Guest guest Posted December 1, 2004 Report Share Posted December 1, 2004 Risk Of Chronic Heart Failure With Insulin Sensitizers Date: Tuesday, November 30 @ 14:44:46 EST Topic: DIC Newsletter Issue 236 More patients were diagnosed with chronic heart failure after 6 months of starting rosiglitazone (Avandia). A group of researchers led by Dr Marceille of the Hines Jr. Veterans Affairs Medical Center in Hines, USA, evaluated the relationship between rosiglitazone therapy and chronic heart failure in patients with type 2 diabetes. A total of 139 patients were identified who were receiving insulin therapy and had rosiglitazone added to their therapy. Medical records were reviewed for 6 months before and 6 months after initiation of rosiglitazone treatment. The researchers found that chronic heart failure was diagnosed in 25% of patients before starting rosiglitazone and in 30% after starting rosiglitazone. Medical intervention for chronic heart failure was needed in 36% of patients after starting rosiglitazone, compared with 14% before rosiglitazone (p<0.0001). Of the patients requiring medical intervention after starting rosiglitazone, 66% had not needed any intervention before starting rosiglitazone. The most common symptom was lower-extremity oedema, which occurred in 18% of patients before starting rosiglitazone and in 36% after starting rosiglitazone (p<0.0001). The researchers concluded that more patients were diagnosed with chronic heart failure during the 6 months after starting rosiglitazone than in the 6 months before starting rosiglitazone in insulin-treated patients with type 2 diabetes. Pharmacotherapy 2004;24:1317-22 cappie Greater Boston Area T-2 10/02 9/04 A1c: 5.3 max 100 carb diet, walking, Metformin. ALA/EPO, Coq10, B12, ALC, Vit C Cal/mag, low dose Biotin, full spectrum E, Policosanol, fish oil cap, fresh flax seed, multi vitamin, Lovastatin 20 mg, Enalapril 10 mg 11/04:143 lbs (highest weight 309), 5' tall /age 66, cappie@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2004 Report Share Posted December 1, 2004 I wonder if the heart problems are associated specifically with the Avandia, or with the combination of Avandia and insulin. I also wonder if the problem is limited only to Avandia or if it's something they'll find later to be also a problem with Actos, and other insulin sensitizers. Oy. And I wonder why I was considering switching to insulin and getting off the Actos, even tho it's 'working.' SulaBlue > Risk Of Chronic Heart Failure With Insulin Sensitizers > Date: Tuesday, November 30 @ 14:44:46 EST > Topic: DIC Newsletter Issue 236 > > More patients were diagnosed with chronic heart failure after 6 months > of starting rosiglitazone (Avandia). <SNIP> > A total of 139 patients were identified who were receiving insulin > therapy and had rosiglitazone added to their therapy. Medical records > were reviewed for 6 months before and 6 months after initiation of > rosiglitazone treatment. <SNIP> > cappie > Greater Boston Area > T-2 10/02 9/04 A1c: 5.3 > max 100 carb diet, walking, Metformin. > > ALA/EPO, Coq10, B12, ALC, Vit C > Cal/mag, low dose Biotin, full spectrum E, > Policosanol, fish oil cap, > fresh flax seed, multi vitamin, > Lovastatin 20 mg, Enalapril 10 mg > > 11/04:143 lbs (highest weight 309), > 5' tall /age 66, > cappie@w... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2004 Report Share Posted December 1, 2004 I believe Actos, altho it is a glitazone is actually proglitazone --don't know if the study included actos or not. cappie Greater Boston Area T-2 10/02 9/04 A1c: 5.3 max 100 carb diet, walking, Metformin. ALA/EPO, Coq10, B12, ALC, Vit C Cal/mag, low dose Biotin, full spectrum E, Policosanol, fish oil cap, fresh flax seed, multi vitamin, Lovastatin 20 mg, Enalapril 10 mg 11/04:143 lbs (highest weight 309), 5' tall /age 66, cappie@... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2004 Report Share Posted December 1, 2004 Actos is pioglitazone, avandia is ros. The study was done with avandia only. However, other studies have shown that avandia and insulin are not a good mix. Actos is supposed to lower c-reactive protein, a risk for cardiac problems and other things. I am taking insulin and actos. Having a senior, fat, diabetic brain, I cannot remember when I started. But it is at least four years, maybe more. Edema? I have had idiopathic edema since 1960. Yes, a very long time. Actos did make it worse. My heart and arteries are fine; just had the chemical stress test a few months ago. When I discontinued actos, because I was diagnosed with champagne leg in Feb 2002 (fluid up and down in my legs everyday damaged the tissues) I did not lose any of the fluid. But I lost control. I went back on it and, sure enough, gained more weight. But I have good numbers. And my compression stockings keep the fluid out of my legs, and in my middle, where, apparently, it is not harmful. Except, imagine a 66 year old looking like she is five months pregnant! Everything has a price. TANSTAAFL - there ain't no such thing as a free lunch - Heinlein. Helen Quote Link to comment Share on other sites More sharing options...
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