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Re: Prednisone vs. MTX

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Tom,

I just had to chuckle on the no pain with prednisone.

It is considered a miracle drug, cuz it's a steroid. HOWEVER, it has a lot of

dangerous side effects if used long term.

That's why they created the biologics......

LeAnn Cayer & Furbrats Blossom & Meriko

Heart Bandits American Eskimo Dog Rescue

Railroad Coordinator www.heartbandits.com

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Tom, you crack me up. I'm taking prednisone too and dog bones are not even safe

from my food detectors. I've gained 15 lbs since before Thanksgiving day. You

are correct, it is only temporary. I want off too but my rheumy said to stay on

for 2 more months. I started with mtx and vioxx and the combination worked very

well for me for the first year, then had to quit those and went on to arava

which worked fairly well. I really think you should see a rheumy asap. Good

Luck, Cheri :-))

The question is how much does prednisone resemble methotrexate? So far

I've only taken vioxx and pain killers for P.A. with little result. Feeling

this

good is bitter-sweet knowing the prednisone is a temporary fix and soon

I'll be back in the valley.

Any input will be appreciated as I don't have a rheumy yet, only my G.P.

and a pain management doctor.

THANX,

Tom in beautiful downtown Clute, Texas

tomjs2@...

Please visit our Psoriatic Arthritis Group's informational web page at:

http://www.wpunj.edu/pa/ -- created and edited by list member

aka(raharris@...).

Also,in August 2001,list member Jack aka Cornishpro@... began to

conduct extensive research which he publishes as the " Psoriatic Arthritis

Research Newsletter " , monthly in our email and digest format. Many thanks to

Jack. Back issues of the newsletter are stored on our PA webpage as well as the

archives of the list.

Don't forget that the list archives comprise a tremendous amount of

information (Over three years of messages and answers).Feel free to browse them

at your convenience.

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At 04:46 PM 1/16/04, you wrote:

>The question is how much does prednisone resemble methotrexate? So far

>I've only taken vioxx and pain killers for P.A. with little result.

>Feeling this

>good is bitter-sweet knowing the prednisone is a temporary fix and soon

>I'll be back in the valley.

Prednisone and methotrexate are completely different types of drugs.

Prednisone helps control the inflammation and, thus, the pain; but it is a

steroid and doesn't really do anything to work at the disease level -- i.e.

by controlling the inflammation it is merely controlling the symptoms of

the disease, not trying to tackle the disease itself. Methotrexate is a

disease-modifying drug that attempts to tackle the actual disease, not to

cure it (since there is no cure) but to halt the progression of the disease

and possibly cause medication-induced remission of the disease. Prednisone

can make you feel good, but it's not necessarily going to prevent joint

damage and have the other disease-level results that methotrexate does.

Prednisone is taken long-term by some people, but it's generally only in

cases where no other drug helps them, or for lupus patients for whom no

other drug actually works. It's not advisable to take it long-term because

of the damage it does to your bones and because of other side effects it

can have with long-term use.

If your question is whether prednisone is a good *alternative* to

methotrexate, the answer is no. It can help you handle symptoms while a

drug like methotrexate is kicking in (it takes MTX 6-12 weeks to begin to

work on most patients), but it's really not meant to replace the DMARDs

(disease-modifying anti-rheumatic drugs).

I'm currently on prednisone because I can't cope without it, but I'm also

on methotrexate and will be starting gold therapy next week, so my hope is

that prednisone is a short-term aid for me while I give the gold time to

work; I am very unhappy about being on prednisone at all, even knowing how

it helps with my pain and inflammation, so I will be looking forward to

when I can stop taking it when/if the gold begins to work for me.

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I know the Prednisone makes you feel good temporarily. That makes it

very attractive as an option to you for now. It's not meant for long

term use and though you have it for the lung problem it also helps

other places that are inflammed. The side effects are increased

appetite, wt.gain, and it will sometimes flare up the psoriasis. If

you haven't already seen an increase in the amount or severity of the

psoriasis that is good. Hope you can get to a Rheumatologist to

treat your PA. You need a DMARD with this disease. Hope you feel

better soon. Cassie

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