was as good as every day but not every 3rd or later.Since 28th of October I have been taking 1.5mg LDN twice a day, morning and before retiring, again I found no negative from this and if anything I felt more awake during the day.This week after discussion with Dr Gilhooly, I have upped this to 2mg twice a day and note no negative effects so far,I can understand why people would rather go with the flow of what people on boards etc are saying has worked for them.However, I would suggest that anyone who is not getting the results they would like might care to experiment, working with their doctor with other ways of taking LDN, during the day or night or splitting dose or trying every second day dosing.The taking LDN

during the day is in line with current theories on LDN that suggest the 2 enantiomers have different effects, one having an endorphin blockade and subsequent boost effect and the other having a more direct effect on inflammation - I am unclear on the details of this, I might have done chemistry at Uni initially but I am no biochemist or pharmacist, but I do understand the scientific method of experimentation and am happy to do it on myself if it helps me keep my Crohn's under control!Fact is, the absence of more clinical research, we are all experimenting with LDN and there is still to much to learn.Best of luck to all on LDN.Cheers,-Bob T.SIGN the EU Parliament LDN Research Funding Petiton - http://www.ipetitions.com/petition/ldnnow/ (Non EU citizens can sign too)WATCH - Dr Steele MBE of ITV's This Morning

supporting Low Dose Naltrexone (LDN)http://bit.ly/DrCS_LDNWATCH - LDN Now at the ish Parliament on LDN on the NHS -http://bit.ly/SPLDNvideoFOLLOW LDNNow on twitter - http://twitter.com/LDNNowWRITE to your MP/MSP/AM to demand LDN on the NHS - http://writetothem.comRECORD your LDN experience - http://ldndatabase.comhttp://ldnnow.comLDNNow, a patient and friend led organisation (so not a charity) with no funding and no affiliation to any

company or organisation, but rather a group of concerned individuals focussed on improving the health of those who suffer from the many diseases and conditions that LDN treats.Crohn's and LDN Links -http://ldnonthenhs.blogspot.comhttp://wearecrohns.org/bobthomson70/journalshttp://ldnforcrohns.blogspot.com

December 14, 2010

I’d just like to share with the group that Dr Bob Lawrence who has PPMS has switched to day time dosing and has been following this protocol very successfully for several months now. He personally feels this provides him with greater benefit purely because of the insomnia (which people are currently discussing in this group). Initially he thought he was just a bad sleeper. It wasn’t until he tried day time dosing did he realize that for him it was the LDN causing sleepless nights. He has been taking LDN for 10 years and having met with him the other week, I don’t think he’ll return to night time dosing as he no longer has sleepless nights. So for those who do have insomnia issues and believe it’s the LDN causing this, it might be worth your while switching to day time dosing. However, many of us do have sleepless nights due to our diseases, with or without LDN. Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of bren_ldnSent: 14 December 2010 05:45low dose naltrexone Subject: [low dose naltrexone] Re: Dr. Zagon e-mail response i am also noticing that LDN works for some illnesses during the daytime hours. So far I have not seen anyone with chronic progressive multiple sclerosis succeed in halting the progression of their disease on the daytime dosing, only succeeding halting progression with night dosing. I have seen those with Relapsing/Remitting MS succeed with day dosing of LDN, not sure all of them(RRMS) succeed with the daytime LDN dosing. Endorphins are so low with chronic progressive MS that I think the largest endorphins boost that takes place in the middle of the night between 2am and 4am is what is needed to halt chronic progressive forms of MS. LDN user over 7 yrs for chronic progressive MS

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