Re: tylenol's a problem w/mito?

March 20, 2004

I don't know why it is exactly a mito toxin. But, I do know Tylenol is very hard on your liver. With my daughter we were told even before the mito diagnosis that I should NEVER give her Tylenol. Her liver is damaged, now we know due to mito, and any thing extra going through it can be dangerous. I hope this is at least a little help for you.

March 20, 2004

I don't know why it is exactly a mito toxin. But, I do know Tylenol is very hard on your liver. With my daughter we were told even before the mito diagnosis that I should NEVER give her Tylenol. Her liver is damaged, now we know due to mito, and any thing extra going through it can be dangerous. I hope this is at least a little help for you.

March 20, 2004

I don't know why it is exactly a mito toxin. But, I do know Tylenol is very hard on your liver. With my daughter we were told even before the mito diagnosis that I should NEVER give her Tylenol. Her liver is damaged, now we know due to mito, and any thing extra going through it can be dangerous. I hope this is at least a little help for you.

March 20, 2004

Does anyone know why they say tylenol is a problem for people with mito?

Shirley, mom to and Jordan

P.S. sorry if this has already been discussed--I just pulled this post

up to read and am not following messages at this time.

> Thanks for all the info and links Jean!!

>

> Deafness following a course of aminoglycoside class

> antibiotics

>

> A few years ago this subject went around this list and I contributed a

> summary of an article I have in my possession, given to me by my friend

> who is an audiologist. I went hunting for this post and had to do some

> digging to find it as it was 1999 that I wrote it and fortunately I

> kept it!

>

> While it makes sense for *all " Mito folk to avoid taking the

> aminoglycosides class of antibiotics, just as it makes sense for all

> Mito folk to use the special protocol for anaesthesia and to avoid the

> use of Valproic Acid (Depakote) etc ..... it makes sense because *SOME*

> of the Mito folks have dire reactions. I mean .... why take the chance?

>

> How I wish that one of our well known Mito doctors would add to our

> articles we can download and take to our doctors by writing an article

> about the issue of contraindicated drugs for Mito folk. I expect they

> are unwilling to take this risk of omitting something, especially since

> problems with these drugs seem to be on a hit or miss basis!!!!

>

> That having been said ... this article was written by two doctors doing

> research on the subject. As you will read ... the listing of

> aminoglycosides as being " ototoxic " is a responsible way of looking at

> them: however, I read from this article that the ototoxicity is quite

> specific.

>

> Jean

>

> *********

>

> Deafness following a course of antibiotics.

>

> The article is called " Mitochondria and Risk of Deafness " by Tim P.

> Hutchin and Gino A. Cortopassi of University of California. It was

> published in the American Journal of Audiology, Vol4, -

> 1059-0889/95/0401-0012 in March of 1995.

>

> It is written in quite technical language, but the essence of the

> article is as follows:

>

> Certain antibiotics (aminoglycosides) perform their antibiotic function

> by inducing errors in bacterial protein synthesis, eventually causing

> cell death. Drugs mentioned are amikasin, neomycin, and streptomycin.

>

> The bacterial cell is entirely cytoplasm; its DNA is not packaged into

> a discrete nucleus as in mammalian cells. Mitochondia are believed to

> more closely resemble bacterial cell than mammalian, making them a

> possible target for aminoglcosides.

>

> A rare genetic trait which cofers hypersensitivity to aminoglycoside

> antibiotics, and is inherited maternally, exists in the human

> population. These humans, when exposed to therapeutic levels of

> aminoglycosides, develop significant hearing loss. A mitochondrial

> mutation occurs in 100% of family pedigrees *with a trait for

> hypersensitivity to aminoglycosides*. The mutation is referred to as

> 1555o degree. Genetic screening could find this mutation prior to

> administration of the antibiotic, thereby preventing the risk to these

> sensitive individuals. Their findings show that if the mutation has

> occurred in a family, it remains linked to that type. This group of

> mtDNA is rare in Caucasian populations, but more frequent in Asian. A

> warning sign for doctors of this problem would be the occurrence of

> deafness after antibiotic (aminoglycosides) use to multiple individuals

> in a family. This can be tested for 1555(o) with a hair or blood

> sample and the avoidance of these drugs for positive families through

> the maternal inheritance pattern could be effected.

>

> The researchers listed above are willing to test, at no charge, as many

> hair or blood samples because they are interested in the distribution

> of the trait. I took him up on his offer several months ago – Dr. Gino

> Cortopassi responded to my Email promptly and gave me the results quite

> promptly too. I found his Email address through the University of

> Southern California's web master, but unfortunately, that address left

> when I got my new computer.

>

> Gino A. Cortopassi

> Institute for Toxicology

> Dept. of Molecular Pharmacology & Toxicology

> School of Pharmacy

> University of Southern California

>

> The address given is Los Angeles, but I believe it is the Campus

> that I found him.

>

> sol8air@... wrote:

>

> In a message dated 3/17/04 7:37:44 AM Pacific Standard Time,

> mitoscottie@... writes:

>

> It is my understanding that the aminoglycoside antibiotics *only*

> affect *hearing* in the *very specific MtDNA deletion A1555G

>

> Gentamycin is ototoxic to everyone not just people with MITO. I don't

> know about specific deletions, I was told by Dr. Saneto that MITO kids

> in general should never recieve: Gentamycin, Tylenol, Ringer's Lactate,

> Gas Anesthesia (I have the name written down somewhere of the specific

> anesthesia drug to avoid) because these and some other drugs put added

> stress on the mitochondria and/or damage mitochondria and increase

> symptoms. I always gave my kid Tylenol until last year when he told me

> " by the way don't give her tylenol " . Then he gave me the list. It was a

> surprise to me.

>

> kj

> mom of De-Arbra age 16

>

> Please contact mito-owner with any problems or

> questions.

>

> Please contact mito-owner with any problems or

> questions.

>

> Please contact mito-owner with any problems or

> questions.

>

> Please contact mito-owner with any problems or

> questions.

>

> Please contact mito-owner with any problems or

> questions.

>

March 20, 2004