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RE: Glucophage

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Well, Art, I'm not Susie...but I think you could just ask her, " why do I need

the sulf when I'm low carbing and exercising heavily? " smile...Vicki

In a message dated 04/22/2002 11:38:42 AM US Mountain Standard Time,

moseart@... writes:

> I'm

> still wondering why you need the sulfonylurea when you are low-carbing and

> exercising heavily.

> >>>>>>>>>>>>

> Dunno. . . .but plan to ask the endo about it when I see her in a couple of

> weeks. What do you suggest I tell her Susie?

> art

>

>

> Art Mc

>

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Art Mc wrote:

<< do you mean a single dose of 1500? I take 2000 per day, 1000 morning,

1000 evening. Also 5 " units " of diabeta. Until recently I took that at 5

pm, but now I am breaking them in half and taking 2.5 at Noon and the other

half at 5. I was getting serious lows (40-50) every night about midnite.

This seems to have helped a bit. . .now at midnight I'm usually in the mid

60's. >>

With the regular Metformin, type 2's would generally take 500 mg three times

a day, to even out the coverage. (Max. recommended is 2,250 daily for the

regular.) I can't find any dosage info at RxList.com on the XR, Art. I'm

still wondering why you need the sulfonylurea when you are low-carbing and

exercising heavily.

Susie

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Art Mc wrote:

<< do you mean a single dose of 1500? I take 2000 per day, 1000 morning,

1000 evening. Also 5 " units " of diabeta. Until recently I took that at 5

pm, but now I am breaking them in half and taking 2.5 at Noon and the other

half at 5. I was getting serious lows (40-50) every night about midnite.

This seems to have helped a bit. . .now at midnight I'm usually in the mid

60's. >>

With the regular Metformin, type 2's would generally take 500 mg three times

a day, to even out the coverage. (Max. recommended is 2,250 daily for the

regular.) I can't find any dosage info at RxList.com on the XR, Art. I'm

still wondering why you need the sulfonylurea when you are low-carbing and

exercising heavily.

Susie

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I'm

still wondering why you need the sulfonylurea when you are low-carbing and

exercising heavily.

>>>>>>>>>>>>

Dunno. . . .but plan to ask the endo about it when I see her in a couple of

weeks. What do you suggest I tell her Susie?

art

Art Mc

moseart@...

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> -----Original Message-----

> From: Susie Muir

> regular.) I can't find any dosage info at RxList.com on the

Using Glucophage as an example, dosing info on rxlist.com can be found as

follows:

Enter either " Glucophage " or " Metformin " (the generic name) in the search

box and click on " go " .

Find the line " Brand Name: Glucophage, Generic Name: Metformin HCL " and

click on the underlined generic name to get to info on the drug.

Then click on " Indications and Dosage " on the menu bar to get do dosage

info.

For metformin, both the maximum dose and the minimum generally found to be

therapeutic can be found here.

Tom the Actuary

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> -----Original Message-----

> From: Susie Muir

> regular.) I can't find any dosage info at RxList.com on the

Using Glucophage as an example, dosing info on rxlist.com can be found as

follows:

Enter either " Glucophage " or " Metformin " (the generic name) in the search

box and click on " go " .

Find the line " Brand Name: Glucophage, Generic Name: Metformin HCL " and

click on the underlined generic name to get to info on the drug.

Then click on " Indications and Dosage " on the menu bar to get do dosage

info.

For metformin, both the maximum dose and the minimum generally found to be

therapeutic can be found here.

Tom the Actuary

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> -----Original Message-----

> From: Susie Muir

> regular.) I can't find any dosage info at RxList.com on the

Using Glucophage as an example, dosing info on rxlist.com can be found as

follows:

Enter either " Glucophage " or " Metformin " (the generic name) in the search

box and click on " go " .

Find the line " Brand Name: Glucophage, Generic Name: Metformin HCL " and

click on the underlined generic name to get to info on the drug.

Then click on " Indications and Dosage " on the menu bar to get do dosage

info.

For metformin, both the maximum dose and the minimum generally found to be

therapeutic can be found here.

Tom the Actuary

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Robin G. wrote:

<< It must still be YMMV, Susie. I'm on 500 mg qd and it's helping me alot.

>>

I've never seen the studies they based their recommendations on. If we

assume that their subjects were doing the Food Pyramid, that would certainly

explain why they required a minimum of 1500 mg daily in order to be

clinically effective.

Susie

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Art Mc wrote:

<< What do you suggest I tell her Susie? >>

Tell her about your major exercise program, and show her your journal of

glucose readings. Tell her you have been researching sulfonylureas and

learned that they can cause sometimes fatal hypos, and that you have been

having frequent hypos. Tell her you are also concerned about the tendency of

sulfonylureas to cause weight gain, and that weight gain is associated with

increased insulin resistance, which worsens your diabetes and causes

elevated insulin levels, which are a danger in themselves. Tell her you read

the warning box at http://www.RxList.com of at least one study showing

increased cardiovascular damage from taking sulfonylureas - then see what

she says. In short, politely ask her to justify your continued use of this

drug, in light of your good control. Most doctors are tickled to pieces to

find a patient like you. It's just that they don't expect their patients to

be so " good, " and so they put them on a drug that will improve their

" control " (meaning: readings) in the short term, while sacrificing their

pancreas beta cells in the long run and pushing the patient onto injected

insulin.

Susie

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Art Mc wrote:

<< What do you suggest I tell her Susie? >>

Tell her about your major exercise program, and show her your journal of

glucose readings. Tell her you have been researching sulfonylureas and

learned that they can cause sometimes fatal hypos, and that you have been

having frequent hypos. Tell her you are also concerned about the tendency of

sulfonylureas to cause weight gain, and that weight gain is associated with

increased insulin resistance, which worsens your diabetes and causes

elevated insulin levels, which are a danger in themselves. Tell her you read

the warning box at http://www.RxList.com of at least one study showing

increased cardiovascular damage from taking sulfonylureas - then see what

she says. In short, politely ask her to justify your continued use of this

drug, in light of your good control. Most doctors are tickled to pieces to

find a patient like you. It's just that they don't expect their patients to

be so " good, " and so they put them on a drug that will improve their

" control " (meaning: readings) in the short term, while sacrificing their

pancreas beta cells in the long run and pushing the patient onto injected

insulin.

Susie

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  • 1 month later...
Guest guest

Hi, Jeanna!

> So since increasing the meds I am now suffering from the " well-Known "

> effects you mentioned

> Does taking something like Imodium AD (sp?) do anything to help?

My mother-in-law says it does for her. Worth a try, IMO. :-)

ette

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Hi, Jeanna...the difference between Glucophage and Glucophage XR is that the

" XR " stands for " extended release " . I can't answer the other part of your

question re dosing times but maybe someone else here can. As I recall, I took

mine before meals.

I don't take Glucophage - I did for a little while before my diagnosis was

clarified as type 1 instead of type 2 . However, when I was taking it I was

taking the highest recommended dose - 2500 mg a day I think it was -- and I

was one of the lucky few who had NO side effects that sent me running to the

bathroom - unfortunately the drug didn't work for me. I now take insulin.

Vicki

In a message dated 05/31/2002 11:57:55 PM US Mountain Standard Time,

Jeanna@... writes:

> Anyway, the PA I saw told me that normally people do their best on

> Glucophage taking

> 1000 mg in the AM and 1000 mg in the PM. Isn't there a difference between

> Glucophage

> and Glucophage XR?

>

> So since increasing the meds I am now suffering from the " well-Known "

> effects you mentioned

> Does taking something like Imodium AD (sp?) do anything to help? I had

> this

> when I initially

> started on the Glucophage and about 6 weeks into it they mostly went away,

> hoping it will do that

> this time too. Anyone got any suggestions on anything to help until then?

>

>

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