Guest guest Posted December 9, 2003 Report Share Posted December 9, 2003 Hi Jack, How disappointing to hear that your brother also has symptoms of IgAN. My sister does too, although she seems to have a much more mild version of IgAN than I do. I for one am convinced that there is a genetic component. I am sorry but I do not know about why the doctor ran immunoglobulins G, A and M on him. To my knowledge, they are not routine kidney related lab tests. Do let us know if you find anything out about it though. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 9, 2003 Report Share Posted December 9, 2003 Thanks Cy! You are a wealth of knowledge :-) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 9, 2003 Report Share Posted December 9, 2003 Oh Jack, I'm sorry to learn about your brother! I'm not sure of the signifigance of serum IgG, IgA and IgM, but will look into it. I've never heard of this one as a test for IgAN. The only conclusive test for IgAN of which I'm aware is a biopsy. Cy Lab work > > > My brother, who has not been diagnosed with IgaN, got the results of lab work > done last week. His BUN and creatinine are high. > The MD also ran a test for immunoglobulins (G,A,M) serum. The results had > the G and M serum high but the A was within the normal range. My neph never had > that particular test done. Is it a normal test for IgaN or for any renal > disease? > > Jack (NY) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 9, 2003 Report Share Posted December 9, 2003 I can't say I've ever heard of it either. For one thing, the amount of IgA immune complexes in circulation really has little to do with why a person has IgAN. Maybe it's more complements they are looking for. Pierre Re: Lab work > Oh Jack, I'm sorry to learn about your brother! > > I'm not sure of the signifigance of serum IgG, IgA and IgM, but will look > into it. I've never heard of this one as a test for IgAN. The only > conclusive test for IgAN of which I'm aware is a biopsy. > > Cy > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 9, 2003 Report Share Posted December 9, 2003 Hi Jack, I just had a spare minute and quickly checked the antequated immunology texts in my house. IgM, IgA and IgM are somewhat related in that IgA and IgA are thought to have evolved from IgM. IgM is a much bigger molecule than IgG or IgA. IgM and IgG work together. When confronted with an antigen, IgG is produced as part of the primary response to the antigen. IgM is produced later and acts as a " memory " of sorts for the antigen. IgA is a totally different antibody and is commonly found in secretions such as breast milk, gut secretions, mucosa, ect. Please double check everything that I have said. A lot has happened since I kept that seat warm in immunololgy class. For more info, check http://www.fpnotebook.com/ID96.htm Cy Lab work > > > My brother, who has not been diagnosed with IgaN, got the results of lab work > done last week. His BUN and creatinine are high. > The MD also ran a test for immunoglobulins (G,A,M) serum. The results had > the G and M serum high but the A was within the normal range. My neph never had > that particular test done. Is it a normal test for IgaN or for any renal > disease? > > Jack (NY) > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2003 Report Share Posted December 10, 2003 " ...In response to an antigen, or foreign substance, our bodies produce antibodies. With appropriate signalling to T cells and B cells transform themselves into plasma cells. Plasma cells make immunoglobulin. These gamma globulins circulate in the plasma and protect the body from infection and other foreign material. there are five types of immunoglobulins: IgG is the major antibody of plasma and the most important part of our antibody response. Most autoimmune diseases are characterized by IgG. IgM is initially produced to fight antigens but soon decreases and allows IgG to take over. It plays an important secondary role in autoimmunity. IgA is the major antibody of external secretions (tears,gi tract secretions, and respiratory tract secretions). It is important in Sjorgen's syndrome (dry eyes, mouth,arthritis) lupus and autoimmune disease of the bowel (ulcerative colitis and Crohn's). IgD is poorly understood but has a role helping B cells recognize antigen IgE binds to mast cells and mediates allergic reactions. " From " The Lupus Book A Guide for Patients and Their Families " by J. Wallace MD...... Hope this is useful, I found it so. Sally UK. -----Original Message----- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2003 Report Share Posted December 10, 2003 Thanks Sally, This explanation is great and very easily understood. Sometimes with my Doctor, I'm more lost after a question is answered than before because of the medical jargon he uses. Then I have to come home and either ask my IgAN buddies or get on the net. Hope things are going well for you! Thanks for the info. Connie Co-Moderator, USA RE: Lab work " ...In response to an antigen, or foreign substance, our bodies produce antibodies. With appropriate signalling to T cells and B cells transform themselves into plasma cells. Plasma cells make immunoglobulin. These gamma globulins circulate in the plasma and protect the body from infection and other foreign material. there are five types of immunoglobulins: IgG is the major antibody of plasma and the most important part of our antibody response. Most autoimmune diseases are characterized by IgG. IgM is initially produced to fight antigens but soon decreases and allows IgG to take over. It plays an important secondary role in autoimmunity. IgA is the major antibody of external secretions (tears,gi tract secretions, and respiratory tract secretions). It is important in Sjorgen's syndrome (dry eyes, mouth,arthritis) lupus and autoimmune disease of the bowel (ulcerative colitis and Crohn's). IgD is poorly understood but has a role helping B cells recognize antigen IgE binds to mast cells and mediates allergic reactions. " >From " The Lupus Book A Guide for Patients and Their Families " by J. Wallace MD...... Hope this is useful, I found it so. Sally UK. -----Original Message----- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 10, 2003 Report Share Posted December 10, 2003 Thanks ! Cy Re: Lab work > Thanks Cy! > > You are a wealth of knowledge :-) > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2003 Report Share Posted December 11, 2003 That's OK Connie, its from a very well written book that although is to do with Lupus, has many very helpful crossovers with IgA. I would be very interested in anything you discover new too, re HSP. Thanks for your good wishes and I hope all works out well with this new Neph. Sally UK RE: Lab work Thanks Sally, This explanation is great and very easily understood. Sometimes with my Doctor, I'm more lost after a question is answered than before because of the medical jargon he uses. Then I have to come home and either ask my IgAN buddies or get on the net. Hope things are going well for you! Thanks for the info. Connie Co-Moderator, USA Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 Hi , YEAH!!!! That is great news about your sister :-) I am sure rejoicing with you on that one! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 Hi , YEAH!!!! That is great news about your sister :-) I am sure rejoicing with you on that one! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 Hi , YEAH!!!! That is great news about your sister :-) I am sure rejoicing with you on that one! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 That is great news, I am really happy for her. I hope everyday that no one else in my family. Martha -- In iga-nephropathy , " brandywinebw " <brandywinebw@y...> wrote: > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 That is great news, I am really happy for her. I hope everyday that no one else in my family. Martha -- In iga-nephropathy , " brandywinebw " <brandywinebw@y...> wrote: > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 That is great news, I am really happy for her. I hope everyday that no one else in my family. Martha -- In iga-nephropathy , " brandywinebw " <brandywinebw@y...> wrote: > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2004 Report Share Posted February 22, 2004 GREAT news about your sister! I hope she continues on with a normal life. Amy Lab work > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2004 Report Share Posted February 22, 2004 GREAT news about your sister! I hope she continues on with a normal life. Amy Lab work > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2004 Report Share Posted February 22, 2004 GREAT news about your sister! I hope she continues on with a normal life. Amy Lab work > My baby sis just got her lab's back and there is no sign of > anything. No blood or protien!!!!! All signs point to a healthy > kidney. She has been living with IgAN for 8 years and this is the > first time she has been normal. That means that there is some sort > of hope out there for me and for everyone else. > > My new kitchen sink was just wheeled in and it's calling my name. I > need to go inspect it. > > BRANDY > > > > To edit your settings for the group, go to our Yahoo Group > home page: > http://groups.yahoo.com/group/iga-nephropathy/ > > To unsubcribe via email, > iga-nephropathy-unsubscribe > Visit our companion website at www.igan.ca. The site is entirely supported by donations. If you would like to help, go to: > http://www.igan.ca/id62.htm > > Thank you > Quote Link to comment Share on other sites More sharing options...
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