Re: Rocephin antibiotic question

[Guest guest]

How did the doc rule out viral infections or low glutathione?

1: Clin Infect Dis. 1992 Oct;15(4):650-3.

Presence of cytomegalovirus and herpes simplex virus in middle ear fluids from

children with acute otitis media.

Chonmaitree T, Owen MJ, Patel JA, Hedgpeth D, Horlick D, Howie VM.

Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.

Twenty-seven (10%) of 271 infants and children with acute otitis media (AOM)

were found to be infected with cytomegalovirus (CMV) or herpes simplex virus

type 1 (HSV). CMV or HSV, alone or in combination with bacteria or other

viruses, was isolated from the middle ear fluid (MEF) of 10 patients. In three

cases, CMV alone was isolated from the MEF, and in one case, HSV alone was

isolated. One of the CMV cases involved an acute primary or reactivation of CMV

infection, with CMV-bacterial otitis and conjunctivitis as major manifestations.

One patient with AOM and stomatitis had purulent otitis associated with the

presence of HSV in MEF, with no other bacterial or viral pathogens noted in MEF

or nasal wash specimens. While most patients with CMV infection were probably

asymptomatic excreters at the time of development of AOM, CMV did enter the

middle ear. The presence of CMV in MEF was prolonged, and the patients continued

to have clinical signs of otitis despite negative bacterial cultures. Among

patients with bacterial otitis, a higher proportion of those who had CMV found

only in nasal wash specimens had persistent bacteria in MEF, compared with those

who were concurrently infected with other viruses (57% vs. 19%; P less than

..04). This report is the first to suggest an etiologic role for CMV and HSV in

AOM.

2: Laryngoscope. 2001 Aug;111(8):1486-9.

Management of chronic otitis media with effusion: the role of glutathione.

Testa B, Testa D, Mesolella M, D'Errico G, Tricarico D, Motta G.

Department of Otolaryngology-Second University School of Medicine of Naples,

Italy.

BACKGROUND: The inflammatory cells documented in chronic otitis media with

effusion (OME) spontaneously release oxidants which can induce middle ear (ME)

epithelial cell damage. Glutathione (GSH), a major extracellular antioxidant in

humans, plays a central role in antioxidant defense. PURPOSE: To evaluate the

effects of GSH treatment on chronic otitis media with effusion (OME). SUBJECTS

AND INTERVENTION: Sixty children with chronic OME were enrolled, 30 of whom were

randomly assigned to the treatment group and 30 to the placebo group. Patients

in the treatment group received 600 mg glutathione in 4 mL saline per day

subdivided into five 2-minute administrations given by nasal aerosol every 3 or

4 waking hours for 2 weeks. Patients in the control group received 4 mL saline

per day following the same procedure as for GSH treatment. RESULTS: Three months

after therapy improvement had occurred in 66.6% of patients in the GSH-treated

group and in 8% of the control subjects (P <.01). CONCLUSION: On the basis of

these results, GSH treatment could be considered for the nonsurgical management

of chronic OME.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 11568588 [PubMed - indexed for MEDLINE]

debbiel3560 wrote:

> Hi all:

>

> Took my son to the doctor today and he has a double ear infection

> and a chest infection. The doctor suggested putting him on

> Zithromax or Omnicef, but I swear omnicef is what made him sick and

> regress nearly 2 years ago.

>

> She suggested giving him a rocephin shot. I agreed without really

> asking any questions because it was so obvious Mark was in pain.

> She said I have to go back two more times for the full dosage

> (tomorrow and tuesday). I'm so scared because I didn't ask more

> questions. Is this safe? I've done some searching on the internet

> and it seems like it is just mixed with water and injected. Is that

> right? Please let me know.

>

> Thanks,

> Debbie

>

>

[Guest guest]

I originally took my son in on Tuesday. No ear infections, no

strep - just a fever (104 degrees). She has opted not to treat my

sons infections in the past and steered me towards a homeopathic

doctor who recommended the following remedies: colostrum,

goldenroot, echinacea, and inflammation drops.

When I went to see the doctor on Tuesday, she told me to try the

natural remedies first and if the fever and symptoms persisted to

come back and see her. His fever was wavering between normal and

104 through thursday and finally on Friday and Saturday was around

101. Today, it spiked up to 104 again. Her office is open on

Sundays so I went in. She said he had a very serious ear infection,

the other one was mildly infected and she could hear some " rattling "

(Mark has asthma) in his lungs. She suggested giving a shot and to

be honest, I didn't even think to ask her how she could rule out a

viral infection because we had given Mark 5 days to try and fight it

on his own and he was getting worse. After seeing the doctor, he

came home, napped, and actually ate something.

Are there tests that can be performed? Can any doctor's office do

them or should I see my DO?

Thanks again,

Debbie

>

> > Hi all:

> >

> > Took my son to the doctor today and he has a double ear infection

> > and a chest infection. The doctor suggested putting him on

> > Zithromax or Omnicef, but I swear omnicef is what made him sick

and

> > regress nearly 2 years ago.

> >

> > She suggested giving him a rocephin shot. I agreed without

really

> > asking any questions because it was so obvious Mark was in pain.

> > She said I have to go back two more times for the full dosage

> > (tomorrow and tuesday). I'm so scared because I didn't ask more

> > questions. Is this safe? I've done some searching on the

internet

> > and it seems like it is just mixed with water and injected. Is

that

> > right? Please let me know.

> >

> > Thanks,

> > Debbie

> >

> >

>

>

>

[Guest guest]

You should put your son on some very large doses of probiotics now and keep him

on them for a long time. My son's first regressive type behavior started with

antibiotics too. He got much better with the probiotics. But the only probiotic

that helped him was Primal Defense. It would be good if you would also put him

on Nystatin or dyflucan while on the antibiotics.

Jennfer

Ruston, Louisiana

[ ] Rocephin antibiotic question

Hi all:

Took my son to the doctor today and he has a double ear infection

and a chest infection. The doctor suggested putting him on

Zithromax or Omnicef, but I swear omnicef is what made him sick and

regress nearly 2 years ago.

She suggested giving him a rocephin shot. I agreed without really

asking any questions because it was so obvious Mark was in pain.

She said I have to go back two more times for the full dosage

(tomorrow and tuesday). I'm so scared because I didn't ask more

questions. Is this safe? I've done some searching on the internet

and it seems like it is just mixed with water and injected. Is that

right? Please let me know.

Thanks,

Debbie

=======================================================

[Guest guest]

First off Rocephin is a drug that is extremely painful to inject and

should be mixed with lidocain,not just sterile water, if it is to be

administed this way. If you are concerned or if your child can't

handle the lidocane (it is a numbing medicine) then I would decline

any further injections, as I would never want to be put through that

kind of pain.....much less my son! I believe that the

dosage/administration recommendation by your doc is a safe way as I

have seen docs give all shots in one day, just in different

locations. I have read (Dr. Jepson's paper, I believe) that

injections are better than oral because you bypass the GI mucosa and

lessen (not totally eliminate) the effects on the bacteria in the

gut. I think what Jen suggested is a good thing to do as you will

cover any of the GI effects that this systemic, broad spectrum

antibiotic may produce via the gut.

Good luck and I hope that you son gets better soon. He sounds like

he is really in need of some good mommy TLC!

Dena