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Has anyone been concerned about the amount of vitamin E children

using Nordic Natural fish oil and carnaware are receiving? vit. E

has been in the news lately with adverse affects noted for adults

using larger doses relative to the RDA. I looked up RDA for 4-6 y/o

and found 7 IU compared to the 171 IU my daughter is getting with 2

ProEFA and 1 EPA and 2 caps of carnaware daily.

Kim

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HI, I read your message and am going to start my son 3 1/2 on the ProEFA

and was just wondering what the nutritionist told you concerning the VitE,

etc... should we be more concerned? I am new to the group and don't have a lot

of the ground information - but would appreciate your assistance. Thx, Phyllis

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Kim,

We too were concerned when we saw the news being released about Vit E.

Having researched many supplement companies we turned to Shaklee for our

supplements for our family and have seen great results. I am sending you an

article that addresses the problems with the that report about Vit E.

Hope this helps.

Setting the Record Straight on Vitamin E

A recently published report in the online edition of the ls of Internal

Medicine (Nov. 10) alleges that high doses of Vitamin E may increase the

risk for mortality, and the report has been widely disseminated this week by

the media.  The Council for Responsible Nutrition and other scientific

experts disagree with the conclusions of the study which is the basis for

this report. In addition, the National Institutes of Health and the

Institute for Medicine, which sets the recommended daily allowance for

vitamins in the United States, both state that Vitamin E is safe.

Why the Study Is Flawed

There are significant flaws and inaccuracies in this meta-analysis conducted

by researchers from s Hopkins University.  A meta-analysis is not a new

study.  It is simply a compilation of previously run large-scale clinical

studies.  Scientific experts have noted major problems with the authors¹

conclusions drawn from this meta-analysis, which ignored the vast majority

of existing published studies, for the following reasons:

* There was a bias in the selection of the studies to review. The

researchers selected only 19 of the 2,170 studies available on Vitamin E

* Eighteen of the 19 studies reviewed did not support the researchers¹

conclusions. The only study that did support their conclusions was a hormone

replacement therapy study that examined the effects of using Vitamin E and

estrogen in combination, which confuses the results of this study.

* Less than half of the studies reviewed were done on Vitamin E alone.

* Additionally, studies using higher than 400 IU were done on diseased

populations, whereas studies using less than 400 IU were done on healthy

people.

* While the authors concluded that Vitamin E supplementation did not

affect all-cause mortality (death risk), with no supporting data they

recommended that people should not exceed a daily dose of 400 IU.

* The National Institutes of Health (NIH) and the Institute of Medicine,

which sets recommended daily dietary guidelines for vitamin supplements,

have identified the tolerable upper level of natural Vitamin E intake at

1500 IU/day for adults.  The Institute of Medicine defines the upper limit

as " the maximum intake of a nutrient that is likely to pose no risk of

adverse health effects in almost all healthy individuals in the general

population. "

Dr. Blumberg, Associate Director of Tufts University¹s Human

Nutrition Research Center on Aging, member of Shaklee¹s Scientific Advisory

Board, and widely recognized nutrition expert, emphasized that the research

used in the study looked at people already at high risk of death, which

can¹t be used to determine what¹s good for healthy people.

Dr. Blumberg also stated that ³these investigators selected 19 specific

studies to analyze. In doing so, they also selected not to employ a vast

number of studies that show no harm from Vitamin E and a great deal of

benefit.²

In reaching their conclusions, the authors ignored a huge body of research

that supports the health benefits of Vitamin E supplementation.

Vitamin E Is Safe and Effective

There are more than 1,000 studies that support the safe and efficacious use

of Vitamin E supplements, including several studies that were reviewed in

this recent analysis.  Research studies on Vitamin E supplements have linked

the antioxidant to numerous health benefits including reduced progression of

advanced age-related macular degeneration, reduced occurrence of cataracts,

slowing the progression of Alzheimer¹s disease, slower progression of

atherosclerosis, lower incidence of non-fatal myocardial infarction, and

reduced incidence of upper respiratory infection, to name just a few.

For instance:

* 1993 ­ supplementation with vitamin E was associated with a 30-40%

reduced risk for coronary disease in a study of 90,000 nurses (Nurses Health

Study; NEJM 328:1444-1449)

* 1993 ­ total vitamin E intake is inversely related to the risk of colon

cancer; those with a highest vitamin E intake had the lowest incidence of

colon cancer (Iowa Women¹s Health Study; Cancer Res:53:4230-4237)

* 1994 ­ Levels of vitamin E intake were inversely correlated with

coronary deaths in both women and men in a large (>5000 people), long-term

(14 year follow-up) Finnish study (Am. J. Epidemiol. 139:1180-1189).

* 1997 ­  A review of the literature concerning vitamin E and breast

cancer concluded  ³although epidemiologic study results have been

inconsistent, further study of this nontoxic vitamin is warranted.² (Nutr.

Cancer 27:109-117).

* 2000 - supplementation with Vitamin E supplementation may prevent

ischemic stroke in high risk hypertensive patients (Arch Neurol.

57:1503-1509; analysis of data from the Alpha-Tocopherol, Beta-Carotene

Cancer Prevention Study)

* 2004 ­ protective effect of vitamin E supplementation on upper

respiratory tract infections in elderly nursing home residents (JAMA

292:828-836)

* 2004 ­ supplementation with vitamins E and C in combination is

associated with reduced prevalence and incidence of Alzheimer Disease (Arch.

Neurol. 61:82-88; this study is from s Hopkins)

* FDA ­ allows qualified health claim regarding ³consumption of

antioxidants (including Vitamin E) and reduced risk of some forms of

cancer.²

This week¹s headlines aside, the preponderance of scientific and clinical

data shows well-established benefits of Vitamin E for otherwise healthy

individuals. Supplementation with vitamins, including Vitamin E, makes sense

in support of a healthy lifestyle, and for people who desire nutritional

insurance for the gaps left unfilled by the typical diet.

For more information about the recent news on Vitamin E, please visit

the Web site for the Council on Responsible Nutrition, which also questions

the conclusions reached by the researchers.

http://www.crnusa.org/PR04_1110CRNAIM.html

> Message: 2

> Date: Sat, 20 Nov 2004 00:10:18 -0000

> From: " dksierra " <torres3@...>

> Subject: Vitamin E in the news

>

>

>

> Has anyone been concerned about the amount of vitamin E children

> using Nordic Natural fish oil and carnaware are receiving? vit. E

> has been in the news lately with adverse affects noted for adults

> using larger doses relative to the RDA. I looked up RDA for 4-6 y/o

> and found 7 IU compared to the 171 IU my daughter is getting with 2

> ProEFA and 1 EPA and 2 caps of carnaware daily.

> Kim

>

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Thank you for posting the article on vit. E research; I have been

gone a few days and am just now getting to read it. I had actually

stopped giving her her supplements but am feeling better after

reading your post. Thanks again

Kim

Setting the Record Straight on Vitamin E

>

> A recently published report in the online edition of the ls of

Internal

> Medicine (Nov. 10) alleges that high doses of Vitamin E may

increase the

> risk for mortality, and the report has been widely disseminated

this week by

> the media.  The Council for Responsible Nutrition and other

scientific

> experts disagree with the conclusions of the study which is the

basis for

> this report. In addition, the National Institutes of Health and the

> Institute for Medicine, which sets the recommended daily allowance

for

> vitamins in the United States, both state that Vitamin E is safe.

>

> Why the Study Is Flawed

> There are significant flaws and inaccuracies in this meta-analysis

conducted

> by researchers from s Hopkins University.  A meta-analysis is

not a new

> study.  It is simply a compilation of previously run large-scale

clinical

> studies.  Scientific experts have noted major problems with the

authors¹

> conclusions drawn from this meta-analysis, which ignored the vast

majority

> of existing published studies, for the following reasons:

>

> * There was a bias in the selection of the studies to review.

The

> researchers selected only 19 of the 2,170 studies available on

Vitamin E

> * Eighteen of the 19 studies reviewed did not support the

researchers¹

> conclusions. The only study that did support their conclusions was

a hormone

> replacement therapy study that examined the effects of using

Vitamin E and

> estrogen in combination, which confuses the results of this study.

> * Less than half of the studies reviewed were done on Vitamin E

alone.

> * Additionally, studies using higher than 400 IU were done on

diseased

> populations, whereas studies using less than 400 IU were done on

healthy

> people.

> * While the authors concluded that Vitamin E supplementation

did not

> affect all-cause mortality (death risk), with no supporting data

they

> recommended that people should not exceed a daily dose of 400 IU.

> * The National Institutes of Health (NIH) and the Institute of

Medicine,

> which sets recommended daily dietary guidelines for vitamin

supplements,

> have identified the tolerable upper level of natural Vitamin E

intake at

> 1500 IU/day for adults.  The Institute of Medicine defines the

upper limit

> as " the maximum intake of a nutrient that is likely to pose no

risk of

> adverse health effects in almost all healthy individuals in the

general

> population. "

>

> Dr. Blumberg, Associate Director of Tufts University¹s

Human

> Nutrition Research Center on Aging, member of Shaklee¹s Scientific

Advisory

> Board, and widely recognized nutrition expert, emphasized that the

research

> used in the study looked at people already at high risk of death,

which

> can¹t be used to determine what¹s good for healthy people.

>

> Dr. Blumberg also stated that ³these investigators selected 19

specific

> studies to analyze. In doing so, they also selected not to employ

a vast

> number of studies that show no harm from Vitamin E and a great

deal of

> benefit.²

>

> In reaching their conclusions, the authors ignored a huge body of

research

> that supports the health benefits of Vitamin E supplementation.

>

> Vitamin E Is Safe and Effective

> There are more than 1,000 studies that support the safe and

efficacious use

> of Vitamin E supplements, including several studies that were

reviewed in

> this recent analysis.  Research studies on Vitamin E supplements

have linked

> the antioxidant to numerous health benefits including reduced

progression of

> advanced age-related macular degeneration, reduced occurrence of

cataracts,

> slowing the progression of Alzheimer¹s disease, slower progression

of

> atherosclerosis, lower incidence of non-fatal myocardial

infarction, and

> reduced incidence of upper respiratory infection, to name just a

few.

>

> For instance:

>

> * 1993 ­ supplementation with vitamin E was associated with a 30-

40%

> reduced risk for coronary disease in a study of 90,000 nurses

(Nurses Health

> Study; NEJM 328:1444-1449)

> * 1993 ­ total vitamin E intake is inversely related to the risk

of colon

> cancer; those with a highest vitamin E intake had the lowest

incidence of

> colon cancer (Iowa Women¹s Health Study; Cancer Res:53:4230-4237)

> * 1994 ­ Levels of vitamin E intake were inversely correlated

with

> coronary deaths in both women and men in a large (>5000 people),

long-term

> (14 year follow-up) Finnish study (Am. J. Epidemiol. 139:1180-

1189).

> * 1997 ­  A review of the literature concerning vitamin E and

breast

> cancer concluded  ³although epidemiologic study results have been

> inconsistent, further study of this nontoxic vitamin is

warranted.² (Nutr.

> Cancer 27:109-117).

> * 2000 - supplementation with Vitamin E supplementation may

prevent

> ischemic stroke in high risk hypertensive patients (Arch Neurol.

> 57:1503-1509; analysis of data from the Alpha-Tocopherol, Beta-

Carotene

> Cancer Prevention Study)

> * 2004 ­ protective effect of vitamin E supplementation on upper

> respiratory tract infections in elderly nursing home residents

(JAMA

> 292:828-836)

> * 2004 ­ supplementation with vitamins E and C in combination is

> associated with reduced prevalence and incidence of Alzheimer

Disease (Arch.

> Neurol. 61:82-88; this study is from s Hopkins)

> * FDA ­ allows qualified health claim regarding ³consumption of

> antioxidants (including Vitamin E) and reduced risk of some forms

of

> cancer.²

>

> This week¹s headlines aside, the preponderance of scientific and

clinical

> data shows well-established benefits of Vitamin E for otherwise

healthy

> individuals. Supplementation with vitamins, including Vitamin E,

makes sense

> in support of a healthy lifestyle, and for people who desire

nutritional

> insurance for the gaps left unfilled by the typical diet.

>

> For more information about the recent news on Vitamin E, please

visit

> the Web site for the Council on Responsible Nutrition, which also

questions

> the conclusions reached by the researchers.

>

> http://www.crnusa.org/PR04_1110CRNAIM.html

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