Air pollution strangles blood supply, causes changes to the body - ozone, mitochondria

[Guest guest]

News article from 2002 remains relevant, many newer cites are linked herein:

Pollution strangles blood supply, causes changes to the body

http://news.bbc.co.uk/1/hi/health/1866673.stm

- - Free online, the peer-reviewed article that prompted the news item:

*

Inhalation of fine particulate air pollution and ozone causes acute

arterial vasoconstriction in healthy adults.*

Brook RD, Brook JR, Urch B, R, Rajagopalan S, Silverman F.

University of Michigan, Ann Arbor, USA.

Circulation. 2002 Apr 2;105(13):1534-6.

http://circ.ahajournals.org/cgi/content/full/105/13/1534

BACKGROUND: Fine particulate air pollution and ozone are associated with

increased cardiovascular events. To help explain the mechanism behind

these observations, we investigated the effect of air pollution exposure

on vascular function.

METHODS AND RESULTS: Twenty-five healthy adults underwent a randomized,

double-blind, crossover study comparing the vascular response to the

2-hour inhalation of approximately 150 microg/m(3) of concentrated

ambient fine particles (CAP) plus ozone (120 ppb) versus the response to

the inhalation of filtered air. High-resolution vascular ultrasonography

was used to measure alterations in brachial artery diameter,

endothelial-dependent flow-mediated dilatation (FMD) and

endothelial-independent nitroglycerin-mediated dilatation (NMD).

Exposure to CAP plus ozone caused a significant brachial artery

vasoconstriction compared with filtered air inhalation (-0.09+/-0.15 mm

versus +0.01+/-0.18 mm, P=0.03). There were no significant differences

in FMD (+0.29+/-4.11% versus -0.03+/-6.63%, P=0.88), NMD (+3.87+/-5.43%

versus +3.46+/-7.92%, P=0.83), or blood pressure responses between

exposures.

CONCLUSIONS: Short-term inhalation of fine particulate air pollution and

ozone at concentrations that occur in the urban environment causes acute

conduit artery vasoconstriction.

PMID: 11927516

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