DMSA causing very low pyroglutamic?

[Guest guest]

We just got our most recent OAT back, and it's the first one since

starting chelation (with ALA and DMSA) a few months ago. The biggest

change (aside from an expected increase in HPHPA indicating

clostridia) is a very, very low pyroglutamic indicator of 1.07

(reference range 20-115). In the previous 8 months we've had several

OATs reporting pyroglutamic in the 20s (that is, low but not out of

range).

The test interpretation suggests that this could be glutathione

deficiency due to oxidative stress. We have added 1000mg extra C,

with a small amt given with each dose of ALA/DMSA, extra E, extra

grapeseed extract. This also seems to have made him calmer at the end

of rounds (when normally he would be unusually hyper for many days --

perhaps another symptom of oxidative stress?).

My husband is worried about this very low pyroglutamic number,

fearing liver problems. Can anyone shed light? We have an appt with

our DAN dr tomorrow morning...

[Guest guest]

High pyroglutamic acid is indicative of glutathione depeletion.

Theoretically you might have low pyroglutamate if you are extremely low

in glutathione or are missing certain co-factors but my understanding is

that pyroglutamate is elevated in glutathione depletion. Now a problem

with the kidneys may explain a low pyroglutamate also.

[ ] DMSA causing very low pyroglutamic?

We just got our most recent OAT back, and it's the first one since

starting chelation (with ALA and DMSA) a few months ago. The biggest

change (aside from an expected increase in HPHPA indicating

clostridia) is a very, very low pyroglutamic indicator of 1.07

(reference range 20-115). In the previous 8 months we've had several

OATs reporting pyroglutamic in the 20s (that is, low but not out of

range).

The test interpretation suggests that this could be glutathione

deficiency due to oxidative stress. We have added 1000mg extra C,

with a small amt given with each dose of ALA/DMSA, extra E, extra

grapeseed extract. This also seems to have made him calmer at the end

of rounds (when normally he would be unusually hyper for many days --

perhaps another symptom of oxidative stress?).

My husband is worried about this very low pyroglutamic number,

fearing liver problems. Can anyone shed light? We have an appt with

our DAN dr tomorrow morning...

=======================================================

[Guest guest]

> High pyroglutamic acid is indicative of glutathione depeletion.

> Theoretically you might have low pyroglutamate if you are extremely low

> in glutathione or are missing certain co-factors but my understanding is

> that pyroglutamate is elevated in glutathione depletion.

I suspect this is another one of the delusions DAN! doctors labor under

that makes them hurt so many kids with inappropriate use of

glutathione.

> Now a problem

> with the kidneys may explain a low pyroglutamate also.

Andy . . .. . . . .