eosinophil - continued

[Guest guest]

,

Suzanne’s GI said there were eosinophil

cells in her esophagus, but at a level common in IBD; these were also present

during her initial scope (at dx). She then said the eosinophil cells in her

colon were significant, much more than could be explained by IBD. Also, this

was the first time they saw eosinophil cells in her colon. I am not sure what

the levels of “normal” elevation related to IBD would be versus

what significant levels of elevation would look like that could not be

explained by IBD. We see the allergist tomorrow and if I remember I will ask

more about this.

LINDA

(Mom of Suzanne,

17; IBD 1/04; PSC 3/04)

From: [mailto: ] On Behalf Of

Sent: Tuesday, May 23, 2006 11:07 AM

To:

Subject: Re: A sigh

of relief

> It is strange how this " eosinophils " business keeps showing up

and

I just wonder what all the connection is with PSC. Bills eosinophils

are still elevated.

Dear Lee;

The connection(s) between elevated eosinophils and PSC might be

related to asthma and allergies, and may in part be genetically

determined. For instance, there's a connection between interleukin-

10 gene variants and elevated eosinophils in asthma. Interleukin-10

is one of the candidate inflammatory bowel disease genes ... mice

deficient in interleukin-10 develop colitis. Interleukin-10 may be

required for the proper control of T cells to inhibit inflammatory

diseases such as asthma and IBD. But there could be many

interactions with other genes, pathogens, and other environmental

factors. I wish I knew how all the puzzle pieces fit together!

Best regards,

Dave

(father of (20); PSC 07/03; UC 08/03)