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Re: Test to Dx PLS vs ALS

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Eva,

What do you mean 'it is only available in Cuba right now'? I ask

because i had a TMS done this year. I haven't seen the report

myself yet but my neuro said it did show a left brain delay which

corresponds with all my 'extra' right sided signs like my tongue

that moves to the right and my right leg walks different than my

left. That said, both sides have the same findings on physical exam

like the same amount of weakness and hyperreflexia.

Just curious...

Colleen

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Colleen

I just was referring to the lack of open communication between Cuba

and the US. Neuros will want to see all the specifics of the study

or they will do the study themselves. Apparently your neuro is

compiling data on his/her own.

>

> Eva,

>

> What do you mean 'it is only available in Cuba right now'? I ask

> because i had a TMS done this year. I haven't seen the report

> myself yet but my neuro said it did show a left brain delay which

> corresponds with all my 'extra' right sided signs like my tongue

> that moves to the right and my right leg walks different than my

> left. That said, both sides have the same findings on physical

exam

> like the same amount of weakness and hyperreflexia.

>

>

> Just curious...

>

> Colleen

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  • 2 months later...

The study description sounds a lot like what Dr. Floeter is doing at

NIH. Lavon

At 06:24 AM 10/27/2004, you wrote:

>I found this article on Medline this morning. Too bad it's only in

>Cuba right now. I also sent a copy of this to my neuro at Cleveland

>Clinic.

>Eva in WV

>*****************

>

>Rev Neurol. 2004 Oct 1-15;39(7):613-7. Related Articles, Links

>

>

>[Corticoespinal dysfunction in patients with primary and amyotrophic

>lateral sclerosis.]

>

>[Article in Spanish]

>

>Gomez-Fernandez L, Maragoto-Rizo C, Calzada-Sierra DJ, Infante-

>Velazquez E, Padilla-Puentes E.

>

>Centro Internacional de Restauracion Neurologica (CIREN), Cubanacan,

>Playa. La Habana, Cuba.

>

>INTRODUCTION. Corticoespinal dysfunction is a common finding in

>primary and amyotrophic lateral sclerosis (PLS and ALS). AIM. To

>compare the behaviour of motor evoked potentials (MEP) with

>transcranial magnetic stimulation (TMS) in patients with ALS and PLS.

>PATIENTS AND METHODS. It was performed a retrospective analysis of

>MEP recordings of 11 patients with PLS and 10 patients with sporadic

>ALS. Central motor conduction time and amplitude ratio were the

>selected variables for the statistical analysis of MEP from abductor

>pollicis brevis and tibialis anterior muscle from the four limbs,

>using non-parametric methods. RESULTS. As a general observation there

>was a high incidence of abnormal recordings in both groups of

>patients; in 30% of recording from ALS patients response to TMS was

>absent, but only the 4.5% in the group of PLS had the same

>characteristic. In PLS patients abnormal central motor conduction

>time was the most frequent finding, as it was the low amplitude ratio

>in ALS patients; both variables showed statistically significant

>differences between groups (Kruskall-Wallis, H = 6.32, p = 0.011; and

>Kruskall-Wallis, H = 5.777, p = 0.0163, respectively). CONCLUSION.

>Corticoespinal dysfunction has different characteristics in ALS and

>PLS patients, and the analysis of MEP could add useful information

>for differential diagnosis of these diseases.

>

>

>

>

>

>

>

>

>

>

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