Vinponcentine for epilepsy

[Guest guest]

Have you tried vinponcentine? Or gaba?

http://en.wikipedia.org/wiki/Vinpocetine

interesting that it is similar to minocycline in that it reverses damage

of seizures induced by penicillin in cats:

2: Farmakol Toksikol. 1986 Jul-Aug;49(4):22-5. Related Articles,

Links

[Effect of Cavinton on convulsions caused by chemical substances]

[Article in Russian] Dutov AA, Tolpyshev BA, Karpov VN, Petrov

AP.

Cavinton was shown to protect mice against convulsions induced by

corazol, strychnine and thiosemicarbazide. In addition, cavinton

exhibited a definite antagonism to convulsive reactions produced by

systemic administration of penicillin to cats and a combined

administration of penicillin (intramuscularly) with tryptophan

metabolite, quinolinic acid (intracerebroventricularly). The

anticonvulsant action of cavinton is suggested to be due to the

involvement of the brain GABA- and serotonergic mechanisms. It is

reasonable to test cavinton as a drug for treating some forms of

epilepsy.

Publication Types:

* Comparative Study * English Abstract

PMID: 3758323 [PubMed - indexed for MEDLINE]

Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(6):850-5.Links

[use of cavinton in epilepsy]

[Article in Russian] Dutov AA, Tolpyshev BA, Petrov AP, Gladun

VN.

The authors studied the effect of cavinton (15-45 mg/day) and its

combinations with different anticonvulsants on the time-course of

different forms of epilepsy. In 20 of the 31 patients studied treatment

with cavinton either significantly decreased the frequency of attacks or

led to their complete disappearance; in 7 patients the improvement was

insignificant and in 4 the condition deteriorated. The greatest effect

of cavinton was observed in generalized tonic-clonic convulsions and

when they were combined with absences. Clinical improvement not always

correlated with EEG normalization. A suggestion is made that the

mechanism of the anticonvulsive action of cavinton may be explained both

by the normalization of the cerebral blood flow and elimination of

hypoxia and by the fact that the drug may possess anticonvulsive

properties unrelated to the normalization of the cerebral hemodynamics.

PMID: 3751419 [PubMed - indexed for MEDLINE]

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(8):21-2.Links

[Cavinton in the prevention of the convulsive syndrome in children

after birth injury]

[Article in Russian] Dutov AA, Gal'tvanitsa GA, Volkova VA,

Sukhanova ON, Lavrishcheva TG, Petrov AP.

The authors studied the efficacy of cavinton as an agent helpful in

preventing neurologic disorders in the newborn with hypoxic ischemic

encephalopathy due to intracranial birth trauma. The short-term results

of the treatment were elucidated in 61 children. In group I including 20

persons given conventional therapy, the disappearance of seizures was

recorded in 6 patients; out of 41 children (group II) given additionally

cavinton, in 27. Twenty-nine children were followed up for a year. In

group I, convulsive paroxysms recurred in 4 patients, whereas in the

group II children, no convulsive syndrome was recorded on the follow-up.

The group II children also showed a decrease of the phenomena of

intracranial hypertension and normalization of the psychomotor

development. The preventive effect of cavinton seen in children with a

history of birth trauma may be accounted for by its capacity of

normalizing cerebrovascular disorders and by its own anticonvulsive

properties.

PMID: 1661506 [PubMed - indexed for MEDLINE]

Biomed Biochim Acta. 1990;49(5):413-9. Related Articles, Links

Comparative studies on the anticonvulsant effectiveness of nootropic

drugs in kindled rats.

Schmidt J. Institute of Pharmacology and Toxicology, Medical

Academy, Carl Gustav Carus, Dresden, GDR.

In an attempt to characterize the anticonvulsant efficacy of

nootropics, their effect on different types of kindled seizures in rats

has been studied. Nootropics in doses known to have protective effects

in damaged brain functions possess anticonvulsant potency preferentially

in pentylenetetrazole (PTZ)-kindled rats and generalized seizures. The

most pronounced potency was seen in PTZ-kindled rats, where all

substances tested (piracetam, meclofenoxate, pyritinol, vinpocetine,

methylglucamine orotate, naftidrofuryl) led to significant

dose-dependent anticonvulsant effects. In amygdala-kindled rats only

vinpocetine, meclofenoxate and piracetam were effective. In

neocortically kindled rats only vinpocetine and, to a smaller extent,

pyritinol showed anticonvulsant effects. The data support the potential

antiepileptic potency of nootropics.

Publication Types: * Comparative Study

PMID: 2271012 [PubMed - indexed for MEDLINE]

Cell Mol Life Sci. 2007 May 18; [Epub ahead of print]Click here to read

Links

Anticonvulsant, antiepileptogenic, and antiictogenic

pharmacostrategies.

Holtkamp M, Meierkord H.

Department of Neurology, Charité – Universitätsmedizin

Berlin (Campus Mitte), Charitéplatz 1, 10117, Berlin, Germany,

martin.holtkamp@....

Pharmacological concepts tailored to status epilepticus, to

epileptogenesis following acquired brain insults, and to ictogenesis in

established epilepsy vary considerably and should ideally be directed at

those pathophysiological mechanisms that presumably underly these

conditions. Currently known important molecular targets include

voltage-gated sodium and calcium channels, the gamma-aminobutyric acid

(GABA) system and ionotropic glutamate receptors. Metabotropic glutamate

receptors, potassium channels, and neurotransmitters such as

acetylcholine, glycine, and monoamines are beyond the scope of this

review.In status epilepticus, immediate failure of GABAergic inhibition

occurs, and administration of benzodiazepines and barbiturates displays

the pharmacostrategic mainstay. In epileptogenesis within limbic

structures, the most important underlying pathophysiological mechanisms

currently discussed are transient loss of inhibition and aberrant mossy

fiber sprouting. Both processes may be facilitated by N-methy-d-aspartat

(NMDA) receptor regulation. NMDA antagonists may exhibit

antiepileptogenic properties in experimental animals, but reliable data

in humans are lacking. In established epilepsy, voltage-gated ion

channels and impairment of GABAergic functions contribute to mechanisms

facilitating ictogenesis. Blockade of sodium and calcium channels and

enhancement of GABAergic inhibition are currently the most important

tools to prevent the occurrence of seizures.

PMID: 17514360 [PubMed - as supplied by publisher]

> > >

> > > PRAYERS work!

> > >

> > > Dear All

> > >

> > > I am overwhelmed by your responses to our request to pray for

> today. Ok, let me tell you the episode.

> > >

> > > Ever since four in the morning, things were not right for .

> His typical wake up time is five, ARGH. He got up and went potty but

had

> very watery diahrreah for the last few days (long story, he has

motility

> loss due to cranial nerve involvement). Yesterday I had this

intuitive

> " oh crap " feeling that was cruising for a major herx. I have

been

> very discouraged of late to have a kid who essentially wanted to lay

> down all day, stim his brains out, and get OCD on his DVD's. He is

> currently on Tegretol, Diflucan, and IM BICILLIN for his lyme.

Naturals,

> here or there. We took him to Sweet Tomatoes last night, got him a

salad

> with chicken in it, brought our own dressing, and he gobbled that

up,

> but when he got up, I had to hold him as if he was going to syncope

or

> faint? SO we went home, I gave his normal meds, and he went to

sleep. He

> acted " drunk " . Then around 6 in the morning, he started to have

minor

> petit mal seizures, (if you can say those are minor), and continued

to

> not really come out, and had stiffening of his body. Then he tried

to

> have breakfast, but still looked funny. Then whamo around eight he

has

> one grand mal, and the post ictal was nasty, blue, getting syanotic.

> Then we noticed after that, that he still was unresponsive. He

started

> to have multiple petit mals, one after another. Then at 11, he has

> another grandmal, this one more nasty than the last. We noticed he

went

> completely paralyzed for about an hour, and I call the doctor. She

said

> to monitor him, and if he gets worse, give him Diastat (valium). I

give

> him his afternoon med for seizures. Then he goes into another

grandmal

> for three minutes, and this time, I felt like I was losing him. He

went

> completely blue, then grey. I called 911 while administrating the

> Diastat. I am panickng at this point. The Er people came pretty

quickly

> and put a heart monitor and he was a fib and was immediately put on

> oxygen/bag. We then got him stabilized, but he was still in a

seizure,

> silent but deadly grand mal type. They put some further meds in him,

and

> got him in the ambulence. He had another seizure in the ambulence

again,

> and by the time I got to the hospital, he was still status. I said,

> that's it, call the Elders of our Church. They got there in about a

half

> hour, and there were nurses over him poking and proding him. They

give

> him a beautiful blessing, and told him to come back essentially.

Within

> 15 minutes, woke up, looked at me, and said mooooommeeee. So I

knew

> we got him back. I asked all the questions, is this going to

permanent

> brain damage him etc. They said, he did ok through this, his blood

work

> looks ok, so, we monitored him for another two hours, and then

> looked like he wanted to go the heck home. I was fully prepared to

stay

> there for a week in the hospital. Other times like this, though not

as

> serious, were hospitalizions for kidney malfunction or dehydration

or

> something like that. They said, I will have to watch him this whole

> week. I got some meds that are a little stronger for him, and will

> probably knock him out further. We made an appointment first thing

> monday morning with neuro, but I know what he will tell me, that my

sons

> should have permanent anti seizure meds, three or more ...not going

> there...

> > >

> > > So, I am frazzled, shaken, scared, tired. I am typing this as

ryan

> is on my lap sleeping, he DOESN'T deserve this crap. I know, between

> VACCINES, LYME, and VIRUSES, this kid had practically no chance.

Tami

> told me had the elders too, though reluctantly. If you can

relay

> this to her, tell her, I think we both know how this works, God

knows

> our kids need to be around so mom powerhouses like us can tell the

world

> what the WORLD has done to them.

> > >

> > > God never is far away from our situations. I pray that this

won't

> be a trend for , but as I heard from the doctor, it is going or

> might be a tough week for him/ I looked at his labs, no white count

out

> of whack, nothing, this is a fluke, and or some healing herxing

action

> going on here? All I know is that I have to go low and slow with

this

> kid. No sudden moves or jumping ship to another protocol.

> > >

> > > Thanks for all your suggestions. Next week I am going to dive

him

> into Hbot, SLOWLY SLOWLY SLOWLY.

> > >

> > >

> > >

> >

>

[Guest guest]

Both of these were disasters for my seizure prone daughter.

> > > >

> > > > PRAYERS work!

> > > >

> > > > Dear All

> > > >

> > > > I am overwhelmed by your responses to our request to pray

for

>

> > today. Ok, let me tell you the episode.

> > > >

> > > > Ever since four in the morning, things were not right for

.

> > His typical wake up time is five, ARGH. He got up and went

potty but

> had

> > very watery diahrreah for the last few days (long story, he has

> motility

> > loss due to cranial nerve involvement). Yesterday I had this

> intuitive

> > " oh crap " feeling that was cruising for a major herx. I

have

> been

> > very discouraged of late to have a kid who essentially wanted

to lay

> > down all day, stim his brains out, and get OCD on his DVD's.

He is

> > currently on Tegretol, Diflucan, and IM BICILLIN for his lyme.

> Naturals,

> > here or there. We took him to Sweet Tomatoes last night, got

him a

> salad

> > with chicken in it, brought our own dressing, and he gobbled

that

> up,

> > but when he got up, I had to hold him as if he was going to

syncope

> or

> > faint? SO we went home, I gave his normal meds, and he went to

> sleep. He

> > acted " drunk " . Then around 6 in the morning, he started to have

> minor

> > petit mal seizures, (if you can say those are minor), and

continued

> to

> > not really come out, and had stiffening of his body. Then he

tried

> to

> > have breakfast, but still looked funny. Then whamo around

eight he

> has

> > one grand mal, and the post ictal was nasty, blue, getting

syanotic.

> > Then we noticed after that, that he still was unresponsive. He

> started

> > to have multiple petit mals, one after another. Then at 11, he

has

> > another grandmal, this one more nasty than the last. We

noticed he

> went

> > completely paralyzed for about an hour, and I call the doctor.

She

> said

> > to monitor him, and if he gets worse, give him Diastat

(valium). I

> give

> > him his afternoon med for seizures. Then he goes into another

> grandmal

> > for three minutes, and this time, I felt like I was losing

him. He

> went

> > completely blue, then grey. I called 911 while administrating

the

> > Diastat. I am panickng at this point. The Er people came pretty

> quickly

> > and put a heart monitor and he was a fib and was immediately

put on

> > oxygen/bag. We then got him stabilized, but he was still in a

> seizure,

> > silent but deadly grand mal type. They put some further meds

in him,

> and

> > got him in the ambulence. He had another seizure in the

ambulence

> again,

> > and by the time I got to the hospital, he was still status. I

said,

> > that's it, call the Elders of our Church. They got there in

about a

> half

> > hour, and there were nurses over him poking and proding him.

They

> give

> > him a beautiful blessing, and told him to come back

essentially.

> Within

> > 15 minutes, woke up, looked at me, and said mooooommeeee.

So I

> knew

> > we got him back. I asked all the questions, is this going to

> permanent

> > brain damage him etc. They said, he did ok through this, his

blood

> work

> > looks ok, so, we monitored him for another two hours, and then

> > looked like he wanted to go the heck home. I was fully

prepared to

> stay

> > there for a week in the hospital. Other times like this,

though not

> as

> > serious, were hospitalizions for kidney malfunction or

dehydration

> or

> > something like that. They said, I will have to watch him this

whole

> > week. I got some meds that are a little stronger for him, and

will

> > probably knock him out further. We made an appointment first

thing

> > monday morning with neuro, but I know what he will tell me,

that my

> sons

> > should have permanent anti seizure meds, three or more ...not

going

> > there...

> > > >

> > > > So, I am frazzled, shaken, scared, tired. I am typing this

as

> ryan

> > is on my lap sleeping, he DOESN'T deserve this crap. I know,

between

> > VACCINES, LYME, and VIRUSES, this kid had practically no

chance.

> Tami

> > told me had the elders too, though reluctantly. If you

can

> relay

> > this to her, tell her, I think we both know how this works, God

> knows

> > our kids need to be around so mom powerhouses like us can tell

the

> world

> > what the WORLD has done to them.

> > > >

> > > > God never is far away from our situations. I pray that this

> won't

> > be a trend for , but as I heard from the doctor, it is

going or

> > might be a tough week for him/ I looked at his labs, no white

count

> out

> > of whack, nothing, this is a fluke, and or some healing herxing

> action

> > going on here? All I know is that I have to go low and slow

with

> this

> > kid. No sudden moves or jumping ship to another protocol.

> > > >

> > > > Thanks for all your suggestions. Next week I am going to

dive

> him

> > into Hbot, SLOWLY SLOWLY SLOWLY.

> > > >

> > > >

> > > >

> > >

> >

>

[Guest guest]

tell me in what way?

Kathy

Re: Vinponcentine for epilepsy

Both of these were disasters for my seizure prone daughter. > > > >> > > > PRAYERS work!> > > >> > > > Dear All> > > >> > > > I am overwhelmed by your responses to our request to pray for> > > today. Ok, let me tell you the episode.> > > >> > > > Ever since four in the morning, things were not right for .> > His typical wake up time is five, ARGH. He got up and went potty but> had> > very watery diahrreah for the last few days (long story, he has> motility> > loss due to cranial nerve involvement). Yesterday I had this> intuitive> > "oh crap" feeling that was cruising for a major herx. I have> been> > very discouraged of late to have a kid who essentially wanted to lay> > down all day, stim his brains out, and get OCD on his DVD's. He is> > currently on Tegretol, Diflucan, and IM BICILLIN for his lyme.> Naturals,> > here or there. We took him to Sweet Tomatoes last night, got him a> salad> > with chicken in it, brought our own dressing, and he gobbled that> up,> > but when he got up, I had to hold him as if he was going to syncope> or> > faint? SO we went home, I gave his normal meds, and he went to> sleep. He> > acted "drunk". Then around 6 in the morning, he started to have> minor> > petit mal seizures, (if you can say those are minor), and continued> to> > not really come out, and had stiffening of his body. Then he tried> to> > have breakfast, but still looked funny. Then whamo around eight he> has> > one grand mal, and the post ictal was nasty, blue, getting syanotic.> > Then we noticed after that, that he still was unresponsive. He> started> > to have multiple petit mals, one after another. Then at 11, he has> > another grandmal, this one more nasty than the last. We noticed he> went> > completely paralyzed for about an hour, and I call the doctor. She> said> > to monitor him, and if he gets worse, give him Diastat (valium). I> give> > him his afternoon med for seizures. Then he goes into another> grandmal> > for three minutes, and this time, I felt like I was losing him. He> went> > completely blue, then grey. I called 911 while administrating the> > Diastat. I am panickng at this point. The Er people came pretty> quickly> > and put a heart monitor and he was a fib and was immediately put on> > oxygen/bag. We then got him stabilized, but he was still in a> seizure,> > silent but deadly grand mal type. They put some further meds in him,> and> > got him in the ambulence. He had another seizure in the ambulence> again,> > and by the time I got to the hospital, he was still status. I said,> > that's it, call the Elders of our Church. They got there in about a> half> > hour, and there were nurses over him poking and proding him. They> give> > him a beautiful blessing, and told him to come back essentially.> Within> > 15 minutes, woke up, looked at me, and said mooooommeeee. So I> knew> > we got him back. I asked all the questions, is this going to> permanent> > brain damage him etc. They said, he did ok through this, his blood> work> > looks ok, so, we monitored him for another two hours, and then > > looked like he wanted to go the heck home. I was fully prepared to> stay> > there for a week in the hospital. Other times like this, though not> as> > serious, were hospitalizions for kidney malfunction or dehydration> or> > something like that. They said, I will have to watch him this whole> > week. I got some meds that are a little stronger for him, and will> > probably knock him out further. We made an appointment first thing> > monday morning with neuro, but I know what he will tell me, that my> sons> > should have permanent anti seizure meds, three or more ...not going> > there...> > > >> > > > So, I am frazzled, shaken, scared, tired. I am typing this as> ryan> > is on my lap sleeping, he DOESN'T deserve this crap. I know, between> > VACCINES, LYME, and VIRUSES, this kid had practically no chance.> Tami> > told me had the elders too, though reluctantly. If you can> relay> > this to her, tell her, I think we both know how this works, God> knows> > our kids need to be around so mom powerhouses like us can tell the> world> > what the WORLD has done to them.> > > >> > > > God never is far away from our situations. I pray that this> won't> > be a trend for , but as I heard from the doctor, it is going or> > might be a tough week for him/ I looked at his labs, no white count> out> > of whack, nothing, this is a fluke, and or some healing herxing> action> > going on here? All I know is that I have to go low and slow with> this> > kid. No sudden moves or jumping ship to another protocol.> > > >> > > > Thanks for all your suggestions. Next week I am going to dive> him> > into Hbot, SLOWLY SLOWLY SLOWLY.> > > >> > > > > > > >> > >> >>