Guest guest Posted March 10, 2004 Report Share Posted March 10, 2004 The problem over here is not high amounts of ascorbic acid, but rather high amounts of 'free' iron. If the ratio of 'free'iron to ascorbic acid increases above a certain level, ascorbic acid can act as a pro-oxidant instead of an anti-oxidant. Two ways to reduce this ratio is either to decrease the iron, or to increase the ascorbic acid. Schlosser wrote: > I have been trying to find the article that I read regarding megadoses > of all vitamins but I haven't been able to locate it. I was just warning > people not to go crazy with vitamin c intake, some websites will tell > you to use up 10,000 mg of vitamin C and this is where you will run into > problems, not 500mg. > I did find this article regarding high doses of vitamin c > - Eur J Clin Invest 1998 Sep;28(9):695-700 -- Relative hyperoxaluria, > crystalluria and haematuria after megadose ingestion of vitamin C. -- > Auer BL, Auer D, Rodgers AL. > > Iron overload could promote the generation of free radicals and result > in deleterious cellular damages. A physiological increase of oxidative > stress has been observed in pregnancy. A routine iron supplement, > especially a combined iron and vitamin C supplementation, without > biological justifications could therefore aggravate this oxidative risk. > These data show that pharmalogical doses of iron, associated with high > vitamin C intakes, can result in uncontrolled lipid peroxidation. > - Biol Trace Elem Res 2001 Nov;83(2):103-10 -- Increased lipid > peroxidation in pregnant women after iron and vitamin C supplementation. > -- Lachili B, Hininger I, Faure H, Arnaud J, MJ, Favier A, > Roussel AM. > > Use caution with high doses as 1 g or more of vitamin C may have adverse > consequences in some people, including diarrhea. > - JAMA 1999 Apr 21;281(15):1415-23 -- Criteria and recommendations for > vitamin C intake. -- Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. > > *High doses may interfere with prescription medications.* > > > > > */ S. > /* > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2004 Report Share Posted March 10, 2004 But of course, the solution is to decrease the iron, and not to increase the ascorbic acid! 'Free' iron will cause the oxidative damage with or without the presence of ascorbic acid. That said, when the ascorbic acid becomes a pro-oxidizer because of the large amounts of iron, that will of course cause even more damage. Rajiv Bhushan wrote: > The problem over here is not high amounts of ascorbic acid, but rather > high amounts of 'free' iron. > > If the ratio of 'free'iron to ascorbic acid increases above a certain > level, ascorbic acid can act as a pro-oxidant instead of an anti-oxidant. > > Two ways to reduce this ratio is either to decrease the iron, or to > increase the ascorbic acid. > > Schlosser wrote: > > >>I have been trying to find the article that I read regarding megadoses >>of all vitamins but I haven't been able to locate it. I was just warning >>people not to go crazy with vitamin c intake, some websites will tell >>you to use up 10,000 mg of vitamin C and this is where you will run into >>problems, not 500mg. >>I did find this article regarding high doses of vitamin c >>- Eur J Clin Invest 1998 Sep;28(9):695-700 -- Relative hyperoxaluria, >>crystalluria and haematuria after megadose ingestion of vitamin C. -- >>Auer BL, Auer D, Rodgers AL. >> >>Iron overload could promote the generation of free radicals and result >>in deleterious cellular damages. A physiological increase of oxidative >>stress has been observed in pregnancy. A routine iron supplement, >>especially a combined iron and vitamin C supplementation, without >>biological justifications could therefore aggravate this oxidative risk. >>These data show that pharmalogical doses of iron, associated with high >>vitamin C intakes, can result in uncontrolled lipid peroxidation. >>- Biol Trace Elem Res 2001 Nov;83(2):103-10 -- Increased lipid >>peroxidation in pregnant women after iron and vitamin C supplementation. >>-- Lachili B, Hininger I, Faure H, Arnaud J, MJ, Favier A, >>Roussel AM. >> >>Use caution with high doses as 1 g or more of vitamin C may have adverse >>consequences in some people, including diarrhea. >>- JAMA 1999 Apr 21;281(15):1415-23 -- Criteria and recommendations for >>vitamin C intake. -- Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. >> >>*High doses may interfere with prescription medications.* >> >> >> >> >>*/ S. >>/* >> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2004 Report Share Posted March 10, 2004 Hello, my name is Darlene and I have been living with RSD/CRPS for 6 months now. I was injured at work six months ago and broke both my arms. My left arm has healed fine but my right arm has developed RSD/CRPS and I have had 12 Stellate Ganglia Block injections in my neck. The Doctor is now telling me I am not getting enough relief from pain so he wants to do a Stellate Ganglion Block/ Ablation which will cauterize my nerve permanently. Has anyone had this done yet? I have been trying to find information about this procedure. I would appreciate any advise or experience. Thanks for listening Darlene From: Rajiv Bhushan Sent: Wednesday, March 10, 2004 10:24 AM To: RSD-CRPSofAmerica Subject: Re: vitamin C The problem over here is not high amounts of ascorbic acid, but rather high amounts of 'free' iron. If the ratio of 'free'iron to ascorbic acid increases above a certain level, ascorbic acid can act as a pro-oxidant instead of an anti-oxidant. Two ways to reduce this ratio is either to decrease the iron, or to increase the ascorbic acid. Schlosser wrote: > I have been trying to find the article that I read regarding megadoses > of all vitamins but I haven't been able to locate it. I was just warning > people not to go crazy with vitamin c intake, some websites will tell > you to use up 10,000 mg of vitamin C and this is where you will run into > problems, not 500mg. > I did find this article regarding high doses of vitamin c > - Eur J Clin Invest 1998 Sep;28(9):695-700 -- Relative hyperoxaluria, > crystalluria and haematuria after megadose ingestion of vitamin C. -- > Auer BL, Auer D, Rodgers AL. > > Iron overload could promote the generation of free radicals and result > in deleterious cellular damages. A physiological increase of oxidative > stress has been observed in pregnancy. A routine iron supplement, > especially a combined iron and vitamin C supplementation, without > biological justifications could therefore aggravate this oxidative risk. > These data show that pharmalogical doses of iron, associated with high > vitamin C intakes, can result in uncontrolled lipid peroxidation. > - Biol Trace Elem Res 2001 Nov;83(2):103-10 -- Increased lipid > peroxidation in pregnant women after iron and vitamin C supplementation. > -- Lachili B, Hininger I, Faure H, Arnaud J, MJ, Favier A, > Roussel AM. > > Use caution with high doses as 1 g or more of vitamin C may have adverse > consequences in some people, including diarrhea. > - JAMA 1999 Apr 21;281(15):1415-23 -- Criteria and recommendations for > vitamin C intake. -- Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. > > *High doses may interfere with prescription medications.* > > > > > */ S. > /* > Community email addresses: Post message:RSD-CRPSofAmerica Shortcut URL to this page:http://groups.yahoo.com/group/RSD-CRPSofAmerica Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 10, 2004 Report Share Posted March 10, 2004 --- In RSD-CRPSofAmerica , Schlosser > High doses may interfere with prescription medications. > S. ==================================================================== As with ANYTHING that you can take OTC...whether its vitamins, Herbal Remedies, Heart Burn meds, or even the Muscle Creams that are Over The Counter.... ALWAYS talk to your doctor BEFORE trying ANYTHING!! That way, you will find out first if anything will interfere with the Prescription meds that you already take. I do know that while on certain meds that aren't for High Blood Pressure, you still can't take OTC Cough meds or Sinus meds. You HAVE to take the High Blood Pressure Friendly stuff or else it will interfere with the Prescription meds. I can't remember exactly what I was on, but i was told this by my Pharmacist when I got the Med filled, because he knows that I take A LOT of OTC Sinus/Allergy meds for my sinus's. He told me NOT to use the Regular Tylenol Sinus Allergy pills or the Benadryl Allergy Sinus while on it....and went and got a box of HBP Sinus medicine. He said that otherwise, everything would interact wrong. So....it doesn't matter exactly WHAT it is....Vitamins or Sinus medicine or even a cream. ALWAYS ask your Doctor or Pharmacist if anything OTC will Interfere with your Prescription Meds...and, what the safest Dosages of those OTC items are. Most Pharmacists will tell you the max dose of what is safe, and what is the overdose dosage is. Tonia Quote Link to comment Share on other sites More sharing options...
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