Guest guest Posted September 12, 2004 Report Share Posted September 12, 2004 > Has anyone else here had gall bladder cancer or cancer in the cystic > duct? > > Mine was found when my gall bladder was removed. This is what > prompted the doctor to look for PSC and UC. Dear ; I don't know of anyone else in the group who has had gall bladder cancer, or cancer of the cystic duct. Arne would be able to comment on this, but I believe that he is out of town until the 17th of Sept., enjoying a canoeing vacation. A quick scan of the literature indicates that about 4% of PSC patients have " benign or malignant neoplasms " of the gall bladder, and a significant number have some sort of gall bladder abnormalities such as gallstones or PSC involving the gallbladder .... hence the high incidence of gall bladder removal in this population: AJR Am J Roentgenol. 1988 Mar;150(3):571-4. Gallbladder disease in patients with primary sclerosing cholangitis. Brandt DJ, MacCarty RL, Charboneau JW, LaRusso NF, Wiesner RH, Ludwig J. Department of Diagnostic Radiology, Mayo Clinic, MN 55905. We evaluated the gallbladders of 121 patients who had well-documented primary sclerosing cholangitis. Sonograms, cholangiograms, and CT scans were reviewed, and the findings were correlated with surgical or autopsy findings, when available. Pathologic examination of the gallbladder was available in 55 (45%) of the 121 patients; of these, 49 (89%) had abnormal gallbladders. Ninety-three of the 121 patients had one or more radiologic examinations of the gallbladder: 77 had sonograms, 80 had cholangiograms, and 18 had CT scans. Seventy-five (62%) of the 121 patients had abnormal gallbladders on histologic examination or had positive findings on one or more imaging study. By excluding 25 patients who had histologic changes of borderline significance and/or patients who had thick-walled gallbladders attributable to end-stage liver disease, we concluded that 50 (41%) of the 121 patients had intrinsic abnormalities of the gallbladder. Thirty-two (26%) had gallstones, 18 (15%) had probable primary sclerosing cholangitis involving the gallbladder, and five (4%) had benign or malignant neoplasms. Our study indicates that gallbladder abnormalities are common among patients with primary sclerosing cholangitis, and sonography is the most useful technique for evaluating these conditions. PMID: 3277348 Helicobacter species have been implicated in gall bladder cancer, but this still remains a matter of some controversy: Aliment Pharmacol Ther. 2002 Jun;16(6):1037-45. Review article: Helicobacter species and hepatobiliary diseases. Leong RW, Sung JJ. The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Division of Gastroenterology and Hepatology, Prince of Wales Hospital, Shatin, Hong Kong. Helicobacter species, which may colonize the biliary tract, have been implicated as a possible cause of hepatobiliary diseases ranging from chronic cholecystitis and primary sclerosing cholangitis to gall- bladder carcinoma and primary hepatic carcinomas. Research in this area has been limited by the lack of a gold standard in the diagnosis of these organisms in bile. Most published data to date have been based on molecular techniques that detect the DNA of Helicobacter species in bile, rather than evidence of viable organisms in bile. Helicobacter species have not been shown to induce histological injury to the biliary epithelium or liver parenchyma. The strongest association of the presence of these organisms in bile is with cholestatic conditions. This article reviews the literature on this newly developing field as it has evolved historically, taking pertinent methodological issues into account. Publication Types: Review Review, Tutorial PMID: 12030944 Best regards, (father of (19); PSC 07/03; UC 08/03) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 15, 2004 Report Share Posted September 15, 2004 Doctors have diagnosed Bile duct cancer to my father , There diagnosis is based upon ERCP ( Brush Bioapsy ) and Biopsy of gall bladder which was removed just 1 week before . They have also confirmed Gall Bladder cancer , Can some one suggest some method of confirming the bile duct cancer . Regards Sandeep India --- wrote: > > > Has anyone else here had gall bladder cancer or > cancer in the > cystic > > duct? > > > > Mine was found when my gall bladder was removed. > This is what > > prompted the doctor to look for PSC and UC. > > Dear ; > > I don't know of anyone else in the group who has had > gall bladder > cancer, or cancer of the cystic duct. Arne would be > able to comment > on this, but I believe that he is out of town until > the 17th of > Sept., enjoying a canoeing vacation. > > A quick scan of the literature indicates that about > 4% of PSC > patients have " benign or malignant neoplasms " of the > gall bladder, > and a significant number have some sort of gall > bladder abnormalities > such as gallstones or PSC involving the gallbladder > .... hence the > high incidence of gall bladder removal in this > population: > > AJR Am J Roentgenol. 1988 Mar;150(3):571-4. > > Gallbladder disease in patients with primary > sclerosing cholangitis. > > Brandt DJ, MacCarty RL, Charboneau JW, LaRusso NF, > Wiesner RH, Ludwig > J. > > Department of Diagnostic Radiology, Mayo Clinic, MN > 55905. > > We evaluated the gallbladders of 121 patients who > had well-documented > primary sclerosing cholangitis. Sonograms, > cholangiograms, and CT > scans were reviewed, and the findings were > correlated with surgical > or autopsy findings, when available. Pathologic > examination of the > gallbladder was available in 55 (45%) of the 121 > patients; of these, > 49 (89%) had abnormal gallbladders. Ninety-three of > the 121 patients > had one or more radiologic examinations of the > gallbladder: 77 had > sonograms, 80 had cholangiograms, and 18 had CT > scans. Seventy-five > (62%) of the 121 patients had abnormal gallbladders > on histologic > examination or had positive findings on one or more > imaging study. By > excluding 25 patients who had histologic changes of > borderline > significance and/or patients who had thick-walled > gallbladders > attributable to end-stage liver disease, we > concluded that 50 (41%) > of the 121 patients had intrinsic abnormalities of > the gallbladder. > Thirty-two (26%) had gallstones, 18 (15%) had > probable primary > sclerosing cholangitis involving the gallbladder, > and five (4%) had > benign or malignant neoplasms. Our study indicates > that gallbladder > abnormalities are common among patients with primary > sclerosing > cholangitis, and sonography is the most useful > technique for > evaluating these conditions. > > PMID: 3277348 > > Helicobacter species have been implicated in gall > bladder cancer, but > this still remains a matter of some controversy: > > Aliment Pharmacol Ther. 2002 Jun;16(6):1037-45. > > Review article: Helicobacter species and > hepatobiliary diseases. > > Leong RW, Sung JJ. > > The Chinese University of Hong Kong, Department of > Medicine and > Therapeutics, Division of Gastroenterology and > Hepatology, Prince of > Wales Hospital, Shatin, Hong Kong. > > Helicobacter species, which may colonize the biliary > tract, have been > implicated as a possible cause of hepatobiliary > diseases ranging from > chronic cholecystitis and primary sclerosing > cholangitis to gall- > bladder carcinoma and primary hepatic carcinomas. > Research in this > area has been limited by the lack of a gold standard > in the diagnosis > of these organisms in bile. Most published data to > date have been > based on molecular techniques that detect the DNA of > Helicobacter > species in bile, rather than evidence of viable > organisms in bile. > Helicobacter species have not been shown to induce > histological > injury to the biliary epithelium or liver > parenchyma. The strongest > association of the presence of these organisms in > bile is with > cholestatic conditions. This article reviews the > literature on this > newly developing field as it has evolved > historically, taking > pertinent methodological issues into account. > > Publication Types: > Review > Review, Tutorial > > PMID: 12030944 > > Best regards, > > > (father of (19); PSC 07/03; UC 08/03) > > ________________________________________________________________________ Yahoo! India Matrimony: Find your life partner online Go to: http://yahoo.shaadi.com/india-matrimony Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 15, 2004 Report Share Posted September 15, 2004 Hello Sandeep; I am very sorry to hear of your father's bile duct cancer. The best method for testing for bile duct cancer is the use of biliary brushings for cytology. It sounds like they have done this already. Imaging studies (CT and ultrasound) have low sensitivity for diagnosing early cholangiocarcinoma. Tumor markers including CA19-9, CEA and CA 125 can be seen in association with cholangiocarcinoma, but they can also rise in association with cholestasis. Best regards, (father of (19); PSC 07/03; UC 08/03) > Doctors have diagnosed Bile duct cancer to my father , > There diagnosis is based upon ERCP ( Brush Bioapsy ) > and Biopsy of gall bladder which was removed just 1 > week before . > > They have also confirmed Gall Bladder cancer , > > Can some one suggest some method of confirming the > bile duct cancer . > > Regards > > Sandeep > India Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 16, 2004 Report Share Posted September 16, 2004 Dear sir , Thanks for information , Can you please suggets how we may go for the treatment .. Regards Sandeep --- wrote: > Hello Sandeep; > > I am very sorry to hear of your father's bile duct > cancer. The best > method for testing for bile duct cancer is the use > of biliary > brushings for cytology. It sounds like they have > done this already. > Imaging studies (CT and ultrasound) have low > sensitivity for > diagnosing early cholangiocarcinoma. Tumor markers > including CA19-9, > CEA and CA 125 can be seen in association with > cholangiocarcinoma, > but they can also rise in association with > cholestasis. > > Best regards, > > > (father of (19); PSC 07/03; UC 08/03) > > > > Doctors have diagnosed Bile duct cancer to my > father , > > There diagnosis is based upon ERCP ( Brush Bioapsy > ) > > and Biopsy of gall bladder which was removed just > 1 > > week before . > > > > They have also confirmed Gall Bladder cancer , > > > > Can some one suggest some method of confirming the > > bile duct cancer . > > > > Regards > > > > Sandeep > > India > > > ________________________________________________________________________ Yahoo! India Matrimony: Find your life partner online Go to: http://yahoo.shaadi.com/india-matrimony Quote Link to comment Share on other sites More sharing options...
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