Re: twice daily dosing of T3

[Guest guest]

--- At 04:10 PM 4/16/2009, ???? ask me! wrote:

>

>Ok thanks for this info. Maybe im feeling hypo as the day goes on because my

dose isnt high enough. Ill try increasing it and see how I feel. What type of

T3 are you taking, regular or slow release?

Regular T3. (I don't trust slow release.)

Bill

---

[Guest guest]

> Apparently, when taking T3 all at once, first thing in the morning,

> the " extra " T3 is immediately converted by the liver into

> " bound T3 " (bound to TBG, thyroid binding globulin). The bound T3

> then converts to free T3 exactly as needed, at all times.

So how long is this bound T3 good for. Does Lowe discuss this on his site

somewhere? And what is needed to convert it?

Dorothy

[Guest guest]

--- At 09:06 PM 4/16/2009, dorothyroeder wrote:

>

>> Apparently, when taking T3 all at once, first thing in the

>> morning, the " extra " T3 is immediately converted by the

>> liver into " bound T3 " (bound to TBG, thyroid binding

>> globulin). The bound T3 then converts to free T3 exactly

>> as needed, at all times.

>

>So how long is this bound T3 good for. Does Lowe discuss this

>on his site somewhere? And what is needed to convert it?

When free T3 levels are lowered, TSH increases, which causes

an increased rate of conversion of bound T3 to free T3 --

apparently by way of reducing the binding coefficient of TBG,

or by some other mechanism.

Result: more free T3 appears, to replace what has been used --

and, this works smoothly when T3 is dosed but once-daily.

Conversely, increasing free T3 by taking Cytomel (etc.) lowers

TSH, and this causes (or parallels) the liver's making of more

of several hormone binding proteins, including TBG and SHBG.

I don't know if Dr. Lowe has addressed this topic, nor do I

know of anyone who has addressed this topic directly.

Bill

---

[Guest guest]

--- At 09:06 PM 4/16/2009, dorothyroeder wrote:

>

>> Apparently, when taking T3 all at once, first thing in the

>> morning, the " extra " T3 is immediately converted by the

>> liver into " bound T3 " (bound to TBG, thyroid binding

>> globulin). The bound T3 then converts to free T3 exactly

>> as needed, at all times.

>

>So how long is this bound T3 good for. Does Lowe discuss this

>on his site somewhere? And what is needed to convert it?

When free T3 levels are lowered, TSH increases, which causes

an increased rate of conversion of bound T3 to free T3 --

apparently by way of reducing the binding coefficient of TBG,

or by some other mechanism.

Result: more free T3 appears, to replace what has been used --

and, this works smoothly when T3 is dosed but once-daily.

Conversely, increasing free T3 by taking Cytomel (etc.) lowers

TSH, and this causes (or parallels) the liver's making of more

of several hormone binding proteins, including TBG and SHBG.

I don't know if Dr. Lowe has addressed this topic, nor do I

know of anyone who has addressed this topic directly.

Bill

---

[Guest guest]

> I don't know if Dr. Lowe has addressed this topic, nor do I

> know of anyone who has addressed this topic directly.

> Bill

So where did you get the idea. Not doubting you, just wondering if there has

been some research on this.

Dorothy

[Guest guest]

> I don't know if Dr. Lowe has addressed this topic, nor do I

> know of anyone who has addressed this topic directly.

> Bill

So where did you get the idea. Not doubting you, just wondering if there has

been some research on this.

Dorothy

[Guest guest]

--- At 01:43 PM 4/17/2009, dorothyroeder wrote:

>

>So where did you get the idea. ...

Where? No where; it is obvious to me because it works.

But I don't think anyone should start taking T3 once-daily

until they have done twice-daily for a few months. And

likewise, don't start taking T3 twice-daily until having

taken T3 thrice-daily for a few months -- this, partly to

build up the liver's capacity to generate TBG in larger

than ordinary quantities. And this may not work at all

in cases of secondary hypothyroidism (TSH deficiency).

Bill

---

[Guest guest]

--- At 01:43 PM 4/17/2009, dorothyroeder wrote:

>

>So where did you get the idea. ...

Where? No where; it is obvious to me because it works.

But I don't think anyone should start taking T3 once-daily

until they have done twice-daily for a few months. And

likewise, don't start taking T3 twice-daily until having

taken T3 thrice-daily for a few months -- this, partly to

build up the liver's capacity to generate TBG in larger

than ordinary quantities. And this may not work at all

in cases of secondary hypothyroidism (TSH deficiency).

Bill

---

[Guest guest]

>-- this, partly to

> build up the liver's capacity to generate TBG in larger

> than ordinary quantities.

> Bill

Interesting. When I started T3 I had to take small doses every 2-3 hrs. Now I am

doing it in 3 doses.

Dorothy

[Guest guest]

>-- this, partly to

> build up the liver's capacity to generate TBG in larger

> than ordinary quantities.

> Bill

Interesting. When I started T3 I had to take small doses every 2-3 hrs. Now I am

doing it in 3 doses.

Dorothy

[Guest guest]

>-- this, partly to

> build up the liver's capacity to generate TBG in larger

> than ordinary quantities.

> Bill

Interesting. When I started T3 I had to take small doses every 2-3 hrs. Now I am

doing it in 3 doses.

Dorothy