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Sensitive to Benzalkonium chloride?

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Benzalkonium chloride is an allergen[4][5][6][7][8][9][10] and several

studies have cast doubt on its reputation for safety.[11][12]

Some products have been reformulated in light of this research, but it

is still widely used in eyewashes, hand and face washes, mouthwashes,

spermicidal creams, and in various other cleaners, sanitizers, and

disinfectants. Manufacturers of over-the-counter artificial tears and

eye washes became concerned about chemical sensitivity from long-term

daily use and have in some products substituted EDTA as a

preservative. Some have added " for sensitive eyes " to labeling. There

has also been concern that long-term use of benzalkonium as a

preservative in nose sprays may cause swelling of mucosa and lead to

rhinitis medicamentosa. Some manufacturers have put 3-day limits on

safe use of such nose sprays.

A disinfectant containing benzalkonium chloride and the related

compound didecyldimethylammonium chloride (DDAC) has been identified

as the most probable cause of birth defects and fertility problems in

caged mice.[13]



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