A. Redlich - Yale Researcher

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A. REDLICH

Yale University

School of Medicine

Internal Medicine/Occupational and Environmental Medicine Pr

Associate Director Appointed: 1997

Yale University

School of Medicine

Internal Medicine/Occupational and Environmental Medicine Pr

Associate Professor Appointed: 1996

Mailing Address

YOEMP

Yale University

135 College St.

3rd Floor

New Haven, Connecticut 06510

United States

Phone: (203) 737-2817

Fax: (203) 785-7391

E-mail:carrie.redlich@...

Qualifications

M.P.H., Yale University School of Medicine, 1988

M.D., Yale University School of Medicine, 1982

B.A., College, 1978

Fellowship, Occupational Medicine - Yale

Pulmonary - University of Washington

Expertise and Research Interests | Other Expertise | Memberships | Previous

Positions | Funding Received | Publications | Search for Funding | COS Quick

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Expertise and Research Interests

My research interests lie in studying the effects of environmental and

occupational exposures on the lung, with hopes of identifying potential

therapeutic and preventive modalities. Recently I have been studying the

immunomodulatory effects of retinoids/vitamin A at both the clinical and

cellular/molecular level. One ongoing clinical study is investigating the

utility of two intermediate endpoints, alveolitis and airway metaplasia, to

assess effectiveness of vitamin A supplementation in a population at high

risk for both lung cancer and fibrosis (asbestos-exposed workers). Most

recently I am investigating the pathogenesis of isocyanate asthma, the most

common cause of occupational asthma in industrialized countries, in

particular the role of T cells in this disorder. These studies involve

integrating advances in cellular and molecular immunology with clinical

research. A related project is an epidemiologic study characterizing the

respiratory hazards of autobody shop workers who are exposed to isocyanates

and are at high risk of developing asthma.

Other Expertise

Academic Experience:

Selected Advisory Positions / Committees:

NIOSH-CDC: Occupational Health and Safety Study Section;

American Lung Association, Environmental and Occupational Health Assembly

Planning Committee, Chair-Elect;

NIOSH-CDC: Special Training Grant Review Committee

Keywords

COS Keywords: Asthma, Cancer or Carcinogenesis, Occupational Health and

Safety, Respiratory Diseases, Toxicology

Additional Terms: biomarker research, isocyanates, occupational asthma,

occupational lung disease, vitamin a

Memberships

American College Chest Physicians

American College Physicians

American College of Occupational and Environmental Medicine

American College of Physicians

American Thoracic Society/American Lung Association

Previous Positions

1990-1996, Yale University School of Medicine, Assistant Professor

Funding Received

T Cells in the Pathogenesis of Human Isocyanate Asthma, National Institutes

of Health (NIH), 12/96-11/01

Epidemiologic Study of Isocyanate Asthma in Autobody Shops, Co.I

(CDC-NIOSH), 9/97-8/02

ALA Clinical Investigator Award, T Cells in the Pathogensis of Isocyanate

Asthma, 7/97-6/00

Publications

Mayne S T;Redlich C A;Cullen M R. Dietary vitamin A and prevalence of

bronchial metaplasia in asbestos-exposed workers. American Journal of

Clinical Nutrition. 68(3): 630-5, Sep 1998.

Redlich C A;Blaner W S;Van Bennekum A M;Chung J S;Clever S L;Holm C T;Cullen

M R. Effect of supplementation with beta-carotene and vitamin A on lung

nutrient levels. Cancer Epidemiology, Biomarkers and Prevention. 7(3):

211-4, Mar 1998.

Redlich C A;Cullen M R. Nonalcoholic steatohepatitis. ls of Internal

Medicine. 127(5): 410; discussion 411, 1 Sep 1997.

Redlich C A;Karol M H;Graham C;Homer R J;Holm C T;Wirth J A;Cullen M R.

Airway isocyanate-adducts in asthma induced by exposure to hexamethylene

diisocyanate. Scandinavian Journal of Work, Environment and Health. 23(3):

227-31, Jun 1997.

Redlich C A;Sparer J;Cullen M R. Sick-building syndrome. Lancet. 349(9057):

1013-6, 5 Apr 1997.

Redlich CA, Sparer J, Cullen MR. Sick building syndrome. The Lancet 1997;

349:1013-6.

Redlich CA, Karol MH, Graham C, Homer RJ, Holm CT, Wirth JA, Cullen MR.

Demonstration of airway isocyanate-adducts in human HDI-induced asthma.

Scand J Work Envir Health 1997; 23:227-31.

Redlich C A;Grauer J N;Van Bennekum A M;Clever S L;Ponn R B;Blaner W S.

Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in

human lung tissue and pulmonary macrophages. American Journal of Respiratory

and Critical Care Medicine. 154(5): 1436-43, Nov 1996.

Redlich C A;Gao X;Rockwell S;Kelley M;Elias J A. IL-11 enhances survival and

decreases TNF production after radiation-induced thoracic injury. Journal of

Immunology. 157(4): 1705-10, 15 Aug 1996.

Cullen M R;Redlich C A;Beckett W S;Weltmann B;Sparer J; G;Ruff

T;Rubinstein E;Holden W. Feasibility study of respiratory questionnaire and

peak flow recordings in autobody shop workers exposed to

isocyanate-containing spray paint: observations and limitations.

Occupational Medicine. 46(3): 197-204, Jun 1996.

Redlich C A;Homer R J; B R;Wirth J A;Cullen M R. Immunologic responses

to isocyanates in sensitized asthmatic subjects. Chest. 109(3 Suppl): 6S-8S,

Mar 1996.

Redlich C A; Grauer J N; Van Bennekum A M; Clever S L; Ponn R B; Blaner W S.

Characterization of carotenoid, vitamin a, and alpha-tocopheral levels in

human lung tissue and pulmonary macrophages. American Journal of Respiratory

and Critical Care Medicine. 154. 1436-43. 1996.

Cullen M R;Redlich C A. Significance of individual sensitivity to chemicals:

elucidation of host susceptibility by use of biomarkers in environmental

health research. Clinical Chemistry. 41(12 Pt 2): 1809-13, Dec 1995.

Redlich C A;Delisser H M;Elias J A. Retinoic acid inhibition of transforming

growth factor-beta-induced collagen production by human lung fibroblasts.

American Journal of Respiratory Cell and Molecular Biology. 12(3): 287-95,

Mar 1995.

Redlich C A;Van Bennekum A M;Wirth J A;Blaner W S; D;Tanoue L T;Holm C

T;Cullen M R. Vitamin A chemoprevention of lung cancer. A short-term

biomarker study. Advances In Experimental Medicine and Biology. 375: 17-29,

1995.

Cullen M R; L R;Pace P E;Buckley P;Duffy T P;McPhedran P;Kelsey K

T;Redlich C A. Morphologic, biochemical, and cytogenetic studies of bone

marrow and circulating blood cells in painters exposed to ethylene glycol

ethers. Environmental Research. 59(1): 250-64, Oct 1992.

Cullen M R;Pace P E;Redlich C A. The experience of the Yale Occupational and

Environmental Medicine Clinics with multiple chemical sensitivities,

1986-1991. Toxicology and Industrial Health. 8(4): 15-9, Jul 1992.

Redlich C A;West A B;Fleming L;True L D;Cullen M R;Riely C A. Clinical and

pathological characteristics of hepatotoxicity associated with occupational

exposure to dimethylformamide. Gastroenterology. 99(3): 748-57, Sep 1990.

Fleming L E;Shalat S L;Redlich C A. Liver injury in workers exposed to

dimethylformamide. Scandinavian Journal of Work, Environment and Health.

16(4): 289-92, Aug 1990.

Record Details

Last Updated: Mar 30, 1999

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