Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis

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http://www.wjgnet.com/1007-9327/abstract_en.asp?f=243 & v=14

Tamizifar B, Lankarani KB, Naeimi S, Rismankar Zadeh M, Taghavi A, Ghaderi A.Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis.World J Gastroenterol 2008 January;14(2):243-247Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitisTamizifar B, Lankarani KB, Naeimi S, Rismankar Zadeh M, Taghavi A, Ghaderi A.Department of Internal Medicine, Nemazi hospital, Zand Ave, Shiraz, Iran. lankaran@...AIM: To elucidate the possible difference in two promoter polymorphisms of the transforming growth factor-beta1 (TGF-beta1) gene (-800G > A, -509C > T) between ulcerative colitis (UC) patients and normal subjects. METHODS: A total of 155 patients with established ulcerative colitis and 139 normal subjects were selected as controls. Two single nucleotide polymorphisms within the promoter region of TGF-beta1 gene (-509C > T and -800G > A) were genotyped using PCR-RFLP. RESULTS: There was a statistically significant difference in genotype and allele frequency distributions between UC patients and controls for the -800G > A polymorphism of the TGF-beta1 gene (P < 0.05). The frequency of the TGF-beta1 gene polymorphism at position -800 showed that the AA genotype and the allele A frequencies significantly differed between the patients and healthy controls (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and control subjects. CONCLUSION: The results of our study indicate that there is a significant difference in both allele and genotype frequency at position -800G > A of TGF-beta1 gene promoter between Iranian patients with UC and normal subjects.