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EDU: DMARD/Arava

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Drug Information: Leflunomide

URL of this page:

http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a600032.html

(le floo' na mide)

Brand name(s):

Arava®

IMPORTANT WARNING:

Pregnant women and women of childbearing age who are not using a reliable

method of birth control should not take leflunomide. Pregnancy must be

avoided during treatment and for 2 years after treatment with leflunomide.

If your period is late or you miss a period during treatment with

leflunomide, call your doctor immediately. Talk to your doctor if you plan

to become pregnant after stopping treatment with leflunomide. Your doctor

can prescribe a treatment that will decrease the risk of harm to the fetus.

Why is this medication prescribed?

Leflunomide is used to treat rheumatoid arthritis. Leflunomide decreases the

symptoms of rheumatoid arthritis and slows damage to joints caused by the

disease.

This medication is sometimes prescribed for other uses; ask your doctor or

pharmacist for more information.

How should this medicine be used?

Leflunomide comes as a tablet to take by mouth. It is usually taken once a

day. You will need to take a larger dose for the first 3 days of treatment.

Follow the directions on your prescription label carefully, and ask your

doctor or pharmacist to explain any part you do not understand. Take

leflunomide exactly as directed. Do not take more or less of it or take it

more often than prescribed by your doctor.

What special precautions should I follow?

Before taking leflunomide,

tell your doctor and pharmacist if you are allergic to leflunomide or any

other drugs.

tell your doctor and pharmacist what prescription and nonprescription

medications you are taking, especially cholestyramine (Cholybar, Questran),

colestipol (Colestid), felbamate (Felbatol), mercaptopurine (Purinethol),

rifampin (Rifadin, Rimactane, Rifater), methotrexate (Rheumatrex),

tolbutamide (Orinase), troglitazone (Rezulin), and vitamins.

tell your doctor if you have or have ever had liver or kidney disease,

hepatitis, severe infections, or conditions affecting the bone marrow or the

immune system (including human immunodeficiency virus [HIV] and acquired

immunodeficiency syndrome [AIDS]).

tell your doctor if you are breast-feeding.if you are planning to father a

child, you should talk to your doctor about stopping leflunomide prior to

conception.

you should not receive any vaccinations while taking leflunomide unless you

have talked with your doctor.

you should know that there is a special treatment for removing leflunomide

from your body once you stop taking it. Ask your doctor or pharmacist for

more information about this treatment.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost

time for your next dose, skip the missed dose and continue your regular

dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Although side effects from leflunomide are not common, they can occur. Tell

your doctor if any of these symptoms are severe or do not go away:

diarrhea

hair loss

headache

dizziness

upset stomach

vomiting

stomach pain

loss of appetite

weight loss

mouth sores

runny nose

back pain

dry or itchy skin

muscle pain or weakness

flu-like symptoms

urinary tract infection

If you experience any of the following symptoms, call your doctor

immediately:

rash

difficulty breathing

chest pain

increased heart rate

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of

reach of children. Store it at room temperature and away from excess heat

and moisture (not in the bathroom). Throw away any medication that is

outdated or no longer needed. Talk to your pharmacist about the proper

disposal of your medication.

In case of emergency/overdose...

In case of overdose, call your local poison control center at

1-. If the victim has collapsed or is not breathing, call local

emergency services at 911.

What other information should I know?

Keep all appointments with your doctor. Your doctor will order certain

laboratory tests to monitor your response to leflunomide.

Do not let anyone else take your medication. Ask your pharmacist any

questions you have about refilling your prescription.

Marilyn

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