from one generation to another....

[Guest guest]

-----Original Message-----

From: Mitzi J <mitzipeterson@...>

egroups <egroups>

Date: Wednesday, January 17, 2001 2:57 PM

Subject: [] from one generation to another....

>Hello All!

>

>Quick question... My mother passed CMT to me and not my brother. Is it

>possible for him to be a carrier and pass it to his children?

>

>THANKS!

>Mitzi

>

>>>>>>Yes it is, he may have it but not show any symptoms as yet or may

never show any.~>Becky M.

[Guest guest]

Mitzi,

Unless it is one of the autosomally recessive types of CMT (usually CMT4) it

is impossible for a male to be a carrier. The autosomally recessive types

require BOTH PARENTS to be a carrier for it to be passed on, so unless your

mother and father BOTH had CMT as an autosomally recessive type it would be

genetically impossible for him to be a carrier. CMT type 4 is usually

found in ethnic groups in which marriage within the family is common, and

usually has a very early onset and very severe symptoms.

If it were CMTX you could have CMT and he could , but he would either have

it or not and could not be a carrier

In autosomally dominant heredity of CMT the male can not be a carrier

Hope this helps.

----- Original Message -----

From: Mitzi J

egroups

Sent: Wednesday, January 17, 2001 06:26 PM

Subject: [] from one generation to another....

Hello All!

Quick question... My mother passed CMT to me and not my brother. Is it

possible for him to be a carrier and pass it to his children?

THANKS!

Mitzi

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[Guest guest]

Dennis,

r status is only associated with CMTX and the Autosomally recessive

types. There is no such thing as a carrier for any autosomally dominant

heredity. It is by the very nature of the pattern impossible.

In autosomally recessive which are

HMSN 3 (Dejerine-Sottas): P0; PMP-22; EGR2; 8q23

CMT 4A: 8q13-q21.1

Focally-folded myelin

CMT 4B: Myotubularin-related protein-2; 11q23

CMT 4B2: 11p15

P0

Juvenile glaucoma

CMT 4C: 5q23-q33

CMT 4D (Lom): N-myc Downstream-Regulated Gene 1; 8q24

CMT 4E: Congenital Hypomyelinating

EGR2; 10q21

P0; 8q23

PMP-22; 17p11

CMT 4F: Periaxin; 19q13

HMSN-Russe: 10q22

Carbohydrate Deficient Glycoprotein (1a): 16p13

Cataracts & Facial dysmorphism: 18qter

Cockayne's: 5

Congenital hypomyelinating: P0, PMP-22 & EGR-2

Farber's lipogranulomatosis

Krabbe: 14q31

Metachromatic leukodystrophy: 22q13

PMP-22 point mutations

Refsum's disease: 10pter-p11.2; 7q21

HMSN + CNS: Heterogeneous

AND

-

AR-CMT2A: 1q21

AR-CMT2B: 19q13.3

Acrodystrophy

Andermann: Corpus callosum D; 15q13

Giant axonal neuropathy: Gigaxonin; 16q24

HMSN + CNS: Heterogeneous

HMSN + Deafness

HMSN + Optic neuropathy ± Deafness

Lethal Neonatal

Neuroaxonal dystrophy

Ouvrier: Early childhood onset

You can either be a carrer, have the disease, or be free of the disease, BUT

BOTH the mother and father would have to have the gene. Since the mother in

the case mentioned had CMT, if this was the case, then BOTH her parents

Mitzi's maternal grandparents) would have had to have the gene. Also since

Mitzi has CMT, if it were autosomally recessive, her father would have had

to have the gene and CMT would be in his family as well. The autosomally

recessive types are very rare and usually have very early onset and very

severe symptoms often including retardation and early death. Though VERY

unlikely, it is possible that Mitzi's maternal grandmother, maternal

grandfather, mother, and father ALL had the same recessive gene, her brother

could be a carrier. Unless all four had carried the recessive gene, it

would be impossible for him to be a carrier or to have an autosomally

recessive type.

In CMTX linked a male can NOT be a carrier as he is XY and not XX, so he

could not have the gene unless his father had CMT. Her brother could have

CMT or be totally CMT free.

The other possibility is that her brother HAS CMT, and has not yet shown

sufficient symptoms for diagnosis. It that was the case he would have CMT

and not be a carrier, but could pass it on.

Again it is only posible for a male to be a carrier in autosomally recessive

types. In autosomally dominant and X linked he either has CMT or is CMT

free.

---- Original Message -----

From: Dennis Overskov

egroups

Sent: Wednesday, January 17, 2001 04:56 PM

Subject: Sv: [] from one generation to another....

but I was told they can BOTH be carriers but not have the cmt them self

----- Original Message -----

From: Lamar son <lls@...>

<egroups>

Sent: Wednesday, January 17, 2001 10:24 PM

Subject: Re: [] from one generation to another....

> Mitzi,

> Unless it is one of the autosomally recessive types of CMT (usually

CMT4) it

> is impossible for a male to be a carrier. The autosomally recessive

types

> require BOTH PARENTS to be a carrier for it to be passed on, so unless

your

> mother and father BOTH had CMT as an autosomally recessive type it would

be

> genetically impossible for him to be a carrier. CMT type 4 is usually

> found in ethnic groups in which marriage within the family is common,

and

> usually has a very early onset and very severe symptoms.

>

> If it were CMTX you could have CMT and he could , but he would either

have

> it or not and could not be a carrier

>

> In autosomally dominant heredity of CMT the male can not be a carrier

>

> Hope this helps.

>

>

> ----- Original Message -----

> From: Mitzi J

> egroups

> Sent: Wednesday, January 17, 2001 06:26 PM

> Subject: [] from one generation to another....

>

>

> Hello All!

>

> Quick question... My mother passed CMT to me and not my brother. Is it

> possible for him to be a carrier and pass it to his children?

>

> THANKS!

> Mitzi

>

> eGroups Sponsor

>

>

>

>

[Guest guest]

Hello All!

Quick question... My mother passed CMT to me and not my brother. Is it

possible for him to be a carrier and pass it to his children?

THANKS!

Mitzi