Re: PubMed: Don't take thyroxine and iron at the same time.

[Guest guest]

Was there anything that you saw anywhere that showed a study using sublingual

dosing with Armour and the ferrous sulfate?

PubMed: Don't take thyroxine and iron at the

same time.

If you take thyroxine and iron at the same time, you will likely have

reduced absorption of the thyroxine.

Ann Intern Med. 1992 Dec 15;117(12):1010-3.

Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism.

NR, Hasinoff BB, Stalts H, Rao B, Wong NC.

Department of Medicine, Faculty of Medicine, University of Calgary, Alberta,

Canada.

OBJECTIVE: To determine whether simultaneous ingestion of ferrous sulfate and

thyroxine reduces the efficacy of thyroid hormone in patients with primary

hypothyroidism. DESIGN: Uncontrolled clinical trial. SETTING: Outpatient

research clinic of a tertiary care center. PATIENTS: Fourteen patients with

established primary hypothyroidism on stable thyroxine replacement.

INTERVENTION: All patients were instructed to ingest simultaneously, a 300-mg

ferrous sulfate tablet and their usual thyroxine dose every day for 12 weeks.

RESULTS: After 12 weeks of ferrous sulfate ingestion with thyroxine, the mean

level of serum thyrotropin (thyroid stimulating hormone, TSH) rose from 1.6

+/-

0.4 to 5.4 +/- 2.8 mU/L (P < 0.01), but the free thyroxine index did not

change

significantly. Subjective evaluation using a clinical score showed that nine

patients had an increase in symptoms and signs of hypothyroidism; the mean

score

for the 14 patients changed from 0 to 1.3 +/- 0.4 (P = 0.011). When iron and

thyroxine were mixed together in vitro, a poorly soluble purple complex

appeared

that indicated the binding of iron to thyroxine. CONCLUSIONS: Simultaneous

ingestion of ferrous sulfate and thyroxine causes a variable reduction in

thyroxine efficacy that is clinically significant in some patients. The

interaction is probably caused by the binding of iron to thyroxine.

Publication Types:

Clinical Trial

PMID: 1443969

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[Guest guest]

PubMed: Don't take thyroxine and iron at the

same time.

> Was there anything that you saw anywhere that showed a study

> using sublingual dosing with Armour

> and the ferrous sulfate?

I could not find anything with either of the following search criteria:

(1) thyroxine AND iron AND sublingual

(2) thyroxine AND iron AND tongue

[Guest guest]

PubMed: Don't take thyroxine and iron at the

same time.

> Thanks anyway. I have been trying to see how much that would help the

conflict, but can find

> nothing either!!!!

Are there any problems with taking the iron before you go to bed at

night?

[Guest guest]

Thanks anyway. I have been trying to see how much that would help the conflict,

but can find nothing either!!!!

PubMed: Don't take thyroxine and iron at the

[Guest guest]

I have to take 325 mg of iron 3x a day. I take one dose before bed, but closer

to dinner since all this iron upsets my stomach. I need to take with food.

PubMed: Don't take thyroxine and iron at the

same time.

> Thanks anyway. I have been trying to see how much that would help the

conflict, but can find

> nothing either!!!!

Are there any problems with taking the iron before you go to bed at

night?

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