Remission of rosacea induced by reduction of gut transit time.

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Remission of rosacea induced by reduction of gut transit time.

Clin Exp Dermatol. 2004 May;29(3):297-9.

Kendall SN.

Mathematics Institute, University of Warwick, Coventry, UK.

PMID: 15115515

Summary:

cea is a chronic disorder characterized by hypersensitivity of the

facial vasculature, presenting with intense flushing eventually leading to

chronic erythema and telangiectasia. Although the precise aetiology of

rosacea is not known, numerous associations with inflammatory

gastrointestinal tract disorders have been reported.

Furthermore, substance P-immunoreactive neurones occur in considerably

greater numbers in tissue surrounding affected blood vessels suggesting

involvement of neurogenic inflammation and moreover plasma kallikrein-kinin

activation is consistently found in patients.

In this report, a patient without digestive tract disease is described, who

experienced complete remission of rosacea symptoms following ingestion of a

material intended to sweep through the digestive tract and reduce transit

time below 30 h. It is possible that intestinal bacteria are capable of

plasma kallikrein-kinin activation and that flushing symptoms and the

development of other characteristic features of rosacea result from

frequent episodes of neurogenic inflammation caused by bradykinin-induced

hypersensitization of facial afferent neurones.

The possible relevance of this hypothesis to other conditions featuring

afferent hypersensitivity, such as fibromyalgia, is considered.

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