Guest guest Posted September 28, 2004 Report Share Posted September 28, 2004 Is there a comprehensive list somewhere of the drugs that are known to cause complications with the keto diet? There's been talk on this list recently about Depakote/Epilim causing false high urine ketone readings. I know from personal research (and experience) that Topamax lowers CO2 serum levels in 67% of kids, causing increased threat of acidosis when combined with the diet. And, now I see today that mentions (sort-of) that a benzo/diet combination is bad. Those are the 3 I have noticed, since they are the 3 that my son was/is on. I'm sure there are many more. I don't believe all keto teams are familiar with these interactions, and it would be great for us newbies to have a list of these along with any relevant research. Let me know if you know of any such list. Thanks, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2004 Report Share Posted September 28, 2004 Pretty sure there is no real list, but you are starting one You can add tegretol, just because it can raise cholesterol which can be double whammy with diet. Also, in my mind, the more important problem with depakote (epilim) is that with the diet and it you can get too acidic dyhopper@... wrote: > Is there a comprehensive list somewhere of the drugs that are known to > cause complications with the keto diet? > There's been talk on this list recently about Depakote/Epilim causing > false high urine ketone readings. > I know from personal research (and experience) that Topamax lowers CO2 > serum levels in 67% of kids, causing increased threat of acidosis when > combined with the diet. > And, now I see today that mentions (sort-of) that a benzo/diet > combination is bad. > > Those are the 3 I have noticed, since they are the 3 that my son > was/is on. I'm sure there are many more. > I don't believe all keto teams are familiar with these interactions, > and it would be great for us newbies to have a list of these along > with any relevant research. Let me know if you know of any such list. > > Thanks, > > > > > > > " The Ketogenic Diet....a realistic treatment option, NOT just a last > resort! " > > List is for parent to parent support only. > It is important to get medical advice from a > professional keto team! > Subscribe: ketogenic-subscribe > Unsubscribe: ketogenic-unsubscribe > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2004 Report Share Posted September 28, 2004 According to " the book " , " phenobarbital and Diamox should be eliminated or sharply reduced to prevent toxicity and too much sleepiness during the fasting the early acidosis " . " Benzodiazepenes should be decreased if sleepiness occurs during diet initiation " . Medication levels in the blood and brain can rise during diet initiation and toxicity is more likely. Bill dyhopper@... wrote: > Is there a comprehensive list somewhere of the drugs that are known to cause complications with the keto diet? > There's been talk on this list recently about Depakote/Epilim causing false high urine ketone readings. > I know from personal research (and experience) that Topamax lowers CO2 serum levels in 67% of kids, causing increased threat of acidosis when combined with the diet. > And, now I see today that mentions (sort-of) that a benzo/diet combination is bad. > > Those are the 3 I have noticed, since they are the 3 that my son was/is on. I'm sure there are many more. > I don't believe all keto teams are familiar with these interactions, and it would be great for us newbies to have a list of these along with any relevant research. Let me know if you know of any such list. > Thanks, > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2004 Report Share Posted September 28, 2004 Hi , fave subject, ish - lol - so a long 'un - No formal list as far as I am aware, all neuros seems to have their own opinions and thoughts on each combo from what I can gather.... But this is what I have observed on here and read from various sources over our 3 yrs with keto.....All the carbonic anhydrase inhibitors (topomax, zonegran and diamox) can have that increased acidosis risk with the diet, but on the other hand, for some kiddies this can be one of the diet mechanisms that is successful for them - ie - swinging their ph over to v acidic, but yes, these combinations can lead to complications, (incl kidney stones, bone density reduction, growth retardation, and even acidosis induced seizures) and have to be v closely monitored. As said, depakote (valproate) can also increase acidity (I was told not to the same extent as topomax etc, but it is still an acid incuding med), it can give sl inaccurate urine ketone readings, and can also 'compete' in fatty acid pathways with the ketones. It can also lead to carnitine deficiency, as both dep and the diet are known in many cases to deplete carn levels, more carn is ued to process/metabolise both, and this is the main reason Dr Ve Vivo (metabolic neurologist) strongly recommends that they are not used in conjunction with each other. Benzos, well horror times here with this class of med, that got worse the longer was left on them. That wasn't just from a diet interaction though, our trouble with these meds started pre-diet, but I think the protein binding mechanism of these sorts of meds being altered (by the state of ketosis/acidity) aggravated things and caused it to eventually hit the fan in our case when 's ketones went sky high late last yr - which increased the effect of the benzos, toxicity/hypersensitvity induced seizures, and away we went.... Another potential problem with benzos and ketosis is that these meds are all fat soluble, and a couple of yrs ago I tried to find out the conequences of this when relating it to the diet - didn't get very far except to find a paper written by a dental anaethetist a few yrs ago which cautioned against eating fatty meals with any of the benzos, as it could cause a rebound effect. I asked our hosp pharmacist to pursue this for me, cos at that point I was convinced was reacting very badly to his then AED - oral diazepam, so extreme in fact, that I had to separate his med doses from his keto meals or he would have a break through seizure about an hr afterwards.... Our pharmacist reached a dead end though - he got as far as contacting the paper author in the US by phone (we are in NZ) who could not remember his original information source that led to his caution being published in the dental paper, and that was the end of that one.... My own thoughts on this one....not that I have ever got far with it....(using logic only, not based on anything scientific)...is that if benzos are fat soluble, it means they will dissolve and metabolise more rapidly in a fatty based environment (hello - keto diet...). This would surely lead to fairly extreme peaks and troughs, meaning potential toxicity induced seizures after giving the med, and an increased risk of inter dose mini-withdrawl type seizures before the next dose is due, because I can't see how it would be possible to keep an even blood level. With benzos, this even blood level state is a must, seizure control wise and all other aspects, and if not able to be maintained, it has to surely spell trouble somewhere along the line. That's my theory and I am sticking to it One med that I have read as being fairly 'keto friendly' is keppra - reason being it is one of the few not metabolised thru the liver, but as far as how it interacts with ketosis in other ways, I'm not too sure - not been there or done that... ----- Original Message ----- From: dyhopper@... Is there a comprehensive list somewhere of the drugs that are known to cause complications with the keto diet? There's been talk on this list recently about Depakote/Epilim causing false high urine ketone readings. I know from personal research (and experience) that Topamax lowers CO2 serum levels in 67% of kids, causing increased threat of acidosis when combined with the diet. And, now I see today that mentions (sort-of) that a benzo/diet combination is bad. Those are the 3 I have noticed, since they are the 3 that my son was/is on. I'm sure there are many more. I don't believe all keto teams are familiar with these interactions, and it would be great for us newbies to have a list of these along with any relevant research. Let me know if you know of any such list. Thanks, Quote Link to comment Share on other sites More sharing options...
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