Re: elevated AST, ALT and LDH

[Guest guest]

This may be one for andy. If it were me I would find a way around

this and continue to chelate.

> We have just completed 3 rounds of DMSA with my son (3.5 yrs, 38

> pounds) following the 3 on/11 off, 12.5mg DMSA every 4 hours

> protocol. We just ran a CBC and metobolic panel about 48 hours after

> the last dose and he is showing:

>

> AST 134 ref range 2-50

> ALT 197 ref range 2-60

> LDH 361 ref range 100-250

>

> All other indicators are in the normal range. Since these are

> measures of liver functions, I am assuming he is not tolerating the

> DMSA and we will have to stop. I am very depressed since he showed

> the best gains ever from this treatment - his behavior was great

> while he was on it and it was sticking. He also has sinus infection

> but I am not sure it matters. We have also run a toxic metal test to

> see what is coming out and an OAT as I am pretty sure he has

> bacteria (no yeast signs).

>

> Has anyone else seen these kind of numbers? Were you able to use

> DMSA as a treatment? We obviously have a call into our doctor but it

> was too late to get her today.

>

> Any help is appreciated.

>

>

[Guest guest]

I have stopped using DMSA, because of changes in the liver values and decline of

neutrophils. I use ALA only now. I am not saying that you need to stop DMSA. I

don't know enough about it, but I am saying, that DMSA is not the only option

for chelation, so if you feel uncomfortable about using it, you can use

something else and still have him improve (hopefully).

All the best,

Dagmar.

[ ] elevated AST, ALT and LDH

We have just completed 3 rounds of DMSA with my son (3.5 yrs, 38

pounds) following the 3 on/11 off, 12.5mg DMSA every 4 hours

protocol. We just ran a CBC and metobolic panel about 48 hours after

the last dose and he is showing:

AST 134 ref range 2-50

ALT 197 ref range 2-60

LDH 361 ref range 100-250

All other indicators are in the normal range. Since these are

measures of liver functions, I am assuming he is not tolerating the

DMSA and we will have to stop. I am very depressed since he showed

the best gains ever from this treatment - his behavior was great

while he was on it and it was sticking. He also has sinus infection

but I am not sure it matters. We have also run a toxic metal test to

see what is coming out and an OAT as I am pretty sure he has

bacteria (no yeast signs).

Has anyone else seen these kind of numbers? Were you able to use

DMSA as a treatment? We obviously have a call into our doctor but it

was too late to get her today.

Any help is appreciated.

=======================================================

[Guest guest]

> This may be one for andy. If it were me I would find a way around

> this and continue to chelate.

These are high enough I would figure out what is going on first, and do

so quickly.

> > We have just completed 3 rounds of DMSA with my son (3.5 yrs, 38

> > pounds) following the 3 on/11 off, 12.5mg DMSA every 4 hours

> > protocol. We just ran a CBC and metobolic panel about 48 hours after

> > the last dose and he is showing:

> >

> > AST 134 ref range 2-50

> > ALT 197 ref range 2-60

> > LDH 361 ref range 100-250

> >

> > All other indicators are in the normal range.

Exactly where in the normal range is quite relevant. Especially total

and direct bilirubin, neutrophils, lymphocytes.

>Since these are

> > measures of liver functions, I am assuming he is not tolerating the

> > DMSA and we will have to stop.

I wouldn't assume this, but SOMETHING is very bad for his liver and I

would figure out what. If it is the DMSA then use DMPS, or ALA by

itself.

Other possibilities include most toxins, alcohol, metabolically

nontolerated foods, and liver disease such as mononucleosis, hepatitis,

etc.

> > I am very depressed since he showed

> > the best gains ever from this treatment - his behavior was great

> > while he was on it and it was sticking.

Then figure out a way to keep chelating.

> > He also has sinus infection

> > but I am not sure it matters. We have also run a toxic metal test to

> > see what is coming out and an OAT as I am pretty sure he has

> > bacteria (no yeast signs).

> >

> > Has anyone else seen these kind of numbers?

They are characteristic of liver disease, not of chelation problems.

> > Were you able to use

> > DMSA as a treatment? We obviously have a call into our doctor but it

> > was too late to get her today.

You want her to NOT assume it is the chelation, but rather to go rule

out all the things she was taught in school that it can be. There are

lots of them and they are relatively common.

Worry about whether it is the DMSA after being sure it isn't something

else.

> > Any help is appreciated.

Large amounts of milk thistle extract may be helpful.

> >

[Guest guest]

> We have just completed 3 rounds of DMSA with my son (3.5 yrs, 38

> pounds) following the 3 on/11 off, 12.5mg DMSA every 4 hours

> protocol. We just ran a CBC and metobolic panel about 48 hours

after

> the last dose and he is showing:

>

> AST 134 ref range 2-50

> ALT 197 ref range 2-60

> LDH 361 ref range 100-250

>

> All other indicators are in the normal range. Since these are

> measures of liver functions, I am assuming he is not tolerating the

> DMSA and we will have to stop. I am very depressed since he showed

> the best gains ever from this treatment - his behavior was great

> while he was on it and it was sticking. He also has sinus infection

> but I am not sure it matters. We have also run a toxic metal test

to

> see what is coming out and an OAT as I am pretty sure he has

> bacteria (no yeast signs).

>

> Has anyone else seen these kind of numbers? Were you able to use

> DMSA as a treatment? We obviously have a call into our doctor but

it

> was too late to get her today.

>

> Any help is appreciated.

>

>

, it's better to err on the side of safety with your precious

child. The infection and elevated liver enzymes are both known side

effects of DMSA.

If it was me I wouldn't continue unless the bloodtests show a

decreased risk.

------------------------------------------------------------------

The child taking succimer will need a complete blood count with

differential, direct platelet count, and serum transaminase levels

before chelation begins, and then once a week during treatment. The

most common side effects are mild vomiting, diarrhea, and rashes.

Some patients develop mild to moderate neutropenia. One in 10

develops mild liver enzyme elevation.11

-----------------------------------------------------------------

What should I avoid while taking succimer?

• Succimer can lower the activity of the immune system making you

more susceptible to infection. Avoid contact with people who have

colds, the flu, or other contagious illnesses. Contact your doctor

immediately if you develop signs of infection such as fever, sore

throat, or coughing.

---------------------------------------------------------

Q. What were the risks of the medication for those in the non-control

group?

A. The parents were advised that there could be short term side

effects such as nausea, vomiting, diarrhea, skin rash or mild to

moderate neutropenia (low white blood cell counts which could lead

to infection).

Q. Taking all of these factors together, was the study appropriately

designed to protect all the subjects (treated patients and placebos)

to the maximum extent possible while allowing this important inquiry

to proceed?

A. Yes. Both the non-control and control groups received information

on their blood levels and vitamin/mineral treatment they would not

otherwise have received. Their homes were inspected and cleaned.

Their participation allowed the efficacy of the medication to be

tested.

The results of the research study showed that the succimer did not

have a long term positive impact on preventing lead-induced changes

in growth, development and behavior. Although some might say this

result proved that the research was a failure, just the opposite is

true. The research was a success in that this form of treatment was

not proven to be effective. Only by performing this type of

controlled research study were the researchers able to make this

important finding.

If one did not have this type of controlled study, this medication

may have been given to thousands of children — exposing them to the

known side effects on the hope it might help — with no study to

prove its effect, one way or the other.

http://www.hopkinsmedicine.org/press/2001/SEPTEMBER/TLC.htm