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One more time - Ferritin & Osteopenia

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Thanks, Amber. I remember you mentioning your reaction to the Miacalcin.

I'm curious, though, what type of reaction did you have, and what's the little

black box warning for the Forteo?

Thanks again,

in NJ

************************

In a message dated 1/24/2004 10:15:32 AM Eastern Standard Time,

rehab2@... writes:

> - I have severe osteoporosis. I could not take the Miacalcin but

> have been taking Evista for maybe 6-8 months without problems. The

> rheumatologist (who I absolutely HATE) has given me an rx for Forteo

> which is a daily injectible parathyroid which studies show return you to

> a normal bone density in 18-24 months. I have not filled the rx as yet

> as I am uncomfortable with the black box warning and I am trying to work

> through that in my mind.

> Amber/FLRN

>

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In a message dated 1/24/04 12:57:52 PM Central Standard Time, watnext@...

writes:

> and what's the little black box warning for the Forteo?

> ---------------

I did a quick search, out of curiosity -- it's a " doosey " ... here it is:

WARNING In male and female rats, teriparatide caused an increase in the

incidence of osteosarcoma (a malignant bone tumor) that was dependent on dose

and

treatment duration. The effect was observed at systemic exposures to

teriparatide ranging from 3 to 60 times the exposure in humans given a 20-mcg

dose.

Because of the uncertain relevance of the rat osteosarcoma finding to humans,

teriparatide should be prescribed only to patients for whom the potential

benefits

are considered to outweigh the potential risk. Teriparatide should not be

prescribed for patients who are at increased baseline risk for osteosarcoma

(including those with Paget’s disease of bone or unexplained elevations of

alkaline

phosphatase, open epiphyses, or prior radiation therapy involving the

skeleton) (see WARNINGS and PRECAUTIONS, Carcinogenesis).

Doesn't make you want to run right out there and take it, does it?

Beth

Houston, TX

VBG - Dr. Srungaram

05/31/00 - 314 lbs.

11/01/02 - Abdominoplasty

11/29/02 - 160 lbs.

5'10 "

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I would bet that the osteoporosis is worse. You can stop taking a drug

if it doesn't help or otherwise makes you ill, but osteoporosis seems to

be permanent. But not fun either way.

Z

Open RNY 09/17/01

http://www.ziobro.us

Re: One more time - Ferritin & Osteopenia

Wow, tough call, Amber. My first question is how is the Evista working

for you? Are you showing any signs of improvement, or is it just

supposed to prevent further bone loss?

in NJ

************************

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My endo wont' give it to me because of the claims of bone cancer

Thanks,

Vitalady, Inc. T

www.vitalady.com

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Re: One more time - Ferritin & Osteopenia

> By the same token, although I don't know which one is worse, one

> consideration is that the osteoporosis is a confirmed diagnosis,

whereas the side effects

> of the Forteo are only a warning, although very serious.

>

> Amber, is there any way of calling the manufacturer to find out

what the true

> stats are. IOW, instead of just stating that XXX drug has been

know to cause

> cancer in laboratory animals, ask what dosage they were receiving

and what

> percentage actually got cancer. Sometimes it's a very high dosgae

and low

> percentage, and the warning is more of a CYA for the manufacturer.

>

> Just a thought,

> in NJ

> ***************************

>

> In a message dated 1/26/2004 2:06:35 PM Eastern Standard Time,

> juliaz@... writes:

>

>

> > I would bet that the osteoporosis is worse. You can stop taking

a drug

> > if it doesn't help or otherwise makes you ill, but osteoporosis

seems to

> > be permanent. But not fun either way.

> >

> > Z

> > Open RNY 09/17/01

> > http://www.ziobro.us

> >

>

>

>

>

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