Re: Does your pain change with time of day--citation

[Guest guest]

I meant to include the citation for this study:

Int Rev Immunol 1998;16(5-6):635-49

The chronobiology of human cytokine production.

Petrovsky N, on LC.

Autoimmunity and Transplantation Division, Walter and Eliza Hall

Institute of Medical Research, Royal Melbourne Hospital, Parkville,

Australia.

> Doing a search on PubMed for melatonin, I came across an abstract

for

> an study that says pain associated with inflammation may change with

> time of day. This is because when blood levels of cortisol rise and

> fall it changes the levels of pro-inflammatory cytokines (cytokines

> IFN-gamma, TNF-alpha, IL-1 and IL-12). The abstract suggests that

> " immuno-inflammatory disorders such as rheumatoid arthritis or

asthma

> exhibit night-time or early morning exacerbations " because cortisol

> (and perhaps other chemicals such as melatonin) are lowest then.

>

> So I'm wondering of those of you who suffer from arthritis-like pain

> see a difference in pain levels at different times of day?

>

> Tenayahh