RE: disappointed about having to use Prednisone for kidney deterioration - from Dr Bob Lawrence

March 9, 2010

Guess we all have our opinions and there are two sides of the

coin but here’s Dr Lawrence’s opinion, I have also asked my partner who

is a scientist to query Dr Zagon on a few things. Will forward them as soon as

we get them. Asking questions and getting responses is excellent, but

scientists like to challenge each other.

Dear

Jayne,

Thank

you for sending this.

I

regret that, once again, I must disagree with Dr Zagon. I have simply

found by experience that those patients on steroids simply DO NOT RESPOND to

LDN in the manner that I would expect.

Anyone

who disagrees with this opinion may either like it or lump it.

Kind

regards,

Bob

L

-----

Original Message -----

From: jaynelcrocker

'Bwmbagus'

; 'Bob

Lawrence'

Sent: Monday, March 08,

2010 5:24 PM

Subject: FW:

[low dose naltrexone] disappointed about having to use Prednisone for kidney

deterioration

FYI:-

Jayne Crocker

www.LDNNow.com

Important! Please sign our LDN petition to the

European Parliament by clicking here

tel: +44 (0) 7877 492 669

Dr Steele MBE, talking about LDN

LDNNow, a patient and friend led organisation (so not a charity)

with no funding and no affiliation to any company or organisation, but rather a

group of concerned individuals focussed on improving the health of those who

suffer from the many diseases and conditions that LDN treats.

From: low dose naltrexone

[mailto:low dose naltrexone ] On Behalf Of Celia

Sent: 08 March 2010 16:36

low dose naltrexone ; zahavi

Subject: Re: [low dose naltrexone] disappointed about having to use

Prednisone for kidney deterioration

You

actually can use more than 10mgs of pred with LDN - Dr Zagon says to

say otherwise is an urban myth, here is part of his mail to me - It would be

good if we could clear things up on this once and for all.......

Celia

Dear Celia:

Prednisone is an

anti-inflammatory agent. What you are

saying is that these folks on the web believe the nonsense that

LDN is a stimulator of immunity, and that prednisone would

counteract this. Well, now the news. LDN - like OGF - is an anti-

inflammatory agent as well!! Yes, all of these rumors by non-

scientists - and some poor science - are in error. LDN works as an

anti-inflammatory as well, and the mechanism is targeting the

cyclin-dependent inhibitory kinase pathway of the cell cycle -

specifically p16 and p21 - those are the very details you may

want. An increase in p16/p21 depresses the G1/S interface of the

cell cycle, causing cells to slow down in cell replication, with

the net result of suppressing the immune system. So, LDN -

like

OGF - diminish cell proliferation - and these include cells of the

immune system (e.g., T cells, B cells). In fact, we are

coming

out with a series of papers showing how this entire show is

working because of the confusion on the part of some erroneous

experiments leading to the wrong conclusion.

As always, there

are rumors and anecdotal information

- and the web is filled with it - and then there is science. You

are putting far to much confidence on the web. Anyone can say

anything - that is why I never bother reading this.

>>

Dr. Zagon