Guest guest Posted September 21, 2004 Report Share Posted September 21, 2004 From the Mitoldies Files. A must read when considering birth control meds. I would recommend that your neuro contact Dr Cohen about this issue. I am afraid that we should not be giving this type of advice and that it is more suitable for a mito specialist. Let me know if you need contact information. Alice Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 21, 2004 Report Share Posted September 21, 2004 I'm sorry - it didn't carry forward for some reason. or Laurie - could you please copy the file on contradictory meds to an e-mail? Thanks, Alice Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 21, 2004 Report Share Posted September 21, 2004 MEDICATIONS CONTRAINDICATED IN MITOCHONDRIAL DIESASE On page 269 of the Syllabus for the International Conference on Mito Disease, 1997 you will find the following recommendations: " Treatment remains largely symptomatic and does not significantly alter the course of the disease. It includes avoidance of drugs and procedures known to have a detrimental effect, symptomatic treatments, supplementation with co-factors, prevention of oxygen radical damage to mitochondrial membranes and dietary recommendations. " " It is advisable to avoid Sodium Valproate and barbiturates, which inhibit the respiratory chain and have occasionally been shown to precipitate hepatic failure in respiratory enzyme deficient children. Tetracyclines and chloramphenical should be avoided as well, as they inhibit protein synthesis. " As well certain types of anesthesia are also contraindicated. There is a wonderful and comprehensive article dealing with the safety of anesthesia in mitochondrial cytopathy patients in the October 98 issue of the United Mitochondrial Disease Federation newsletter, as well as at the UMDF site. It is not always possible to avoid these drugs but at least if you are informed ahead of time and the possibility of an alternative exists, you can make an informed decision. There is no doubt that some folks with mitochondrial cytopathy have used these drugs uneventfully, although the potential is still there. Be an informed consumer! Cohen and Shoffner lists about anaesthetic agents. Barbiturates - Inhibits complex I activity at high levels Benzodiazepines - Inhibits adenosine nucleotide translocase Propofol and/or lipid carrier - Inhibits mitochondrial function Halothane - Increased risk for heart rhythm disturbance Nitrous Oxide - Neurotoxic, possibly by increasing nitric oxide production, which inhibits cisacotinase and iron-containing electron transport enzymes: affecting energy production Non-depolarizing Agents - Increased sensitivity to the paralytic effects and prolonged responses reported Local Anaesthetic - Bupivacaine uncouples oxidation and phosphorylation Should never use Lactated Ringer's solution (Ringer's Lactate) because it contains lactic acid. Depolarizing agents (Succinylcholine) bothers some people. **************************** Valpro or Epilim (Sodium Valporate) is an anti-convulsant. It is known to be a potential toxin to those with either mitochondrial disorders or metabolic disease. It can cause severe hepatoxicity or liver failure in susceptible persons. Phenobarbital is another potential mitochondrial toxin that can also be dangerous to those with mitochondrial cytopathy. It is wise to always ask your pharmacist for the generic name of any drug being prescribed for someone with mitochondrial cytopathy. Hormonal Birth Control Aminoglycosides are ototoxic for *some forms of Mitochondrial Cytopathies - a specific genetic variation ( Mitochondrial 12S and 16S ribosomal RNA - mutation of A to G in the 12S rRNA at position 1555)* {Hutchins, Cortopassi 1994}. Aminoglycosides are *some* of the antibiotics which end in " _______mycin " . Ototoxic means that these drugs can cause hearing loss or deafness. ASK YOUR PHARMACIST AND PRESCRIBING DOCTOR. Ergotamines due to the impact on hepatic function. Neuroleptic drugs such as Haloperidol, Chlorpromazine, and Thiothixene. Lipitor should not be used by someone with Mitochondrial disease as it depletes CoQ10 from the cells. Steroids can be used but should be used only when absolutely necessary and this should be a very low dosage and not for an extended period of time. Friendly alternatives (?) Lamictal seems to be being used successfully. Topomax also appears to be mitochondrial-friendly for intractable seizures. A ADAMS wrote: >I'm sorry - it didn't carry forward for some reason. or Laurie - could you please copy the file on contradictory meds to an e-mail? > >Thanks, >Alice > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 21, 2004 Report Share Posted September 21, 2004 Thanks Alice for your concern. I have been in contact with Dr. Gropman and Dr. Whiteman today. Both felt it would be worth a try. They have had good and bad experiences with birth control meds. It seems to be individual. Neither are aware of any mito contraindications. Thanks also to all who responded and have been supportive of our current difficult situation. Shelby > > From the Mitoldies Files. A must read when considering birth control > meds. I would recommend that your neuro contact Dr Cohen about this > issue. I am afraid that we should not be giving this type of advice > and that it is more suitable for a mito specialist. Let me know if > you need contact information. > > Alice > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 22, 2004 Report Share Posted September 22, 2004 Thank you, and Alice! Suny > MEDICATIONS CONTRAINDICATED IN MITOCHONDRIAL DIESASE > > > > On page 269 of the Syllabus for the International Conference on Mito > Disease, 1997 you will find the following recommendations: > > " Treatment remains largely symptomatic and does not significantly > alter > the course of the disease. It includes avoidance of drugs and > procedures > known to have a detrimental effect, symptomatic treatments, > supplementation with co-factors, prevention of oxygen radical damage > to > mitochondrial membranes and dietary recommendations. " > > " It is advisable to avoid Sodium Valproate and barbiturates, which > inhibit the respiratory chain and have occasionally been shown to > precipitate hepatic failure in respiratory enzyme deficient children. > Tetracyclines and chloramphenical should be avoided as well, as they > inhibit protein synthesis. " > > > As well certain types of anesthesia are also contraindicated. There > is a > wonderful and comprehensive article dealing with the safety of > anesthesia in mitochondrial cytopathy patients in the October 98 issue > of the United Mitochondrial Disease Federation newsletter, as well as > at > the UMDF site. > > It is not always possible to avoid these drugs but at least if you are > informed ahead of time and the possibility of an alternative exists, > you > can make an informed decision. There is no doubt that some folks with > mitochondrial cytopathy have used these drugs uneventfully, although > the > potential is still there. Be an informed consumer! > > > > Cohen and Shoffner lists about anaesthetic agents. > > Barbiturates - Inhibits complex I activity at high levels > > Benzodiazepines - Inhibits adenosine nucleotide translocase > > Propofol and/or lipid carrier - Inhibits mitochondrial function > > Halothane - Increased risk for heart rhythm disturbance > > Nitrous Oxide - Neurotoxic, possibly by increasing nitric oxide > production, which inhibits cisacotinase and iron-containing electron > transport enzymes: affecting energy production > > Non-depolarizing Agents - Increased sensitivity to the paralytic > effects > and prolonged responses reported > > Local Anaesthetic - Bupivacaine uncouples oxidation and > phosphorylation > > Should never use Lactated Ringer's solution (Ringer's Lactate) because > it contains lactic acid. > > Depolarizing agents (Succinylcholine) bothers some people. > > > **************************** > > Valpro or Epilim (Sodium Valporate) is an anti-convulsant. It is known > to be a potential toxin to those with either mitochondrial disorders > or > metabolic disease. It can cause severe hepatoxicity or liver failure > in > susceptible persons. > > Phenobarbital is another potential mitochondrial toxin that can also > be > dangerous to those with mitochondrial cytopathy. It is wise to always > ask your pharmacist for the generic name of any drug being prescribed > for someone with mitochondrial cytopathy. > > Hormonal Birth Control > > Aminoglycosides are ototoxic for *some forms of Mitochondrial > Cytopathies - a specific genetic variation ( Mitochondrial 12S and 16S > ribosomal RNA - mutation of A to G in the 12S rRNA at position 1555)* > {Hutchins, Cortopassi 1994}. Aminoglycosides are *some* of the > antibiotics which end in " _______mycin " . Ototoxic means that these > drugs > can cause hearing loss or deafness. ASK YOUR PHARMACIST AND > PRESCRIBING DOCTOR. > > > > Ergotamines due to the impact on hepatic function. > > Neuroleptic drugs such as Haloperidol, Chlorpromazine, and > Thiothixene. > > > > Lipitor should not be used by someone with Mitochondrial disease as it > depletes CoQ10 from the cells. > > Steroids can be used but should be used only when absolutely necessary > and this should be a very low dosage and not for an extended period of > time. > > > > Friendly alternatives (?) > Lamictal seems to be being used successfully. Topomax also appears to > be > mitochondrial-friendly for intractable seizures. > > > > > > A ADAMS wrote: > > >I'm sorry - it didn't carry forward for some reason. or > Laurie - could you please copy the file on contradictory meds to an > e-mail? > > > >Thanks, > >Alice > > > > Quote Link to comment Share on other sites More sharing options...
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