Guest guest Posted September 10, 2006 Report Posted September 10, 2006 ahhh, a girl after my own heart - I love stuff like this - it just gives me more ammunition - I have booked Mike in for an appointment with a naturopath - we will manage his NORMAL cholesterol through her - he's already on omega 3-6-9, lecithin, and psyllium (sp?) - so, we'll see if we can take it even lower on the normal end of the scale than it is now...... I've also bought him those funky eggs with omega's in them - and he's cut down his consumption of eggs to three times a week - I can't seem to get a clear straight story on if eggs are good or bad - everything depends on who wrote the article....... keep any and all info coming... I really appreciate it... Patti " a good retreat is better than a bad stand " > >Reply-To: >To: < > >Subject: AIH Triggered by Statins - >Date: Fri, 8 Sep 2006 11:02:29 -0500 > >((Patti, thought you might be interested in this just released study)) > > >Autoimmune Hepatitis Triggered by Statins. > >Journal of Clinical Gastroenterology. 40(8):757-761, September 2006. >Alla, Vamsee MD; Abraham, ph MD; Siddiqui, Junaid MD; Raina, Dimple >MD; Wu, Y. MD, PhD; Chalasani, Naga P. MD; Bonkovsky, Herbert L. >MD >Abstract: >Although the cause of autoimmune hepatitis (AIH) is unknown, drugs are >believed to be potential triggers in some patients. In isolated case >reports, statins have been considered such triggers. Here we describe 3 >patients in whom it is probable that statins initiated the development >of AIH. Two men (aged 47 and 51) and one woman (aged 57) developed AIH >after the initiation of statin therapy. They developed positive titers >of antinuclear antibodies, antismooth muscle antibodies (1/40 to 1/160), >and hypergammaglobulinemia. Features of all 3 patients met the criteria >for AIH according to the International Autoimmune Hepatitis Panel. Liver >biopsies in all 3 showed varying stages of fibrosis and plasma cell >infiltration, compatible with AIH. The woman developed hepatitis due to >statins on 2 separate occasions: the first in 1999, due to simvastatin, >and the second in 2001 to 2002, due to atorvastatin, which was severe >and persisted even after discontinuing medication. Similarly, in the 2 >other cases, exposure to statins preceded development of AIH, which >persisted despite discontinuing medications. All 3 patients responded >well to prednisone and azathioprine or mycophenolate therapy. 3 similar >previously reported cases are reviewed. We conclude that the 3 cases >reported here and 3 similar previously reported cases, indicate that >severe, ongoing AIH on rare occasions can be triggered by statins. >© 2006 Lippincott & Wilkins, Inc. >Barb in Texas - Together in the Fight, Whatever it Takes! >Son Ken (32) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas > > Quote
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