Effects of Fish Oils on Lipid Profile

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Effects of Fish Oils on Lipid Profile

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Reference: " Effect of sex and genotype on cardiovascular biomarker

response to fish oils: the FINGEN Study, " Caslakel MJ, Miles EA, et al,

Am J Clin Nutr, 2008; 88(3): 618-29. (Address: AM Minihane, Hugh

Sinclair Human Nutrition Group, School of Chemistry, Food Biosciences

and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom.

E-mail: a.m.minihane@... ).

Summary: In a double-blind, placebo-controlled, crossover study

involving 312 adults between the ages of 20 and 70 years of age,

consumption of fish oil (in doses of 0.7 g/d EPA+DHA, and 1.8 g/d

EPA+DHA) was found to be associated with 8% and 11% lower plasma

concentrations of triglycerides in the study population as a whole. When

the data was broken down by sex and genotype, fish oil was found to

exert the greatest triglyceride-lowering effect in men with the APOE4

genotype - with a 15% reduction after 0.7 g/d EPA+DHA, and a 23%

reduction after 1.8 g/d EPA+DHA. After supplementation with fish oil,

reductions in VLDL cholesterol and increases in LDL, HDL, and HDL2

cholesterol concentrations were found. The authors conclude,

" Supplements providing EPA+DHA at doses as low as 0.7 g/d have a

significant effect on the plasma lipid profile. "

--

ne Holden, MS, RD

" Ask the Parkinson Dietitian " http://www.parkinson.org/

" Eat well, stay well with Parkinson's disease "

" Parkinson's disease: Guidelines for Medical Nutrition Therapy "

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