Preservative MArket Update

[Guest guest]

Someone brought this to my attention on another group

- wouldn't you know, I only received the COVER for

this month's issue.

This is very long but makes many interesting pertinent

points.

Preservative Market Update

Happi Magazine May 2008

A high profile health issue puts preservatives in a

good light, but regulators, consumers and many

marketers continue to search for alternatives to

traditional systems.

Tom Branna

Editorial Director

When is bad news really good news? For the embattled

preservative industry, recent news reports about

poorly-preserved skin care products that ultimately

became contaminated and infected hospital patients

have put preservatives in a more positive light.

While consumers clamor for natural cosmetics, the

first focus should always be on safety.

“The biggest issue confronting the preservative market

is the potential for misinformation to impact a

formulator’s choice in product preservation and

imperil consumers,” said Mark , McIntyre.

“Marketing claims are fine – if they’re backed by

safety testing and demonstrated efficacy of

preservative systems via challenge studies in test

formulas. Formulator’s should demand that cosmetic

preservative suppliers provide challenge test data

from a reputable testing lab before using a novel

preservative system.”

It all started in a Barcelona hospital back in

January. Five intensive care patients became infected

with a deadly bacteria called Burkholderia cepacia (B.

cepacia). Officials traced the illness to a

moisturizing body milk used in the patients’ care.

The outbreak occurred at the Universitari del Mar

Hospital in Barcelona, where it was common practice to

apply moisturizer after washing intensive care

patients. The lotion was available from treatment

carts used in the ward. When a number of patients in

nonadjacent beds came down with the same infections,

investigators became suspicious of the treatment cart.

“Those infections were due to inadequately preserved

cosmetics,” observed Steinberg, Steinberg &

Associates, Inc. “You just need one major incident

like what happened in Spain and the cosmetic companies

start rethinking about ‘preservative-free’

formulations. Even many of the NGOs may start

realizing that preservatives are really necessary.”

Mr. Steinberg also noted that there has been

reluctance on the part of formulators to move away

from parabens because they realize parabens work. At

the same time, there are no new preservative systems

are on the horizon.

“The costs are just far too expensive,” he observed.

“Even if you discover a new system and get it

approved, you’ll be attacked by the NGOs. As a result,

very few companies are doing research on new

preservatives for cosmetics.”

Hinden of Arch Chemical warned that as companies

migrate away from traditional preservatives such as

formaldehyde donors, parabens and isothiazolones, the

number of replacements being offered is confusing and

must be carefully screened to ensure that they are

safe and effective.

“Since many simply do not function very well it is

important to work with suppliers that have the

technical resources skilled in art and science of

preservation,” he observed.

In fact, Dean Bostic of Acme-Hardesty called consumer

lack of information on the safety and efficacy of

paraben and paraben blends the biggest issue facing

the preservative industry.

“This is followed very closely by the impending

changes that will occur with REACH and its far

reaching implications for global cosmetic

formulations,” he added.

To overcome these issues, Acme-Hardesty is constantly

educating its customer base with the reality of

paraben safety and efficacy. But Mr. Bostic warned

that the REACH initiative has only made this education

process more difficult.

Will Consumers See the Light?

Nearly every preservative executive contacted by Happi

agreed that consumers’ misconceptions about

preservatives continue to have a negative impact on

the industry.

“The biggest issue confronting the preservative market

are still the misleading reports by some groups

spreading false information and rumors about the risks

and safety of preservatives making the consumer

feeling more and more unsure what to believe and what

to buy,” said Frederic Pilz of Clariant. “Many

well-established and well-investigated preservatives

like the parabens are under attack and some cosmetic

formulators are trying to substitute these safe

substances with trendy ‘green’ or even

‘preservative-free’ alternatives, where safety and

efficacy of these substances are often not known to

the extent of well-known systems.”

To improve paraben profile, Clariant, via EfFCI,

participated in a hearing on parabens in October 2007

at the SCCP in Europe to defend the parabens in

cosmetic products. Colipa and the Cosmetic

Preservative Council (CPC) & #8200;also participated.

Lonza is investigating alternative approaches to

preservation, whether it’s novel synergistic blends

that utilize existing chemistries, botanicals or

technological methods.

“There is an increased demand for controversy-free

preservative systems,” explained Rosita Nunez of

Lonza. “Our customers seek alternatives to traditional

preservative chemistries. The most often cited

requests are paraben-free, non-formaldehyde releasing,

non-IPBC and non-isothiazolinone.”

Sedlewicz of schülke inc., said that consumer

concerns about cosmetic raw materials have had an

increasing effect on global regulation and global

regulation has had similar effect on consumer

concerns.

“Bad news travels fast. The more bad press (accurate

or not) the consumer sees about our industry, the more

manufacturers are influenced to change their

formulations,” said Ms. Sedlewicz. “The same bad press

heightens the sensitivity of regulators, prompting

them to tighten regulations. The consumer sees this as

more evidence that they should avoid certain raw

materials completely.”

Creative Chemistry

Dan Beio of RITA noted that with demand for

“preservative-free” on the rise, many customers are

asking for RITA to get very creative with the

chemistry revolving around its ingredients. RITA is

searching for ways to build preservation activity into

more of its products. This can be done by choosing a

particular class of chemical, such as lactylates,

which have known antimicrobial activity, and combining

them with natural essential extracts. At the same

time, marketers are rethinking product development

when it comes to preservation.

“We see them using less traditional emulsion systems,

which puts heavier burdens on their preservatives, and

moving more toward thickening emulsifiers, like our

Viscolam AT100EF,” said Mr. Beio. “You get the same

emulsifying power of traditional nonionic emulsifiers

with virtually no emulsifiers, which reduces the

requirement of preservatives.”

In a similar manner, Sinerga has improved its

preservative-free claim by using self-preserving

intermediates, explained a Storni.

In today's global market, a health scare involving

body cream in a Barcelona hospital could have

implications for the use of preservatives in the

cosmetic market.

International Specialty Products is tracking any

developments on the different preservative actives

with respect to consumer insistence or changes in

regulations, according to Sangeetha Subramanian of

ISP. “We are working with industry trade organizations

to provide the scientific information and data on

these actives as needed.”

ISP is also generating analytical data on formaldehyde

donors so as to present and communicate the safety of

formaldehyde donors to its customers and consumers.

Many suppliers bemoaned the lack of a comprehensive

preservative regulation that is accepted worldwide.

Executives at Ciba noted, for example, in the U.S.,

there is no positive list while in EU and Japan there

is, making it difficult for new preservatives to be

globally approved.

A Lot of Activity in the EU

Still, Mr. Steinberg said that, overall, regulators

have backed off on their scrutiny of preservatives in

cosmetics. What’s more there may be some relief on the

way in Europe. That’s because the EU has proposed an

8th Amendment to the Cosmetic Directive that

specifically explains what is required of a safety

assessment.

“Microbiology is a part of the 8th Amendment,” noted

Mr. Steinberg, “So that is a positive thing for the

preservative industry.”

Despite this positive move, issues remain in Europe.

Lambros Kromidas of Coty observed that

methyldibromoglutaronitrile is no longer permitted in

cosmetics or on the market as of March 23, 2008, per

the EU’s 41st ATP. Products already on the market must

not be sold to the final consumer/users after June 23,

2008.

In that same ATP, the use of benzoic acid and salts

thereof was changed.

“Benzoic acid may be used in rinse-off products at

2.5% or less, in oral care products at 1.7% or less,

and on leave-on products at 0.5% or less,” said Dr.

Kromidas. “For salts of benzoic acid, like sodium

benzoate and methyl benzoate, they can only be used at

0.5% or less.”

Dr. Kromidas noted too that the 42nd ATP, published

April 17, 2007, amended the use of iodopropynyl

butylcarbamate (IPBC). As a result, it cannot be used

in oral and lip products, or in children’s products

(age three or below) except in bath and rinse-off

products.

In fact, if used in any cosmetic product except bath

and rinse-off, the product must contain the warning

statement, “not to be used for children under three

years of age.” IPBC should also not be used in creams

and lotions aimed to be applied on a large part of the

body. Otherwise, it may be used in rinse-off products

at 0.02% or below, in leave-on products at 0.01% or

below, and in antiperspirants/deodorants at 0.0075% or

below.

Dr. Kromidas also warned that the uproar caused by S.

Oishi that linked parabens to reproductive toxicity

remains fresh in some people’s minds.

That’s why on Feb. 12, 2008, Colipa wrote to DG SANCO

proposing to conduct pharmacokinetic studies to

evaluate the absorption, distribution and elimination

of oral doses of methyl, propyl and butyl parabens in

rats. Two additional studies will examine the fate of

parabens under dermal application and subcutaneous

dosing. All of these studies are seeking to answer

questions raised by the SCCP and hopefully secure a

favorable opinion from the commission about the safety

of parabens.

“The bad publicity with parabens does not end there,”

said Dr. Kromidas. “In January, an Environmental

Health Perspective paper by R. Danovaro and others

claimed that butyl paraben damages coral. This paper

was picked up by the National Geographic website, the

Nature Conservancy and others.”

More Attacks

Although parabens make the biggest headlines, Louis L.

Punto of Jeen Chemical, pointed out that other

preservatives are under attack as well.

“The drive to eliminate phenoxyethanol in Europe is of

concern because phenoxyethanol works so well and is so

frequently used,” explained Mr. Punto. “With the drive

to eliminate parabens and now phenoxyethanol and more

companies having an aversion to using formaldehyde

donors, the formulation chemist will face greater

challenges preserving personal care products which

increasing contain active ingredients prone to

microbial contamination.”

But luckily for the industry, both the Personal Care

Products Council and the CPC have been working to try

to counteract the attacks on preservatives, according

to Ms. Sedlewicz.

“The CPC has addressed these issues through its

consumer website and directly with regulators in

Europe. The CPC has also spoken directly to regulators

in Europe,” she said. “The persistence of these

organizations and others has succeeded in postponing

any decision being made on the banning of long-chain

parabens in Europe. It is a small step, but

significant.”

Mr. Punto agreed that the efforts of the CPC have

provided a lift for the industry.

“The members of CPC are from many companies in the

preservative industry that have joined together to

defend all cosmetic preservatives from regulatory

restrictions or prohibitions,” he noted. “It is an

uphill battle that unfortunately the industry will be

addressing for many years.”

What About Formaldehyde?

Two years ago, Mr. Steinberg formed the CPC. Most

recently, the group has defended the use of isopropyl

parabens in Europe and, in the U.S., is trying to get

the INCI name of formaldehyde changed to methylene

glycol, a move that should relieve some of the

pressure caused by California’s Safe Cosmetic Act,

according to Mr. Steinberg. The Act cites California’s

Prop. 65, which only refers to formaldehyde gas and

does not regulate the use of methylene glycol.

However, the cosmetic industry does not use

formaldehyde gas and as a result, The CPC has

petitioned the Personal Care Product Council to get

the name changed.

of The Council agreed with the CPC

position.

“It’s a valid point. Formaldehyde gas is different

than the formaldehyde used in cosmetic products,” he

told Happi.

Dr. noted that The Council is the custodian of

the INCI process. Yet, it is a process that must

include opportunities for comment from regulatory

authorities.

Some Words on Naturals

Real or imagined, public concern about some

preservative systems has marketers calling for natural

preservation systems. According to Ellen Werner and

Dr. Karla Wilzer of Ciba, there are natural

preservatives, but their efficacy is formulation

dependent. They noted, for example, that Ciba’s

Tinosan SDC silver-based preservative is natural, but

has some limitations when used in highly cationic

systems.

Ms. Sedlewicz noted that batch-to-batch consistency is

very difficult to accomplish in a truly natural

product—and consistency is exactly what is required in

a preservative.

“Synthetic organic acids are used to preserve foods,

making them consumer-friendly alternatives,” said Ms.

Sedlewicz. “The Euxyl K 700-series (K 700, 701, and

702) is based on organic acid chemistry, formulated to

provide broad-spectrum, safe and effective

preservation.”

Mr. Hinden agreed that consistency questions continue

to dog naturals.

“The fundamental issue is what the definition of

‘natural’ is and whether or not they are any safer

than synthetic technologies. Naturals that are based

on botanicals may be subject to a natural variation in

the biomass and resultant composition that may cause

inconsistencies in efficacy, safety and odor,” he

explained.

Dr. Pilz of Clariant had an interesting take on the

natural issue when he called parabens the most

effective and mostly used “natural” preservative.

“Parabens are ubiquitously found in many different

plants and organisms and are also readily

biodegradable; a fact which is normally not

appreciated,” he insisted. “Other natural,

non-classical preservatives often have the

disadvantage that they show relatively low activity

and a narrow anti-microbial spectrum.

Natural preservatives also often have color and odor

issues. As a result, there is no real “natural”

preservative on the market that is broadly being used

or accepted, according to Dr. Pilz.

But there are some suppliers who have embraced the

natural preservative issue.

“Here at Bio-Botanica we can provide our customers

with an all-natural preservative,” explained Ellen

Delisle of Bio-Botanica. “As an alternative to

synthetic preservatives, plant materials are a

significant source of active constituents with a high

level of antimicrobial activity.”

Ms. Delisle insisted that plant components have a

strong scientific validation supporting their active

role as antimicrobials, and she pointed out that many

different plants are already recognized by CAS and

EINECS for their antimicrobial benefits.

“The benefit is having a preservative- free claim on

your label that the consumer perceives as being less

toxic and more beneficial,” she added.

To meet market demand, Bio-Botanica offers three

patented natural preservatives: Suprapein, Biopein

and Neopein. All three are propriety blends of

botanical fractions having anti-microbial activity

against a broad spectrum of organisms, including

possible pathogenic organisms such as S. aureus, E.

coli, Salmonella typhimurim and Candida albacans.

RITA has generated data to show that natural

ingredients can have preservation activity.

“There are essential oils, some extracts, various

glycols and some chemistries that have antimicrobial

activity,” explained Mr. Beio. “The biggest benefits

are their natural names and the comfort level with

consumers. The more natural sounding, the better, and

in the customers’ eyes, that translates into safer

products from an irritation and sensitization

standpoint.”

He warned, however, that these naturals are not as

potent as traditional preservatives and use levels can

often reach “a couple of percent” of a formula.

“At these levels, you not only have to worry about

safety issues, you must look at them as possible

formulation functional ingredients that could effect

aesthetics, stability, odor and color, in addition to

adding cost,” said Mr. Beio.

What’s New from Suppliers?

With the cost of introducing a new preservative

prohibitive, suppliers are taking different tacks when

it comes to new product development. Mr. Bostic of

Acme-Hardesty, for example, noted that Acme/Sharon has

not introduced any new preservatives into the market.

“In fact, the market has not approved any new

molecules and the only introductions occurring are

merely blends of already approved materials,” he

noted. “From this perspective, Acme and Sharon are

very active in the custom blending category to meet

demands.”

Dr. Pilz said Clariant remains confident about the

safety of parabens, safety that has been proven by the

toxicological data and the history of their safe and

broad use.

“Nevertheless, the cosmetic formulator should have a

real choice what kind of preservative he wants to use

and to offer to the consumer,” explained Dr. Pilz.

“Therefore, we have developed two new special and

extremely effective preservative blends based on

Piroctone olamine, which can be seen as substitutes

for all kind of blends containing the long-chain

parabens.”

The new blends Nipaguard POB (phenoxyethanol (and)

piroctone olamine (and) benzoic acid) and Nipaguard

POM (phenoxyethanol (and) piroctone olamine (and)

methylparaben) are said to combine the good efficacies

of the single components to create highly synergistic

and extremely powerful broad-spectrum blends. These

clear liquid blends are easily incorporated in every

kind of formulation even at temperatures as high as

80°C. They are most powerful between a pH value of

4-10 and so they give the utmost freedom of handling

to the formulator. Although the allowed maximum use

concentration is as high as 1.25%, typical use

concentrations of 0.5-0.8% are enough to preserve a

formulation and achieve the best marks in a challenge

test.

Dr. Pilz said even hard to preserve formulations like

sunscreens or wet wipes can be easily preserved with

these effective, though mild, new blends.

“As we expect that piroctone olamine will be listed as

a preservative in the Japanese positive list this

year, formulators will be able to launch their

products globally in the near future,” concluded Dr.

Pilz.

One of the recent additions to the list of globally

approved preservatives is methylisothiazolinone (MIT).

Euxyl K 220, from schülke, combines MIT with

ethylhexylglycerin to boost its efficacy and broaden

the spectrum of antimicrobial activity. The globally

approved combination can be used up to pH 10 in both

leave-on and rinse-off products.

When developing products, RITA looks at the entire

chemistry and starting materials to get as much

functionality out its ingredients as possible.

“With preservatives, we are using as many naturals as

possible mixed with some traditional ingredients to

yield some interesting combinations,” said Mr. Beio.

For example, Ritative SR4L Magnolia is a unique

combination of the natural components of Magnolia

acuminata bark extract with the antimicrobial

chemistry of glyceryl caprylate. This blend is

augmented with phenoxyethanol.

“This gives a nice blend of natural and traditional

ingredients which will give broad spectrum coverage,”

he explained

McIntyre recently introduced two new preservative

systems and one antimicrobial ester at In-Cosmetics.

These patent-pending products are based on a

high-monoester content glyceryl caprylate with

demonstrated efficacy in shampoo, conditioner and skin

lotion formulation challenge studies.

“Of course, the results of these challenge studies are

available to formulators’ complete with formulation

guidelines on use, formulation pH, and heat, to ensure

finished product integrity,” added Mr. .

Antimicrobial Aromatics

ISP has introduced two aromatics that have

antimicrobial properties—Conarom P and Conarom H-3.

Both work over a broad pH range (4-8) and can be used

in both leave-on and rinse-off applications. They can

be labeled as perfume or aroma or with their INCI

names in end-use packaging.

“We have broadened our offering of acid-based

preservative systems,” added Ms. Subramanian.

“Optiphen BSP consists of a combination of

nature-identical benzoic and sorbic acid in

phenoxyethanol. Optiphen BSB-N combines benzoic and

sorbic acid with benzyl alcohol. Both mild

preservatives are effective against bacteria, yeast

and mold at acid pH values. Optiphen BSB-N ingredients

are compliant with Ecocert.”

Three of Lonza’s existing preservatives have been

added to Ecocert’s list of permitted preservatives for

certified organic products: Geogard 111A, Geogard 111S

and Geogard 221.

“We are continuing to work with Ecocert to gain

approval of other preservatives in our portfolio,”

added Ms. Nunez.

Looking for a preservative system for your new

formula? Start with the list below.

Preservative Directory

Here is a list of preservatives available from

suppliers. For more information on the preservatives

listed here, please contact the company at the number

provided.

Acme-Hardesty

Blue Bell, PA

Tel: ,

Methyl Paraben

INCI: methylparaben

Propyl Paraben

INCI: propylparaben

Ethyl Paraben

INCI: ethylparaben

Butyl Paraben

INCI: butylparaben

Sodium Methyl Paraben

INCI: sodium methylparaben

Phenochem

INCI: phenoxyethanol, methylparaben, ethylparaben,

n-butylparaben, propylparaben, iso-butylparaben

Phenoxyethanol

INCI: phenoxyethanol

DMDMH 55%

INCI: dimethyl dimethylol hydantoin (55% aqueous)

Sharomix DMP

INCI: propylene glycol, diazolidinyl urea,

methylparaben, propylparaben

Sharomix DMP II

INCI: propylene glycol, diazolidinyl urea,

methylparaben, propylparaben

Sodium Propylparaben

INCI: sodium propyl paraben

Isobutyl Paraben

INCI: isobutyl paraben

Sharonox 2000

INCI: polyaminopropyl biguanide (PHMB),

phenoxyethanol, methylparaben, propylparaben,

butylparaben, isobutylparaben, propylene glycol

Phenopol

INCI: phenoxyethanol, methylparaben, propylparaben,

ethylparaben, butylparaben, isobutylparaben,

2-bromo-2-nitropropane–1,3 diol, propylene glycol

Arch Personal Care Products, L.P.

South Plainfield, NJ

Tel:

E-mail: archpc@...

Website: www.archpersonalcare.com

Biovert Enzyme & Substrate

INCI: lactoperoxidase and glucose oxidase and glucose

Cosmocil CQ

INCI: polyaminopropyl biguanide

Mikrokill COS

INCI: phenoxyethanol and caprylyl glycol and

chlorphenesin

Mikrokill PCC

INCI: phenoxyethanol and chloroxylenol and caprylyl

glycol

Bio-Botanica, Inc.

Hauppauge, NY

Tel:

Website: www.bio-botanica.com

E-mail: msysler@...

Suprapein

INCI: Origanum vulgare leaf extract, thymus vulgaris

(thyme) extract, cinnamomum zeylancum bark extract,

olea europaea (olive) leaf extract, rosmarinus

officinalis (rosemary) leaf extract, mentha piperita

leaf extract, lavandula angustifolia (lavender) flower

extract, hydrastis canadensis (golden seal) root

extract

Neopein

INCI: Origanum vulgare leaf extract, thymus vulgaris

(thyme) extract, olea europaea (olive) leaf extract,

rosmarinus officinalis (rosemary) leaf extract,

lavandula angustifolia (lavender) flower extract,

hydrastis canadensis (golden seal) root extract

Biopein

INCI: Origanum vulgare leaf extract, thymus vulgaris

(thyme) extract, cinnamomum zeylancum bark extract,

rosmarinus officinalis (rosemary) leaf extract,

lavandula angustifolia (lavender) flower extract,

hydrastis canadensis (golden seal) root extract

Ciba Specialty Chemicals

High Point, NC

Tel:

Website: www.cibasc.com/personalcare

E-mail: personalcare@...

Ciba Tinosan SDC

Clariant Corporation

Mt. Holly, NC

Tel:

Website: www.clariant-personalcare.com

E-mail: personalcare@...

Nipabutyl

INCI: butylparaben

Nipagin A

INCI: ethylparaben

Nipagin M

INCI: methylparaben

Nipasol M

INCI: propylparaben

Nipabutyl Sodium

INCI: sodium butylparaben

Nipagin A Sodium

INCI: sodium ethylparaben

Nipagin M Sodium

INCI: sodium methylparaben

Nipasol M Sodium

INCI: sodium propylparaben

Nipa Biopure 100

INCI: imidazolidinyl urea

Nipa Biopure 200

INCI: diazolidinyl urea

Nipacide BNPD

INCI: 2-bromo-2-nitropropane-1,3-diol

Nipaguard DMDMH

INCI: DMDM hydantoin

Nipaguard SMG

INCI: sodium hydroxymethylglycinate

Phenoxetol

INCI: phenoxyethanol

Propylene Phenoxetol

INCI: phenoxyisopropanol

Nipasept

INCI: methylparaben, ethylparaben, propyl- paraben

Nipastat

INCI: methylparaben, butylparaben, ethylparaben,

propylparaben, isobutylparaben

Nipasept Sodium

INCI: sodium methylparaben, sodium ethyl- paraben,

sodium propylparaben

Nipastat Sodium

INCI: sodium methylparaben, sodium butylparaben,

sodium ethylparaben, sodium propylparaben, sodium

isobutylparaben

Nipacide A

INCI: methylparaben, butylparaben, isobutylparaben

Nipacide A Sodium

INCI: sodium methylparaben, sodium butylparaben,

sodium isobutylparaben

Nipacombin A

INCI: sodium propylparaben, sodium methylparaben,

sodium ethylparaben, sodium benzoates

Nipacombin SK

INCI: sodium propylparaben, sodium butylparaben

Nipaguard BPX

INCI: phenoxyethanol, methylparaben, propylparaben,

2-bromo-2-nitropropane-1,3-diol

Nipaguard CMB

INCI: triethylene glycol, benzyl alcohol, propylene

glycol, methylchloroisothiazolinone and

methylisothiazolinone 3:1

Nipaguard IPF

INCI: PEG-4 laurate, iodopropynyl butylcarbamate

Nipaguard IPP2

INCI: phenoxyethanol, iodopropynyl butylcarbamate

Nipaguard MPA

INCI: benzyl alcohol, methylparaben, propylparaben

Nipaguard MPS

INCI: propylene glycol, methylparaben, propylparaben

Nipaguard PBI

INCI: iodopropynyl butylcarbamate, phenoxyethanol,

bronopol

Nipaguard PDU

INCI: propylene glycol, diazolidinyl urea,

methylparaben, propylparaben

Nipaguard PO 5

INCI: Phenoxyethanol (and) piroctone olamine

Nipaguard POB

INCI: Phenoxyethanol (and) piroctone olamine (and)

benzoic acid

Nipaguard POM

INCI: Phenoxyethanol (and) piroctone olamine (and)

methylparaben

JM ActiCare

INCI: silver chloride, titanium dioxide, diethylhexyl

sodium sulfosuccinate, propylene glycol

Phenonip

INCI: phenoxyethanol, methylparaben, ethylparaben,

butylparaben, propylparaben, isobutylparaben

Phenonip XB

INCI: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) propylparaben

Phenonip ME

INCI: phenoxyethanol (and) methylparaben (and)

ethylparaben

International Specialty Products

Wayne, NJ

Preservatives Technical Services

North America

Tel:

Optiphen BSB-N

(sold under Rokonsal tradename in Europe)

Description: benzyl alcohol (and) glycerin (and)

benzoic acid (and) sorbic acid

Conarom P

Description: phenethyl alcohol (and) caprylyl glycol

(and) trideceth-8

Conarom H-3

Description: PPG-2 methylether (and) piperonal (and)

phenylpropanol

Germall Plus

Description: diazolidinyl urea (and) iodopropynyl

butylcarbamate

Liquid Germall Plus

Description: propylene glycol (and) diazolidinyl urea

(and) iodopropynyl butylcarbamate

LiquaPar Optima

Description: phenoxyethanol (and) methylparaben (and)

isopropylparaben (and) isobutylparaben (and)

butylparaben

LiquaPar PE

Description: phenoxyethanol (and) isopropylparaben

(and) isobutylparaben (and) butylparaben

Germall 115

Description: imidazolidinyl urea

Germall II

Description: diazolidinyl urea

Germaben II and II E

Description: propylene glycol (and) diazolidinyl urea

(and) methylparaben (and) propylparaben

Suttocide A, 50% solution

Description: sodium hydroxymethylglycinate

LiquaPar Oil

Description: isopropylparaben (and) isobutylparaben

(and) butylparaben

Optiphen

Description: phenoxyethanol and caprylyl glycol

Optiphen Plus

Description: phenoxyethanol (and) caprylyl glycol

(and) sorbic acid

Optiphen ND

(sold under Rokonsal tradename in Europe)

Description: phenoxyethanol (and) benzoic acid (and)

dehydroacetic acid

Optiphen MIT Plus

Description: methylisothiazolinone (and) phenethyl

alcohol (and) PPG-2-methyl ether

Optiphen MIT

Description: methylisothiazolinone

Germaben M

Description: diazolidinyl urea (and) methylparaben

(and) propylene glycol

LiquaGard

Description: butylene glycol (and) iodopropynyl

butylcarbamate

LiquaPar PN

Description: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) propylparaben (and) butylparaben

LiquaPar MEP

(sold under Rokonsal tradename in Europe)

Description: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) propylparaben

Jeen International Corp.

Fairfield, NJ

Tel:

Website: www.jeen.com

E-mail: info@...

Jeecide CAP-1

Description: caprylyl glycol, phen-oxyethanol,

hexylene glycol, iodopropynyl butylcarbamate

Jeecide CAP-2

Description: caprylyl glycol, phen- oxyethanol,

hexylene glycol

Jeecide CAP-3

Description: caprylyl glycol, phen- oxyethanol,

propylene glycol, iodopropynyl butylcarbamate

Jeecide CAP-4

Description: caprylyl glycol, phen- oxyethanol

Jeecide CAP-5

Description: phenoxyethanol, caprylyl glycol,

potassium sorbate, water, hexylene glycol

Jeecide PMB

Description: iodopropynyl butylcarbamate, methyl

paraben, butylparaben

Jeecide MP

Description: propylene glycol, methyl paraben and

propylparaben

Jeecide DMDM Hydantoin

Description: DMDM hydantoin

Jeecide IPBC 100%

Description: iodopropyl butyl carbamate

Jeecide IPBC 10%

Description: iodopropyl butyl carbamate

Jeecide U-13

Description: imidazolidinyl urea

Jeecide U-14

Description: diazolidinyl urea

Jeecide P

Description: phenoxyethanol (and) methylparaben (and)

butylparaben (and) propylparaben (and) isobutylparaben

Jeecide G-II

Description: propylene glycol, diazolidinyl urea,

methyl paraben and propyl paraben

Kemira

Northvale, NJ

Tel: or

E-mail: info@...

Website: www.kemira.com

Trisept Complex K

Description: phenoxyethanol, methylparaben,

ethylparaben, propylparaben, butylparaben,

isobutylparaben

Trisept Complex U

Description: phenoxyethanol, methylparaben,

butylparaben, ethylparaben, propylparaben

Trisept Complex HP

Description: phenoxyethanol, hinokitiol

Tristat D

Description: diazolidinyl urea

Tristat D-2

Description: propylene glycol, diazolidinyl urea,

methylparaben, propylparaben

Tristat SDHA

Description: sodium dehydroacetate

Tristat IU

Description: imidazolidinyl urea

Phenoxyethanol

Description: phenoxyethanol

Trisept E

Description: ethyl paraben

Trisept B

Description: butylparaben

Trisept M

Description: methylparaben

Trisept P

Description: propylparaben

Twincide A

Description: phenoxyethanol and benzyl PCA

Twincide PG

Description: phenoxyethanol and benzyl PCA and

propylene glycol

Twincide BG

Description: phenoxyethanol and benzyl PCA and

butylene glycol

Twincide EDG

Description: phenoxyethanol and benzyl PCA and

ethoxydiglycol

Twincide G

Description: phenoxyethanol and benzyl PCA and

glycerin

Twincide MPD

Description: phenoxyethanol and benzyl PCA and

methylpropanediol

Lipo Chemicals, Inc.

Paterson, NJ

Tel:

Website: www.lipochemicals.com

E-mail: salesandmarketinglipochemicals (DOT) com

Liposerve IU

Description: imidazolidinyl urea

Liposerve PP

Description: phenoxyethanol, methylparaben,

butylparaben, ethylparaben, propylparaben

Liposerve DU

Description: diazolidinyl urea

Liposerve DUP

Description: propylene glycol, diazolidinyl urea,

methylparaben, propylparaben

Lonza

dale, NJ

Tel:

E-mail: contact.allendale@...

Website: www.lonza.com

Geogard 111A

Description: dehydroacetic acid

Geogard 111S

Description: sodium dehydroacetate

Geogard 221

Description: dehydroacetic acid and benzyl alcohol

Geogard 361

Description: six-component preservative system

Geogard Ultra

Description: multi-functional powder blend. Patent

still pending in the U.S. and EU

Glydant

Description: dimethylol dimethyl hydantoin

Glydant LTD

Description: dimethylol dimethyl hydantoin (liquid)

Glydant XL-1000

Description: dimethylol dimethyl hydantoin

Glydant 2000

Description: patented dimethylol dimethyl hydantoin

Glydant Plus

Description: patented dimethylol dimethyl hydantoin

and iodopropynyl butyl carbamate (solid)

Glydant Plus Liquid

Description: patented dimethylol dimethyl hydantoin

and iodopropynyl butyl carbamate

Glyacil L

Description: patented iodopropynyl butyl carbamate

(liquid carrier)

Glycacil S

Description: patented iodopropynyl butyl carbamate

(solid carrier)

Glycacil 2000

Description: patented iodopropynyl butylcarbamate

(aqueous form)

Glycacil SG

Description: patented iodopropynyl butylcarbamate

(aqueous form, EPA registered version)

Dantogard

Description: dimethylol dimethyl hydantoin (liquid,

EPA registered version)

Dantogard 2000

Description: patented dimethylol-5,

5-dimethylhydantoin (liquid, EPA registered version)

Dantogard XL-1000

Description: dimethylol dimethyl hydantoin (solid, EPA

registered version)

Dantogard Plus

Description: patented dimethylol dimethyl hydantoin

(and) iodopropynyl butyl carbamate (solid, EPA

registered version)

Dantogard Plus Liquid

Description: patented dimethylol dimethyl hydantoin

(and) iodopropynyl butyl carbamate (EPA registered

version)

Dantoserve SG

Description: patented dimethylol-5, 5

dimethylhydantoin (DMDMH) (and) benzisothiazolinone

Isocil PC

Description: methylchloroisothiazolone/

methylisothiazolone (available outside the U.S.)

Lonzaserve PC

Description: patented methylchloro-

isothiazolone/methylisothiazolone and DMDMH (available

outside the US)

Lonzagard Benzethonium Chloride USP

Description: benzethonium chloride

Lonzabac PC

Description: polyaminopropyl bi-guanide (Europe only)

McIntyre Group

University Park, IL

Tel:

E-mail: infous@...

Website: www.mcintyregroup.com

Phenagon PBD

INCI: phenoxyethanol (and) benzoic acid (and)

dehydroacetic acid

Mackstat GCM

INCI: glyceryl caprylate (and) methylisothiazolinone

Mackaderm GCP

INCI: phenethyl alcohol (and) glyceryl caprylate

RITA Corporation

Crystal Lake , IL

Tel:

E-mail: sales@...

Website: www.ritacorp.com

Ritative SR4L Magnolia

Description: glyceryl caprylate, phenoxyethanol,

magnolia acuminata bark extract

Ritative SR4L

Description: glyceryl caprylate, phenoxyethanol

Ritative SR5

Description: glyceryl caprylate, chlorphenesin,

butylene glycol

Ritalab Duboisia Leaf 100% Extract P

Description: duboisia leaf extract

Ritalab Aspen Bark Extract P

Description: aspen bark extract

Ritalab Ligustrum 100% Extract P

Description: ligustrum extract

Ritative CFS

Description: phenoxyethanol, chlorophenesin, benzoic

acid, sorbic acid, butylene glycol, dipropylene

glycol

Ritative CFS-US

Description: chlorophenesin, benzoic acid,

phenoxyethanol, sorbic acid

Propylparaben NF

Description: propylparaben

Lanodant DM

Description: DMDM hydantoin

Methylparaben NF

Description: methylparaben

Butylparaben NF

Description: butylparaben

Ethylparaben NF

Description: ethylparaben

Ritative AN

Description: sodium coco PG-dimonium chloride and

caprylyl glycol and glyceryl laurate

Ruger Chemical

Linden, NJ

Tel:

Website: www.rugerchemical.com

Email: info@...

Benzoic Acid Crystal

Description: benzoic acid

Butyl Paraben NF

Description: butylparaben

Germaben II

Description: propylene glycol and diazolidinyl Urea

and Methylparaben and Propylparaben

Germaben IIE

Description: propylene glycol and diazolidinyl urea

and methylparaben and propylparaben

Germall II (olidinyl Urea)

Description: diazolidinyl urea

Germall Plus (solid)

Description: DMDM hydantoin and iodopropynyl

butylcarbamate

Glydant Plus (granular)

Description: DMDM hydantoin and iodopropynyl

butylcarbamate

Glydant Plus (liquid)

Description: DMDM hydantoin and iodopropynyl

butylcarbamate

Methyl Paraben NF

Description: methyl paraben

Potassium Benzoate Granular Food Grade

Description: potassium benzoate

Potassium Benzoate Powder Food Grade

Description: potassium benzoate

Potassium Sorbate Granular NF FCC

Description: potassium sorbate

Potassium Sorbate Powder NF FCC

Description: DMDM hydantoin and iodopropynyl

butylcarbamate

Propyl Paraben NF

Description: propyl paraben

Quaternium 15 (Dowicil 200)

Description: quaternium 15

Sodium Benzoate Powder NF FCC

Description: sodium benzoate

Sodium Nitrite Granular Food Grade

Description: sodium nitrite

Sodium Nitrite Granular USP

Description: sodium nitrite

Suttocide 'A' 50% Solution

Description: sodium hydroxymethylglycinate

Schülke & Mayr GmbH

Norderstedt, Germany

Tel: (49) 40 521 00 0

In the U.S.: schülke inc

Tel:

Euxyl PE 9010

Description: phenoxyethanol (and) ethylhexylglycerin

Euxyl K 100

Description: benzyl alcohol (and)

methylchloroisothiazolinone (and)

methylisothiazolinone

Euxyl K 145

Description: water (and)

2-bromo-2-nitropropane-1,3-diol (and) methylchloro-

isothiazolinone (and) methylisothiazolinone

Euxyl K 220

Description: methylisothiazolinone (and)

ethylhexylglycerin

Euxyl K 400

Description: methyldibromo glutaronitrile (and)

phenoxyethanol

Euxyl K 300

Description: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) butylparaben (and) propylparaben

(and) isobutylparaben

Euxyl K 320

Description: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) propylene glycol

Euxyl K 350

Description: phenoxyethanol (and) methylparaben (and)

ethylparaben (and) ethylhexylglycerin (and) propylene

glycol

Euxyl K 500

Description: diazolidinyl urea (and) sodium benzoate

(and) potassium sorbate

Euxyl K 510

Description: DMDM hydantion (and)

methylchloroisothiazolinone (and)

methylisothiazolinone

Euxyl K 701

Description: phenoxyethanol (and) benzoic acid (and)

dehydroacetic acid (and) ethylhexylglycerin

Euxyl K 702

Description: phenoxyethanol (and) benzoic acid (and)

dehydroacetic acid (and) ethylhexylglycerin (and)

polyaminopropyl biguanide

Euxyl K 700

Description: phenoxyethanol (and) benzyl alcohol (and)

potassium sorbate (and) tocopherol

Sinerga S.p.A.

20016 Pero (MI) Italy

Tel: 0039 02 339401.1

E-mail: vendite3@...

Website: www.sinerga.it

Fenilight

INCI: phenetyl alcohol, methyl paraben, propyl

paraben, glycerin

Feniol

INCI: phenetyl alcohol, caprylyl glycol, glycerin

Naticide

INCI: fragrance

Fenossiparaben MPJ

INCI: : phenoxyethanol, methyl paraben, propyl

paraben, glycerin

Fenossiparaben

INCI: phenoxyethanol, methyl paraben, propyl paraben,

ethyl paraben, butyl paraben

Gram 1

INCI: imidazolidinyl urea

Gramcide III

INCI: sodium hydrohymethylglycinate

Gramben II

INCI: diazolidinyl urea, methylparaben, propylparaben,

propylene glycol

MCI-MI

INCI: methylchloroisothiazolinone, methyl-

isothiazolinone

Vertellus Health

& Specialty Products LLC

Indianapolis, IN

Website: www.vertellus.com

ZeStat

Description: cetylpyridinium chloride