Vitamin D and Suppression??

[Guest guest]

Can you show us an actual study where this was documented in real live

people with HIV, not just a theory about an adverse effect?

So far, from what I can tell -- there is no data I could locate that showed

that Vitamin D supplementation caused any problem that resulted of adverse

immune suppression in people with HIV.

Often theories about effects don't pan out in real live subjects (in vivo)

because of other factors that affect what really happens. (A study detailed

below said that Vitamin D's effects were optimized when calcium was

adequate.)

And what is a large dose, if there are studies on this.

The theory that was stated that testosterone production was inhibited by

Vitamin D does not appear to happen in real live subjects. Again, please

provide some hard data.

In fact, I did find a study that said that Vitamin D was considered to be

" safe and potentially useful.... " in studies with HIV+ subjects.

See: Mondy K; et al. Alendronate, vitamin D, and calcium for the treatment

of osteopenia/osteoporosis associated with HIV infection. J Acquir Immune

Defic Syndr. 2005; 38(4):426-31.

And a study said titled " HIV-protease inhibitors impair vitamin D

bioactivation to 1,25-dihydroxyvitamin D " so PI's can cause bone loss.

Campochiaro, et al. AIDS. 2003; 17(4):513-20. So, people with HIV may need

more Vitamin D to reach optimal levels in the body.

Another study looked at Vitamin D and it's effect on various immune disease

and stated: " Vitamin D is a selective regulator of the immune system, and

the outcome of 1,25(OH)2D3 treatment, vitamin D deficiency, or VDR

deficiency depends on the nature of the immune response (eg, infectious

disease, asthma, or autoimmune disease). An additional factor that

determines the effect of vitamin D status on immune function is dietary

calcium.

This study pointed to calcium status and pointed to calcium status being a

consideration, because low calcium could be involved with Vitamin D's

effects.

Cantorna MT; et al. Vitamin D status, 1,25-dihydroxyvitamin D3, and the

immune system.

Am J Clin Nutr. 2004; 80(6 Suppl):1717S-20S.

Vitamin D is an important immune system regulator. The active form of

vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], has been shown to inhibit

the development of autoimmune diseases, including inflammatory bowel disease

(IBD). Paradoxically, other immune system-mediated diseases (experimental

asthma) and immunity to infectious organisms were unaffected by 1,25(OH)2D3

treatment. There are similar paradoxical effects of vitamin D deficiency on

various immune system functions. Vitamin D and vitamin D receptor (VDR)

deficiency resulted in accelerated IBD. Experimental asthma was unaffected

by 1,25(OH)2D3 treatment and was less severe among VDR-deficient mice.

Vitamin D is a selective regulator of the immune system, and the outcome of

1,25(OH)2D3 treatment, vitamin D deficiency, or VDR deficiency depends on

the nature of the immune response (eg, infectious disease, asthma, or

autoimmune disease). An additional factor that determines the effect of

vitamin D status on immune function is dietary calcium. Dietary calcium has

independent effects on IBD severity. Vitamin D-deficient mice on low-calcium

diets developed the most severe IBD, and 1,25(OH)2D3 treatment of mice on

low-calcium diets improved IBD symptoms. However, the best results for IBD

were observed when the calcium concentration was high and 1,25(OH)2D3 was

administered. Both the type of immune response and the calcium status of the

host determine the effects of vitamin D status and 1,25(OH)2D3 on immunity.

Again, can you provide us with hard data in published studies that shows an

adverse effect happening with Vitamin D supplementation in people with HIV?

Thanks,

Mooney

Message: 3

Date: Sat Jun 3, 2006 3:58 pm (PDT)

From: " nwstuart " nspop2@...

Subject: Re: Vitamin D and " suppression " and testosterone

Vitamin D supplementation has been shown to have beneficial effects for

people with multiple sclerosis, precisely because of its immuno-suprssive

effects.

For those wishing to supress their immune system, large doses of Vitamin D

are ideal. For those HIV+ people opposed to using Interleukin-2 usage to

rebuid their immune system, Vitamin D can help further suppress what remains

of their own natural Interleukin-2 production.