Guest guest Posted January 21, 2004 Report Share Posted January 21, 2004 My son is five years old and weighs 40 pounds. He takes two 500mg capsules twice a day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2004 Report Share Posted January 21, 2004 > I was wondering if anyone had any thoughts on this, particularly dosage if > you happen to be using L-Carnosine. I used Carnosine from my local health food store. It helped one of my kids with behavior issues for about 3-4 months. Did nothing for the other 2 kids I tried it with. As I remember it, it came as 500 mg capsules and I gave my son 1/2 capsule either 1 or 2 times per day. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 23, 2004 Report Share Posted September 23, 2004 , I am including some links at the end that pretty much sum up what is out there about L Carnosine. Carnosine is a 100 % natural substance, a so-called dipeptide, formed of two amino acids (ß-alanyl-L-histidine). It is often called a neuropeptide due to its brainprotective properties. Carnosine is found naturally in healthy muscles, hearth, brain, liver, kidneys and other tissues. The muscles contain about 20 µmol/g dry weight. (The more meat contains carnosine, the longer is its shelf life, as carnosine - a superb antioxidant - prevents it from going rancid.) Carnosine acts together with other biological antioxidants, e.g., vitamin E and vitamin C, zinc and selenium, and it spares their consumption in the tissues. Persons with latent vitamin E deficiency consume carnosine more than normally. [it is stressed that the intake of vitamin E is deficient in a major part of the general population, as suggested by epidemiological studies world wide.] In the human body, the enzyme carnosine synthetase, forms carnosine from the amino acids alanine and histidine. This reaction occurs mainly in the brain and in the musclulature. Another group of enzymes, called dipeptidases or carnosinases, in turn inactivate carnosine in the blood and other tissues. Meat is the main dietary source of carnosine. High doses of carnosine are necessary for therapeutic effect because the body naturally degrades carnosine with the enzyme carnosinase. Absorption of carnosine from food is 30 to 70 % (depending on the amount of various amino acids in the meal) and that of pure L-carnosine greater than 70%. A greater part of the absorption occurs in the small intestine (jejunum, but not in the ileum). From the blood carnosine moves into the muscles, brain and other tissues. The human plasma does not contain measurable quantities of carnosine, in other words a blood test does not detect a possible deficiensy state. Austism patients have been shown to have higher levels of free oxygen radicals like Nitric Oxide (NO) than healthy individuals. Individuals with Autism have also been found to have lower blood levels of antioxidants, which can reduce the damaging effects of free radicals. As antioxidants help protect cells against damage from free radicals, a diet that is high in antioxidant rich foods, as well as antioxidant supplements, may be sensible for Austism patients. L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with gamma-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. In the first study, 31 children with autistic spectrum disorders were investigated in an 8-week, double-blinded study to determine if 800 mg L-carnosine daily would result in observable changes versus placebo. Outcome measures were the Childhood Autism Rating Scale, the Gilliam Autism Rating Scale, the Expressive and Receptive One-Word Picture Vocabulary tests, and Clinical Global Impressions of Change. Children on placebo did not show statistically significant changes. After 8 weeks on L-carnosine, children showed statistically significant improvements on the Gilliam Autism Rating Scale (total score and the Behavior, Socialization, and Communication subscales) and the Receptive One-Word Picture Vocabulary test (all P < .05). Improved trends were noted on other outcome measures. Although the mechanism of action of L-carnosine is not well understood, it may enhance neurologic function, perhaps in the enterorhinal or temporal cortex. L Carnosine has been around for a number of years and has been studied and used for a variety of problems: Carnosine therapy: Year: Polyarthritis 1935 Gastric and duodenal ulcer 1936 Wound healing 1940 Hypertension 1941 Antibiotic 1969 Anti-inflammatory 1971, 1986 Adrenal cortex effect 1976 Sleep apnea 1977 Trauma 1980 Immunologic effects 1986,1989 Seizures 1989 Coronary heart disease 1989 Cataract 1989 Anti-carcinogenic 1989 Prevention of radiation damage 1990 ADHD, Autistic Spectrum Disorder, epilepsy, other neurological & psychiatric 2001 Since excess is excreted from the body and it is a naturally occuring enzyme in the body, there have not been reports of side effects and there are no long term health side effects. Though the studies to date on treating autism with L Carnosine are fairly small, the funding has come through for larger studies over longer periods of time. In the mean time, many doctors have determined that it is safe (as the body does not retain more than it needs and it is naturally occuring within the body) and have encouraged patients and parents of patients dealing with autism/autistic spectrum disorders to try it. We did, and it has made a difference. Some that I know did, and have also reported a notable difference. The worst that can happen is that someone tries it and it doesn't work! Anyway, I have rambled long enough... Here are some links!!! http://www.carn-aware.com/aarticle.pdf (found one!) http://www.carn-aware.com/aarticle.html (same thing, different format) http://www.1stvitality.co.uk/az/carnosine/carnosine_neurological_brain ..htm (towards the end) http://www.1stvitality.co.uk/health/autism/250301_carnosine_supplement ation_children_autistic_spectrum_.htm http://www.1stvitality.co.uk/az/carnosine/l-carnosine_pharmacology.htm http://www.enzymestuff.com/rtcarnosine.htm http://autismcoach.com/Carnosine%20Study.htm http://www.wizardofeyez.com/carnosine.html http://www.geocities.com/fishstep/carnosine.html http://www.autismhelpforyou.com/New%20Options%20For%20The% 20Autistic.htm http://www.carn-aware.com/faq.html (Q & A put out by one particular pharmaceutical company... Tyler currently takes 800 mg of L-Carnosine a day with a multivitamin rather than taking this one that has it all combined. He started with 400 mg and we noted quite a difference prior to his last 13 inches and 60 pounds of growth... Now he just needs more due to size!!!) http://www.kirkmanlabs.com/products/amino_acids/l_carnosine/l_carnosin e277_90.html (a children's multivitamin works!) http://www.greatvistachemicals.com/amino_acids/l-carnosine.html (an explanation of what it is) http://groups.msn.com/AUTISMCHATANDSHARE/lcarnosine.msnw http://www.speech-express.com/alternative-therapy/carnosine.html http://www.lef.org/protocols/abstracts/abstr-124.html http://www.cerebra.org.uk/CD%20Project/autismcontempbib.html http://remedyfind.com/rem.asp?ID=7186 http://www.althealth.co.uk/services/info/ailments/autism1.php I hope each link fits on one line. If not, you may have to cut and paste both " lines of the link " to get it to take you to the site!!! Good luck! ~hugs~ Rabecca PS... We get ours from GNC. Tyler takes a children's chewable multivitamin with it to increase absorption. It can be taken with or without food. If your child has trouble swollowing capsiles, they can be opened and the contents sprinkled on food or as Tyler used to do it, put in a medicine cup with a teaspoon of water. He notices the difference even more than we do and won't go without! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 23, 2004 Report Share Posted September 23, 2004 , I thought you might also be interested in seeing this! Rabecca ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Taken from Autism Awakening Newsletter - October 9, 2002 http://autismawakeninginia.bizland.com/autismworldnewspaper/id16.html Part of the article is reproduced below: Natural protein called l-carnosine. Dr. Chez of Lake Bluff, Ill., has recently completed the first study of the substance. " It affected language, receptive language, eye contact, communication, all of which are things which children with autism have big gaps with, " Chez said. Over an eight-week period, Chez's study showed that carnosine improved behavior and communication by 16 percent. Social interaction improved by 27 percent and, in just four weeks, parents reported an overall improvement that more than doubled through the length of the study. More and more research shows that the frontal lobes and the temporal lobes in the brain control emotion, epileptic activity, cognitive, expressive speech, and abstract thinking. Chez said I-carnozine apparently works in the front part of the brain. So far, he said he's used it on about 1,000 children, with a 90 percent success rate. On some children, the change has been dramatic. More studies will be needed to confirm the results of Chez's study. For more information contact Dr. Chez at (847) 735-0901. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2005 Report Share Posted May 16, 2005 How exactly would L carnosine do this? Sounds Bizzarre to me better to have good stores of Vitamin C & E and Selenium on board IMHO Mandi in Dorset I have been advised to use some to prevent the redistribution of metals after the three day stint on ALA. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2005 Report Share Posted May 16, 2005 Joy, We use carn-aware, which is L-carnosine with a bit of zinc. I think it helped kick start my son's verbalising. Initially I think he went a tad hyper on it, so we've left it at half dose - we need to up it to 400mg next. I tried it out following a recommendation and researching the Dr.Chez study. I haven't ever heard about it stopping metal distribution though - do you have any info on how this occurs or reference studies? Stuart >From: joymroscoe@... >Reply-Desperate4DMPSEurope >Desperate4DMPSEurope >Subject: L-Carnosine >Date: Mon, 16 May 2005 07:07:47 EDT > >Hi all >Does anyone have experience of L-Carnosine?? >I have been advised to use some to prevent the redistribution of metals >after the three day stint on ALA. >I have found an article by someone called Dr Chez who claims it enhances >social skills in autistic children. >Thanks, >Joy _________________________________________________________________ Want to block unwanted pop-ups? Download the free MSN Toolbar now! http://toolbar.msn.co.uk/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2005 Report Share Posted May 16, 2005 Redistribution is redistribution and the end result of starting anything LOL. I think the antoxodinats help the process whats left, Seleni8um helps to bind it. We haven;t really had big ssues. Usually a bit tired first day off and can be hyper with over-tiredness but nothing bad. If you see worrying issues on stopping a round I would try going for longer. I only ever got up to 6 days with the orals before faiting from my own tiredness. It didn;t seem to make any difference in Sams case but I have efriend whose child also had CP and his cramps got worse coming off 3 days I think, she used to do 7 on and 7 off and he got better and better. He uses FC and typed out I want more chelation - bless him! As the ALA dose got bigger than the DMSA - at around 50 rounds we were doing 50mg ALA/25mg DMSA per dose and he didn't get tired. He was very switched on this weekend with ALA and today had brilliant day at school (again!) Mandi I thought redistribution was a major issue whatever you do - do c & e reduce it? Any ideas on sources of E? (vitamin e, i should clarify - don' t want to get picked up by the drug squad)ALso, I've got some selennium in the cupboard - have you found it's made real dfiference? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2005 Report Share Posted May 16, 2005 Hi Mandi, I thought redistribution was a major issue whatever you do - do c & e reduce it? Any ideas on sources of E? (vitamin e, i should clarify - don' t want to get picked up by the drug squad) ALso, I've got some selennium in the cupboard - have you found it's made real dfiference? >From: Mum231ASD@... >Reply-Desperate4DMPSEurope >Desperate4DMPSEurope >Subject: Re: L-Carnosine >Date: Mon, 16 May 2005 12:17:34 EDT > >How exactly would L carnosine do this? > >Sounds Bizzarre to me > >better to have good stores of Vitamin C & E and Selenium on board IMHO > >Mandi in Dorset > > >I have been advised to use some to prevent the redistribution of metals >after the three day stint on ALA. > > > _________________________________________________________________ Be the first to hear what's new at MSN - sign up to our free newsletters! http://www.msn.co.uk/newsletters Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 27, 2005 Report Share Posted May 27, 2005 Hi , We tried this and I'd recommend it as worth a go. Around 8 - 12 weeks after we started giving it (which is when it's supposed to take effect) we started to see the first vebalisations from my son. I can't say it was all due to the carnosine, but I believe it was a factor. I've also heard that it's good at mopping up mobilised metals after a round of chelation - I've nothing to support this - it was third hand from someone else who was interested in carnosine. Stuart > Has anyone tried l-carnosine? Can you share your experience? Any side effects? > > Thanks. > - > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 28, 2005 Report Share Posted May 28, 2005 > Has anyone tried l-carnosine? Can you share your experience? Any side effects? Very helpful for language and behaviors for my kids. It does tend to increase copper levels tho, so I give it with a sprinkle of zinc. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 11, 2005 Report Share Posted July 11, 2005 If I had a dime for everytime I purchased something AFTER doing the research, then found something else negative, I would be rich. I still have the carnosine I purchased as I read an article right after the purchase that talked about producing brain trauma in the very area of the brain that carnosine was supposed to help. I could never find the article again. The article's logic appeared plausible to me and I have found when searching onibasu that some kids did not do well on it, specifically causing OCD and hyperactivity symptoms to worsen. According to some of the parents' reports, once the carnosine was discontinued, the troublesome symptoms remained for quite a while, which I found particularly concerning. Andy, however, thinks it is okay. I have never given it. Dr. Chez himself says carnosine is only good for receptive language, not expressive and many of these kids already have receptive language, expressive language is the problem. Interestingly, my husband, Mr. ADD himself, took it as we take many of the supplements ourself before we give them, and it caused a great deal of gastrointestinal problems, which carnosine is supposed to help. Count these as one of the many things we have purchased, and will not try. [ ] L-Carnosine Many on this forum and have heard about the study performed by Dr. Chez, indicating that l-carnosine can enhance receptive language. I decided to purchase the supplement, Carn-aware, the same one used in the study and then found this disturbing group google post: http://groups- beta.google.com/group/alt.support.autism/browse_th read/thread/f36c72578 e72e015/d8a0c920626098fa?lnk=st & q=l- carnosine+may+not+be+good & rnum=1 & hl=en#d8a0c920626098fa Has anyone tried l-carnosine and what was the outcome? Are there conceivably negative long-term effects with this supplement. Thanks for sharing any feedback. ======================================================= Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 26, 2005 Report Share Posted July 26, 2005 > Has anyone tried l-carnosine and what was the outcome? Are there > conceivably negative long-term effects with this supplement. I used it for my kids for about 3-4 months. It was very helpful for receptive language, and visual stims for my #2. It did tend to increase copper levels, so I had to give it with zinc. I removed it after several months when it started causing problems. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 Please remove me from the email list. [ ] Re: L-Carnosine > Has anyone tried l-carnosine and what was the outcome? Are there > conceivably negative long-term effects with this supplement. I used it for my kids for about 3-4 months. It was very helpful for receptive language, and visual stims for my #2. It did tend to increase copper levels, so I had to give it with zinc. I removed it after several months when it started causing problems. Dana ======================================================= Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 19, 2005 Report Share Posted October 19, 2005 > > Hi > This is my first posting. I am just wondering whether it is okay > to open the carnosine capsule and sprinkle on toast as this is what > I usually have to do to get supplements down my little girl, she has > asd and candida. I opened Carnosine capsules and mixed them into peanut butter and honey. Your method sounds fine. It did tend to increase copper levels for my son, so I had to give it with some zinc. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 22, 2005 Report Share Posted October 22, 2005 > > > > Hi > > This is my first posting. I am just wondering whether it is okay > > to open the carnosine capsule and sprinkle on toast as this is what > > I usually have to do to get supplements down my little girl, she has > > asd and candida. > > > I opened Carnosine capsules and mixed them into peanut butter and > honey. Your method sounds fine. It did tend to increase copper > levels for my son, so I had to give it with some zinc. > > Dana > Thanks Dana, I will get some zinc to go with it. BW Sue Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 18, 2006 Report Share Posted July 18, 2006 Okay... i was looking up the Carnaware website and I was wondering if L-Carnosine tablets would work just as well??? I could probably get those at GNC or some other vitamin store. ANY thoughts???? --------------------------------- Talk is cheap. Use Messenger to make PC-to-Phone calls. Great rates starting at 1¢/min. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 20, 2006 Report Share Posted July 20, 2006 The dose that has been used in most of the studies I've read was 400 mg twice a day. That is the dose we use. I've never seen a liquid l-carnosine supplement, though if you get the carnaware brand, it has no taste - you can easily mix it in a bite of soy ice cream (that's what we used until my 4 year old started swallowing pills) and it adds no taste to the ice cream. You only need a rather small amount of both vitamin E and zinc, which are included in the carnaware caps. As long as you aren't giving more than the RDA for vit E, I don't think you should worry about it too much. > > > > > > Okay... i was looking up the Carnaware website and I was wondering > >if L-Carnosine tablets would work just as well??? I could probably > >get those at GNC or some other vitamin store. ANY thoughts???? > > > > > > --------------------------------- > > > Talk is cheap. Use Messenger to make PC-to-Phone calls. > >Great rates starting at 1¢/min. > > > > > > Quote Link to comment Share on other sites More sharing options...
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