Air pollution, oxidative stress, dietary supplementation: a review

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*Air pollution, oxidative stress and dietary supplementation: a review*.

Romieu I, Castro-Giner F, Kunzli N, Sunyer J.

Eur Respir J. 2008 Jan;31(1):179-97.

http://erj.ersjournals.com/cgi/content/full/31/1/179

The aim of the present review was to provide an up-to-date overview of

the biological and epidemiological evidence of the role of oxidative

stress as a major underlying feature of the toxic effect of air

pollutants, and the potential role of dietary supplementation in

enhancing antioxidant defences. A bibliographic search was conducted

through PubMed. The keywords used in the search were " air pollutant " ,

" oxidative stress " , " inflammation " , " antioxidant polyunsaturated fatty

acids " and " genetics " . In addition, the authors also searched for

biomarkers of oxidative stress and nutrients. The review presents the

most recent data on: the biological and epidemiological evidence of the

oxidative stress response to air pollutants; the role of dietary

supplementation as a modulator of these effects; and factors of

inter-individual variation in human response. The methodology for

further epidemiological studies will be discussed in order to improve

the current understanding on how nutritional factors may act. There is

substantial evidence that air pollution exposure results in increased

oxidative stress and that dietary supplementation may play a modulating

role on the acute effect of air pollutants. Further epidemiological

studies should address the impact of supplementation strategies in the

prevention of air-pollution-related long-term effects in areas where

people are destined to be exposed for the distant future.

PMID: 18166596

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