Re: confused

September 2, 2010

on days that I gave my son b12 shots--he was more engaged and would attempt to communicate and "chatter" more. Only drawback--we couldn't give it every day, it was making him too hyper and hyper is a problem for us already.

confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?J Altern Complement Med. 2010 May;16(5):555-60.Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.AbstractAbstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.PMID: 20804367 [PubMed - in process]All help is welcomethanks,Jeff

September 2, 2010

It definitely helped my boys. My youngest requires really high doses though. But it really helps his language, eye contact, and social areas. It's a big wow for him. My other doesn't require as much. Not a big wow for him. I added sonic cholesterol and both boys started doing great! The combo is awesome! Hth Rhonda Masengale

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 2, 2010

many times that hyperness can be counteracted with something like folic acid. our sons gains would fade in 24 hours, and we found he NEEDED it daily. for a while he was even getting it 2 times a day

confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?J Altern Complement Med. 2010 May;16(5):555-60.Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.AbstractAbstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.PMID: 20804367 [PubMed - in process]All help is welcomethanks,Jeff

September 2, 2010

One of the best things I did for my son. His processing was screwed up and confused. Right after we started MB-12, we saw big gains (within days) and the connections in his brain just started firing. For example, before he would guess and get colors correct about 40% of the time. 3 days after his first shot, he just new them all. In the beginning if we missed a day, or towards the 3rd day, (we gave every 3rd day), he would have problems like pausing in the middle of saying something, and acting confused sometimes. The morning after his shot, he was right on and quick. He is recovered now, but I still give MB-12 shots and the diet. I have tried coming off both of those, but he just doesn't do well without them. I know MB-12 does wonders for

my son. I hate giving shots every time I do it (almost 2 years now), but the benefits outweigh the thought of sticking him with a needle. If I didn't notice a big difference, I wouldn't do it anymore. It is different for every kid, but for my son, it was big. (we did other biomedical stuff too, not just diet and MB-12) To: mb12 valtrex Sent: Thu, September 2, 2010 3:56:28 PMSubject: confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 2, 2010

Interestingly enough, we are participating in the follow up study to this one.

So far I have seen better recall and focus, but no WOW moments for us. Our WOW

was starting SCD 1 1/2 ago. Please note that this study only involved 30

subjects. 1/2 were on placebo (15), 9 showed significant improvement. 9 out of

15 seems like good enough odds to me

Janet

>

> Interested in trying MB12 with my son but a pubmed search gave me this

article. UC is pretty reputable I believe, so now I want to hear from you

is it a " WOW " for anyone and in what areas? Can improvement be measured?

>

> J Altern Complement Med. 2010 May;16(5):555-60.

>

> Pilot study of the effect of methyl B12 treatment on behavioral and biomarker

measures in children with autism.

> Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

>

> 1 Department of Psychiatry and Behavioral Sciences, University of California ,

Medical Center, Sacramento, CA.

>

> Abstract

> Abstract Objectives: The study objectives were to determine whether methyl B12

treatment improves behavioral measures in children with autism and whether

improvement is associated with increased plasma concentrations of glutathione

(GSH) and an increased redox ratio of reduced glutathione to oxidized

glutathione (GSH/GSSG), both of which have been previously identified to be low

in children with autism. Design: This was a 12-week, double-blind,

placebo-controlled, cross-over clinical trial of injectable methyl B12.

Following this 12-week study, subjects were given the option of entering a

6-month open-label trial of methyl B12. Settings/location: All procedures took

place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years

old with autism. Interventions: All subjects received 6 weeks of placebo and 6

weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered

subcutaneously into the buttocks. Outcome measures: Blood

> for GSH analysis and behavioral assessments were obtained at baseline, week

6, and week 12. Results: Thirty (30) subjects completed the 12-week,

double-blind study and 22 subjects completed the 6-month extension study. No

statistically significant mean differences in behavior tests or in glutathione

status were identified between active and placebo groups. Nine (9) subjects

(30%) demonstrated clinically significant improvement on the Clinical Global

Impression Scale and at least two additional behavioral measures. More notably,

these responders exhibited significantly increased plasma concentrations of GSH

and GSH/GSSG. Conclusions: Comparison of the overall means between groups

suggests that methyl B12 is ineffective in treating behavioral symptoms of

autism. However, detailed data analysis suggests that methyl B12 may alleviate

symptoms of autism in a subgroup of children, possibly by reducing oxidative

stress. An increase in glutathione redox status

> (GSH/GSSG) may provide a biomarker for treatment response to methyl B12.

Additional research is needed to delineate a subgroup of potential responders

and ascertain a biomarker for response to methyl B12.

>

> PMID: 20804367 [PubMed - in process]

> All help is welcome

> thanks,

> Jeff

>

September 3, 2010

We've been on MB12 for 18mos. and it's been great. It really helped boost our son's language. Also, all of his sensory issues went away. Our first WOW came from diet -- that had as hooked on biomed. Our second WOW came from MB12..For the first 6 weeks we did the shots every third day. We then moved to everyday. And everyday has been better than every three days.If I had to rate our top 5 biomedical interventions, and things that gave us the WOW factor, they would be:1. GFCF diet2. MB12 (every day)3. SCD diet4. Valtrex/Diflucan (tie, b/c they really go together)5. LDN/fermented CLO (tie)HTH,

To: mb12 valtrex Sent: Fri, September 3, 2010 12:45:22 AMSubject: Re: confused

Interestingly enough, we are participating in the follow up study to this one. So far I have seen better recall and focus, but no WOW moments for us. Our WOW was starting SCD 1 1/2 ago. Please note that this study only involved 30 subjects. 1/2 were on placebo (15), 9 showed significant improvement. 9 out of 15 seems like good enough odds to me

Janet

>

> Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

>

> J Altern Complement Med. 2010 May;16(5):555-60.

>

> Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

> Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

>

> 1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

>

> Abstract

> Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures:

Blood

> for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox

status

> (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

>

> PMID: 20804367 [PubMed - in process]

> All help is welcome

> thanks,

> Jeff

>

September 3, 2010

btw, this list is not in order from greatest to least - it's the order of how we did things... (IE., for us GFCF was better than a "regular diet" a year later we switched to SCD, and that brought even more gains.)To: mb12 valtrex Sent: Fri, September 3, 2010 8:30:53 AMSubject: Re: Re: confused

We've been on MB12 for 18mos. and it's been great. It really helped boost our son's language. Also, all of his sensory issues went away. Our first WOW came from diet -- that had as hooked on biomed. Our second WOW came from MB12..For the first 6 weeks we did the shots every third day. We then moved to everyday. And everyday has been better than every three days.If I had to rate our top 5 biomedical interventions, and things that gave us the WOW factor, they would be:1. GFCF diet2. MB12 (every day)3. SCD diet4. Valtrex/Diflucan (tie, b/c they really go together)5. LDN/fermented CLO (tie)HTH,

To: mb12 valtrex Sent: Fri, September 3, 2010 12:45:22 AMSubject: Re: confused

Interestingly enough, we are participating in the follow up study to this one. So far I have seen better recall and focus, but no WOW moments for us. Our WOW was starting SCD 1 1/2 ago. Please note that this study only involved 30 subjects. 1/2 were on placebo (15), 9 showed significant improvement. 9 out of 15 seems like good enough odds to me

Janet

>

> Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

>

> J Altern Complement Med. 2010 May;16(5):555-60.

>

> Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

> Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

>

> 1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

>

> Abstract

> Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures:

Blood

> for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox

status

> (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

>

> PMID: 20804367 [PubMed - in process]

> All help is welcome

> thanks,

> Jeff

>

September 3, 2010

, We had a similar experience with the shots in just a few days and progress continues ( began in May). What diet do you follow?Thanks,Sent from my iPhone

One of the best things I did for my son. His processing was screwed up and confused. Right after we started MB-12, we saw big gains (within days) and the connections in his brain just started firing. For example, before he would guess and get colors correct about 40% of the time. 3 days after his first shot, he just new them all. In the beginning if we missed a day, or towards the 3rd day, (we gave every 3rd day), he would have problems like pausing in the middle of saying something, and acting confused sometimes. The morning after his shot, he was right on and quick. He is recovered now, but I still give MB-12 shots and the diet. I have tried coming off both of those, but he just doesn't do well without them. I know MB-12 does wonders for

my son. I hate giving shots every time I do it (almost 2 years now), but the benefits outweigh the thought of sticking him with a needle. If I didn't notice a big difference, I wouldn't do it anymore. It is different for every kid, but for my son, it was big. (we did other biomedical stuff too, not just diet and MB-12) To: mb12 valtrex Sent: Thu, September 2, 2010 3:56:28 PMSubject: confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 3, 2010

We saw amazing overnight improvement that has leveled out but still seems to be causing strong gains: language, turning things on and off independently ( tv, DVD, cd player, lights), greater social engagement, improved mood, better focus, academics. It did cause some sleepless nights but when the teacher is asking "did he get his shot last night?" eagerly, you know it is pretty significant. The shots do hurt and as a parent it is distressing to have to inject your child but in our case well worth it. I come from a family with membSent from my iPhone On Sep 2, 2010,rss at 6:56 PM, "jeffkingsfancollins" wrote:

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 3, 2010

For about 2 years now he's been GFCF, but for 3 months a while back we did SCD. We also did glutathione daily, but I haven't done that in a month or two. I am kinda testing him to see what he still needs. We have done several vitamins, a 6 or 8 week round of chelation, in the past, and we just started ABA in July. To:

"mb12 valtrex " <mb12 valtrex >Sent: Fri, September 3, 2010 7:05:45 AMSubject: Re: confused

, We had a similar experience with the shots in just a few days and progress continues ( began in May). What diet do you follow?Thanks,Sent from my iPhone

One of the best things I did for my son. His processing was screwed up and confused. Right after we started MB-12, we saw big gains (within days) and the connections in his brain just started firing. For example, before he would guess and get colors correct about 40% of the time. 3 days after his first shot, he just new them all. In the beginning if we missed a day, or towards the 3rd day, (we gave every 3rd day), he would have problems like pausing in the middle of saying something, and acting confused sometimes. The morning after his shot, he was right on and quick. He is recovered now, but I still give MB-12 shots and the diet. I have tried coming off both of those, but he just doesn't do well without them. I know MB-12 does wonders for

my son. I hate giving shots every time I do it (almost 2 years now), but the benefits outweigh the thought of sticking him with a needle. If I didn't notice a big difference, I wouldn't do it anymore. It is different for every kid, but for my son, it was big. (we did other biomedical stuff too, not just diet and MB-12) To: mb12 valtrex Sent: Thu, September 2, 2010 3:56:28 PMSubject: confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 3, 2010

What did you think of SCD? What do others think. I can't see any draw backs other than my childs reaction to the food choices. He will probably stop eating.Sent from my iPhone

For about 2 years now he's been GFCF, but for 3 months a while back we did SCD. We also did glutathione daily, but I haven't done that in a month or two. I am kinda testing him to see what he still needs. We have done several vitamins, a 6 or 8 week round of chelation, in the past, and we just started ABA in July. To:

"mb12 valtrex " <mb12 valtrex >Sent: Fri, September 3, 2010 7:05:45 AMSubject: Re: confused

, We had a similar experience with the shots in just a few days and progress continues ( began in May). What diet do you follow?Thanks,Sent from my iPhone

One of the best things I did for my son. His processing was screwed up and confused. Right after we started MB-12, we saw big gains (within days) and the connections in his brain just started firing. For example, before he would guess and get colors correct about 40% of the time. 3 days after his first shot, he just new them all. In the beginning if we missed a day, or towards the 3rd day, (we gave every 3rd day), he would have problems like pausing in the middle of saying something, and acting confused sometimes. The morning after his shot, he was right on and quick. He is recovered now, but I still give MB-12 shots and the diet. I have tried coming off both of those, but he just doesn't do well without them. I know MB-12 does wonders for

my son. I hate giving shots every time I do it (almost 2 years now), but the benefits outweigh the thought of sticking him with a needle. If I didn't notice a big difference, I wouldn't do it anymore. It is different for every kid, but for my son, it was big. (we did other biomedical stuff too, not just diet and MB-12) To: mb12 valtrex Sent: Thu, September 2, 2010 3:56:28 PMSubject: confused

Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?

J Altern Complement Med. 2010 May;16(5):555-60.

Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.

Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.

1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.

Abstract

Abstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood

for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status

(GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.

PMID: 20804367 [PubMed - in process]

All help is welcome

thanks,

Jeff

September 3, 2010

for us the drawback was oxalate issues. We were SCD for 8 months which is not a terribly long time and I did not do stages or remove supps that were illegal, so I guess you could say I didn't give it a fair shot. We didn't get gains, my son lost weight, and (again my fault) we over did meat as my son is a sensory picky eater and I had a devil of a time getting other protein into him, so we ended up with very high ammonia levels which led to aggressive behavior. My son's clostridia got worse (probably from overdoing meat) and we saw no improvement in other gut bugs so we quit. My thinking then was then was that I would try again later and do it properly. I am a working mom and the cooking was tough, I have to tell you. I used to love to cook but after scd you couldn't get me back into the kitchen for months. We saw no regression when we went back to gfcf. That said, I think Elaine's book is brilliant and there are tons of families who report fabulous improvement for their child. Best of luck with it. confused Interested in trying MB12 with my son but a pubmed search gave me this article. UC is pretty reputable I believe, so now I want to hear from you is it a "WOW" for anyone and in what areas? Can improvement be measured?J Altern Complement Med. 2010 May;16(5):555-60.Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism.Bertoglio K, Jill S, Deprey L, Brule N, Hendren RL.1 Department of Psychiatry and Behavioral Sciences, University of California , Medical Center, Sacramento, CA.AbstractAbstract Objectives: The study objectives were to determine whether methyl B12 treatment improves behavioral measures in children with autism and whether improvement is associated with increased plasma concentrations of glutathione (GSH) and an increased redox ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), both of which have been previously identified to be low in children with autism. Design: This was a 12-week, double-blind, placebo-controlled, cross-over clinical trial of injectable methyl B12. Following this 12-week study, subjects were given the option of entering a 6-month open-label trial of methyl B12. Settings/location: All procedures took place at the UC M.I.N.D. Institute. Subjects: Subjects were 3 to 8 years old with autism. Interventions: All subjects received 6 weeks of placebo and 6 weeks of methyl B12 at a dose of 64.5 mcg/kg every three days administered subcutaneously into the buttocks. Outcome measures: Blood for GSH analysis and behavioral assessments were obtained at baseline, week 6, and week 12. Results: Thirty (30) subjects completed the 12-week, double-blind study and 22 subjects completed the 6-month extension study. No statistically significant mean differences in behavior tests or in glutathione status were identified between active and placebo groups. Nine (9) subjects (30%) demonstrated clinically significant improvement on the Clinical Global Impression Scale and at least two additional behavioral measures. More notably, these responders exhibited significantly increased plasma concentrations of GSH and GSH/GSSG. Conclusions: Comparison of the overall means between groups suggests that methyl B12 is ineffective in treating behavioral symptoms of autism. However, detailed data analysis suggests that methyl B12 may alleviate symptoms of autism in a subgroup of children, possibly by reducing oxidative stress. An increase in glutathione redox status (GSH/GSSG) may provide a biomarker for treatment response to methyl B12. Additional research is needed to delineate a subgroup of potential responders and ascertain a biomarker for response to methyl B12.PMID: 20804367 [PubMed - in process]All help is welcomethanks,Jeff

September 3, 2010

We do a low oxalate form of SCD. We aren't doing the stages and we aren't using the nuts or eggs (or carrots, celery, garlic, and more because of allergies/sensitivities). It has been life changing for us.We have kept with most of our supplements and just use a legal version. If you are combatting yeast and have oxalate issues, doing SCD the way that some people suggest (with all the almonds / nuts) you will probably have big problems. We also do a 4 day rotation to help with allergies/sensitivities. My biggest complaint with the way some people outline SCD is the oxalates are not discussed and the daily zucchini/chicken/whatever can be a big problem for anyone with leaky gut.The cooking is tough - I work and travel for work and the only solution for us was to have someone come in to help about 5 hours per week. I still cook a ton more than before but it is manageable and we only had to pay $10/hour for the extra help. Totally worth it even though we have no babysitting budget!My daughter is an entirely different child and it has been only 5 weeks. I doubt that is the response everyone would have but it has been nothing short of a healing miracle for three of us in the family. Many of my issues are abating so the cooking (which I generally don't enjoy) is worth it.If you decide to try it, I would highly recommend spending 2 weeks planning out how your trial month will go and then another week gathering foods / getting rid of your old foods, spices, etc.. It's intense but SO valuable for some kids. You just won't know unless you try it. I can do anything for 4 weeks and we saw changes within the first week that helped push through the tantrums (mine). LOL We've now been on it 5 weeks and my child is an entirely different kid.- Kati for us the drawback was oxalate issues. We were SCD for 8 months which is not a terribly long time and I did not do stages or remove supps that were illegal, so I guess you could say I didn't give it a fair shot. We didn't get gains, my son lost weight, and (again my fault) we over did meat as my son is a sensory picky eater and I had a devil of a time getting other protein into him, so we ended up with very high ammonia levels which led to aggressive behavior. My son's clostridia got worse (probably from overdoing meat) and we saw no improvement in other gut bugs so we quit. My thinking then was then was that I would try again later and do it properly. I am a working mom and the cooking was tough, I have to tell you. I used to love to cook but after scd you couldn't get me back into the kitchen for months. We saw no regression when we went back to gfcf. That said, I think Elaine's book is brilliant and there are tons of families who report fabulous improvement for their child. Best of luck with it.

September 3, 2010

My son has been on SCD for over 1 1/2 years. For us it was the big WOW

treatment for him, new boy in 3 days. As Kati mentioned, the drawback is all of

the cooking. We do no nuts (through trial and error). I also recommend after

seeing so many families get stuck on the stages, to make sure you just keep

trialing new foods and pre-plan as much as possible before starting. A rotation

diet is a good thing Also, don't let your kids food issues be an obstacle.

My son ate 5-6 things when we started. Now he eats a wide variety including

meat, veggies & fruits. It took over a year to add these foods, but we just

kept plugging away. When you look at the big picture 1 year is nothing in the

scheme of things.

Janet

>

> One of the best things I did for my son. His processing was screwed up and

confused. Right after we started MB-12, we saw big gains (within days) and the

connections in his brain just started firing. For example, before he would

guess and get colors correct about 40% of the time. 3 days after his first

shot, he just new them all. In the beginning if we missed a day, or towards the

3rd day, (we gave every 3rd day), he would have problems like pausing in the

middle of saying something, and acting confused sometimes. The morning after

his shot, he was right on and quick. He is recovered now, but I still give

MB-12 shots and the diet. I have tried coming off both of those, but he just

doesn't do well without them. I know MB-12 does wonders for my son. I hate

giving shots every time I do it (almost 2 years now), but the benefits outweigh

the thought of sticking him with a needle. If I didn't notice a big difference,

I wouldn't do it anymore. It is

> different for every kid, but for my son, it was big. (we did other

biomedical stuff too, not just diet and MB-12)

>

> To: mb12 valtrex

> Sent: Thu, September 2, 2010 3:56:28 PM

> Subject: confused