Re: RESEARCH - Inflammatory and hormonal measures predict neuropsychological functioning in SLE and RA

[Guest guest]

So is this an explanation for why I don't know where I am sometimes,

I hear people talking but don't understand and word they're saying

and I forget very important things like they never happened?

--- In , " " <Matsumura_Clan@...>

wrote:

>

> J Int Neuropsychol Soc. 2001 Sep;7(6):745-54. Links

>

> Inflammatory and hormonal measures predict neuropsychological

functioning in

> systemic lupus erythematosus and rheumatoid arthritis patients.

>

> National Jewish Medical and Research Center, Denver, Colorado

80206, USA.

> KozoraE@...

>

> Abnormalities of inflammatory and hormonal measures are common in

SLE

> patients. Although cognitive dysfunction has been documented in SLE

> patients, the biological mechanism of these deficits has not been

clarified.

> The goal of this study was to explore the relationship between

inflammatory

> and hormonal activity and measures of learning, fluency, and

attention in

> systemic lupus erythematosus patients without neuropsychiatric

symptoms

> (non-CNS-SLE), patients with rheumatoid arthritis (RA), and healthy

controls

> (HC). Fifteen non-CNS-SLE patients, 15 RA patients and 15 HC

participants

> similar in age, education, and gender (female) were compared on

tests of

> cognition, depression, and plasma levels of interleukin-6 (IL-6),

> dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-

S) and

> cortisol. Non-CNS-SLE patients demonstrated lower learning and

poorer

> attention. Furthermore, non-CNS-SLE and RA patients had

significantly lower

> levels of DHEA and DHEA-S than HC participants. Hierarchical

regression

> analysis demonstrates that DHEA-S and IL-6 accounts for a unique

portion of

> the variance in subject performance on measures of learning and

attention

> after controlling for depression and corticosteroid treatment. This

data

> highlights the value of hierarchical analyses with covariates, and

provides

> evidence in humans of a relationship between peripheral cytokine

levels and

> cognitive function.

>

> PMID: 11575596

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=11575596

>

>

>

>

> Not an MD

>

> I'll tell you where to go!

>

> Mayo Clinic in Rochester

> http://www.mayoclinic.org/rochester

>

> s Hopkins Medicine

> http://www.hopkinsmedicine.org

>

[Guest guest]

It's possible. Did you ask your physician about it, ?

Not an MD

I'll tell you where to go!

Mayo Clinic in Rochester

http://www.mayoclinic.org/rochester

s Hopkins Medicine

http://www.hopkinsmedicine.org

[ ] Re: RESEARCH - Inflammatory and hormonal measures

predict neuropsychological functioning in SLE and RA

> So is this an explanation for why I don't know where I am sometimes,

> I hear people talking but don't understand and word they're saying

> and I forget very important things like they never happened?

>

>>

>> J Int Neuropsychol Soc. 2001 Sep;7(6):745-54. Links

>>

>> Inflammatory and hormonal measures predict neuropsychological

> functioning in

>> systemic lupus erythematosus and rheumatoid arthritis patients.

>>

>> National Jewish Medical and Research Center, Denver, Colorado

> 80206, USA.

>> KozoraE@...

>>

>> Abnormalities of inflammatory and hormonal measures are common in

> SLE

>> patients. Although cognitive dysfunction has been documented in SLE

>> patients, the biological mechanism of these deficits has not been

> clarified.

>> The goal of this study was to explore the relationship between

> inflammatory

>> and hormonal activity and measures of learning, fluency, and

> attention in

>> systemic lupus erythematosus patients without neuropsychiatric

> symptoms

>> (non-CNS-SLE), patients with rheumatoid arthritis (RA), and healthy

> controls

>> (HC). Fifteen non-CNS-SLE patients, 15 RA patients and 15 HC

> participants

>> similar in age, education, and gender (female) were compared on

> tests of

>> cognition, depression, and plasma levels of interleukin-6 (IL-6),

>> dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-

> S) and

>> cortisol. Non-CNS-SLE patients demonstrated lower learning and

> poorer

>> attention. Furthermore, non-CNS-SLE and RA patients had

> significantly lower

>> levels of DHEA and DHEA-S than HC participants. Hierarchical

> regression

>> analysis demonstrates that DHEA-S and IL-6 accounts for a unique

> portion of

>> the variance in subject performance on measures of learning and

> attention

>> after controlling for depression and corticosteroid treatment. This

> data

>> highlights the value of hierarchical analyses with covariates, and

> provides

>> evidence in humans of a relationship between peripheral cytokine

> levels and

>> cognitive function.

>>

>> PMID: 11575596

>>

>> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

> db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=11575596