Re: HWRC Document: Mycophenolate mofetil ameliorates human IgA nephro

[Guest guest]

Thanks Betsy!

Cy

HWRC Document: Mycophenolate mofetil ameliorates human IgA

nephro

> > Thought this might be of interest.

>

> Betsy

>

> >>

> >> Mycophenolate mofetil ameliorates human IgA nephropathy.

> >> Immunotherapy

> >> Weekly. April 14, 2004 p68.

> >>

> >> Full Text: COPYRIGHT 2004 NewsRX

> >>

> >> 2004 APR 14 - (NewsRx.com & NewsRx.net) -- IgA nephropathy patients

> >> may

> >> benefit from mycophenolate mofetil therapy.

> >>

> >> " Mycophenolate mofetil is an immunosuppressive agent in

> >> transplantation

> >> which inhibits the purin neogenesis. Proliferating lymphocytes are

> >> suppressed

> >> and antibody production is decreased, " nephrologists in Germany

> >> explained.

> >> " Many cases of successful therapy in different kidney diseases are

> >> reported,

> >> such as diffuse proliferative lupus nephritis, pauci-immune

> >> necrotizing glomerulonephritis, focal segmental glomerular sclerosis

> >> and IgA nephropathy. "

> >>

> >> R. Bergner and colleagues at Ludwigshafen City Hospital described

> >> their

> >> experience with three IgA nephropathy patients " who were treated with

> >> mycophenolate

> >> mofetil for more than 1 year. " " In all patients, proteinuria

> >> decreased significantly and the renal function remained stable, "

> >> according to the report. " In two patients, kidney biopsy

> >> was repeated after 12 months and 18 months, respectively. There were

> >> no

> >> histological signs of progression of the disease. "

> >>

> >> " Two patients developed infections during treatment, " published data

> >> indicated.

> >> " One patient had a pneumonia, and a second patient an infection with

> >> varizella

> >> zoster. " These results suggest that " mycophenolate mofetil can be a

> >> potential treatment

> >> of IgA nephropathy, " the researchers concluded. " Further controlled

> >> studies

> >> are warranted to investigate the role of mycophenolate mofetil in IgA

> >> nephropathy. "

> >>

> >> Bergner and coauthors published their findings in Clinical Nephrology

> >> (Therapy of IgA nephropathy with mycophenolate mofetil - report of 3

> >> cases.

> >> Clin Nephrol, 2004;61(3):207-212).

> >>

> >> Additional information can be obtained by contacting R. Bergner,

> >> Ludwigshafen

> >> City Hospital, Medical Clinic A, Bremserstr. 79, D-67063 Ludwigshafen,

> >> Germany.

> >>

> >> The publisher of the journal Clinical Nephrology can be contacted at:

> >> Dustri-Verlag, Dr. Karl Feistle, Bajuwarenring 4, D-82041 Oberhaching,

> >> Germany.

> >>

> >> The information in this article comes under the major subject areas

> >> of

> >> Biotechnology, Immunology and Nephropathy.

> >>

> >> This article was prepared by Immunotherapy Weekly editors from staff

> >> and

> >> other reports. Copyright 2004, Immunotherapy Weekly via NewsRx.com &

> >> NewsRx.net.

> >>

> >> Record Number: A115184339

> >>

> >> Copyright © 2003 by Gale Group . All rights reserved.

> >> Gale Group is a Thomson Corporation Company.

> >>

> >>

> >>

>

>

>

>

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[Guest guest]

Thanks Betsy. By the way, the common name for Mycophenolate Mofetil is

Cellcept.

I tried it for 3 months, but my renal function declined each of the three

months so I discontinued it due to the adverse side effects. It does seem to be

working well for Rita though. I am glad they will be doing further research.

[Guest guest]

Hi Betsy,

That's a very interesting study. I am curious to see if eventually

it can be used as an alternate treatment for prednisone and other

current medications being used.

Thanks for sharing this information!

Sophia

> > Thought this might be of interest.

>

> Betsy

>

> >>

> >> Mycophenolate mofetil ameliorates human IgA nephropathy.

> >> Immunotherapy

> >> Weekly. April 14, 2004 p68.

> >>

> >> Full Text: COPYRIGHT 2004 NewsRX

> >>

> >> 2004 APR 14 - (NewsRx.com & NewsRx.net) -- IgA nephropathy

patients

> >> may

> >> benefit from mycophenolate mofetil therapy.

> >>

> >> " Mycophenolate mofetil is an immunosuppressive agent in

> >> transplantation

> >> which inhibits the purin neogenesis. Proliferating lymphocytes

are

> >> suppressed

> >> and antibody production is decreased, " nephrologists in Germany

> >> explained.

> >> " Many cases of successful therapy in different kidney diseases

are

> >> reported,

> >> such as diffuse proliferative lupus nephritis, pauci-immune

> >> necrotizing glomerulonephritis, focal segmental glomerular

sclerosis

> >> and IgA nephropathy. "

> >>

> >> R. Bergner and colleagues at Ludwigshafen City Hospital

described

> >> their

> >> experience with three IgA nephropathy patients " who were

treated with

> >> mycophenolate

> >> mofetil for more than 1 year. " " In all patients, proteinuria

> >> decreased significantly and the renal function remained

stable, "

> >> according to the report. " In two patients, kidney biopsy

> >> was repeated after 12 months and 18 months, respectively. There

were

> >> no

> >> histological signs of progression of the disease. "

> >>

> >> " Two patients developed infections during treatment, "

published data

> >> indicated.

> >> " One patient had a pneumonia, and a second patient an infection

with

> >> varizella

> >> zoster. " These results suggest that " mycophenolate mofetil can

be a

> >> potential treatment

> >> of IgA nephropathy, " the researchers concluded. " Further

controlled

> >> studies

> >> are warranted to investigate the role of mycophenolate mofetil

in IgA

> >> nephropathy. "

> >>

> >> Bergner and coauthors published their findings in Clinical

Nephrology

> >> (Therapy of IgA nephropathy with mycophenolate mofetil - report

of 3

> >> cases.

> >> Clin Nephrol, 2004;61(3):207-212).

> >>

> >> Additional information can be obtained by contacting R.

Bergner,

> >> Ludwigshafen

> >> City Hospital, Medical Clinic A, Bremserstr. 79, D-67063

Ludwigshafen,

> >> Germany.

> >>

> >> The publisher of the journal Clinical Nephrology can be

contacted at:

> >> Dustri-Verlag, Dr. Karl Feistle, Bajuwarenring 4, D-82041

Oberhaching,

> >> Germany.

> >>

> >> The information in this article comes under the major subject

areas

> >> of

> >> Biotechnology, Immunology and Nephropathy.

> >>

> >> This article was prepared by Immunotherapy Weekly editors from

staff

> >> and

> >> other reports. Copyright 2004, Immunotherapy Weekly via

NewsRx.com &

> >> NewsRx.net.

> >>

> >> Record Number: A115184339

> >>

> >> Copyright © 2003 by Gale Group . All rights reserved.

> >> Gale Group is a Thomson Corporation Company.

> >>

> >>

> >>