Retransplant

[Guest guest]

Hi,

This is my first posting but have been reading for a few months.

I was diagnosed with PSC and UC in 1989, transplanted 1997. I have

been doing well with my new liver until the last year or so. My

bile ducts are blocking again because of a reoccurance of my PSC. I

have had a PTC tube for 14 months and it has helped until recently.

My billirubin has been at 15 and 13 the last few weeks and my

transplant doctors are doing the necessary test to get me on the

transplant list again. I go in Friday for an ultra sound and to

talk to the transplant team. I was wondering if any one else here

has been retransplanted because of the PSC destroying the new liver?

Thanks,

Hutek

[Guest guest]

PSC has in fact returned in about 10-20% of patients post

transplant. We have several in this group that have been either

retransplanted or relisted because of this. Although transplant is

a " cure " for most of us that is not always the case.

There has been no conclusive study that has shown Ursodiol helps with

PSC patients. There have been some promising studies but we are in

the early stages of understanding the effect of Urso on PSC. The

thought is URSO thins the bile and thus improves bile flow which may

make you less likely to get cholangitis since the bile is not backing

up in your system allowing bacteria to invade the ducts.

in Seattle

[Guest guest]

The reason I found it interesting is because I'm wondering if there were ever any studies that compared PBC with PSC. For instance, in PBC, mostly females get it whereas in PSC mostly males get it. The symptoms and experiences of both diseases share some similarities. I wonder if the same results in PBC can actually be applied to PSC. Of course, as you say, there needs to be studies to confirm the benefits, etc. You are definitely right about the varying consensus from community to community. More studies... the only problem is some of us can't wait.

Re: Retransplant> > > PSC has in fact returned in about 10-20% of patients post > transplant. We have several in this group that have been either > retransplanted or relisted because of this. Although transplant is > a "cure" for most of us that is not always the case.> > There has been no conclusive study that has shown Ursodiol helps with > PSC patients. There have been some promising studies but we are in > the early stages of understanding the effect of Urso on PSC. The > thought is URSO thins the bile and thus improves bile flow which may > make you less likely to get cholangitis since the bile is not backing > up in your system allowing bacteria to invade the ducts.> > in Seattle> > > > > >

[Guest guest]

By the way, I just read Barb's post about the differences between PBC and PSC so you can pretty much ignore this now... hehe or you could still read it if you want ;-)

Re: Retransplant> > > PSC has in fact returned in about 10-20% of patients post > transplant. We have several in this group that have been either > retransplanted or relisted because of this. Although transplant is > a "cure" for most of us that is not always the case.> > There has been no conclusive study that has shown Ursodiol helps with > PSC patients. There have been some promising studies but we are in > the early stages of understanding the effect of Urso on PSC. The > thought is URSO thins the bile and thus improves bile flow which may > make you less likely to get cholangitis since the bile is not backing > up in your system allowing bacteria to invade the ducts.> > in Seattle> > > > > >