Re: pharmaceutical grade DMSO

[Guest guest]

Thanks, Doug. Good info. Saralou

>

> I just obtained a copy of Dr. ' book, " DMSO, The Complete

> Up-to-Date Guidebook' (1993). In it I found interesting that he said the

> only difference between industrial grade DMSO and pharma grade was this:

>

> " Basically, prescription DMSO goes through two procedures that

> " over-the-counter " DMSO doesn't. First it is sterilized by filtration.

> Second, it is pyrogen tested. To sterilize DMSO, the product is passed

> through a very fine filter that removes any particles the size of

> bacteria

> and larger. Most researchers, clinicians and medical professionals

> consulted, questioned the need for sterilization. If you remember DMSO is

> bacteriostatic at concentrations of 35% or above; at these

> concentrations,

> it stops bacteria growth. Pyrogen testing is a costly and time consuming

> procedure. A pyrogen is any substance that causes a fever. To test a

> batch

> of DMSO for pyrogens, laboratory animals treated with the drug and then

> their temperatures are monitored on a regular basis. This procedure is

> felt

> by many to be another instance of FDA " overkill " . Most informed

> authorities

> agree that pyrogen testing is definitely not necessary for DMSO

> intended for

> topical use. Many even question its necessity for DMSO used to treat

> interstitial cystitis by catheter. "

>

> I say to this, if this is true, one can easily filter over-the-counter

> DMSO with .22 micron filter set-ups and save hundreds of dollars.

>

> doug

>

>

[Guest guest]

Excellent Doug !!

in the same manner ... Cooks Illustrated says that the difference between

top-shelf vodka and the worst is a matter of Filtration. Using a cheap Brita

they made top-shelf from the cheapest stuff imaginable. Good idea and I can't

wait to try this on some really smelly DMSO I have. Likely a Zero-Water pitcher

wd be a good investment for me as it filters much better than Brita. ---tls

pharmaceutical grade DMSO

Dr. ' book, " DMSO, The Complete Up-to-Date Guidebook' (1993).

.. he said the only difference between industrial grade DMSO and pharma grade:

" Basically, prescription DMSO goes through two procedures that

" over-the-counter " DMSO doesn't. First it is sterilized by filtration.

Second, it is pyrogen tested. To sterilize DMSO, the product is passed

through a very fine filter that removes any particles the size of bacteria

and larger. Most researchers, clinicians and medical professionals

consulted, questioned the need for sterilization. ...

I say to this, if this is true, one can easily filter over-the-counter

DMSO with .22 micron filter set-ups and save hundreds of dollars.

doug

[Guest guest]

From where does one purchase 22 micron filters ? Prices ?

Obviously, filtration is faster with liquid. One needs to use a sterile spoon

to force the gel through the filter.

How often can the filter be used before needing its own sterilization ?

How long does a filter last before needing to be discarded ?

Bruce Chesley

----- pharmaceutical grade DMSO

Date: Mon, 4 Jun 2012 15:01:13 -0500

I just obtained a copy of Dr. ' book, " DMSO, The Complete

Up-to-Date Guidebook' (1993). In it I found interesting that he said the

only difference between industrial grade DMSO and pharma grade was this:

" Basically, prescription DMSO goes through two procedures that

" over-the-counter " DMSO doesn't. First it is sterilized by filtration.

Second, it is pyrogen tested. To sterilize DMSO, the product is passed

through a very fine filter that removes any particles the size of bacteria

and larger. Most researchers, clinicians and medical professionals

consulted, questioned the need for sterilization. If you remember DMSO is

bacteriostatic at concentrations of 35% or above; at these concentrations,

it stops bacteria growth. Pyrogen testing is a costly and time consuming

procedure. A pyrogen is any substance that causes a fever. To test a batch

of DMSO for pyrogens, laboratory animals treated with the drug and then

their temperatures are monitored on a regular basis. This procedure is felt

by many to be another instance of FDA " overkill " . Most informed authorities

agree that pyrogen testing is definitely not necessary for DMSO intended for

topical use. Many even question its necessity for DMSO used to treat

interstitial cystitis by catheter. "

I say to this, if this is true, one can easily filter over-the-counter

DMSO with .22 micron filter set-ups and save hundreds of dollars.

doug

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[Guest guest]

Just throwing this 'out here'... I wonder if using natural processed paper

coffee filters might be a better choice to filter the DMSO? I wonder if

the coffee filters would filter as fine as other options? Lola

> **

>

>

> Excellent Doug !!

> in the same manner ... Cooks Illustrated says that the difference between

> top-shelf vodka and the worst is a matter of Filtration. Using a cheap

> Brita they made top-shelf from the cheapest stuff imaginable. Good idea and

> I can't wait to try this on some really smelly DMSO I have. Likely a

> Zero-Water pitcher wd be a good investment for me as it filters much better

> than Brita. ---tls

>

>

> pharmaceutical grade DMSO

>

> Dr. ' book, " DMSO, The Complete Up-to-Date Guidebook'

> (1993).

> .. he said the only difference between industrial grade DMSO and pharma

> grade:

>

>

> " Basically, prescription DMSO goes through two procedures that

> " over-the-counter " DMSO doesn't. First it is sterilized by filtration.

> Second, it is pyrogen tested. To sterilize DMSO, the product is passed

> through a very fine filter that removes any particles the size of bacteria

> and larger. Most researchers, clinicians and medical professionals

> consulted, questioned the need for sterilization. ...

>

>

> I say to this, if this is true, one can easily filter over-the-counter

> DMSO with .22 micron filter set-ups and save hundreds of dollars.

>

> doug

>

>

[Guest guest]

a gold mesh filter w/ a paper ones inside might do it ..

If you like how this works, please post abt it. -- tls

Re: pharmaceutical grade DMSO

Just throwing this 'out here'... I wonder if using natural processed paper

coffee filters might be a better choice to filter the DMSO? I wonder if

the coffee filters would filter as fine as other options? Lola

[Guest guest]

There are a number of laboratory filter systems that one can use. Ebay is

some times a cheap place to find them. I would use either a syringe filter,

a 47mm filter holder syringe system set up or a media jar filtration vacuum

filter set up. Scroll down to the bottom of this page:

http://www.racehorseherbal.com/phpbb/viewtopic.php?f=9 & t=66

and you see two types of filters I use.

Depends on how dirty they get to when they can be reused or discarded.

doug

Re: pharmaceutical grade DMSO

> From where does one purchase 22 micron filters ? Prices ?

> Obviously, filtration is faster with liquid. One needs to use a sterile

> spoon to force the gel through the filter.

> How often can the filter be used before needing its own sterilization ?

> How long does a filter last before needing to be discarded ?

> Bruce Chesley

[Guest guest]

No, not fine enough. You should use at least a .22 micron filter as used in

labs.

doug

Re: pharmaceutical grade DMSO

> Just throwing this 'out here'... I wonder if using natural processed paper

> coffee filters might be a better choice to filter the DMSO? I wonder if

> the coffee filters would filter as fine as other options? Lola

[Guest guest]

Great info Doug, thanks so much for posting this. I have never had any sense

that the DMSO I buy for my horses is in any way problematic. My large animal vet

uses this grade of DMSO for direct venous infusion in dogs. Apparently he feels

it is pure enough to put directly into the blood stream.

I am curious to know what you thought of the book? I have only read DMSO

Nature's Healer and MSM the Definitive Guide. Can you give us a short book

report when you have time?

Thanks again!

Janet

>

> I just obtained a copy of Dr. ' book, " DMSO, The Complete

> Up-to-Date Guidebook' (1993). In it I found interesting that he said the

> only difference between industrial grade DMSO and pharma grade was this:

>

> " Basically, prescription DMSO goes through two procedures that

> " over-the-counter " DMSO doesn't. First it is sterilized by filtration.

> Second, it is pyrogen tested. To sterilize DMSO, the product is passed

> through a very fine filter that removes any particles the size of bacteria

> and larger. Most researchers, clinicians and medical professionals

> consulted, questioned the need for sterilization. If you remember DMSO is

> bacteriostatic at concentrations of 35% or above; at these concentrations,

> it stops bacteria growth. Pyrogen testing is a costly and time consuming

> procedure. A pyrogen is any substance that causes a fever. To test a batch

> of DMSO for pyrogens, laboratory animals treated with the drug and then

> their temperatures are monitored on a regular basis. This procedure is felt

> by many to be another instance of FDA " overkill " . Most informed authorities

> agree that pyrogen testing is definitely not necessary for DMSO intended for

> topical use. Many even question its necessity for DMSO used to treat

> interstitial cystitis by catheter. "

>

> I say to this, if this is true, one can easily filter over-the-counter

> DMSO with .22 micron filter set-ups and save hundreds of dollars.

>

> doug

>

[Guest guest]

Janet,

Yeah, ' book is rather obscure and wildly expensive in the used

book shops online. I have been looking for a cheap copy for years and

finally found one a few weeks ago. I would say that DMSO, NATURE " S HEALER is

the best book. book is a thin paperback of 77 or so pages and

covers about the same thing that s book does. However, I did get a few

tidbits from this book of which the difference between pharma and industrial

grade DMSO was one. I suspect he might be right. Filtering is probably the

main procedure that separates the two and how it is handled after it is

filtered.

has an excellent piece on using DMSO for frostbite which I

found very interesting as I occasionally have to deal with frostbite calves

dropped in late winter. He wrote:

" DMSO's first major use was to act as a type of antifreeze to preserve

tissue. Keeping this in mind, it should come as no surprise that it can

perform miracles on frostbitten tissue. In one animal study, if DMSO was

applied prior to the tissue freeze, damage was practically nonexistent.

Amazingly, humans using DMSO up to 24 hours after the freeze showed total

recovery without any gangrene or necessity for amputation. DMSO should be

applied within 12-24 hours of the freezing, however, it works even better if

applied before freezing. A 70-90% solution seems to work best prior to a

freeze. In acute incidents when it is necessary to apply the DMSO after the

freeze, a soak may be indicated. "

goes on to say that DMSO may be very helpful for orchard growers

when frost comes around. Spraying the fruit or young plants with .5%

solution of DMSO has saved plants experiencing 4 hours of 20*F weather.

Interesting!!

may have covered the same thing, but I don't recall it.

I guess that is about it. Not a too bad of a little book, but not worth

the price they are asking in most cases. Stick with !

doug

Re: pharmaceutical grade DMSO

>

> Great info Doug, thanks so much for posting this. I have never had any

> sense that the DMSO I buy for my horses is in any way problematic. My

> large animal vet uses this grade of DMSO for direct venous infusion in

> dogs. Apparently he feels it is pure enough to put directly into the blood

> stream.

>

> I am curious to know what you thought of the book? I have only read DMSO

> Nature's Healer and MSM the Definitive Guide. Can you give us a short book

> report when you have time?

>

> Thanks again!

>

> Janet