PubMed--benign CPK elevation

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There are some references to benign CPK/CK elevations in PubMed, a

database of medical journals. You can search PubMed from this page:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

Here are two quotes from a case of drug-induced CPK elevations:

1. " Nonetheless, none of the 16 patients with the CPK elevations

developed severe conditions such as rhabdomyolysis despite an

absence of therapeutic intervention, and their CPK elevations were

proven to be benign. "

2. " Patients engaging in more physical activity or receiving higher

neuroleptic doses are at greater risk of developing such CPK

elevations. However, most of these increases are benign, and it is

not considered necessary to treat them. "

There are also references to benign CPK/CK elevations in patients

following heart surgery. In these papers, one- to five-fold

increases in CPK/CK were considered benign. Generally that would

mean under 1,000.

Just to add that the label " benign " as applied to muscle disease is

at least partly in the eye of the beholder. When I first went to the

NIH in 1985, Dr. Dalakas told me that CPT deficiency is a " very

benign " disease and he repeated this on several occasions. Another

CPT researcher, Dr. Vladutiu, strongly disagrees. She says: " The

disorder [CPT deficiency] has even been called " benign " in some

scientific reports which could not be farther from the truth among

individuals who have experienced life-threatening kidney failure

following a severe episode of rhabdomyolysis (trigger-induced muscle

breakdown). "

Quote from: http://www.fodsupport.org/cpt2.htm

Sometimes it takes time to find a doctor who understands. I had

symptoms for 19 years before I had a diagnosis. Most people don't

have to wait that long now because there is more awareness of these

disorders. I sure hope this happens sooner rather than later for

you!

Take care,

Barbara