Re: UroToday - SUO 2007 - Prostate Cancer II: HRQOL and Prostate Cancer Treatment:Impact of Androgen Deprivation Therapy on the Health of Prostate Cancer

[Guest guest]

Apparently, registration is needed to read the article, and it appears that the process is designed to eliminate non-physicians.

Louis. . .

UroToday - SUO 2007 - Prostate Cancer II: "HRQOL and Prostate Cancer Treatment":"Impact of Androgen Deprivation Therapy on the Health of Prostate Cancer"

http://www.urotoday .com/99999999/ browse_categorie s/prostate_ cancer/suo_ 2007__prostate_ cancer_ii_ hrqol_and_ prostate_ cancer_treatment impact_of_ androgen_ deprivation_ therapy_on_ the_health_ of_prostate_ cancer.html

or

http://tinyurl. com/2pm5uy

hope that every man is maintaining a relationship with his primary care physician/internist while he is dealing with his prostate cancer.

Kathy

[Guest guest]

Yes you have to register but it is free

and you do not have to be a physician. You are an advocate/patient and if not

other designations click other. I did it a while ago and do not remember what I

used but I was able to register with factual information.

Kathy

From: ProstateCancerSupport [mailto:ProstateCancerSupport ] On Behalf Of Louis Carliner

Sent: Tuesday, December 04, 2007

12:29 PM

To: ProstateCancerSupport

Subject: Re:

UroToday - SUO 2007 - Prostate Cancer II: " HRQOL

and Prostate Cancer Treatment " : " Impact of Androgen Deprivation

Therapy on the Health of Prostate Cancer "

Apparently, registration is needed to read the article, and

it appears that the process is designed to eliminate non-physicians.

Louis. . .

UroToday - SUO 2007 - Prostate Cancer II:

" HRQOL and Prostate Cancer Treatment " : " Impact of Androgen

Deprivation Therapy on the Health of Prostate Cancer "

http://www.urotoday .com/99999999/ browse_categorie s/prostate_

cancer/suo_ 2007__prostate_ cancer_ii_ hrqol_and_ prostate_ cancer_treatment

impact_of_ androgen_ deprivation_ therapy_on_ the_health_ of_prostate_

cancer.html

or

http://tinyurl. com/2pm5uy

hope that every man is maintaining a relationship with

his primary care physician/internist while he is dealing with his prostate

cancer.

Kathy

[Guest guest]

>

> Yes you have to register but it is free and you do not have to be a

> physician. You are an advocate/patient and if not other

designations click

> other. I did it a while ago and do not remember what I used but I

was able

> to register with factual information.

>

> Kathy

------------------------

Hi all:

Here is my take on my experience with Lupron, and an excerpt from

Strum on the subject.

>

.... about two or three weeks after the shot, the predicted hot

flashes arrived with a vengeance. They did not seem to bother me so

much during the day, but did disturb me when they awakened me at

night.

There was also the complete loss of sexual capability, and another

side effect of the Lupron (not told to me by the doctor) was a loss

of muscle strength, which was very apparent since I go regularly to a

gym with weight machines, and I found that I had to reduce weights to

do the same number of reps that I had been doing previously. Another

unexpected happening was weight gain, in spite of exercise and no

change in eating habits. Later I experienced another side effect:

unexpected mood swings and emotional reactions to events. There were

other minor effects, none good. Some persist now, at this writing.

Later, my research found the following by Dr. Strum:

---------------------------------------------

" Testosterone Deprivation Therapy and Its Far-Reaching Implications:

If there is any area of PC management that necessitates a

comprehensive understanding by the physician, it is in knowing the

spectrum of effects of ADT on male physiology. A lack of such

understanding deprives the patient of available supportive care that

can mean the difference between success and failure in the patient's

life. This not only relates to preventing or minimizing side effects

due to treatment, but also to the patient's compliance with therapy--

whether he will remain on the medications used in ADT or stop them

due to adverse effects. In the early 1980s, I began treating PC

patients using anti-androgen therapy in combination with an LHRH

agonist as one of the first American collaborators working with

Fernand Labrie.

My observation of patients taught me a great deal about the effects

of an accelerated and intensified male menopause. The lowering of

serum testosterone to castrate levels, defined as less than 20 ng/dL

(less than 0.68 nM/L), resulted in a spectrum of possible signs and

symptoms that varied from man to man. Some of these symptoms occurred

acutely, while others developed over time. However, all were

potentially troublesome, if not aggravating, for the patient. If not

treated in a preventive manner, such signs and symptoms can have a

negative impact upon the patient's overall health. Except for hot

flashes and impotency, many symptoms resulting from androgen

deprivation have been discounted by physicians as being due to old

age or due to medical problems such as arthritis or heart disease.

However, this constellation of clinical and laboratory abnormalities

quickly develops in younger men or older men in otherwise good health

after the initiation of ADT. This clearly suggests that these

symptoms are not due to " old age " but are characteristics of the

androgen deprivation syndrome (ADS). … " [

-------------------------------------------------------

The thing to be learned from this is that when diagnosed with

prostate cancer, you had better find a doctor who SPECIALIZES in

prostate cancer and who is current with all the latest treatments and

drugs. Do your homework. Call the local hospitals and ask for the

names of doctors that specialize in prostate cancer. Use the Internet

and search for well known prostate cancer specialists. Learn before

your appointment, so that you will know what questions to ask!

Fuller

[Guest guest]

Here is the abstract:

SUO 2007 - Prostate Cancer II: " HRQOL and Prostate Cancer Treatment " : " Impact

of Androgen Deprivation Therapy on the Health of Prostate Cancer "

  

Monday, 03 December 2007

BETHESDA, MD (UroToday.com) - Dr. presented " Impact of

Androgen Deprivation Therapy on the Health of Prostate Cancer " .

He stated that longer term use of ADT has doubled from 1993 to 2000. The

most recognized adverse effects LHRH agonists include loss of libido,

fatigue and anemia. However, osteoporosis, obesity, diabetes and cardiac

disease are more recently recognized.

ADT increases fracture risk by decreasing bone mineral density by 3% per

year. This bone loss increased the risk of any fracture by 25%, and up to

46% for hip fractures and 63% for vertebral fractures. In older men the risk

for a fracture is 1% per year. Prevention of bone loss includes use of oral

calcium and vitamin D in asymptomatic men without bone metastasis and

addition of zoledronic acid for symptomatic CaP and those with bone

metastasis. It is the severe estradiol deficiency in older men on LHRH

agonists that promotes the bone loss. Raloxifene increases bone mineral

density in this setting. A study of men treated with Denosumab (targeting

RANK ligand) and another study using Toremifene (selective estrogen receptor

modulator) will be report in 2008.

Lean muscle mass is decreased by 3% and fat mass increases by 10% at 12

months of LHRH agonist therapy. These shifts are noted as early as 12 weeks.

Subcutaneous fat mass accumulation is more predominant than visceral fat

increase. This increase in fat mass results in increased cholesterol and

triglycerides. ADT decreases insulin sensitivity in non-diabetic men. It can

continue following cessation of treatment. In the SEER database, a 44%

increase in diabetes was noted with smaller increases in coronary artery

disease. As recently reported by Dr. Carroll, coronary artery disease is

increased in men on LHRH therapy and this has been unappreciated in the

past. The increase of coronary artery disease affecting survival is about

3%. These adverse variables need to be considered in the long term

administration of LHRH agonists.

Presented at the 8th Annual Meeting of the Society of Urologic Oncology

(SUO) - November 29 - December 1, 2007. Natcher Conference Center, National

Institutes of Health - Bethesda, land.

Society for Urologic Oncology - SUO

UroToday.com Full Conference Reports

 

________________________________________

From: ProstateCancerSupport

[mailto:ProstateCancerSupport ] On Behalf Of Louis Carliner

Sent: Tuesday, December 04, 2007 12:29 PM

To: ProstateCancerSupport

Subject: Re: UroToday - SUO 2007 - Prostate Cancer

II: " HRQOL and Prostate Cancer Treatment " : " Impact of Androgen Deprivation

Therapy on the Health of Prostate Cancer "

 

Apparently, registration is needed to read the article, and it appears that

the process is designed to eliminate non-physicians.

 

Louis. . .

UroToday - SUO 2007 - Prostate Cancer II:

" HRQOL and Prostate Cancer Treatment " : " Impact of Androgen Deprivation

Therapy on the Health of Prostate Cancer "

http://www.urotoday .com/99999999/ browse_categorie s/prostate_ cancer/suo_

2007__prostate_ cancer_ii_ hrqol_and_ prostate_ cancer_treatment impact_of_

androgen_ deprivation_ therapy_on_ the_health_ of_prostate_ cancer.html

or

http://tinyurl. com/2pm5uy

 hope that every man is maintaining a relationship with his primary care

physician/internist while he is dealing with his prostate cancer.

 

Kathy

 

 

[Guest guest]

Fuller wrote:

> Hi all:

> Here is my take on my experience with Lupron, and an excerpt from

> Strum on the subject.

(snip)

Dr. Strum thoroughly covers Androgen Deprivation Syndrome on the

authoritative website of the Prostate Cancer Research Institute (PCRI)

at http://www.prostate-cancer.org/education/sidefx/Strum_ADS.html

Also on the site's Resources page there is a link to a list of some PCa

specialists.

Regards,

Steve J

" Empowerment: taking responsibility for and authority over one's own

outcomes based on education and knowledge of the consequences and

contingencies involved in one's own decisions. This focus provides the

uplifting energy that can sustain in the face of crisis. "

--Donna Pogliano, co-author of _A Primer on Prostate Cancer_, subtitled

" The Empowered Patient's Guide. "

[Guest guest]

I was 51 years old when I experienced the same problems under ADT.

Severe depression, hot flashes, sweating a lot all the time, muscle

weakness, feeling of hopelessness, absolutely no sex drive. When I

switched to an estrogen based ADT, all the side effects went away

except for the suppressed sex drive, and muscle weakness. I think

doctors should consider alternating estrogen based ADT with primary

ADT just for improved quality of life.

> >

> > Yes you have to register but it is free and you do not have to be

a

> > physician. You are an advocate/patient and if not other

> designations click

> > other. I did it a while ago and do not remember what I used but I

> was able

> > to register with factual information.

> >

> > Kathy

> ------------------------

>

> Hi all:

> Here is my take on my experience with Lupron, and an excerpt from

> Strum on the subject.

> >

> ... about two or three weeks after the shot, the predicted hot

> flashes arrived with a vengeance. They did not seem to bother me so

> much during the day, but did disturb me when they awakened me at

> night.

> There was also the complete loss of sexual capability, and another

> side effect of the Lupron (not told to me by the doctor) was a loss

> of muscle strength, which was very apparent since I go regularly to

a

> gym with weight machines, and I found that I had to reduce weights

to

> do the same number of reps that I had been doing previously.

Another

> unexpected happening was weight gain, in spite of exercise and no

> change in eating habits. Later I experienced another side effect:

> unexpected mood swings and emotional reactions to events. There

were

> other minor effects, none good. Some persist now, at this writing.

>

> Later, my research found the following by Dr. Strum:

> ---------------------------------------------

> " Testosterone Deprivation Therapy and Its Far-Reaching

Implications:

> If there is any area of PC management that necessitates a

> comprehensive understanding by the physician, it is in knowing the

> spectrum of effects of ADT on male physiology. A lack of such

> understanding deprives the patient of available supportive care

that

> can mean the difference between success and failure in the

patient's

> life. This not only relates to preventing or minimizing side

effects

> due to treatment, but also to the patient's compliance with therapy-

-

> whether he will remain on the medications used in ADT or stop them

> due to adverse effects. In the early 1980s, I began treating PC

> patients using anti-androgen therapy in combination with an LHRH

> agonist as one of the first American collaborators working with

> Fernand Labrie.

> My observation of patients taught me a great deal about the effects

> of an accelerated and intensified male menopause. The lowering of

> serum testosterone to castrate levels, defined as less than 20

ng/dL

> (less than 0.68 nM/L), resulted in a spectrum of possible signs and

> symptoms that varied from man to man. Some of these symptoms

occurred

> acutely, while others developed over time. However, all were

> potentially troublesome, if not aggravating, for the patient. If

not

> treated in a preventive manner, such signs and symptoms can have a

> negative impact upon the patient's overall health. Except for hot

> flashes and impotency, many symptoms resulting from androgen

> deprivation have been discounted by physicians as being due to old

> age or due to medical problems such as arthritis or heart disease.

> However, this constellation of clinical and laboratory

abnormalities

> quickly develops in younger men or older men in otherwise good

health

> after the initiation of ADT. This clearly suggests that these

> symptoms are not due to " old age " but are characteristics of the

> androgen deprivation syndrome (ADS). … " [

> -------------------------------------------------------

>

> The thing to be learned from this is that when diagnosed with

> prostate cancer, you had better find a doctor who SPECIALIZES in

> prostate cancer and who is current with all the latest treatments

and

> drugs. Do your homework. Call the local hospitals and ask for the

> names of doctors that specialize in prostate cancer. Use the

Internet

> and search for well known prostate cancer specialists. Learn before

> your appointment, so that you will know what questions to ask!

>

> Fuller

>