Re: Re: unofficial fertility questions

[Guest guest]

As a follow up .... many adults with Mito experience infertility. I feel

it is more likely that the total metabolics of fertility (both male and female)

is affected by mitochondrial lack of cellular energy, particularly glandular.

This therefore affects the production of testosterone and estrogen/progesterone,

which, in turn, causes infertility..

So ..... Mito in your children .... is about genetics ( either Mitochondrial

genetics or nuclear genetics). I would doubt that mitochondrial defects

in the eggs CAUSE infertility. Don't think this is a case of "chicken and

egg"! <grin>

Jean

sygeek wrote:

<...snip....>

However, having said all that...it seems possible that eggs carrying

mitochondrial mutations are less likely to mature or be fertilized,

or may even abort spontaneously shortly after fertilization due to

inadequate mitochondrial function. Perhaps the infertility is

secondary to the mitochondrial defects in the eggs.

[Guest guest]

Hi Theresa,

I picked up a pattern of infertility among these parents, and I wondered if it is not an issue with the medications but rather the infertility causing the need for the medications. I did not take any meds to conceive our first child, however he was born with a severe cleft lip/palate. Our twins were born after Clomid and multiple meds for pre-term labor, one of which has mito. I took these meds because of polycystic ovarian syndrome as well as other secondary reproductive issues. I have wondered if PCOS is a possible cause of mito or even a manisfestation of mito. My mother had it as well as polycystic kidney syndrome and was diagnosed with ALS, though her ALS resembled mito in some forms. So, just a thought- could ovarian problems be a mito symptom or be a cause of mito ? Joni

Re: unofficial fertility questions

Sharon,As a scientist, I cannot imagine any possible interaction between hyperstimulating drugs (clomid, etc.) and the occurance of mitochondrial disorders. The genetic makeup of each egg is determined during oocyte formation, while we are still in-utero. We are born with all the oocytes that will ever develop into eggs. Hyperstimulating drugs will induce oocyte maturation and release (ovulation), but have no impact on the genetics of the egg.In looking at the prescribing information for clomid, the incidence of birth defects is no greater in women taking clomid than in the general population.However, having said all that...it seems possible that eggs carrying mitochondrial mutations are less likely to mature or be fertilized, or may even abort spontaneously shortly after fertilization due to inadequate mitochondrial function. Perhaps the infertility is secondary to the mitochondrial defects in the eggs.I took clomid for six months to conceive my first daughter. I was 23 at the time, and had not yet been diagnosed. It wasn't until after my daughter died at four months old from primary carnitine deficiency that we were both diagnosed (through muscle biopsy).Theresa> Hi all! I was reading an article in "O" today and it kinda struck me > weird. It was about fertility drugs and the increase in ovarian > cancer. My question to you all, is how many with confirmed Mito > children took Clomid or Perganol (or other hyperstimulating drugs) to > concieve? I took four rounds of Clomid to concieve Hailey!! It just > ran across my mind to see what the outcome would be. > Thanks,> Sharon, mom to Hailey (2 1/2), suspected MitoPlease contact mito-owner with any problems or questions.

[Guest guest]

I tend to agree that it isn't the drug that causes the Mito in our kids. What the important issue that is popping up amonst a lot of us is the inability to conceive. Many of us have had trouble with it. I had problems shortly before Asenath and was told I had PCOS too, but later found it to NOT be accurate as an ultrasound was normal. For several years I was unable to ovulate and therefore menstruate. That is why we have a gap between our 7 1/2 year old and Asenath who is 4 years old. We were told we couldn't have any more children. One question we have is if my body wasn't up to par to help build healthy children and thus they were more easily affected with the Mito genes. This is one suggestion Dr. Whiteman has wondered about. I didn't take fertility drugs, just suddenly started menstruating again and have had no problems with it since, but have had two affected children in a row since then. We are planning to "fix" ourselves when we get a chance because we don't want to take the chance with another baby being affected, especially if my body isn't up to par. Darla Re: unofficial fertility questions Sharon,As a scientist, I cannot imagine any possible interaction between hyperstimulating drugs (clomid, etc.) and the occurance of mitochondrial disorders. The genetic makeup of each egg is determined during oocyte formation, while we are still in-utero. We are born with all the oocytes that will ever develop into eggs. Hyperstimulating drugs will induce oocyte maturation and release (ovulation), but have no impact on the genetics of the egg.In looking at the prescribing information for clomid, the incidence of birth defects is no greater in women taking clomid than in the general population.However, having said all that...it seems possible that eggs carrying mitochondrial mutations are less likely to mature or be fertilized, or may even abort spontaneously shortly after fertilization due to inadequate mitochondrial function. Perhaps the infertility is secondary to the mitochondrial defects in the eggs.I took clomid for six months to conceive my first daughter. I was 23 at the time, and had not yet been diagnosed. It wasn't until after my daughter died at four months old from primary carnitine deficiency that we were both diagnosed (through muscle biopsy).Theresa> Hi all! I was reading an article in "O" today and it kinda struck me > weird. It was about fertility drugs and the increase in ovarian > cancer. My question to you all, is how many with confirmed Mito > children took Clomid or Perganol (or other hyperstimulating drugs) to > concieve? I took four rounds of Clomid to concieve Hailey!! It just > ran across my mind to see what the outcome would be. > Thanks,> Sharon, mom to Hailey (2 1/2), suspected MitoPlease contact mito-owner with any problems or questions. Please contact mito-owner with any problems or questions. Get more from the Web. FREE MSN Explorer download : http://explorer.msn.com

[Guest guest]

I tend to agree that it isn't the drug that causes the Mito in our kids. What the important issue that is popping up amonst a lot of us is the inability to conceive. Many of us have had trouble with it. I had problems shortly before Asenath and was told I had PCOS too, but later found it to NOT be accurate as an ultrasound was normal. For several years I was unable to ovulate and therefore menstruate. That is why we have a gap between our 7 1/2 year old and Asenath who is 4 years old. We were told we couldn't have any more children. One question we have is if my body wasn't up to par to help build healthy children and thus they were more easily affected with the Mito genes. This is one suggestion Dr. Whiteman has wondered about. I didn't take fertility drugs, just suddenly started menstruating again and have had no problems with it since, but have had two affected children in a row since then. We are planning to "fix" ourselves when we get a chance because we don't want to take the chance with another baby being affected, especially if my body isn't up to par. Darla Re: unofficial fertility questions Sharon,As a scientist, I cannot imagine any possible interaction between hyperstimulating drugs (clomid, etc.) and the occurance of mitochondrial disorders. The genetic makeup of each egg is determined during oocyte formation, while we are still in-utero. We are born with all the oocytes that will ever develop into eggs. Hyperstimulating drugs will induce oocyte maturation and release (ovulation), but have no impact on the genetics of the egg.In looking at the prescribing information for clomid, the incidence of birth defects is no greater in women taking clomid than in the general population.However, having said all that...it seems possible that eggs carrying mitochondrial mutations are less likely to mature or be fertilized, or may even abort spontaneously shortly after fertilization due to inadequate mitochondrial function. Perhaps the infertility is secondary to the mitochondrial defects in the eggs.I took clomid for six months to conceive my first daughter. I was 23 at the time, and had not yet been diagnosed. It wasn't until after my daughter died at four months old from primary carnitine deficiency that we were both diagnosed (through muscle biopsy).Theresa> Hi all! I was reading an article in "O" today and it kinda struck me > weird. It was about fertility drugs and the increase in ovarian > cancer. My question to you all, is how many with confirmed Mito > children took Clomid or Perganol (or other hyperstimulating drugs) to > concieve? I took four rounds of Clomid to concieve Hailey!! It just > ran across my mind to see what the outcome would be. > Thanks,> Sharon, mom to Hailey (2 1/2), suspected MitoPlease contact mito-owner with any problems or questions. Please contact mito-owner with any problems or questions. Get more from the Web. FREE MSN Explorer download : http://explorer.msn.com